Clozapine combined with Depakote

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Myositis Other Serious 1/25/2006 France
Primary
Secondary
Concomitant
Pyrexia Life Threatening 7/8/2005 47 Male 193 lb 1/13/2006 Physician United States
Primary
Concomitant
Neutropenia Hospitalization 10/10/2005 40 Male 212 lb 2/16/2006 Other Health Professional United States
Primary
Concomitant
Fall Hospitalization 1/15/2006 Female 2/24/2006 Other Health Professional United States
Primary
Secondary
White Blood Cell Count Decreased Life Threatening 7/8/2005 47 Male 193 lb 2/5/2006 Physician United States
Primary
Concomitant
Drug Ineffective Hospitalization 2/25/2005 45 Male 6/20/2005 Physician United States
Primary
Concomitant
Diabetic Ketoacidosis Other Serious 4/22/2005 26 Male 257 lb 6/27/2005 Physician United States
Primary
Concomitant
Suicidal Ideation Hospitalization 4/1/2005 46 Male 5/13/2005 Physician United States
Primary
Concomitant
Agranulocytosis Required Intervention 3/17/2005 59 Female 160 lb 4/27/2005 Physician United States
Primary
Concomitant
Somnolence Other Serious 12/22/2004 44 Female 1/11/2005 Other Health Professional United States
Primary
Secondary
Concomitant
Mania Hospitalization 2/1/2002 55 Male 5/10/2005 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Other Serious 9/30/2004 44 Male 11/29/2004 Physician United States
Primary
Concomitant
Psychotic Disorder Hospitalization 11/1/2004 39 Female 12/20/2004 Other Health Professional United States
Primary
Concomitant
Gastrointestinal Disorder Hospitalization 7/1/2005 51 Female 185 lb 8/1/2005 Other Health Professional United States
Primary
Concomitant
Staphylococcal Infection Required Intervention 11/2/2004 44 Male 1/25/2005 Physician United States
Primary
Concomitant
Granulocytopenia Other Serious 5/27/2005 27 Male 134 lb 6/7/2005 Pharmacist United States
Primary
Concomitant
Myocardial Infarction Required Intervention 12/28/2004 61 Male 207 lb 2/15/2005 Physician United States
Primary
Concomitant
Pulmonary Embolism Death 1/6/2005 25 Female 2/2/2005 Pharmacist United States
Primary
Concomitant
Neutropenia Other Serious 1/14/2005 44 Female 2/8/2005 Pharmacist United States
Primary
Concomitant
Agranulocytosis Required Intervention 12/17/2004 41 Male 1/18/2005 Other Health Professional United States
Primary
Concomitant
Leukocytosis Hospitalization 6/1/2004 40 Male 12/28/2004 Physician United States
Primary
Concomitant
Mental Disorder Hospitalization 11/24/2005 26 Male 4/12/2006 United States
Primary
Secondary
Sepsis Life Threatening 3/24/2006 22 Male 287 lb 5/15/2006 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased 2/14/2006 62 Male 177 lb 5/16/2006 Pharmacist United States
Primary
Concomitant
Granulocytopenia Required Intervention 7/25/2005 17 Female 180 lb 1/10/2006 United States
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 1/19/2006 43 Male 6/2/2006 Pharmacist United States
Primary
Secondary
Respiratory Failure Death 9/19/2005 31 Male 375 lb 6/5/2006 Physician France
Primary
Secondary
Concomitant
Convulsion Death 3/8/2006 Female 150 lb 6/8/2006 Physician United States
Primary
Secondary
Granulocytopenia 50 Female 6/29/2006 Physician United States
Primary
Concomitant
Death Death 6/27/2006 77 Female 7/13/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/25/2006 43 Male 150 lb 3/21/2006 United States
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 12/1/2005 44 Male 163 lb 6/30/2006 United States
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 12/6/2005 50 Male 201 lb 3/7/2006 Consumer United States
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 11/1/2005 44 Male 217 lb 5/17/2006 United States
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 6/27/2006 77 Female 8/30/2006 Consumer United States
Primary
Concomitant
