Clozapine combined with Valproate Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Weight Increased Required Intervention 35 Female 174 lb 12/28/2005 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 2/5/2000 27 Male 12/23/2005 Australia
Primary
Concomitant
Lung Neoplasm Malignant Death 11/25/2005 55 Male 12/29/2005 United States
Primary
Concomitant
Pneumonia Hospitalization 9/15/2005 44 Female 1/10/2006 Consumer United Kingdom
Primary
Secondary
X-ray Gastrointestinal Tract Abnormal Life Threatening 10/31/2005 44 Female 1/13/2006 Physician United Kingdom
Primary
Concomitant
Aneurysm Death 43 Male 1/11/2006 United States
Primary
Concomitant
Necrosis Other Serious 1/1/2003 38 Female 1/25/2006 Other Health Professional Singapore
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 11/17/2005 44 Male 2/1/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Neutrophil Count Decreased Other Serious 9/21/2005 64 Female 2/3/2006 United Kingdom
Primary
Secondary
Concomitant
Death Death 12/1/2005 50 Male 2/6/2006 United States
Primary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 2/10/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Leukopenia Required Intervention 42 Male 2/8/2006 United States
Primary
Concomitant
Sudden Cardiac Death Death 9/13/2005 74 Male 174 lb 2/8/2006 United States
Primary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 2/14/2006 United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 2/15/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 1/21/2006 33 Male 2/17/2006 Physician United States
Primary
Concomitant
Shock Life Threatening 19 Male 143 lb 2/21/2006 Physician France
Primary
Concomitant
Pharmaceutical Product Complaint Hospitalization 51 Female 3/7/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tachypnoea Hospitalization 36 Female 3/15/2006 Physician United States
Primary
Concomitant
Fatigue Other Serious 50 Female 3/16/2006 Physician Switzerland
Primary
Concomitant
Neutrophil Count Decreased Other Serious 8/9/2005 54 Male 3/13/2006 United States
Primary
Secondary
Concomitant
Renal Failure Death 2/24/2006 55 Female 3/14/2006 United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 9/18/2005 36 Female 126 lb 12/14/2005 Physician United States
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/22/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombocythaemia Required Intervention 5/1/2005 46 Male 12/14/2005 Physician United States
Primary
Concomitant
Unevaluable Event Death 8/10/2005 49 Male 12/14/2005 Pharmacist United States
Primary
Concomitant
Leukopenia Other Serious 7/25/2005 42 Female 163 lb 12/14/2005 Pharmacist United States
Primary
Concomitant
Granulocytopenia Other Serious 7/19/2005 12 Male 90 lb 12/14/2005 Physician United States
Primary
Concomitant
Intentional Drug Misuse Death 8/5/2005 46 Male 290 lb 12/14/2005 Pharmacist United States
Primary
Concomitant
Granulocytopenia Required Intervention 8/23/2005 50 Male 201 lb 12/14/2005 Other Health Professional United States
Primary
Concomitant
Granulocytopenia Hospitalization 8/2/2005 60 Female 12/14/2005 Pharmacist United States
Primary
Concomitant
Myocarditis Required Intervention 8/30/2005 41 Female 12/14/2005 Pharmacist United States
Primary
Concomitant
Fatigue Other Serious 50 Female 4/1/2006 Physician Switzerland
Primary
Concomitant
Convulsion Other Serious 8/31/2005 40 Female 178 lb 12/14/2005 Pharmacist United States
Primary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 4/6/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Hospitalization 2/3/2006 43 Female 183 lb 4/3/2006 United States
Primary
Concomitant
Speech Disorder Hospitalization 38 Female 4/7/2006 Physician Thailand
Primary
Concomitant
Sedation Other Serious 41 Female 5/17/2006 Other Health Professional France
Primary
Interacting
Mucosal Erosion Other Serious 12/1/2004 38 Female 5/19/2006 Other Health Professional United States
Primary
Concomitant
Hypertension Death 4/1/2006 46 Female 5/19/2006 United States
Primary
Concomitant
Subdural Haematoma Death 4/30/2006 34 Male 5/22/2006 United States
Primary
Concomitant
Neutrophil Count Decreased 10/1/2004 27 Female 5/15/2006 United Kingdom
Primary
Concomitant
Cardiac Disorder Death 1/1/2006 90 Female 5/22/2006 United States
Primary
Concomitant
Respiratory Failure Death 9/19/2005 31 Male 375 lb 6/5/2006 Physician France
Primary
Secondary
Concomitant
Death Death 4/15/2006 52 Male 6/6/2006 United States
Primary
Concomitant
Mental Disorder Required Intervention 1/26/2006 45 Female 6/14/2006 United States
Primary
Concomitant
Cardiac Death Death 5/27/2006 62 Male 6/21/2006 United States
Primary
Concomitant
Aortic Dissection Death 1/1/2006 90 Female 6/21/2006 United States
Primary
Concomitant
White Blood Cell Count Increased Death 4/30/2006 34 Male 205 lb 6/29/2006 United States
Primary
Concomitant
Treatment Noncompliance Required Intervention 6/12/2006 47 Male 6/28/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 6/12/2006 47 Male 7/13/2006 United States
Primary
Concomitant
Cardiac Disorder Death 5/27/2006 62 Male 7/19/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/7/2005 55 Female 5/16/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/28/2005 16 Male 192 lb 3/13/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/3/2006 52 Female 3/13/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/19/2005 53 Male 3/24/2006 United States
Primary
Concomitant
Granulocytopenia Hospitalization 1/10/2006 25 Male 3/14/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/10/2006 49 Male 230 lb 3/27/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/25/2005 55 Female 200 lb 5/16/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/3/2006 60 Male 3/24/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/14/2006 31 Female 4/3/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/28/2005 21 Male 5/17/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/13/2006 42 Male 3/27/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/17/2006 45 Male 5/17/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/23/2006 24 Male 180 lb 3/22/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/18/2006 46 Female 3/22/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/16/2006 29 Male 170 lb 4/5/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/25/2006 23 Female 167 lb 5/17/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/30/2006 