Clozapine combined with Folic Acid

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pulmonary Embolism Other Serious 8/24/2005 Female 1/20/2006 United States
Primary
Secondary
Concomitant
Renal Failure Death 2/24/2006 55 Female 3/14/2006 United States
Primary
Concomitant
Thrombotic Thrombocytopenic Purpura Hospitalization 2/3/2006 43 Female 183 lb 4/3/2006 United States
Primary
Concomitant
Lung Cancer Metastatic Death 3/19/2006 42 Male 5/1/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/7/2006 66 Male 5/18/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 12/6/2005 53 Female 3/7/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/6/2005 50 Male 201 lb 3/7/2006 Consumer United States
Primary
Secondary
Concomitant
Tremor Hospitalization 10/1/2005 29 Male 2/27/2006 Pharmacist United States
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 9/9/2005 46 Male 1/13/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/31/2005 28 Female 2/15/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/6/2005 45 Male 5/11/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/23/2005 55 Male 2/27/2006 Consumer United States
Primary
Concomitant
Leukopenia Required Intervention 9/30/2005 62 Female 1/18/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 2/6/2006 55 Female 4/3/2006 United States
Primary
Concomitant
Sudden Death Hospitalization 12/31/2006 74 Female 2/12/2007 Physician United States
Primary
Concomitant
Hysterectomy Other Serious 11/1/2006 43 Female 3/10/2007 United States
Primary
Secondary
Concomitant
Sudden Death Hospitalization 12/31/2006 74 Female 4/2/2007 Physician United States
Primary
Concomitant
Electroencephalogram Abnormal Hospitalization 10/10/2005 29 Male 205 lb 1/22/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 3/19/2008 44 Male 4/21/2008 Germany
Primary
Secondary
Concomitant
Leukopenia Other Serious 3/17/2008 65 Male 164 lb 5/27/2008 Physician United States
Primary
Secondary
Concomitant
Insomnia Hospitalization 58 Female 7/25/2008 Consumer United States
Primary
Secondary
Rhabdomyolysis Hospitalization 3/19/2008 44 Male 9/5/2008 Physician Germany
Primary
Secondary
Concomitant
Rash 9/1/2008 Male 12/16/2008 Consumer United States
Primary
Concomitant
Insomnia Hospitalization 58 Female 5/29/2009 Consumer United States
Primary
Secondary
Tachycardia Other Serious 2/1/2008 Female 6/1/2009 Physician Norway
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 7/12/2006 36 Female 6/15/2009 Other Health Professional United Kingdom
Primary
Secondary
Craniotomy Other Serious 12/9/2008 57 Female 6/26/2009 Other Health Professional United Kingdom
Primary
Concomitant
Craniotomy Other Serious 12/9/2008 57 Female 7/7/2009 United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious Female 7/8/2009 Other Health Professional United States
Primary
Concomitant
Vomiting Other Serious 6/30/2009 Female 8/10/2009 Other Health Professional United States
Primary
Concomitant
Wound Sepsis Hospitalization 53 Male 8/12/2009 Other Health Professional United States
Primary
Concomitant
Hysterectomy Other Serious 11/1/2006 Female 8/25/2009 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 11/1/2006 Female 9/10/2009 Physician United States
Primary
Concomitant
Electrocardiogram Qt Prolonged Hospitalization 5/29/2007 39 Female 12/11/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 7/12/2006 36 Female 5/10/2010 Other Health Professional United Kingdom
Primary
Secondary
Myocardial Infarction Death 3/23/2010 47 Male 5/17/2010 Consumer Colombia
Primary
Concomitant
Suicide Attempt Other Serious 1/7/2010 52 Male 6/10/2010 Other Health Professional Denmark
Primary
Concomitant
Salivary Hypersecretion Other Serious Male 6/21/2010 Consumer Argentina
Primary
Concomitant
Granulocytopenia Other Serious Male 216 lb 6/24/2010 United States
Primary
Concomitant
Interacting
Death Death 64 Male 6/24/2010 Pharmacist United States
Primary
Concomitant
Death Death 82 Male 6/24/2010 Pharmacist United States
