Clozapine combined with Metformin Hcl

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Mental Impairment Other Serious 8/1/2003 42 Male 2/6/2006 Other Health Professional United States
Primary
Concomitant
Neutropenia Other Serious 2/22/2005 38 Male 245 lb 4/1/2005 Pharmacist United States
Primary
Concomitant
Leukopenia Required Intervention 7/13/2005 53 Female 155 lb 7/15/2005 Physician United States
Primary
Concomitant
Neutropenia Required Intervention 11/16/2004 38 Female 211 lb 12/20/2004 Physician United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/13/2006 48 Female 203 lb 5/18/2006 Consumer United States
Primary
Concomitant
Leukopenia Required Intervention 9/12/2005 60 Male 156 lb 1/9/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 3/3/2006 46 Male 5/9/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 8/31/2005 43 Male 1/6/2006 Consumer United States
Primary
Concomitant
Leukopenia Required Intervention 11/2/2005 43 Male 196 lb 6/16/2006 Consumer United States
Primary
Concomitant
Leukopenia Required Intervention 9/27/2005 42 Female 328 lb 2/3/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 2/10/2006 54 Female 6/1/2006 United States
Primary
Concomitant
Neutrophil Count Decreased Life Threatening 12/7/2006 Male 12/28/2006 Pharmacist United States
Primary
Concomitant
Hepatitis Life Threatening 12/13/2004 Female 1/16/2007 Canada
Primary
Secondary
Concomitant
Pancreatitis Other Serious 1/1/2002 Female 121 lb 10/10/2006 Lawyer United States
Primary
Concomitant
Refusal Of Treatment By Patient Hospitalization 11/24/2006 54 Male 2/26/2007 Pharmacist United States
Primary
Secondary
Concomitant
Thrombocytopenia Required Intervention 1/8/2007 46 Female 3/28/2007 United States
Primary
Secondary
Concomitant
Thrombocytopenia Required Intervention 1/8/2007 46 Female 187 lb 4/10/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Cardiac Failure Hospitalization 12/21/2006 46 Female 150 lb 5/1/2007 Other Health Professional France
Primary
Secondary
Concomitant
Death Other Serious Male 284 lb 5/11/2007 Physician Australia
Primary
Secondary
Thrombocytopenia Required Intervention 1/8/2007 46 Female 187 lb 5/16/2007 United States
Primary
Secondary
Concomitant
Drug Effect Decreased Death 6/1/2007 42 Male 279 lb 9/11/2007 Consumer United States
Primary
Concomitant
Sudden Death Death 42 Female 281 lb 10/6/2007 United Kingdom
Primary
Concomitant
Hypertension Death 11/6/2007 Male 280 lb 12/1/2007 Consumer United States
Primary
Secondary
Concomitant
Hypertensive Heart Disease Death 11/6/2007 Male 280 lb 12/1/2007 Consumer United States
Primary
Secondary
Concomitant
Hypertension Death 11/6/2007 Male 280 lb 12/1/2007 Consumer United States
Primary
Secondary
Concomitant
Somnolence Hospitalization 1/16/2008 Other Health Professional China
Primary
Secondary
Lung Disorder Life Threatening 1/1/2007 Female 141 lb 3/12/2008 Physician Switzerland
Primary
Concomitant
Vomiting Hospitalization 4/5/2008 18 Male 6/23/2008 Other Health Professional Germany
Primary
Concomitant
Interacting
Metastases To Breast Other Serious 3/1/2008 Female 6/27/2008 Other Health Professional United States
Primary
Concomitant
Vomiting Hospitalization 4/5/2008 18 Male 6/30/2008 Other Health Professional Germany
Primary
Concomitant
Interacting
Breast Cancer Metastatic Other Serious 3/1/2008 56 Female 7/14/2008 Other Health Professional United States
Primary
Concomitant
Drug Level Increased Other Serious 1/22/2008 Female 146 lb 8/5/2008 Physician Germany
Primary
Interacting
Stress Other Serious 8/26/2008 Male 208 lb 9/10/2008 Physician United States
Primary
Concomitant
Drug Toxicity Death 5/28/2008 Female 10/9/2008 Physician United States
Primary
Concomitant
Vomiting Hospitalization 7/28/2008 Female 10/29/2008 Physician France
Primary
Secondary
Concomitant
Stress Other Serious 8/26/2008 Male 208 lb 9/10/2008 Physician United States
Primary
Concomitant