24 Male 4/4/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/2/2006 49 Male 3/21/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/31/2006 59 Male 4/3/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/7/2006 66 Male 5/18/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/12/2005 47 Female 2/28/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/20/2005 37 Female 5/16/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/7/2005 27 Male 3/21/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/13/2005 33 Male 5/15/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/21/2005 58 Female 3/27/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/5/2005 48 Male 6/16/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 12/6/2005 53 Female 3/7/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/12/2005 45 Female 1/30/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/24/2005 26 Female 1/27/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/1/2005 61 Male 173 lb 5/12/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/17/2005 20 Female 1/27/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 8/30/2005 64 Male 177 lb 2/8/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/26/2005 36 Male 259 lb 1/17/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 9/13/2005 44 Male 197 lb 1/18/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/30/2005 47 Male 1/18/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/3/2005 22 Male 180 lb 1/19/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 9/19/2005 44 Female 1/19/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/28/2005 41 Male 1/20/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/4/2005 42 Male 5/24/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/4/2005 17 Male 6/20/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 9/6/2005 46 Male 5/24/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/3/2005 42 Male 1/25/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/14/2005 47 Male 6/16/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/4/2005 53 Male 372 lb 1/23/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/27/2005 72 Female 1/23/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/30/2005 21 Male 1/31/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/23/2005 44 Male 4/25/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/14/2005 30 Male 1/30/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/1/2005 26 Female 3/6/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/6/2005 47 Male 2/27/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/7/2005 24 Male 6/16/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/12/2005 51 Female 2/27/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/13/2005 23 Male 5/17/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/18/2005 56 Female 5/16/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/21/2005 29 Male 3/9/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/27/2005 70 Female 228 lb 3/9/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 12/26/2005 53 Female 3/9/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/27/2005 33 Male 3/7/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/14/2005 53 Male 3/29/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/3/2005 47 Male 2/14/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/17/2005 19 Male 6/16/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/18/2005 54 Female 2/14/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/16/2005 37 Male 210 lb 2/14/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/17/2005 35 Male 1/30/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/13/2006 50 Female 5/12/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/18/2005 30 Male 1/30/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/20/2005 37 Male 220 lb 1/31/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/19/2005 31 Male 1/27/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/17/2005 30 Female 153 lb 2/8/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/11/2005 46 Female 2/7/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/19/2005 59 Female 6/1/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 11/16/2005 38 Male 135 lb 2/10/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/12/2005 27 Male 2/10/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/14/2005 29 Male 150 lb 3/22/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/8/2005 54 Male 2/7/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/10/2005 48 Male 5/17/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/9/2004 19 Male 250 lb 5/23/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/28/2005 48 Male 5/23/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/31/2005 47 Female 92 lb 2/13/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/31/2005 33 Male 2/9/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 10/31/2005 48 Female 3/7/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 4/17/2006 38 Male 115 lb 6/6/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/31/2005 50 Female 2/7/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/8/2005 59 Female 3/22/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 4/6/2006 35 Male 5/26/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 4/6/2006 37 Male 5/26/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/5/2006 47 Female 5/23/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 4/11/2006 56 Female 5/23/2006 United States
Primary
Concomitant
Pyrexia Life Threatening 4/13/2006 29 Male 218 lb 5/23/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 4/11/2006 54 Male 5/23/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 4/17/2006 35 Male 268 lb 5/30/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 4/3/2006 26 Female 5/30/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 4/13/2006 23 Female 5/23/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 3/28/2006 48 Female 5/31/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 3/22/2006 17 Female 6/12/2006 Pharmacist United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/27/2005 47 Female 2/8/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/27/2005 20 Male 6/1/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 3/30/2006 54 Female 5/17/2006 United States
Primary
Concomitant

Drug Data