Primary
Concomitant
Granulocytopenia Other Serious 12/28/2009 40 Male 6/24/2010 Other Health Professional United States
Primary
Concomitant
Leukopenia Other Serious 21 Male 6/24/2010 Physician United States
Primary
Concomitant
Ventricular Hypertrophy Other Serious 1/7/2010 52 Male 6/28/2010 Other Health Professional Denmark
Primary
Concomitant
Fracture Displacement Hospitalization 8/1/2010 52 Male 262 lb 9/24/2010 Other Health Professional United States
Primary
Concomitant
Pathological Fracture Hospitalization 8/1/2010 52 Male 262 lb 11/11/2010 Physician United States
Primary
Concomitant
Back Pain Disability 10/1/2009 68 Male 235 lb 3/30/2011 Consumer United States
Primary
Secondary
Concomitant
Abasia Other Serious 10/1/2009 70 Male 235 lb 4/11/2011 Consumer United States
Primary
Secondary
Concomitant
Myalgia Other Serious 1/1/2009 69 Male 236 lb 4/11/2011 Consumer United States
Primary
Secondary
Concomitant
Nausea Disability 10/1/2009 69 Male 235 lb 4/14/2011 Consumer United States
Primary
Secondary
Concomitant
Skin Irritation Disability 10/1/2009 68 Male 235 lb 4/13/2011 Consumer United States
Primary
Concomitant
Vomiting Disability 10/1/2009 70 Male 235 lb 4/18/2011 Consumer United States
Primary
Secondary
Concomitant
Asthenia Other Serious 10/1/2009 70 Male 235 lb 4/7/2011 United States
Primary
Secondary
Concomitant
Cardiopulmonary Failure Hospitalization 2/2/2005 44 Female 209 lb 6/3/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious Male 6/4/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Death Death 3/22/2004 78 Male 6/4/2011 Physician New Zealand
Primary
Concomitant
Pulmonary Oedema Death Male 5/31/2011 Physician United Kingdom
Primary
Concomitant
Diarrhoea Hospitalization 5/14/2004 42 Male 163 lb 6/14/2011 Pharmacist United Kingdom
Primary
Concomitant
Haemoglobin Decreased Other Serious 1/1/1999 44 Male 6/15/2011 Physician United Kingdom
Primary
Concomitant
Treatment Noncompliance Death 2/2/2005 44 Female 209 lb 6/17/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Granulocytopenia Other Serious 8/18/2010 19 Female 6/22/2011 Pharmacist United States
Primary
Concomitant
Granulocytopenia Other Serious 10/18/2010 39 Male 172 lb 6/22/2011 Pharmacist United States
Primary
Concomitant
Leukopenia Other Serious 3/2/2011 46 Male 6/22/2011 Pharmacist United States
Primary
Concomitant
Sepsis Death 3/17/2011 59 Female 6/22/2011 Pharmacist United States
Primary
Concomitant
Granulocytopenia Other Serious 4/4/2011 53 Female 184 lb 6/22/2011 Pharmacist United States
Primary
Concomitant
Psychotic Disorder Other Serious 1/1/2010 47 Male 6/22/2011 Consumer United States
Primary
Secondary
Concomitant
Bronchopneumonia Death 4/7/2011 56 Male 115 lb 6/24/2011 Physician United Kingdom
Primary
Concomitant
Sickle Cell Trait Other Serious 5/3/2011 36 Male 7/20/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pyrexia Other Serious 4/3/2011 55 Male 142 lb 7/25/2011 Pharmacist United Kingdom
Primary
Concomitant
Sickle Cell Trait Other Serious 5/3/2011 36 Male 8/3/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Lymphocyte Count Increased Other Serious 7/6/2010 49 Female 8/9/2011 Physician United Kingdom
Primary
Concomitant
Pyrexia Other Serious 4/3/2011 55 Male 142 lb 8/19/2011 Other Health Professional United Kingdom
Primary
Concomitant
Injection Site Induration Hospitalization 7/4/2011 41 Male 8/26/2011 Other Health Professional France
Primary
Secondary
Concomitant
Femoral Neck Fracture Other Serious 7/7/2011 84 Female 9/2/2011 Other Health Professional New Zealand
Primary
Concomitant
Blood Glucose Increased Other Serious 7/1/2010 72 Female 111 lb 8/31/2011 Lawyer United States
Primary
Concomitant
Leukaemia Other Serious 7/6/2010 49 Female 9/22/2011 Physician United Kingdom
Primary
Concomitant
Lymphocyte Count Increased Other Serious 7/6/2010 49 Female 9/29/2011 Other Health Professional United Kingdom
Primary
Concomitant
Pyrexia Other Serious 4/3/2011 55 Male 142 lb 10/7/2011 Physician United Kingdom
