Clozapine combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Diabetes Mellitus Insulin-dependent Hospitalization 11/4/2005 39 Male 1/17/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Respiratory Disorder Death 12/26/2005 63 Male 1/16/2006 United States
Primary
Concomitant
Diabetes Mellitus Insulin-dependent Hospitalization 10/4/2005 39 Male 1/12/2006 United Kingdom
Primary
Secondary
Concomitant
Death Death 12/20/2005 76 Male 1/19/2006 United States
Primary
Concomitant
Mental Status Changes Other Serious 9/14/2005 44 Male 135 lb 1/26/2006 Pharmacist United States
Primary
Secondary
Concomitant
Treatment Noncompliance Other Serious 8/1/2004 42 Male 1/30/2006 United States
Primary
Concomitant
Mental Impairment Other Serious 8/1/2003 42 Male 2/6/2006 Other Health Professional United States
Primary
Concomitant
Mental Status Changes Other Serious 9/14/2005 44 Male 135 lb 2/13/2006 Pharmacist United States
Primary
Secondary
Concomitant
Urinary Tract Infection Life Threatening 1/12/2006 76 Male 2/14/2006 Physician Netherlands
Primary
Concomitant
Respiratory Disorder Death 12/26/2005 63 Male 2/16/2006 United States
Primary
Concomitant
Troponin Increased Death 2/6/2006 58 Male 198 lb 3/3/2006 United Kingdom
Primary
Concomitant
Neutropenia Other Serious 2/22/2005 38 Male 245 lb 4/1/2005 Pharmacist United States
Primary
Concomitant
Mental Status Changes Other Serious 9/14/2005 44 Male 135 lb 12/14/2005 Physician United States
Primary
Secondary
Concomitant
Sudden Death Death 2/28/2006 72 Male 3/22/2006 United States
Primary
Concomitant
Sudden Death Death 3/1/2006 72 Male 4/7/2006 United States
Primary
Concomitant
Post Procedural Complication Death 2/1/2006 53 Male 5/1/2006 United States
Primary
Concomitant
Neutrophil Count Decreased Other Serious 3/14/2006 49 Male 212 lb 5/8/2006 United States
Primary
Concomitant
Posturing Life Threatening 3/21/2006 Male 5/17/2006 Pharmacist United States
Primary
Concomitant
Hypertension Death 4/1/2006 46 Female 5/19/2006 United States
Primary
Concomitant
Vomiting Hospitalization 2/22/2006 46 Male 5/26/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 1/17/2006 45 Male 5/17/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/13/2005 33 Male 5/15/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/3/2005 42 Male 1/25/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/12/2005 51 Female 2/27/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/18/2005 56 Female 5/16/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/26/2005 53 Female 132 lb 2/8/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/11/2005 46 Female 2/7/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 4/19/2006 62 Male 180 lb 6/21/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/6/2006 47 Male 4/18/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 3/8/2006 61 Female 4/10/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 3/13/2006 73 Male 5/19/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/13/2005 58 Male 1/9/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/15/2005 54 Male 198 lb 1/9/2006 United States
Primary
Concomitant
Renal Failure Life Threatening 2/22/2006 46 Male 9/21/2006 United Kingdom
Primary
Secondary
Concomitant
Vomiting Life Threatening 2/22/2006 46 Male 10/5/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 3/14/2006 49 Male 212 lb 10/4/2006 United States
Primary
Concomitant
Renal Failure Acute Life Threatening 2/22/2006 46 Male 10/12/2006 United Kingdom
Primary
Secondary
Concomitant
Vomiting Life Threatening 2/22/2006 46 Male 10/24/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Life Threatening 2/22/2006 46 Male 11/3/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Psychotic Disorder Required Intervention 35 Male 11/7/2006 United States
Primary
Concomitant
Postictal State Other Serious 7/13/2006 42 Female 1/3/2007 United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 11/28/2006 44 Male 2/21/2007 United States
Primary
Secondary
Concomitant
Sudden Death Hospitalization 12/31/2006 74 Female 2/12/2007 Physician United States
Primary
Concomitant
Sepsis Hospitalization 2/1/2007 47 Male 154 lb 4/3/2007 Other Health Professional United Kingdom
Primary
Concomitant
Sudden Death Hospitalization 12/31/2006 74 Female 4/2/2007 Physician United States
Primary
Concomitant
Sepsis Hospitalization 2/1/2007 47 Male 154 lb 4/17/2007 Other Health Professional United Kingdom
Primary
Concomitant
Pyrexia Hospitalization 1/30/2007 58 Female 4/20/2007 Finland
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/14/2006 49 Male 212 lb 4/23/2007 United States
Primary
Concomitant
Pyrexia Hospitalization 1/30/2007 58 Female 5/2/2007 Finland
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/14/2006 49 Male 212 lb 5/17/2007 United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/14/2006 49 Male 212 lb 5/31/2007 United States
Primary
Concomitant
Leukocytosis 5/23/2007 60 Male 169 lb 5/31/2007 Pharmacist United States
Primary
Concomitant