Accidental Exposure Other Serious 51 Male 12/29/2008 Other Health Professional Germany
Primary
Secondary
Accidental Exposure Other Serious 51 Male 12/29/2008 Other Health Professional Germany
Primary
Secondary
Weight Increased 35 Male 3/12/2009 Consumer United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 28 Female 3/13/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Multiple Drug Overdose Intentional Hospitalization 28 Male 3/18/2009 Canada
Primary
Concomitant
Suicidal Ideation Hospitalization 3/14/2002 38 Female 276 lb 4/10/2009 United States
Primary
Concomitant
Sinusitis Other Serious 1/1/2003 29 Male 328 lb 7/9/2009 United States
Primary
Concomitant
Hysterectomy Other Serious 11/1/2006 Female 8/25/2009 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 11/1/2006 Female 9/10/2009 Physician United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 2/17/2009 39 Male 10/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Hypoglycaemia Other Serious 2/20/2004 41 Male 208 lb 11/4/2009 United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 2/17/2009 39 Male 11/10/2009 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Hypoglycaemia Other Serious 2/20/2004 41 Male 208 lb 11/30/2009 United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 2/17/2009 39 Male 11/30/2009 Pharmacist United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 2/17/2009 39 Male 12/18/2009 Pharmacist United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 2/17/2009 39 Male 12/28/2009 Pharmacist United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 2/17/2009 39 Male 1/4/2010 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 4/5/2008 18 Male 1/25/2010 Other Health Professional Germany
Primary
Concomitant
Interacting
White Blood Cell Count Increased Other Serious 2/17/2009 39 Male 1/16/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Treatment Noncompliance Other Serious 8/12/2009 Female 129 lb Pharmacist United States
Primary
Concomitant
Pneumonia Other Serious 60 Male 5/3/2010 United Kingdom
Primary
Secondary
Concomitant
Drug Level Decreased 10/1/2008 34 Male 6/24/2010 Physician United States
Primary
Concomitant
Leukopenia Other Serious 22 Male 450 lb 6/24/2010 Pharmacist United States
Primary
Concomitant
Staphylococcal Infection Other Serious 49 Male 290 lb 6/24/2010 Pharmacist United States
Primary
Concomitant
Leukopenia Other Serious 6/22/2009 52 Male 6/24/2010 Physician United States
Primary
Concomitant
Leukopenia Other Serious 9 Female 81 lb 6/24/2010 Pharmacist United States
Primary
Concomitant
Type 2 Diabetes Mellitus Death 9/2/2009 55 Male 207 lb 6/24/2010 Pharmacist United States
Primary
Concomitant
Myocardial Infarction Death 65 Female 6/24/2010 Pharmacist United States
Primary
Concomitant
Leukopenia Other Serious 10/29/2009 41 Male 134 lb 6/24/2010 Pharmacist United States
Primary
Concomitant
Death Death 11/28/2009 88 Female 6/24/2010 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/15/2009 60 Female 6/24/2010 Other Health Professional United States
Primary
Concomitant
Death Death 11/27/2009 58 Male 6/24/2010 Pharmacist United States
Primary
Concomitant
Sudden Death Death 11/1/2009 42 Female 6/24/2010 Physician United States
Primary
Concomitant
Granulocytopenia Other Serious 1/13/2010 54 Female 6/24/2010 Pharmacist United States
Primary
Concomitant
Death Death 1/26/2010 65 Male 6/24/2010 Pharmacist United States
Primary
Concomitant
Granulocytopenia Other Serious 2/1/2010 75 Female 6/24/2010 Pharmacist United States
Primary
Concomitant
Granulocytopenia Other Serious 3/29/2010 38 Female 6/24/2010 Pharmacist United States
Primary
Concomitant
Tooth Abscess Other Serious 56 Male 7/9/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 23 Female 7/30/2010 Other Health Professional Australia
Primary
Concomitant
Fracture Displacement Hospitalization 8/1/2010 52 Male 262 lb 9/24/2010 Other Health Professional United States