Primary
Concomitant
Asthenia Hospitalization 6/11/2011 50 Male 10/10/2011 Pharmacist Australia
Primary
Concomitant
Hypertension Hospitalization 49 Male 10/14/2011 Other Health Professional Netherlands
Primary
Concomitant
Antipsychotic Drug Level Above Therapeutic Hospitalization 9/16/2011 44 Male 10/14/2011 Physician Netherlands
Primary
Concomitant
Hypertension Hospitalization 49 Male 10/14/2011 Other Health Professional Netherlands
Primary
Concomitant
Lacunar Infarction Hospitalization 50 Male 11/14/2011 Physician Netherlands
Primary
Secondary
Concomitant
Periorbital Oedema Hospitalization 50 Male 11/14/2011 Physician Netherlands
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 49 Male 11/30/2011 Physician Netherlands
Primary
Secondary
Concomitant
Congenital Hypothyroidism Congenital Anomaly 29 Female 7 lb 12/1/2011 Physician France
Primary
Concomitant
Tachycardia Other Serious 49 Male 11/28/2011 Physician Netherlands
Primary
Secondary
Concomitant
Umbilical Cord Short Congenital Anomaly 29 Female 7 lb 1/11/2012 Other Health Professional France
Primary
Concomitant
Lymphocyte Count Decreased Hospitalization 12/13/2011 2/7/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Other Serious 12/13/2011 52 Female 2/9/2012 Physician United Kingdom
Primary
Concomitant
Interacting
Drug Interaction Hospitalization 12/13/2011 52 Female 2/9/2012 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Lymphocyte Count Decreased Other Serious 12/13/2011 52 Female 2/9/2012 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Hepatic Function Abnormal Death 1/9/2012 36 Male 2/13/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Dystonia Other Serious 12/13/2011 52 Female 2/8/2012 Other Health Professional
Primary
Secondary
Concomitant
Drug Level Increased Hospitalization 12/13/2011 2/14/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Death 1/9/2012 36 Male 2/15/2012 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Lymphocyte Count Decreased Other Serious 12/13/2011 52 Female 2/15/2012 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Dystonia Other Serious 12/13/2011 52 Female 2/15/2012 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Haemoglobin Decreased Other Serious 1/9/2012 36 Male 2/16/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Malaise Other Serious 1/9/2012 36 Male 2/16/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Dystonia Hospitalization 12/13/2011 52 Female 2/16/2012 Physician United Kingdom
Primary
Concomitant
Interacting
Hepatic Function Abnormal Death 1/9/2012 36 Male 2/16/2012 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Haemoglobin Decreased Other Serious 1/9/2012 36 Male 2/13/2012 Other Health Professional
Primary
Secondary
Concomitant
Renal Impairment Other Serious 1/9/2012 36 Male 2/22/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Lymphocyte Count Decreased Other Serious 12/13/2011 52 Female 2/14/2012 Other Health Professional
Primary
Secondary
Concomitant
Neutropenia Other Serious 52 Female 2/10/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Circulatory Collapse Death 1/9/2012 36 Male 2/22/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Death 1/9/2012 36 Male 2/22/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Death 1/9/2012 36 Male 2/17/2012 Consumer United Kingdom
Primary
Secondary
Concomitant
Lymphocyte Count Decreased Other Serious 12/13/2011 52 Female 3/8/2012 Physician United Kingdom
Primary
Concomitant
Interacting
Drug Level Increased Other Serious 12/13/2011 52 Female 3/13/2012 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Dysarthria Hospitalization 12/13/2011 52 Female 3/14/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Dystonia Other Serious 12/13/2011 52 Female 3/16/2012 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Drug Interaction Hospitalization 12/13/2011 52 Female 3/19/2012 Physician United Kingdom
Primary
Concomitant
Interacting
