Clozapine combined with Lamotrigine

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Renal Tubular Necrosis Other Serious 10/9/2005 51 Male 1/9/2006 France
Primary
Secondary
Concomitant
Menorrhagia Hospitalization 10/2/2005 47 Female 2/15/2006 United States
Primary
Concomitant
Drug Exposure During Pregnancy Other Serious 24 Female 3/16/2006 Other Health Professional Canada
Primary
Concomitant
Treatment Noncompliance Hospitalization 1/1/2005 62 Female 12/14/2005 Physician United States
Primary
Concomitant
Schizophrenia, Disorganised Type Required Intervention 1/31/2006 55 Male 190 lb 5/8/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/15/2005 13 Male 6/1/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/19/2005 48 Male 3/21/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/25/2006 43 Male 150 lb 3/21/2006 United States
Primary
Secondary
Concomitant
Leukopenia Required Intervention 12/16/2005 30 Female 178 lb 3/3/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/5/2005 48 Male 6/16/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/17/2005 20 Female 1/27/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/27/2005 44 Male 1/18/2006 Consumer United States
Primary
Concomitant
Leukopenia Required Intervention 10/3/2005 54 Female 137 lb 5/31/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/15/2005 22 Male 2/8/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/15/2005 48 Female 88 lb 2/24/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/31/2005 40 Male 2/6/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 8/15/2005 26 Male 5/17/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/9/2005 41 Female 1/13/2006 United States
Primary
Concomitant
Tonic Convulsion 29 Male 212 lb 1/30/2006 Pharmacist United States
Primary
Secondary
Concomitant
Leukopenia Required Intervention 8/29/2005 49 Male 200 lb 1/20/2006 Consumer United States
Primary
Concomitant
Leukopenia Required Intervention 1/31/2006 36 Male 4/19/2006 Consumer United States
Primary
Concomitant
Leukopenia Required Intervention 3/1/2006 60 Female 5/18/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 3/9/2006 22 Male 5/9/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 3/16/2006 10 Male 4/13/2006 Consumer United States
Primary
Concomitant
Respiratory Rate Increased Other Serious 54 Female 8/29/2006 United Kingdom
Primary
Secondary
Concomitant
Hypoglycaemia Life Threatening 10/20/2006 31 Male 11/6/2006 Physician Argentina
Primary
Concomitant
Death Death 10/1/2006 41 Female 11/6/2006 United States
Primary
Concomitant
Posture Abnormal Other Serious 52 Female 1/19/2007 Other Health Professional Spain
Primary
Secondary
Pneumonia Aspiration Hospitalization 10/25/2006 39 Male 181 lb 1/25/2007 Pharmacist United States
Primary
Concomitant
Psoriasis Other Serious 2/9/2007 Physician Belgium
Primary
Concomitant
Convulsion Other Serious 5/1/2006 51 Male 12/19/2006 Physician United States
Primary
Concomitant
Treatment Noncompliance Hospitalization 2/1/2007 16 Female 3/29/2007 Other Health Professional United States
Primary
Secondary
Thermal Burn Other Serious 12/1/2006 Male 198 lb 4/26/2007 Physician Belgium
Primary
Concomitant
White Blood Cell Count Decreased 2/14/2007 9 Female 4/25/2007 Pharmacist United States
Primary
Concomitant
Pneumonia Hospitalization Male 12/7/2007 Physician United States
Primary
Concomitant
Completed Suicide Death 50 Female 1/21/2008 United States
Primary
Secondary
Heart Rate Increased Other Serious 1/7/2008 Female 136 lb 1/28/2008 Consumer United States
Primary
Concomitant
Completed Suicide Death 50 Female 1/29/2008 Physician United States
Primary
Secondary
Renal Failure Other Serious Male 2/21/2008 United States
