Aripiprazole combined with Clozapine

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Weight Increased Required Intervention 35 Female 174 lb 12/28/2005 Consumer United States
Primary
Concomitant
Staphylococcal Infection Death 11/28/2005 44 Male 1/10/2006 Pharmacist United States
Primary
Concomitant
Treatment Noncompliance Other Serious 8/1/2004 42 Male 1/30/2006 United States
Primary
Concomitant
Mental Impairment Other Serious 8/1/2003 42 Male 2/6/2006 Other Health Professional United States
Primary
Concomitant
Leukopenia Required Intervention 42 Male 2/8/2006 United States
Primary
Concomitant
Pulmonary Embolism Death 7/8/2005 36 Female 309 lb 2/8/2006 United States
Primary
Concomitant
Staphylococcal Infection Death 11/28/2005 44 Male 352 lb 2/9/2006 Physician United States
Primary
Concomitant
Infected Skin Ulcer Hospitalization 6/1/2002 31 Male 2/16/2006 Pharmacist France
Primary
Concomitant
Menorrhagia Hospitalization 10/2/2005 47 Female 2/15/2006 United States
Primary
Concomitant
Tachycardia Other Serious 1/1/2006 64 Female 2/24/2006 Physician United States
Primary
Concomitant
Infected Skin Ulcer Hospitalization 6/1/2002 31 Male 3/3/2006 Physician France
Primary
Concomitant
Road Traffic Accident Death 1/25/2006 48 Male 3/6/2006 United States
Primary
Concomitant
Febrile Neutropenia Other Serious 8/5/2005 19 Female 12/14/2005 Other Health Professional United States
Primary
Concomitant
Unevaluable Event Death 8/10/2005 49 Male 12/14/2005 Pharmacist United States
Primary
Concomitant
Road Traffic Accident Death 1/25/2006 48 Male 3/23/2006 United States
Primary
Concomitant
Neutrophil Count Increased Other Serious 3/14/2006 49 Male 4/10/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 8/22/2005 42 Male 4/7/2006 United States
Primary
Concomitant
Tachycardia Other Serious 1/1/2006 64 Female 125 lb 4/7/2006 Pharmacist United States
Primary
Concomitant
Tachycardia Other Serious 1/1/2006 64 Female 125 lb 4/4/2006 Physician United States
Primary
Concomitant
Tachypnoea Other Serious 36 Female 5/5/2006 Other Health Professional United States
Primary
Concomitant
Neutrophil Count Decreased Other Serious 3/14/2006 49 Male 212 lb 5/8/2006 United States
Primary
Concomitant
Psychotic Disorder Required Intervention 4/10/2006 44 Male 6/5/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/10/2006 49 Male 230 lb 3/27/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/28/2005 21 Male 5/17/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/16/2006 29 Male 170 lb 4/5/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/17/2006 35 Male 4/4/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 2/7/2006 55 Female 3/22/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/17/2005 20 Female 1/27/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/4/2005 17 Male 6/20/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/11/2005 46 Female 2/7/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 11/17/2005 38 Male 226 lb 5/17/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 1/20/2005 53 Female 6/21/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 4/24/2006 38 Male 5/26/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/27/2005 20 Male 6/1/2006 Consumer United States
Primary
Concomitant
Tremor Hospitalization 10/1/2005 29 Male 2/27/2006 Pharmacist United States
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 3/10/2006 31 Male 300 lb 5/17/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 8/25/2005 25 Male 5/31/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/13/2005 29 Male 210 lb 1/16/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/9/2005 35 Male 1/17/2006 Consumer United States
Primary
Concomitant
Leukopenia Required Intervention 8/17/2005 33 Male 1/5/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/19/2005 39 Female 1/16/2006 Consumer United States
Primary
Concomitant
Drug Withdrawal Syndrome Hospitalization 7/30/2006 24 Female 8/21/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 8/29/2005 14 Male 1/11/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 3/7/2006 52 Male 4/18/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/27/2006 44 Male 5/26/2006 United States
Primary
Concomitant
Leukopenia Life Threatening 3/14/2006 48 Male 164 lb 5/18/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 3/16/2006 10 Male 4/13/2006 Consumer United States
Primary
Concomitant
Leukopenia Required Intervention 11/2/2005 43 Male 196 lb 6/16/2006 Consumer United States
Primary
Concomitant
Leukopenia Required Intervention 12/5/2005 58 Male 3/6/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 9/30/2005 62 Female 1/18/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 2/8/2006 23 Male 3/21/2006 United States
Primary
Concomitant
Treatment Noncompliance Death 8/6/2006 81 Female 112 lb 9/11/2006 United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/14/2006 49 Male 212 lb 10/4/2006 United States