Psychotic Disorder Death 6/1/2007 Male 195 lb 10/18/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Acute Life Threatening 2/22/2006 10/24/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Life Threatening 2/22/2006 10/31/2007 United Kingdom
Primary
Secondary
Concomitant
Myocardial Infarction Death Male 6/12/2008 United States
Primary
Concomitant
Obesity Other Serious 6/12/2008 Female 322 lb 8/7/2008 Other Health Professional United Kingdom
Primary
Concomitant
Staphylococcal Sepsis Hospitalization 9/1/2008 Male 10/22/2008 Physician United States
Primary
Concomitant
Accidental Exposure Other Serious 51 Male 12/29/2008 Other Health Professional Germany
Primary
Secondary
Accidental Exposure Other Serious 51 Male 12/29/2008 Other Health Professional Germany
Primary
Secondary
Suicidal Ideation 1/14/2008 Female 232 lb 7/30/2008 Pharmacist United States
Primary
Concomitant
Asthma Life Threatening 1/12/2009 Female 172 lb 3/10/2009 Other Health Professional Germany
Primary
Concomitant
Asthma Life Threatening 50 Female 172 lb 3/16/2009 Physician Germany
Primary
Concomitant
Asthma Life Threatening 1/12/2009 50 Female 172 lb 3/18/2009 Physician Germany
Primary
Concomitant
Heat Stroke Hospitalization 4/27/2009 Male 6/18/2009 Physician United States
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 5/12/2007 6/19/2009 Other Health Professional Sweden
Primary
Secondary
Concomitant
Craniotomy Other Serious 12/9/2008 57 Female 6/26/2009 Other Health Professional United Kingdom
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious Male 7/1/2009 United States
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 5/12/2007 41 Female 6/29/2009 Sweden
Primary
Secondary
Concomitant
Craniotomy Other Serious 12/9/2008 57 Female 7/7/2009 United Kingdom
Primary
Secondary
Concomitant
Anaemia 4/30/2009 Female 180 lb 7/30/2009 Physician United States
Primary
Concomitant
Jaundice Hospitalization 5/26/2009 Male 8/13/2009 Other Health Professional France
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 5/12/2007 42 Female 8/13/2009 Other Health Professional Sweden
Primary
Secondary
Concomitant
Somnolence Other Serious 3/29/2009 29 Male 9/16/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vision Blurred Other Serious 3/15/2006 38 Female 230 lb 9/23/2009 United States
Primary
Concomitant
Embolism Venous Death 34 Female 9/24/2009 Other Health Professional United Kingdom
Primary
Concomitant
Non-cardiac Chest Pain Other Serious 8/30/2009 31 Male 10/6/2009 Other Health Professional United Kingdom
Primary
Concomitant
Platelet Count Decreased Hospitalization 7/31/2009 52 Male 10/6/2009 Other Health Professional United Kingdom
Primary
Concomitant
Syncope Hospitalization 7/31/2009 52 Male 10/13/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Syncope Hospitalization 7/31/2009 52 Male 10/14/2009 Other Health Professional France
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 2/17/2009 39 Male 10/23/2009 Other Health Professional United Kingdom
Primary
Secondary
White Blood Cell Count Increased Other Serious 2/17/2009 39 Male 10/26/2009 Other Health Professional United Kingdom
Primary
Secondary
White Blood Cell Count Increased Other Serious 2/17/2009 39 Male 11/4/2009 Other Health Professional United Kingdom
Primary
Secondary
Syncope Other Serious 7/31/2009 52 Male 11/10/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Salivary Hypersecretion Hospitalization 7/31/2009 52 Male 11/10/2009 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 2/17/2009 39 Male 11/10/2009 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 7/31/2009 52 Male 11/17/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Syncope Life Threatening 7/31/2009 52 Male 11/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Syncope Life Threatening 7/31/2009 52 Male 11/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Syncope Hospitalization 7/31/2009 52 Male 11/13/2009 United Kingdom
Primary
Concomitant
Hyponatraemia Hospitalization 7/31/2009 52 Male 11/19/2009
Primary
Secondary
Concomitant
Respiratory Disorder Hospitalization 69 Female 11/30/2009 Other Health Professional United Kingdom
Primary
Secondary
White Blood Cell Count Increased Other Serious 2/17/2009 39 Male 11/30/2009 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Syncope Hospitalization 7/31/2009 52 Male 12/8/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ultrafiltration Failure Other Serious 1/1/2009 74 Male 12/23/2009 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 2/17/2009 39 Male 12/18/2009 Pharmacist United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 2/17/2009 39 Male 12/28/2009 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Syncope Hospitalization 7/31/2009 52 Male 1/8/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2003 47 Male 257 lb 1/13/2010 United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 2/17/2009 39 Male 1/4/2010 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Respiratory Disorder Other Serious 69 Female 1/7/2010