Primary
Secondary
Concomitant
Rash Generalised Other Serious 20 Male 3/9/2008 Consumer
Primary
Secondary
Concomitant
Heart Rate Increased Other Serious 1/7/2008 Female 136 lb 3/19/2008 Consumer United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2008 20 Male 4/9/2008 Consumer United States
Primary
Secondary
Concomitant
Pickwickian Syndrome Death 4/15/2008 Male 7/21/2008 Physician United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 52 Male 9/8/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 8/1/2007 22 Male 9/24/2008 Consumer United States
Primary
Concomitant
Tremor Hospitalization 72 Female 11/14/2008 France
Primary
Concomitant
Interacting
Tremor Other Serious 72 Female 11/7/2008 Taiwan, Province Of China
Primary
Secondary
Concomitant
Varicose Vein Hospitalization 12/16/2008 Female 1/2/2009 Physician New Zealand
Primary
Concomitant
Sudden Death Other Serious 1/1/2007 33 Male 6/12/2009 Physician Canada
Primary
Concomitant
Hallucination, Auditory Hospitalization 27 Male 6/23/2009 Physician Korea, Republic Of
Primary
Secondary
Ventricular Hypertrophy Other Serious Male 7/13/2009 Other Health Professional Korea, Republic Of
Primary
Concomitant
Ventricular Hypertrophy Other Serious 1/15/2009 14 Male 7/31/2009 Other Health Professional Korea, Republic Of
Primary
Concomitant
Psychotic Disorder Other Serious 47 Female 9/16/2009 Other Health Professional Spain
Primary
Concomitant
Terminal State Other Serious 1/22/2009 70 Female 10/15/2009 Physician United Kingdom
Primary
Interacting
Sepsis Hospitalization 61 Male 11/10/2009 Physician Canada
Primary
Secondary
Concomitant
Terminal State Other Serious 70 Female 11/5/2009 United Kingdom
Primary
Secondary
Concomitant
Sepsis Hospitalization 1/1/2009 61 Male 11/19/2009 Physician Canada
Primary
Secondary
Concomitant
Intestinal Obstruction Hospitalization 61 Male 11/23/2009 Physician Canada
Primary
Secondary
Concomitant
Sepsis Hospitalization 61 Male 1/8/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Myoclonus Other Serious Male 1/21/2010 Other Health Professional United States
Primary
Secondary
Myoclonus Other Serious Male 1/22/2010 Other Health Professional United States
Primary
Secondary
Upper Respiratory Tract Infection Other Serious 43 Male 1/8/2010 Physician Austria
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 10/26/2009 66 Male 163 lb 10/29/2009 United States
Primary
Concomitant
Drug Toxicity Other Serious 43 Male 1/26/2010 Austria
Primary
Secondary
Concomitant
Pneumonia Aspiration Hospitalization 1/16/2010 65 Male 220 lb 3/9/2010 Physician Sweden
Primary
Concomitant
Unresponsive To Stimuli Other Serious 1/18/2010 79 Male 3/3/2010 Physician
Primary
Concomitant
Unresponsive To Stimuli Other Serious 1/18/2010 79 Male 3/15/2010 Physician United Kingdom
Primary
Concomitant
Unresponsive To Stimuli Other Serious 1/15/2010 79 Male 3/19/2010 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Drug Toxicity Other Serious Male 4/5/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Sepsis Other Serious 36 Male 4/9/2010 Other Health Professional United Kingdom
Primary
Secondary
Drug Level Increased Life Threatening 3/3/2010 40 Male 254 lb 4/14/2010 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Sepsis Hospitalization 36 Male 4/30/2010 Other Health Professional United Kingdom
Primary
Secondary
Drug Level Increased Life Threatening 3/3/2010 40 Male 254 lb 5/3/2010 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Upper Respiratory Tract Infection Other Serious 43 Male 5/25/2010 Other Health Professional Austria
Primary
Secondary
Concomitant
Vomiting Hospitalization 44 Male 95 lb 5/27/2010 Consumer United Kingdom
