Clozapine combined with Lactulose

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Convulsion Death 11/6/2005 56 Male 1/24/2006 Other Health Professional United States
Primary
Concomitant
Neoplasm Malignant Death 1/1/2006 70 Male 154 lb 2/2/2006 United States
Primary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 2/9/2006
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 2/10/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Life Threatening 1/12/2006 76 Male 2/14/2006 Physician Netherlands
Primary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 2/13/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 2/14/2006 United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 2/15/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 2/16/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rash 6/3/2005 55 Female 165 lb 2/28/2006 Consumer United States
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 51 Male 2/28/2006
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 2/28/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Male 3/1/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 51 Male 3/8/2006
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/7/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/7/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/3/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Unknown 3/3/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 51 Male 3/2/2006 United Kingdom
Primary
Secondary
Concomitant
Pharmaceutical Product Complaint Hospitalization 51 Female 3/7/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/16/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/2/2006 United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/10/2006 United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/16/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/22/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 51 Female 3/27/2006 United Kingdom
Primary
Secondary
Concomitant
Pharmaceutical Product Complaint Hospitalization 51 Female 3/29/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 4/6/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 4/6/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 1/17/2006 29 Female 157 lb 4/11/2006 United States
Primary
Secondary
Concomitant
Leukopenia Life Threatening 10/5/2005 72 Male 263 lb 4/26/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/3/2005 42 Male 1/25/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 8/19/2005 22 Male 1/24/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/22/2005 35 Male 269 lb 1/30/2006 United States
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 9/26/2005 53 Female 132 lb 2/8/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/31/2005 40 Male 2/6/2006 Consumer United States
Primary
Concomitant
Leukopenia Life Threatening 3/14/2006 48 Male 164 lb 5/18/2006 Consumer United States
Primary
Concomitant
Small Cell Carcinoma Death 7/26/2006 45 Female 8/31/2006 United States
Primary
Concomitant
Pneumonia Aspiration Death 9/19/2006 90 Male 10/11/2006 United States
Primary
Concomitant
Death Death 8/26/2006 74 Male 127 lb 11/3/2006 United States
Primary
Concomitant
Constipation Other Serious 12/3/2005 29 Male 12/16/2006 Other Health Professional United Kingdom
Primary
Concomitant
Neutrophil Count Decreased Life Threatening 12/7/2006 Male 12/28/2006 Pharmacist United States
Primary
Concomitant
Head Injury Other Serious 12/6/2006 38 Male 157 lb 12/27/2006 Physician United Kingdom
Primary
Concomitant
Head Injury Other Serious 12/6/2006 38 Male 157 lb 12/22/2006 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Death 12/1/2006 28 Female 1/16/2007 United Kingdom
Primary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 2/15/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Small Intestinal Obstruction Hospitalization 1/11/2007 56 Male 190 lb 2/27/2007 Pharmacist United States
Primary
Concomitant
Liver Injury Hospitalization 3/8/2007 76 Female 132 lb 5/11/2007 Consumer Switzerland
Primary
Secondary
Concomitant
Splenomegaly Other Serious 40 Male 2/27/2008 United Kingdom
Primary
Concomitant
Splenomegaly Other Serious 40 Male 2/27/2008 United Kingdom
Primary
Concomitant
Malaise Other Serious 4/19/2008 Female 6/2/2008 Physician Canada
Primary
Concomitant
Malaise Other Serious 4/19/2008 Female 6/2/2008 Physician Canada
Primary
Concomitant
Overdose Hospitalization 6/6/2007 Male 148 lb 7/3/2008 Physician Germany
Primary
Concomitant
Urinary Tract Obstruction Hospitalization 1/1/1991 47 Male 7/21/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Lymphocytosis Other Serious 1/1/2008 Male 8/7/2008 Physician France
Primary
Concomitant