Primary
Concomitant
Anxiety Hospitalization 9/29/2006 34 Female 10/16/2006 Other Health Professional Sweden
Primary
Concomitant
Anxiety Hospitalization 9/29/2006 34 Female 11/9/2006 Other Health Professional Sweden
Primary
Concomitant
Myocardial Infarction Hospitalization 10/1/2003 45 Male 210 lb 12/13/2006 Consumer United States
Primary
Concomitant
Weight Increased Hospitalization 1/1/2004 47 Female 312 lb 10/10/2006 Lawyer United States
Primary
Concomitant
Neutropenia Other Serious 36 Female 3/7/2007 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
White Blood Cell Count Decreased Other Serious 3/14/2006 49 Male 212 lb 4/23/2007 United States
Primary
Concomitant
White Blood Cell Count Decreased 2/14/2007 9 Female 4/25/2007 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/14/2006 49 Male 212 lb 5/17/2007 United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/14/2006 49 Male 212 lb 5/31/2007 United States
Primary
Concomitant
Weight Increased Hospitalization 11/1/2006 46 Female 309 lb 6/26/2007 Physician United Kingdom
Primary
Concomitant
Sedation Other Serious 32 Male 10/9/2007 Other Health Professional Spain
Primary
Secondary
Speech Disorder Other Serious 27 Male 10/9/2007 Other Health Professional Spain
Primary
Concomitant
Sedation Other Serious 49 Male 10/9/2007 Other Health Professional Spain
Primary
Concomitant
Therapy Regimen Changed 12/2/2005 32 Female 348 lb 12/2/2005 Pharmacist United States
Primary
Concomitant
Suicidal Ideation Hospitalization 7/1/2005 Female 156 lb 1/22/2008 Other Health Professional United Kingdom
Primary
Concomitant
Intentional Self-injury Other Serious 33 Female 2/29/2008 United States
Primary
Secondary
Concomitant
Rash Generalised Other Serious 20 Male 3/9/2008 Consumer
Primary
Secondary
Concomitant
Torticollis Other Serious 59 Male 3/14/2008 Other Health Professional United States
Primary
Secondary
Weight Increased Hospitalization 1/1/2000 15 Male 4/7/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2008 20 Male 4/9/2008 Consumer United States
Primary
Secondary
Concomitant
Somnolence Other Serious Female 6/30/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Supraventricular Tachycardia Other Serious 5/16/2008 33 Female 7/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Supraventricular Tachycardia Other Serious 5/16/2008 33 Female 7/3/2008 Other Health Professional United Kingdom
Primary
Secondary
Somnolence Other Serious Female 7/10/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Somnolence Other Serious Female 7/14/2008 United Kingdom
Primary
Secondary
Concomitant
Supraventricular Tachycardia Other Serious 5/16/2008 33 Female 7/15/2008 Other Health Professional United Kingdom
Primary
Concomitant
Somnolence Other Serious Female 7/15/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 8/1/2007 22 Male 9/24/2008 Consumer United States
Primary
Concomitant
Tardive Dyskinesia Disability 30 Male 9/29/2008 Other Health Professional Germany
Primary
Secondary
Unresponsive To Stimuli Death 1/13/2008 Male 360 lb 10/8/2008 Other Health Professional United States
Primary
Concomitant
Weight Increased Other Serious 32 Male 11/18/2008 Other Health Professional Italy
Primary
Secondary
Grand Mal Convulsion Other Serious 10/14/2007 28 Male 9/12/2008 Other Health Professional United States
Primary
Concomitant
Lower Limb Fracture Other Serious 27 Female 12/23/2008 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Hospitalization 8/3/2008 49 Male 212 lb 12/19/2008 Pharmacist United States
Primary
Concomitant
Granulocytopenia Other Serious 10/17/2007 38 Female 130 lb 11/25/2008 Physician United States
Primary
Concomitant
Pulmonary Embolism Other Serious 28 Male 1/27/2009 Other Health Professional United States
Primary
Secondary
Troponin Increased Other Serious 28 Male 2 lb 1/23/2009 Physician United States
Primary
Secondary
Rhabdomyolysis Other Serious 28 Male 2/6/2009 France
Primary
Secondary
Weight Increased Hospitalization 12/1/2005 Male 245 lb 2/22/2009 Consumer United States
Primary
Concomitant
Mania Other Serious 22 Male 2/27/2009 Consumer United States
Primary
Secondary
Xanthoma Hospitalization 23 Male 3/6/2009 Physician Ireland
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/1/2008 Male 3/12/2009 Other Health Professional United States
Primary
Concomitant
Weight Increased Other Serious 32 Male 3/17/2009 Other Health Professional Italy
Primary
Secondary
Pulmonary Oedema Hospitalization 28 Male 3/23/2009 United States
Primary
Concomitant
Tachypnoea Other Serious 28 Male 3/26/2009 France
Primary
Secondary
Pulmonary Oedema Other Serious 28 Male 3/27/2009 United Kingdom
Primary
Secondary
Withdrawal Syndrome Hospitalization 45 Female 4/3/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/1/2008 Male 4/30/2009 Other Health Professional United States
Primary
Concomitant