Primary
Concomitant
Vomiting Hospitalization 6/2/2010 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 44 Male 95 lb 6/3/2010 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 44 Male 95 lb 6/3/2010 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 44 Male 95 lb 6/7/2010 Consumer United Kingdom
Primary
Concomitant
Vomiting Other Serious 5/11/2010 44 Male 6/9/2010 Other Health Professional United Kingdom
Primary
Secondary
Upper Respiratory Tract Infection Other Serious 43 Male 6/10/2010 Other Health Professional Austria
Primary
Secondary
Concomitant
Rash Hospitalization 43 Male 6/14/2010 Other Health Professional Austria
Primary
Concomitant
Interacting
Vomiting Hospitalization 44 Male 6/10/2010 United Kingdom
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 43 Male 6/18/2010
Primary
Secondary
Death Death 67 Male 6/24/2010 Pharmacist United States
Primary
Concomitant
Convulsion Other Serious 30 Male 6/24/2010 Other Health Professional United States
Primary
Concomitant
Vomiting Hospitalization 44 Male 95 lb 6/28/2010 Consumer United Kingdom
Primary
Concomitant
Vomiting Hospitalization 44 Male 6/24/2010 United Kingdom
Primary
Concomitant
Pyrexia Hospitalization 43 Male 7/2/2010 Consumer United Kingdom
Primary
Secondary
White Blood Cell Count Increased Hospitalization 44 Male 7/15/2010 United Kingdom
Primary
Concomitant
Schizophrenia Other Serious Male 7/30/2010 Other Health Professional United Kingdom
Primary
Secondary
Myocardial Infarction Other Serious 7/1/2010 58 Female 9/8/2010 Physician United States
Primary
Concomitant
Subdural Haematoma Hospitalization 8/1/2010 51 Female 9/10/2010 Physician United States
Primary
Concomitant
Pulmonary Oedema Other Serious 48 Male 9/16/2010 Other Health Professional United Kingdom
Primary
Concomitant
Drug Level Increased Life Threatening 3/3/2010 40 Male 254 lb 9/16/2010 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Hypertension Death 48 Male 9/21/2010 Other Health Professional United Kingdom
Primary
Secondary
Breast Cancer Other Serious 8/1/2010 49 Female 9/21/2010 Other Health Professional Netherlands
Primary
Secondary
Restlessness Hospitalization 49 Female 9/23/2010 Other Health Professional United States
Primary
Concomitant
Pulmonary Oedema Other Serious 48 Male 9/20/2010 United Kingdom
Primary
Secondary
Catatonia Other Serious 49 Female 9/28/2010 Physician United States
Primary
Concomitant
Withdrawal Syndrome Hospitalization 49 Female 9/20/2010 Physician United States
Primary
Concomitant
Pulmonary Oedema Death 48 Male 10/5/2010 Other Health Professional United Kingdom
Primary
Secondary
Pulmonary Oedema Death 48 Male 10/5/2010 Other Health Professional United Kingdom
Primary
Secondary
Pulmonary Oedema Death 48 Male 10/5/2010 Other Health Professional United Kingdom
Primary
Secondary
White Blood Cell Count Increased Other Serious 1/1/2010 49 Female 10/14/2010 Other Health Professional Netherlands
Primary
Secondary
Pulmonary Oedema Death 48 10/6/2010 Other Health Professional
Primary
Secondary
Platelet Count Decreased Other Serious 49 Female 10/11/2010 United Kingdom
Primary
Secondary
Concomitant
Sepsis Other Serious 36 Male 10/25/2010 Consumer Croatia (Local Name: Hrvatska)
Primary
Secondary
Concomitant
Somnolence Other Serious 36 Male 10/29/2010 Consumer Croatia (Local Name: Hrvatska)
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 49 Female 10/23/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 8/1/2010 49 Female 10/28/2010 Physician
Primary
Secondary
Concomitant
Sepsis Hospitalization 36 Male 11/15/2010 Other Health Professional Croatia (Local Name: Hrvatska)
Primary
Concomitant
White Blood Cell Count Increased Other Serious 49 Female 11/6/2010 United Kingdom