Primary
Concomitant
Fatigue 10/5/2010 58 Female 11/10/2010 Consumer
Primary
Concomitant
Pathological Fracture Hospitalization 8/1/2010 52 Male 262 lb 11/11/2010 Physician United States
Primary
Concomitant
Skin Haemorrhage Other Serious 9/26/2010 48 Female 115 lb 9/27/2010 Pharmacist United States
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 9/20/2010 45 Male 12/2/2010 United Kingdom
Primary
Secondary
Concomitant
Pyrexia Other Serious 3/18/2011 Other Health Professional Australia
Primary
Concomitant
Back Pain Disability 10/1/2009 68 Male 235 lb 3/30/2011 Consumer United States
Primary
Secondary
Concomitant
Nausea Disability 10/1/2009 69 Male 235 lb 4/14/2011 Consumer United States
Primary
Secondary
Concomitant
Vomiting Disability 10/1/2009 70 Male 235 lb 4/18/2011 Consumer United States
Primary
Secondary
Concomitant
Asthenia Other Serious 10/1/2009 70 Male 235 lb 4/7/2011 United States
Primary
Secondary
Concomitant
Liver Function Test Abnormal Hospitalization 41 Female 4/20/2011 Physician United States
Primary
Concomitant
Pulmonary Toxicity Other Serious 41 Female 4/14/2011 Physician United States
Primary
Concomitant
Myocarditis Death 5/12/2011 Pharmacist Australia
Primary
Concomitant
Granulocytopenia Other Serious 3/22/2011 39 Female 5/18/2011 Pharmacist United States
Primary
Concomitant
Musculoskeletal Pain Other Serious Male 309 lb 6/6/2011 Other Health Professional United Kingdom
Primary
Concomitant
Haemorrhage Other Serious Male 6/4/2011 Consumer United Kingdom
Primary
Concomitant
Neoplasm Malignant Death Male 6/8/2011 Physician United Kingdom
Primary
Concomitant
Haemoglobin Decreased Other Serious Male 6/8/2011 Physician United Kingdom
Primary
Concomitant
Orthostatic Hypotension Other Serious 10/18/2008 58 Male 6/5/2011 Other Health Professional United Kingdom
Primary
Concomitant
Blood Urea Increased Death 12/1/2007 81 Male 6/6/2011 Other Health Professional Canada
Primary
Concomitant
Walking Aid User Other Serious 1/1/2006 60 Male 6/4/2011 Other Health Professional Canada
Primary
Concomitant
Death Death 7/4/2007 50 Female 6/2/2011 Pharmacist Australia
Primary
Concomitant
Convulsion Life Threatening Female 6/13/2011 Pharmacist United Kingdom
Primary
Concomitant
Anaemia Other Serious 1/16/2006 29 Male 154 lb 6/13/2011 Physician United Kingdom
Primary
Concomitant
Urinary Tract Infection Hospitalization 3/19/2005 57 Female 6/12/2011 Pharmacist Australia
Primary
Concomitant
Blood Sodium Decreased Other Serious 12/7/2007 23 Female 6/11/2011 Other Health Professional Australia
Primary
Concomitant
Myeloproliferative Disorder Hospitalization 1/1/2004 38 Male 6/12/2011 Consumer United Kingdom
Primary
Concomitant
Death Death 7/19/2008 50 Male 6/13/2011 Physician Australia
Primary
Concomitant
Chest Pain Hospitalization 9/15/2003 43 Male 6/14/2011 Consumer United Kingdom
Primary
Concomitant
Full Blood Count Increased Hospitalization 9/1/2003 4 Male 6/14/2011 United Kingdom
Primary
Concomitant
Lower Respiratory Tract Infection Life Threatening 7/12/2004 39 Female 6/14/2011 Consumer United Kingdom
Primary
Concomitant
Electrocardiogram Abnormal Hospitalization 5/10/2006 39 Female 190 lb 6/14/2011 Consumer United Kingdom
Primary
Concomitant
Haematemesis Hospitalization 7/9/2004 57 Female 6/15/2011 Physician United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 12/15/2005 52 Male 6/15/2011 Other Health Professional Canada
Primary
Concomitant
Multiple Drug Overdose Intentional Hospitalization 1/10/2007 42 Female 6/15/2011 Other Health Professional United Kingdom
Primary
Secondary
Multiple Drug Overdose Intentional Hospitalization 1/10/2007 42 Female 6/16/2011 Consumer Germany
Primary
Secondary
Ankle Fracture Other Serious 11/20/2010 63 Female 6/17/2011 Pharmacist United Kingdom
Primary
Concomitant
Anaemia Other Serious 2/22/2011 62 Female 6/21/2011 Physician United Kingdom