Primary
Secondary
Concomitant
Somnolence Other Serious 3/25/2009 29 Male 1/22/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 2/17/2009 39 Male 1/16/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Treatment Noncompliance Other Serious 8/12/2009 Female 129 lb Pharmacist United States
Primary
Concomitant
Restlessness Other Serious Male 3/3/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Restlessness Other Serious 41 Male 3/5/2010 Other Health Professional France
Primary
Secondary
Concomitant
Drug Level Increased Life Threatening 3/3/2010 40 Male 254 lb 4/14/2010 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Sinus Tachycardia Other Serious 19 Male 4/30/2010 Other Health Professional France
Primary
Secondary
Concomitant
Drug Level Increased Life Threatening 3/3/2010 40 Male 254 lb 5/3/2010 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Drug Level Increased Other Serious 11/24/2009 49 Male 250 lb 5/7/2010 Other Health Professional United States
Primary
Concomitant
Interacting
Sedation Other Serious 11/24/2009 49 Male 269 lb 5/14/2010 Consumer United States
Primary
Secondary
Concomitant
Interacting
White Blood Cell Count Increased Other Serious 11/10/2009 42 Male 5/17/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 44 Male 95 lb 5/27/2010 Consumer United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/26/2010 49 Female 5/27/2010 Other Health Professional France
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/2/2010 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 44 Male 95 lb 6/3/2010 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 44 Male 95 lb 6/3/2010 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 44 Male 95 lb 6/7/2010 Consumer United Kingdom
Primary
Concomitant
Vomiting Hospitalization 44 Male 6/10/2010 United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/26/2010 49 Female 6/23/2010 Other Health Professional France
Primary
Secondary
Concomitant
Granulocytopenia Other Serious 5/7/2009 51 Female 6/24/2010 United States
Primary
Concomitant
Death Death 64 Male 6/24/2010 Pharmacist United States
Primary
Concomitant
Leukopenia Other Serious 22 Male 450 lb 6/24/2010 Pharmacist United States
Primary
Concomitant
Staphylococcal Infection Other Serious 49 Male 290 lb 6/24/2010 Pharmacist United States
Primary
Concomitant
Granulocytopenia Other Serious 7/7/2009 80 Female 125 lb 6/24/2010 Pharmacist United States
Primary
Concomitant
Myocardial Infarction Death 65 Female 6/24/2010 Pharmacist United States
Primary
Concomitant
Granulocytopenia Other Serious 10/6/2009 47 Male 6/24/2010 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/15/2009 60 Female 6/24/2010 Other Health Professional United States
Primary
Concomitant
Death Death 1/26/2010 65 Male 6/24/2010 Pharmacist United States
Primary
Concomitant
Death Death 2/10/2010 56 Male 6/24/2010 Pharmacist United States
Primary
Concomitant
Leukopenia Other Serious 3/18/2010 58 Male 6/24/2010 Pharmacist United States
Primary
Concomitant
Vomiting Hospitalization 44 Male 95 lb 6/28/2010 Consumer United Kingdom
Primary
Concomitant
Vomiting Hospitalization 44 Male 6/24/2010 United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 2/1/2010 33 Male 7/2/2010 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/7/2010 19 Male 7/12/2010 Other Health Professional France
Primary
Secondary
Concomitant
Fall Other Serious 6/1/2010 58 Male 184 lb 7/14/2010 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 44 Male 7/15/2010 United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/26/2010 49 Female 8/17/2010 Other Health Professional France
Primary
Secondary
Concomitant
Overdose Death 51 Female 8/24/2010 Pharmacist United States
Primary
Concomitant
Tardive Dyskinesia Hospitalization 1/1/2009 74 Male 9/14/2010 Pharmacist Switzerland
Primary
Secondary
Concomitant
Drug Level Increased Life Threatening 3/3/2010 40 Male 254 lb 9/16/2010 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Fall Other Serious 6/1/2010 58 Male 184 lb 9/16/2010 Other Health Professional United Kingdom
Primary
Concomitant
Vision Blurred Other Serious 3/15/2006 38 Female 230 lb 9/20/2010 United States
Primary
Concomitant
Refusal Of Treatment By Patient 9/21/2010 51 Female 149 lb 10/7/2010 Pharmacist United States
Primary
Concomitant
Paranoia Other Serious 9/25/2010 38 Male 192 lb 10/29/2010 Other Health Professional United Kingdom
Primary
Concomitant
Off Label Use Death Male 10/20/2010 Other Health Professional Denmark
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 9/25/2010 67 Female 185 lb 11/2/2010 Other Health Professional United Kingdom
Primary
Concomitant
Paranoia Disability 9/25/2010 38 Male 192 lb 11/2/2010 Other Health Professional United Kingdom
Primary
Concomitant
Paranoia Disability 9/25/2010 11/3/2010 Other Health Professional United Kingdom
Primary
Concomitant
Paranoia Disability 38 Male 192 lb 10/26/2010 United Kingdom
Primary
Concomitant

Drug Data