Vomiting Other Serious 6/24/2008 31 Male 12/1/2008 United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/24/2008 31 Male 12/1/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pneumonia Other Serious 6/24/2008 31 Male 12/1/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Post Procedural Complication Other Serious 7/12/2008 31 Male 12/5/2008 Other Health Professional United Kingdom
Primary
Concomitant
Tachycardia Other Serious 2/1/2008 Female 6/1/2009 Physician Norway
Primary
Concomitant
Sudden Death Other Serious 1/1/2007 33 Male 6/12/2009 Physician Canada
Primary
Concomitant
White Blood Cell Count Increased Other Serious 5/24/2008 69 Female 6/15/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 7/12/2006 36 Female 6/15/2009 Other Health Professional United Kingdom
Primary
Secondary
Duodenal Ulcer Haemorrhage Life Threatening 5/24/2008 69 Female 115 lb 6/18/2009 Other Health Professional Germany
Primary
Concomitant
Interacting
Peptic Ulcer Life Threatening 5/24/2008 69 Female 115 lb 6/17/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Platelet Count Decreased Hospitalization 7/31/2009 52 Male 10/6/2009 Other Health Professional United Kingdom
Primary
Concomitant
Syncope Hospitalization 7/31/2009 52 Male 10/13/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Syncope Hospitalization 7/31/2009 52 Male 10/14/2009 Other Health Professional France
Primary
Secondary
Concomitant
Syncope Other Serious 7/31/2009 52 Male 11/10/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Salivary Hypersecretion Hospitalization 7/31/2009 52 Male 11/10/2009 Other Health Professional United Kingdom
Primary
Concomitant
Hyponatraemia Hospitalization 7/31/2009 52 Male 11/17/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Syncope Life Threatening 7/31/2009 52 Male 11/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Syncope Life Threatening 7/31/2009 52 Male 11/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Syncope Hospitalization 7/31/2009 52 Male 11/13/2009 United Kingdom
Primary
Concomitant
Hyponatraemia Hospitalization 7/31/2009 52 Male 11/19/2009
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 5/24/2008 69 Female 115 lb 12/1/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Interacting
Overdose Hospitalization 6/6/2007 Male 148 lb 12/1/2009 Physician Germany
Primary
Concomitant
Syncope Hospitalization 7/31/2009 52 Male 12/8/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Duodenal Ulcer Haemorrhage Life Threatening 5/24/2008 69 Female 115 lb 12/9/2009 Other Health Professional Germany
Primary
Concomitant
Interacting
Duodenal Ulcer Haemorrhage Life Threatening 5/24/2008 69 Female 115 lb 12/9/2009 Other Health Professional Germany
Primary
Concomitant
Interacting
Duodenal Ulcer Haemorrhage Life Threatening 5/24/2008 69 Female 115 lb 12/9/2009 Other Health Professional Germany
Primary
Concomitant
Interacting
White Blood Cell Count Increased Life Threatening 5/24/2008 69 Female 115 lb 12/8/2009 Other Health Professional Denmark
Primary
Secondary
Concomitant
Syncope Hospitalization 7/31/2009 52 Male 1/8/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Myoclonus Required Intervention 7/15/2008 54 Male 225 lb 10/21/2008 Pharmacist United States
Primary
Concomitant
Sudden Death Death 5/8/2009 Female 188 lb 3/25/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 7/12/2006 36 Female 5/10/2010 Other Health Professional United Kingdom
Primary
Secondary
Neuroleptic Malignant Syndrome Hospitalization 2/24/2010 40 Male 6/16/2010 Physician Germany
Primary
Secondary
Concomitant
Death Death 67 Male 6/24/2010 Pharmacist United States
Primary
Concomitant
Death Death 11/27/2009 58 Male 6/24/2010 Pharmacist United States
Primary
Concomitant
Leukopenia Other Serious 11/24/2009 25 Male 161 lb 6/24/2010 Pharmacist United States
Primary
Concomitant
Death Death 12/19/2009 67 Male 6/24/2010 Pharmacist United States
Primary
Concomitant
Death Death 12/7/2009 82 Male 6/24/2010 Pharmacist United States
Primary
Concomitant
Sepsis Life Threatening 5/3/2010 86 Female 7/23/2010 Pharmacist Germany
Primary
Secondary
Concomitant
Sepsis Life Threatening 5/3/2010 86 Female 8/12/2010 Pharmacist Germany
Primary
Secondary
Concomitant
Vomiting Other Serious 9/1/2008 41 Male 9/16/2010 Other Health Professional United Kingdom
Primary
Concomitant
Spleen Congestion Death 41 9/22/2010 Other Health Professional
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 9/20/2010 45 Male 12/2/2010 United Kingdom
Primary
Secondary
Concomitant
Renal Failure Hospitalization 9/1/2010 63 Female 2/24/2011 Physician United States
Primary
Secondary
Concomitant
Asthma Death 3/1/2011 Other Health Professional Australia
Primary
Concomitant
Myocarditis Other Serious 3/1/2011 Other Health Professional Australia
Primary
Concomitant
Asthma Death 3/18/2011 Other Health Professional Australia
Primary
Concomitant
Intestinal Perforation Hospitalization 41 Male 4/13/2011 Other Health Professional United Kingdom