Dystonia Hospitalization 12/13/2011 52 Female 3/16/2012 Other Health Professional
Primary
Secondary
Concomitant
Lymphocyte Count Decreased Hospitalization 12/13/2011 52 Female 3/21/2012 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Neutrophil Count Increased Other Serious 5/12/2006 Female 3/28/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Other Serious 12/13/2011 52 Female 3/29/2012 Physician Netherlands
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 12/13/2011 52 Female 4/6/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Pyrexia Other Serious 5/12/2006 36 Female 4/9/2012 Other Health Professional United Kingdom
Primary
Secondary
Dysarthria Hospitalization 12/13/2011 52 Female 4/9/2012 Physician United Kingdom
Primary
Concomitant
Interacting
Dystonia Hospitalization 11/19/2010 52 Female 4/9/2012 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Lymphocyte Count Decreased Hospitalization 12/13/2011 52 Female 4/15/2012 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Hypertension Other Serious 5/12/2006 Female 4/17/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Potentiating Drug Interaction Other Serious 12/13/2011 52 Female 4/13/2012 Physician
Primary
Secondary
Concomitant
Monocyte Count Increased Other Serious 36 Female 4/13/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Sleep Disorder Disability 10/1/2009 68 Male 225 lb 5/9/2012 Consumer United States
Primary
Secondary
Concomitant
Hypertension Other Serious 5/12/2006 36 Female 5/11/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/1/2009 70 Male 235 lb 5/16/2012 Consumer United States
Primary
Secondary
Concomitant
Constipation Other Serious 5/12/2006 36 Female 5/24/2012 Consumer United Kingdom
Primary
Secondary
Concomitant
Hiatus Hernia Other Serious 5/12/2006 36 Female 5/24/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Dyspnoea Disability 10/1/2009 70 Male 225 lb 5/24/2012 Consumer United States
Primary
Secondary
Concomitant
Sleep Disorder Disability 1/1/2009 69 Male 225 lb 5/29/2012 Consumer United States
Primary
Secondary
Concomitant
Malaise Other Serious 5/12/2006 36 Female 5/29/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Hypertension Hospitalization 5/12/2006 36 Female 5/29/2012 Physician United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Disorder Other Serious 5/12/2006 36 Female 5/30/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Fatigue Other Serious 10/22/2010 71 Male 236 lb 6/8/2012 Consumer United States
Primary
Secondary
Concomitant
Chest Discomfort Other Serious 10/1/2009 70 Male 235 lb 6/11/2012 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Disorder Hospitalization 5/12/2006 36 Female 6/12/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Monocyte Count Increased Hospitalization 5/12/2006 36 Female 6/27/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Abdominal Distension Death 4/28/2011 64 Male 6/28/2012 Pharmacist United States
Primary
Concomitant
Nausea Hospitalization 43 Female 232 lb 6/28/2012 Physician United States
Primary
Concomitant
Granulocytopenia Other Serious 2/27/2012 51 Male 220 lb 6/28/2012 Pharmacist United States
Primary
Secondary
Concomitant
Granulocytopenia Other Serious 3/14/2012 44 Male 6/28/2012 Pharmacist United States
Primary
Concomitant
Granulocytopenia Other Serious 4/27/2011 26 Male 6/28/2012 Pharmacist United States
Primary
Concomitant
Inflammation Hospitalization 7/4/2011 41 Male 6/29/2012 Other Health Professional France
Primary
Secondary
Concomitant
Physical Assault Other Serious 5/12/2006 36 Female 7/6/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Convulsion Death 12/3/2010 43 Female 220 lb 7/10/2012 Other Health Professional United Kingdom
Primary
Concomitant
Convulsion Death 12/3/2010 43 Female 220 lb 7/11/2012 Other Health Professional United Kingdom
Primary
Concomitant
Thrombocytosis Other Serious 5/12/2006 35 Female 7/12/2012 Physician United Kingdom
Primary
Secondary
Concomitant

Drug Data