Weight Increased Other Serious 9/21/2006 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 10/1/2005 35 Male 10/30/2006 Physician United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2004 47 Female 312 lb 10/10/2006 Lawyer United States
Primary
Concomitant
Pancreatitis Other Serious 1/1/2002 Female 121 lb 10/10/2006 Lawyer United States
Primary
Concomitant
Obesity Hospitalization 1/1/2002 44 Male 199 lb 10/10/2006 Lawyer United States
Primary
Concomitant
White Blood Cell Count Decreased 17 Female 172 lb 2/2/2007 Physician United States
Primary
Concomitant
Psychotic Disorder Hospitalization 1/1/2007 70 Female 2/16/2007 Physician Italy
Primary
Secondary
Concomitant
Neutropenia Other Serious 1/1/2007 Female 2/27/2007 Physician France
Primary
Secondary
Concomitant
Thirst Hospitalization 3/7/2007 38 Male 205 lb 3/21/2007 Physician United States
Primary
Concomitant
Tremor Other Serious 8/1/2002 21 Male 4/18/2007 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 2/1/2007 Male 196 lb 4/26/2007 Other Health Professional United States
Primary
Concomitant
Treatment Noncompliance Required Intervention 4/10/2007 46 Female 180 lb 5/31/2007 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/25/2006 46 Female 4/12/2007 Other Health Professional United States
Primary
Secondary
Vomiting Hospitalization 6/1/2007 17 Male 6/27/2007 Physician France
Primary
Concomitant
Vaginal Haemorrhage Other Serious 7/2/2007 Female 116 lb 7/12/2007 Consumer United States
Primary
Concomitant
Vomiting Other Serious 2/1/2007 Male 196 lb 7/24/2007 Other Health Professional United States
Primary
Concomitant
Drug Ineffective Hospitalization 7/24/2007 Male 9/6/2007 Other Health Professional France
Primary
Secondary
Concomitant
Suicide Attempt Life Threatening 11/18/2006 Male 9/21/2007 Other Health Professional France
Primary
Concomitant
Vomiting Other Serious 2/1/2007 Male 180 lb 10/11/2007 Physician United States
Primary
Concomitant
Vasculitis Hospitalization 9/20/2007 Male 11/29/2007 Other Health Professional France
Primary
Secondary
Hyperglycaemia Other Serious 8/1/2001 33 Female 156 lb 10/9/2007 Lawyer United States
Primary
Concomitant
Tachycardia 7/5/2006 37 Male 292 lb 7/12/2006 Pharmacist United States
Primary
Concomitant
Therapy Regimen Changed 12/2/2005 32 Female 348 lb 12/2/2005 Pharmacist United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 5/1/2007 Female 12/21/2007 United States
Primary
Secondary
Stupor Hospitalization 2/1/2007 51 Male 1/7/2008 Other Health Professional France
Primary
Secondary
Somnolence Hospitalization 1/1/2004 Male 2/9/2008 Consumer United States
Primary
Concomitant
Atrial Fibrillation Hospitalization 1/30/2008 60 Female 213 lb 2/12/2008 Physician United States
Primary
Concomitant
Atrial Fibrillation Hospitalization 1/30/2008 60 Female 213 lb 2/13/2008 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 1/1/2007 33 Male 173 lb 3/4/2008 United States
Primary
Secondary
Concomitant
Neutrophil Count Decreased Other Serious 3/19/2007 Male 4/11/2008 Physician United States
Primary
Secondary
Concomitant
Neutrophil Count Decreased 55 Female 4/11/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Leukopenia Male 4/11/2008 Physician United States
Primary
Concomitant
White Blood Cell Count Abnormal Other Serious 1/31/2008 32 Male 4/29/2008 Pharmacist United States
Primary
Concomitant
Urinary Tract Infection Other Serious 4/23/2008 48 Female 5/6/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Neutropenia Other Serious 1/31/2008 32 Male 5/16/2008 Pharmacist United States
Primary
Concomitant
Urinary Tract Infection Other Serious 4/23/2008 48 Female 5/23/2008 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 12/17/2002 Male 181 lb 7/1/2008 Physician France
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 2/27/2008 Male 7/2/2008 United States