Primary
Concomitant
Myocarditis Death 5/12/2011 Other Health Professional Australia
Primary
Concomitant
Dyspnoea Hospitalization 6/9/2004 71 Male 6/8/2011 Other Health Professional Canada
Primary
Concomitant
Metastatic Neoplasm Death 12/1/2003 56 Male 6/8/2011 Other Health Professional New Zealand
Primary
Concomitant
Death Death 12/7/2005 66 Female 6/6/2011 Physician New Zealand
Primary
Concomitant
Death Death 3/22/2004 78 Male 6/4/2011 Physician New Zealand
Primary
Concomitant
Pneumonia Hospitalization 1/21/2005 77 Male 138 lb 6/4/2011 Physician Canada
Primary
Concomitant
Lung Neoplasm Malignant Hospitalization Male 6/4/2011 Physician United Kingdom
Primary
Concomitant
Epididymitis Other Serious 6/24/2008 31 Male 6/8/2011 Physician United Kingdom
Primary
Concomitant
Myocardial Infarction Death 2/7/2007 69 Female 5/30/2011 Physician United Kingdom
Primary
Concomitant
Circulatory Collapse Death 8/17/2001 60 Male 6/10/2011 Consumer United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Death 9/11/2007 61 Female 190 lb 6/10/2011 Other Health Professional United Kingdom
Primary
Concomitant
Peptic Ulcer Haemorrhage Hospitalization Male 6/13/2011 Consumer United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Hospitalization Male 6/11/2011 Consumer United Kingdom
Primary
Concomitant
Tooth Abscess Hospitalization 10/1/2002 37 Female 6/11/2011 Consumer United Kingdom
Primary
Concomitant
Oropharyngeal Pain Other Serious Male 6/12/2011 Consumer United Kingdom
Primary
Concomitant
Asthma Death 7/6/2007 53 Male 6/13/2011 Physician United Kingdom
Primary
Concomitant
Myocarditis Death Male 6/2/2011 Physician Australia
Primary
Concomitant
Mobility Decreased Hospitalization Male 6/14/2011 Consumer United Kingdom
Primary
Concomitant
Pneumonia Hospitalization Female 6/14/2011 Consumer United Kingdom
Primary
Concomitant
Hepatitis C Virus Test Positive Death Male 6/14/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Pneumonia Hospitalization 3/8/2004 6/14/2011 Other Health Professional United Kingdom
Primary
Concomitant
Fractured Sacrum Other Serious 7/11/2005 55 Male 6/14/2011 Physician United Kingdom
Primary
Concomitant
Fibula Fracture Death 6/1/2004 47 Female 6/14/2011 Consumer United Kingdom
Primary
Concomitant
Renal Cancer Death Male 6/15/2011 Pharmacist United Kingdom
Primary
Concomitant
Blood Creatine Phosphokinase Increased Other Serious 7/16/2004 50 Male 6/15/2011 Consumer United Kingdom
Primary
Concomitant
Fatigue Disability 6/30/2004 41 Male 6/15/2011 Consumer United Kingdom
Primary
Concomitant
Confusional State Hospitalization Male 6/15/2011 Physician United Kingdom
Primary
Concomitant
Cyanosis Other Serious Female 6/17/2011 Physician United Kingdom
Primary
Concomitant
Respiratory Failure Death 6/9/2010 43 Male 6/22/2011 Pharmacist United States
Primary
Concomitant
Granulocytopenia Other Serious 6/30/2010 70 Female 6/22/2011 Other Health Professional United States
Primary
Concomitant
Granulocytopenia Other Serious 10/18/2010 39 Male 172 lb 6/22/2011 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 7/13/2010 46 Female 6/22/2011 Pharmacist United States
Primary
Secondary
Concomitant
Granulocytopenia Other Serious 12/1/2010 41 Male 190 lb 6/22/2011 Pharmacist United States
Primary
Concomitant
Agranulocytosis Other Serious 12/16/2010 80 Female 6/22/2011 Pharmacist United States
Primary
Concomitant
Leukopenia Other Serious 2/15/2011 50 Male 138 lb 6/22/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Granulocytopenia Other Serious 3/7/2011 40 Male 6/22/2011 Pharmacist United States
Primary
Concomitant
Death Death 2/2/2011 65 Male 6/22/2011 Pharmacist United States
Primary
Concomitant
Granulocytopenia Other Serious 4/19/2011 48 Male 194 lb 6/22/2011 Pharmacist United States
Primary
Concomitant
Syncope Hospitalization 5/30/2011 41 Male 6/23/2011 Physician United Kingdom
Primary
Concomitant
Pancreatitis Death 5/30/2011 41 Male 6/29/2011 Pharmacist United Kingdom
Primary
Concomitant
Personality Disorder Other Serious Female 6/30/2011 Physician United Kingdom
Primary
Concomitant
Lower Respiratory Tract Infection Other Serious 6/26/2011 63 Male 7/11/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hyperthyroidism Death 1/1/1998 50 Male 7/15/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Syncope Other Serious 1/31/2011 65 Male 7/19/2011 Physician Ireland
Primary
Concomitant
Diarrhoea Hospitalization Female 7/21/2011 Other Health Professional United Kingdom
Primary
Concomitant
Faecal Incontinence Other Serious Female 8/8/2011 Physician United Kingdom
Primary
Concomitant
Haemoglobin Increased Other Serious 4/11/2011 26 Male 199 lb 8/29/2011 Physician United Kingdom
Primary
Concomitant
Malignant Melanoma Hospitalization 1/1/2010 Male 9/9/2011 Physician United Kingdom
Primary
Secondary
Concomitant

Drug Data