Craniotomy Other Serious 12/9/2008 57 Female 6/26/2009 Other Health Professional United Kingdom
Primary
Concomitant
Craniotomy Other Serious 12/9/2008 57 Female 7/7/2009 United Kingdom
Primary
Secondary
Concomitant
Ventricular Hypertrophy Other Serious Male 7/13/2009 Other Health Professional Korea, Republic Of
Primary
Concomitant
Ventricular Hypertrophy Other Serious 1/15/2009 14 Male 7/31/2009 Other Health Professional Korea, Republic Of
Primary
Concomitant
Somnolence Other Serious 3/1/2007 42 Male 8/3/2009 Physician India
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious Female 9/8/2009 Other Health Professional Germany
Primary
Concomitant
Psychotic Disorder Other Serious Male 9/8/2009 Other Health Professional Germany
Primary
Concomitant
Psychotic Disorder Other Serious Male 9/8/2009 Other Health Professional Germany
Primary
Concomitant
Psychotic Disorder Other Serious Male 9/8/2009 Other Health Professional Germany
Primary
Concomitant
Psychotic Disorder Other Serious Male 9/8/2009 Other Health Professional Germany
Primary
Concomitant
Psychotic Disorder Other Serious Male 9/8/2009 Other Health Professional Germany
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 11/1/2006 Female 9/10/2009 Physician United States
Primary
Concomitant
Psychomotor Hyperactivity Other Serious 46 Female 9/15/2009
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious 47 Female 9/16/2009 Other Health Professional Spain
Primary
Concomitant
Non-cardiac Chest Pain Other Serious 8/30/2009 31 Male 10/6/2009 Other Health Professional United Kingdom
Primary
Concomitant
Somnolence Other Serious 3/1/2007 42 Male 11/5/2009 Physician India
Primary
Secondary
Concomitant
Myocarditis Other Serious 12/1/2009 Physician Germany
Primary
Secondary
Sudden Death Death 12/2/2009 Physician Germany
Primary
Secondary
Weight Increased Hospitalization 12/1/2005 Male 245 lb 12/1/2009 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 2/4/2008 37 Male 12/10/2009 Other Health Professional United Kingdom
Primary
Secondary
Electrocardiogram Qt Prolonged Hospitalization 5/29/2007 39 Female 12/11/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/15/2008 37 Male 12/17/2009 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 2/4/2008 37 Male 12/17/2009 Pharmacist Denmark
Primary
Secondary
Catatonia Other Serious 61 Male 12/31/2009 Other Health Professional Hungary
Primary
Secondary
Concomitant
Myoclonus Required Intervention 9/21/2008 31 Male 200 lb 10/21/2008 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 7 Female 75 lb 3/15/2010
Primary
Secondary
Weight Increased Other Serious 36 Male 4/6/2010 Other Health Professional Austria
Primary
Secondary
Taciturnity Other Serious 44 Female 4/13/2010 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Tardive Dyskinesia Hospitalization 26 Female 5/12/2010 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Respiratory Failure Other Serious 26 Female 5/13/2010 Taiwan, Province Of China
Primary
Secondary
Neuroleptic Malignant Syndrome Life Threatening 27 Male 5/17/2010 Other Health Professional France
Primary
Interacting
Respiratory Failure Other Serious 1/1/2009 26 Female 5/18/2010
Primary
Secondary
Psychotic Disorder Other Serious 26 Female 5/23/2010 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Tardive Dyskinesia Hospitalization 26 Female 5/19/2010 Taiwan, Province Of China
Primary
Secondary
Myasthenia Gravis Hospitalization 26 Female 5/24/2010 Taiwan, Province Of China
Primary
Secondary
Respiratory Failure Other Serious 2/1/2009 26 Female 5/27/2010 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Thought Broadcasting Hospitalization 26 Female 5/25/2010 Taiwan, Province Of China
Primary
Secondary
Tardive Dyskinesia Other Serious 26 Female 6/2/2010 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Psychotic Disorder Other Serious 21 Male 6/22/2010 Other Health Professional Canada
Primary
Interacting
Granulocytopenia Other Serious 4/6/2010 47 Female 6/24/2010 Pharmacist United States
Primary
Concomitant
Treatment Failure Other Serious 21 Male 6/29/2010 Other Health Professional Canada
Primary
Interacting
Psychotic Disorder Other Serious 21 Male 7/1/2010 Physician Canada
Primary
Interacting
Ventricular Hypertrophy Other Serious 1/7/2010 52 Male 6/28/2010 Other Health Professional Denmark
Primary
Concomitant
Psychotic Disorder Other Serious 21 Male 7/6/2010 Other Health Professional Canada
Primary
Interacting
Psychotic Disorder Other Serious 21 Male 7/6/2010 Other Health Professional Canada
Primary
Interacting
Psychotic Disorder Other Serious 21 Male 7/22/2010 Physician Canada
Primary
Interacting
Pleurothotonus Other Serious 44 Female 8/2/2010 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 26 Female 8/10/2010 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Respiratory Failure Hospitalization 26 Female 8/27/2010 Other Health Professional Taiwan, Province Of China
Primary
Secondary

Drug Data