Primary
Secondary
Concomitant
Insomnia Hospitalization 58 Female 7/25/2008 Consumer United States
Primary
Secondary
Weight Increased Other Serious 1/1/2004 Male 9/11/2008 Consumer United States
Primary
Concomitant
Infection Hospitalization 8/23/2008 Male 10/8/2008 Pharmacist United States
Primary
Interacting
Weight Increased Other Serious 1/1/2004 Male 10/2/2008 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 33 Male 9/26/2008 Physician United States
Primary
Secondary
Concomitant
Troponin I Increased Hospitalization 1/30/2008 Female 213 lb 1/9/2009 Physician United States
Primary
Concomitant
Neutrophil Count Decreased Other Serious 10/14/2008 Male 2/10/2009 Physician United States
Primary
Secondary
Concomitant
Granulocytopenia Other Serious 10/14/2008 Male 2/11/2009 Consumer United States
Primary
Concomitant
Granulocytopenia Other Serious 11/24/2008 23 Female 2/4/2009 Physician United States
Primary
Concomitant
Weight Decreased 6/6/2008 33 Male 212 lb 6/9/2008 Pharmacist United States
Primary
Concomitant
Somnolence Hospitalization 1/13/2009 2/26/2009 Other Health Professional France
Primary
Secondary
Concomitant
Atrial Fibrillation Hospitalization 1/30/2008 Female 213 lb 3/9/2009 Physician United States
Primary
Concomitant
Somnolence 3/12/2009 Other Health Professional United States
Primary
Interacting
Liver Function Test Abnormal 3/12/2009 Physician United States
Primary
Concomitant
Leukopenia Male 3/12/2009 Pharmacist United States
Primary
Secondary
Weight Increased 35 Male 3/12/2009 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased 4/3/2008 Male 3/12/2009 Physician United States
Primary
Secondary
Ammonia Increased Male 3/12/2009 Physician United States
Primary
Concomitant
Pancreatitis Other Serious 4/10/2008 Male 3/12/2009 United States
Primary
Secondary
Drug Level Increased 3/12/2009 Other Health Professional United States
Primary
Interacting
Neutropenia 12/9/2008 Female 3/12/2009 Pharmacist United States
Primary
Secondary
Pulmonary Embolism Death 2/2/2009 Male 295 lb 3/26/2009 Other Health Professional United States
Primary
Secondary
Vomiting Other Serious 1/14/2009 48 Male 100 lb 3/19/2009 Pharmacist United States
Primary
Concomitant
Hypoxia Hospitalization 1/30/2009 Male 4/1/2009 Physician France
Primary
Secondary
Leukopenia 40 Male 4/3/2009 Pharmacist United States
Primary
Secondary
Hypoxia Hospitalization Male 4/14/2009 Other Health Professional France
Primary
Secondary
Neutrophil Count Decreased Other Serious 2/27/2009 Male 4/23/2009 Other Health Professional United States
Primary
Secondary
Vomiting Other Serious 4/1/2009 Female 5/19/2009 Other Health Professional United States
Primary
Secondary
Insomnia Hospitalization 58 Female 5/29/2009 Consumer United States
Primary
Secondary
Treatment Noncompliance Other Serious 2/17/2009 40 Male 5/22/2009 Physician United States
Primary
Secondary
Concomitant
Drug Level Increased Death 8/28/2008 Female 6/17/2009 Physician United States
Primary
Concomitant
Overdose Other Serious 12/15/2006 Male 142 lb 7/6/2009 Physician United States
Primary
Concomitant
Sinusitis Other Serious 1/1/2003 29 Male 328 lb 7/9/2009 United States
Primary
Concomitant
Platelet Count Decreased 7/13/2009 Male 171 lb 7/14/2009 United States
Primary
Secondary
Concomitant
Platelet Count Abnormal 7/13/2009 Male 171 lb 7/16/2009 United States
Primary
Secondary
Concomitant
Red Blood Cell Count Decreased Other Serious 10/14/2008 Male 7/27/2009 Physician United States
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2003 42 Female 320 lb 7/28/2009 United States
Primary
Concomitant
Platelet Count Decreased 7/21/2009 Male 173 lb 7/22/2009 United States
Primary
Secondary
Concomitant
Hepatocellular Injury Hospitalization 3/31/2009 30 Male 8/4/2009 Other Health Professional France