Primary
Secondary
Concomitant
Rash Hospitalization 27 Male 11/22/2010 Other Health Professional United Kingdom
Primary
Secondary
Rash Hospitalization 27 Male 11/29/2010 Other Health Professional United Kingdom
Primary
Secondary
Vomiting Other Serious 5/11/2010 44 Male 12/2/2010 Other Health Professional United Kingdom
Primary
Secondary
Rash Hospitalization 27 Male 12/2/2010 Other Health Professional United Kingdom
Primary
Secondary
Rash Hospitalization 27 Male 12/3/2010 Other Health Professional United Kingdom
Primary
Secondary
Drug Level Increased Life Threatening 3/3/2010 40 Male 254 lb 5/3/2010 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Sudden Death Death 7/28/2010 27 Male 12/15/2010 Physician Canada
Primary
Concomitant
Rash Hospitalization 27 Male 12/9/2010 Other Health Professional
Primary
Secondary
Sudden Death Death 7/28/2010 27 Male 12/29/2010 Physician Canada
Primary
Concomitant
Somnolence 45 Female 1/10/2011 Physician United States
Primary
Secondary
Rash Other Serious Male 1/17/2011 Other Health Professional India
Primary
Secondary
White Blood Cell Count Decreased Other Serious 10/1/2010 59 Male 199 lb 10/19/2010 Pharmacist United States
Primary
Secondary
Rash Other Serious Male 1/25/2011 Other Health Professional India
Primary
Secondary
Sepsis Hospitalization 61 Male 1/5/2011 Canada
Primary
Secondary
Concomitant
Somnolence 12/9/2010 45 Female 1/29/2011 Physician United States
Primary
Secondary
Concomitant
General Physical Health Deterioration Other Serious 49 Female 1/17/2011 United Kingdom
Primary
Secondary
Concomitant
Delirium Hospitalization 1/8/2011 57 Female 201 lb 1/28/2011 Pharmacist United States
Primary
Concomitant
Toxicity To Various Agents Death 1/1/2009 48 Male 1/25/2011 Physician United States
Primary
Secondary
Completed Suicide Death 48 Male 1/28/2011 Denmark
Primary
Secondary
Completed Suicide Death 48 Male 2/2/2011 United States
Primary
Secondary
Drug Level Changed Other Serious 40 Male 3/10/2011 Physician United Kingdom
Primary
Concomitant
Left Ventricular Hypertrophy Death 48 Male 4/13/2011 Other Health Professional United Kingdom
Primary
Concomitant
Gastrointestinal Hypomotility Death 48 Male 4/27/2011 Other Health Professional United Kingdom
Primary
Concomitant
Tardive Dyskinesia Other Serious 61 Female 5/6/2011 Physician Turkey
Primary
Secondary
Hypertension Other Serious 48 Male 5/23/2011 Other Health Professional United Kingdom
Primary
Concomitant
Drug Ineffective 29 Female 5/31/2011 Physician United States
Primary
Secondary
Extrasystoles Other Serious Male 5/27/2011 Physician Canada
Primary
Secondary
Concomitant
Drug Ineffective 29 Female 6/7/2011 Physician United States
Primary
Secondary
Metastases To Spine Other Serious 8/1/2010 49 Female 5/31/2011 Physician
Primary
Secondary
Concomitant
Electrocardiogram Abnormal Other Serious 1/10/2006 28 Female 6/2/2011 Consumer United Kingdom
Primary
Concomitant
Asthma Hospitalization 10/5/2008 47 Female 225 lb 6/5/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Spinal X-ray Disability Female 6/5/2011 Physician United Kingdom
Primary
Concomitant
Neutrophil Count Decreased Other Serious Male 6/4/2011 Physician Ireland
Primary
Concomitant
Haemoglobin Decreased Hospitalization 5/19/2011 62 Male 6/9/2011 Pharmacist United Kingdom
Primary
Concomitant
Neutrophil Count Increased Hospitalization 7/5/2007 61 Female 104 lb 6/5/2011 Physician Ireland
Primary
Concomitant
Neoplasm Malignant Other Serious 4/8/2003 49 Female 6/9/2011 Other Health Professional Canada
Primary
Secondary
Concomitant
Fall Congenital Anomaly Female 6/13/2011 Other Health Professional Canada
Primary
Concomitant

Drug Data