Primary
Concomitant
Granulocytopenia Other Serious 6/11/2010 29 Male 214 lb 6/22/2011 Pharmacist United States
Primary
Concomitant
Granulocytopenia Other Serious 6/22/2010 54 Female 6/22/2011 Pharmacist United States
Primary
Concomitant
Granulocytopenia Other Serious 6/28/2010 29 Female 6/22/2011 Pharmacist United States
Primary
Concomitant
Granulocytopenia Other Serious 8/18/2010 19 Female 6/22/2011 Pharmacist United States
Primary
Concomitant
Granulocytopenia Other Serious 10/15/2010 43 Male 180 lb 6/22/2011 Pharmacist United States
Primary
Concomitant
Death Death 51 Male 6/22/2011 Pharmacist United States
Primary
Concomitant
Death Death 11/11/2010 31 Female 6/22/2011 Other Health Professional United States
Primary
Concomitant
Leukopenia Other Serious 12/8/2010 56 Male 6/22/2011 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/15/2010 48 Female 200 lb 6/22/2011 Pharmacist United States
Primary
Concomitant
Erectile Dysfunction 1/1/2000 32 Male 381 lb 6/22/2011 Consumer United States
Primary
Concomitant
Death Death 2/13/2011 36 Male 6/22/2011 Pharmacist United States
Primary
Concomitant
Death Other Serious 2/8/2011 69 Male 6/22/2011 Pharmacist United States
Primary
Concomitant
Granulocytopenia Other Serious 11/24/2010 71 Female 164 lb 6/22/2011 Physician United States
Primary
Secondary
Concomitant
Leukopenia Life Threatening 4/5/2011 46 Female 168 lb 6/22/2011 Pharmacist United States
Primary
Concomitant
Granulocytopenia Other Serious 4/4/2011 53 Female 184 lb 6/22/2011 Pharmacist United States
Primary
Concomitant
Death Death 4/12/2011 58 Male 6/22/2011 Pharmacist United States
Primary
Concomitant
Death Death 10/21/2010 37 Female 6/22/2011 Physician United States
Primary
Concomitant
Lung Neoplasm Malignant Other Serious 4/1/2011 56 Female 6/27/2011 Physician United Kingdom
Primary
Concomitant
Diabetes Mellitus Life Threatening Female 6/29/2011 Pharmacist United Kingdom
Primary
Concomitant
Schizophrenia Other Serious Female 7/1/2011 Pharmacist Canada
Primary
Concomitant
Atrophy Other Serious 7/18/2010 64 Female 7/5/2011 Physician Canada
Primary
Concomitant
Incontinence Other Serious Female 7/7/2011 Physician Canada
Primary
Concomitant
Antipsychotic Drug Level Below Therapeutic Hospitalization 6/16/2011 37 Male 7/13/2011 Physician Australia
Primary
Concomitant
Transient Ischaemic Attack Other Serious 10/1/2010 55 Male 7/13/2011 Physician United Kingdom
Primary
Concomitant
Mean Cell Haemoglobin Increased Other Serious 4/26/2011 42 Male 176 lb 7/6/2011 Physician United Kingdom
Primary
Concomitant
Haemoglobin Decreased Hospitalization 7/1/1995 46 Female 7/14/2011 Physician Ireland
Primary
Concomitant
Mania Hospitalization 6/22/2011 39 Male 7/15/2011 Pharmacist Australia
Primary
Concomitant
Overdose Other Serious 1/3/2011 40 Male 7/19/2011 Other Health Professional United Kingdom
Primary
Concomitant
Haemoglobin Decreased Disability 2/10/2011 62 Female 148 lb 7/22/2011 Physician United Kingdom
Primary
Concomitant
Gamma-glutamyltransferase Increased Other Serious 10/29/2009 40 Male 176 lb 7/22/2011 Other Health Professional United Kingdom
Primary
Concomitant
Lung Neoplasm Malignant Other Serious 1/1/2001 59 Female 7/22/2011 Physician United Kingdom
Primary
Concomitant
Lung Neoplasm Malignant Other Serious 4/1/2011 56 Female 7/25/2011 Physician United Kingdom
Primary
Concomitant
Fatigue Other Serious 1/1/2011 38 Male 243 lb 8/1/2011 Physician Australia
Primary
Concomitant
Haemorrhage Other Serious 1/1/2011 18 Female 143 lb 8/3/2011 Physician United Kingdom
Primary
Concomitant
Lymphocyte Count Increased Other Serious 7/6/2010 49 Female 8/9/2011 Physician United Kingdom
Primary
Concomitant
Cardiac Arrest Death 7/23/2011 57 Male 8/12/2011 Other Health Professional Canada
Primary
Concomitant
Alanine Aminotransferase Increased Other Serious 4/1/2011 71 Female 8/16/2011 Physician United Kingdom
Primary
Concomitant

Drug Data