Clozapine



Indications and Reactions:

Role Indications Reactions
Primary
Schizophrenia 55.8%
Schizoaffective Disorder 9.1%
Schizophrenia, Paranoid Type 8.5%
Psychotic Disorder 7.1%
Depression 3.0%
Bipolar Disorder 2.6%
Hypertension 1.5%
Anxiety 1.5%
Product Used For Unknown Indication 1.4%
Constipation 1.2%
Parkinson's Disease 1.1%
Diabetes Mellitus 1.0%
Salivary Hypersecretion 1.0%
Insomnia 0.9%
Affective Disorder 0.8%
Agitation 0.8%
Dementia 0.7%
Hypothyroidism 0.7%
Asthma 0.6%
Epilepsy 0.6%
Granulocytopenia 24.1%
Death 23.8%
Leukopenia 10.9%
White Blood Cell Count Decreased 3.8%
Pneumonia 3.7%
Treatment Noncompliance 3.2%
Myocardial Infarction 3.1%
White Blood Cell Count Increased 3.0%
Psychotic Disorder 2.6%
Unevaluable Event 2.6%
Vomiting 2.4%
Pyrexia 2.3%
Urinary Tract Infection 2.2%
Neutrophil Count Decreased 2.0%
Neutropenia 1.9%
Pre-existing Disease 1.9%
Weight Increased 1.8%
Lung Neoplasm Malignant 1.6%
Neoplasm Malignant 1.6%
Tachycardia 1.5%
Secondary
Schizophrenia 29.4%
Product Used For Unknown Indication 24.5%
Schizophrenia, Paranoid Type 9.0%
Psychotic Disorder 5.7%
Drug Use For Unknown Indication 5.6%
Schizoaffective Disorder 4.2%
Depression 3.3%
Hypertension 2.9%
Bipolar Disorder 2.4%
Constipation 1.9%
Drug Abuse 1.6%
Anxiety 1.5%
Diffuse Large B-cell Lymphoma 1.4%
Hypothyroidism 1.1%
Blood Cholesterol Increased 1.1%
Ill-defined Disorder 1.0%
Non-hodgkin's Lymphoma Unspecified Histology Aggressive 1.0%
Agitation 0.8%
Parkinson's Disease 0.8%
Urinary Tract Infection 0.8%
Granulocytopenia 19.6%
Leukopenia 13.5%
Death 7.6%
White Blood Cell Count Decreased 6.5%
Neutropenia 5.5%
Tremor 5.1%
White Blood Cell Count Increased 5.0%
Weight Increased 4.2%
Psychotic Disorder 3.8%
Vomiting 3.2%
Pyrexia 3.0%
Somnolence 2.9%
Overdose 2.9%
Suicide Attempt 2.9%
Tachycardia 2.6%
Thrombocytopenia 2.5%
Drug Interaction 2.4%
Neutrophil Count Decreased 2.4%
Pneumonia 2.4%
Agranulocytosis 2.2%
Concomitant
Product Used For Unknown Indication 32.4%
Schizophrenia 16.3%
Drug Use For Unknown Indication 10.8%
Depression 6.8%
Bipolar Disorder 4.1%
Schizophrenia, Paranoid Type 3.9%
Parkinson's Disease 3.9%
Psychotic Disorder 3.9%
Anxiety 3.2%
Hypertension 1.9%
Schizoaffective Disorder 1.9%
Diabetes Mellitus 1.5%
Pain 1.5%
Cardiac Disorder 1.2%
Insomnia 1.2%
Sleep Disorder 1.2%
Epilepsy 1.1%
Smoking Cessation Therapy 1.1%
Salivary Hypersecretion 1.1%
Back Pain 1.0%
Overdose 11.4%
Weight Increased 9.3%
Vomiting 8.8%
White Blood Cell Count Decreased 7.9%
Neuroleptic Malignant Syndrome 5.6%
White Blood Cell Count Increased 4.9%
Somnolence 4.6%
Type 2 Diabetes Mellitus 4.6%
Death 4.4%
Neutropenia 4.4%
Psychotic Disorder 4.4%
Tremor 4.4%
Granulocytopenia 3.7%
Schizophrenia 3.5%
Drug Interaction 3.2%
Treatment Noncompliance 3.2%
Tachycardia 3.0%
Weight Decreased 3.0%
Hyponatraemia 2.8%
Paranoia 2.8%
Interacting
Product Used For Unknown Indication 28.7%
Schizophrenia 16.7%
Drug Use For Unknown Indication 11.0%
Schizophrenia, Paranoid Type 10.1%
Obsessive-compulsive Disorder 3.4%
Constipation 3.3%
Salivary Hypersecretion 3.0%
Psychotic Disorder 2.9%
Rheumatoid Arthritis 2.5%
Gastrooesophageal Reflux Disease 2.2%
Bipolar Disorder 2.1%
Hepatitis C 1.9%
Non-hodgkin's Lymphoma Unspecified Histology Aggressive 1.9%
Schizoaffective Disorder 1.8%
Anxiety 1.6%
Insomnia 1.6%
Schizophrenia, Catatonic Type 1.6%
Aggression 1.5%
Agitation 1.1%
Depression 1.1%
Drug Interaction 20.3%
Drug Level Increased 6.5%
Grand Mal Convulsion 6.5%
Neutropenia 5.5%
Psychotic Disorder 5.1%
Toxicity To Various Agents 5.1%
White Blood Cell Count Decreased 5.1%
Cough 4.6%
Decreased Appetite 4.6%
Asterixis 4.1%
Diarrhoea 4.1%
Restlessness 4.1%
Dystonia 3.7%
Lymphocyte Count Decreased 3.7%
Urinary Tract Infection 3.7%
Repetitive Speech 3.2%
Rhabdomyolysis 2.8%
Somnolence 2.8%
Antipsychotic Drug Level Increased 2.3%
Depressed Mood 2.3%