Primary
Secondary
Suicidal Ideation Other Serious 61 Female 160 lb 8/5/2009 Physician United States
Primary
Concomitant
Wound Sepsis Hospitalization 53 Male 8/12/2009 Other Health Professional United States
Primary
Concomitant
Somnolence Other Serious 3/29/2009 29 Male 9/16/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tardive Dyskinesia Other Serious 1/1/2003 11 Female 78 lb 9/23/2009 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/2004 Male 9/28/2009 Physician United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2003 42 Female 320 lb 10/16/2009 United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/2004 Male 10/21/2009 Physician United States
Primary
Concomitant
Hypoglycaemia Other Serious 2/20/2004 41 Male 208 lb 11/4/2009 United States
Primary
Concomitant
Asphyxia Death 11/6/2009 Male 11/6/2009 Pharmacist United States
Primary
Secondary
Concomitant
Hypoglycaemia Other Serious 2/20/2004 41 Male 208 lb 11/30/2009 United States
Primary
Concomitant
Atrial Fibrillation Hospitalization 1/29/2008 Female 213 lb 12/9/2009 Physician United States
Primary
Concomitant
Treatment Noncompliance Hospitalization 12/1/2009 Male 12/29/2009 Physician United States
Primary
Concomitant
Tachycardia Other Serious 3/9/2007 Male 12/31/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Somnolence Other Serious 3/25/2009 29 Male 1/22/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Sudden Death Death 5/21/2009 34 Male 1/22/2010 Other Health Professional France
Primary
Secondary
Sudden Death Death 5/21/2009 34 Male 1/27/2010 Other Health Professional France
Primary
Secondary
Weight Increased 6/6/2008 33 Male 212 lb 6/9/2008 Other Health Professional United States
Primary
Concomitant
Oedema Peripheral 5/26/2009 47 Male 280 lb 7/21/2009 Pharmacist United States
Primary
Secondary
Concomitant
Myoclonus Required Intervention 9/21/2008 31 Male 200 lb 10/21/2008 Pharmacist United States
Primary
Concomitant
Sedation 10/18/2008 54 Male 219 lb 11/18/2008 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9/22/2009 34 Male 3/12/2010 Other Health Professional France
Primary
Interacting
Granulocytopenia 3/26/2009 10 Male 3/15/2010 United States
Primary
Secondary
Leukopenia 1/1/2009 Male 3/15/2010 United States
Primary
Secondary
Sepsis Hospitalization 57 Male 3/22/2010 Pharmacist United States
Primary
Concomitant
Sudden Death Death 34 Male 1/20/2010 Other Health Professional France
Primary
Secondary
Diabetes Mellitus Death 282 lb 4/15/2010 United States
Primary
Concomitant
Sepsis Hospitalization 57 Male 4/20/2010 Pharmacist United States
Primary
Concomitant
Hyperglycaemic Hyperosmolar Nonketotic Syndrome Other Serious 6/20/2008 48 Female 4/22/2010 United States
Primary
Concomitant
Respiratory Depression Hospitalization 1/30/2010 54 Male 5/19/2010 Physician France
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 1/1/2010 54 Male 5/26/2010 Other Health Professional France
Primary
Secondary
Granulocytopenia Hospitalization 5/13/2010 35 Male 6/3/2010 Pharmacist United States
Primary
Concomitant
Respiratory Depression Hospitalization 1/30/2010 54 Male 6/4/2010 Other Health Professional France
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious 9/22/2009 26 Male 6/15/2010 Physician United States
Primary
Concomitant
Psychotic Disorder Other Serious 9/22/2009 26 Male 6/16/2010 Physician United States
Primary
Concomitant
Granulocytopenia Life Threatening 5/13/2010 35 Male 157 lb 6/18/2010 Pharmacist United States
Primary
Concomitant
Leukopenia Other Serious 31 Male 6/24/2010 Pharmacist United States
Primary
Concomitant
Granulocytopenia 56 Female 199 lb 6/24/2010 Physician United States
Primary
Concomitant
Granulocytopenia Other Serious 5/7/2009 51 Female 6/24/2010 United States
Primary
Concomitant

Drug Data