Clozapine combined with Lorazepam

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pleurothotonus Hospitalization 3/1/2005 Male 1/4/2006 Physician Germany
Primary
Secondary
Concomitant
Cardiomegaly Death Female 1/16/2006 United States
Primary
Concomitant
Cardiac Arrest Death 1/3/2006 64 Female 1/19/2006 United States
Primary
Concomitant
Necrosis Other Serious 1/1/2003 38 Female 1/25/2006 Other Health Professional Singapore
Primary
Concomitant
Treatment Noncompliance Hospitalization 1/1/2005 56 Male 1/26/2006 Pharmacist Canada
Primary
Secondary
Concomitant
Death Death 12/1/2005 50 Male 2/6/2006 United States
Primary
Concomitant
Dementia Alzheimer's Type Death 1/10/2006 83 Female 2/27/2006 United States
Primary
Concomitant
Neutropenia Other Serious 2/27/2006 50 Male 3/9/2006 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Cardiomegaly Death 12/1/2005 49 Female 3/7/2006 United States
Primary
Concomitant
Death Death 10/1/2005 55 Female 3/3/2006 Other Health Professional United States
Primary
Concomitant
Infection Death 3/4/2006 63 Male 3/17/2006 United States
Primary
Concomitant
Unevaluable Event Death 8/7/2005 54 Female 170 lb 12/14/2005 Other Health Professional United States
Primary
Concomitant
Pyrexia Other Serious 17 Female 3/28/2006 Physician Chile
Primary
Secondary
Concomitant
Neutrophil Count Decreased 2/27/2006 Male 175 lb 4/3/2006 Pharmacist United States
Primary
Concomitant
Speech Disorder Hospitalization 38 Female 4/7/2006 Physician Thailand
Primary
Concomitant
Disease Progression Death 1/10/2006 83 Female 4/17/2006 United States
Primary
Concomitant
Sinus Tachycardia Other Serious 10/1/2005 48 Male 4/7/2006 Physician United States
Primary
Concomitant
Tardive Dyskinesia Other Serious 1/1/2005 80 Female 130 lb 4/4/2006 Other Health Professional United States
Primary
Concomitant
Salivary Hypersecretion Hospitalization 11/1/2005 40 Female 130 lb 5/11/2006 France
Primary
Secondary
Concomitant
Mucosal Erosion Other Serious 12/1/2004 38 Female 5/19/2006 Other Health Professional United States
Primary
Concomitant
Posturing Life Threatening 3/21/2006 Male 5/17/2006 Pharmacist United States
Primary
Concomitant
Medication Error Death 45 5/23/2006 Physician United States
Primary
Secondary
Weight Increased Other Serious 1/1/2005 37 Female 188 lb 5/25/2006 United States
Primary
Concomitant
Surgery Hospitalization 6/8/2006 41 Female 71 lb 6/19/2006 Physician Malaysia
Primary
Concomitant
Death Death 1/1/2006 55 Female 6/14/2006 United States
Primary
Concomitant
Gastrointestinal Haemorrhage Death 5/30/2006 55 Female 7/6/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 8/16/2005 43 Male 1/17/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/12/2005 44 Female 1/30/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/20/2005 32 Male 2/3/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/1/2005 26 Female 3/6/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/6/2005 50 Male 201 lb 3/7/2006 Consumer United States
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 11/9/2005 24 Male 6/16/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/16/2005 43 Female 2/21/2006 United States
Primary
Concomitant
Malaise Required Intervention 11/22/2005 39 Female 180 lb 2/15/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/13/2006 50 Female 5/12/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/17/2005 30 Female 153 lb 2/8/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/26/2005 53 Female 132 lb 2/8/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/12/2005 49 Male 225 lb 3/1/2006 United States
Primary
Concomitant
Leukopenia Life Threatening 11/17/2005 17 Female 3/6/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/11/2005 30 Male 191 lb 3/2/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/15/2005 48 Female 88 lb 2/24/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/14/2005 29 Male 150 lb 3/22/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/1/2005 44 Male 217 lb 5/17/2006 United States
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 11/1/2005 57 Male 2/24/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 4/7/2006 81 Female 5/23/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 4/19/2006 62 Male 180 lb 6/21/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/8/2005 33 Male 153 lb 3/14/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/8/2006 49 Male 4/3/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/26/2006 35 Female 4/18/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/15/2006 43 Female 202 lb 4/17/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/20/2006 38 Female 3/27/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 8/29/2005 14 Male 1/11/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 3/8/2006 61 Female 4/10/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 3/9/2006 59 Female 100 lb 5/16/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/30/2006 43 Male 118 lb 5/15/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 3/13/2006 56 Female 180 lb 5/11/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 3/7/2006 38 Male 158 lb 6/1/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 3/10/2006 52 Female 5/22/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/13/2006 38 Female 143 lb 6/1/2006 Consumer United States
Primary
Concomitant
Leukopenia Life Threatening 3/14/2006 48 Male 164 lb 5/18/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/16/2006 38 Male 5/19/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 8/31/2005 43 Male 1/6/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/9/2005 35 Male 1/17/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/6/2005 19 Female 6/16/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/3/2006 52 Female 3/24/2006 United States
Primary
Concomitant
Intentional Overdose Death 3/1/2006 32 Female 8/11/2006 Physician France
Primary
Concomitant
Social Avoidant Behaviour Other Serious 42 Male 8/24/2006 Physician Germany
Primary
Secondary
Concomitant
Ventricular Extrasystoles Other Serious 3/24/2006 57 Male 8/28/2006 United Kingdom
Primary
Secondary
Concomitant
Sudden Death Death 8/1/2006 57 Female 141 lb 8/29/2006 Physician United States
Primary
Concomitant
Treatment Noncompliance Death 8/6/2006 81 Female 112 lb 9/11/2006 United States
Primary
Concomitant
Grand Mal Convulsion Other Serious 4/24/2004 34 Male 9/18/2006 Other Health Professional Germany
Primary
Secondary
Granulocytopenia Death 1/1/2006 56 Male 9/18/2006 United States
Primary
Concomitant
Death Death 8/4/2006 71 Male 9/27/2006 United States
Primary
Concomitant
Weight Decreased Other Serious 39 Male 10/10/2006 Other Health Professional Germany
Primary
Concomitant
Myocarditis Hospitalization 9/20/2006 26 Male 179 lb 9/22/2006 Pharmacist United States
Primary
Concomitant
Treatment Noncompliance Death 3/1/2006 33 Female 170 lb 10/10/2006 Physician France
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 5/1/2006 54 10/24/2006 Other Health Professional Austria
Primary
Secondary
Concomitant
Premature Baby Other Serious 10/4/2005 0 Female 10/19/2006 Physician Germany
Primary
Concomitant
Disinhibition Other Serious 1/1/2005 56 Male 11/2/2006 Pharmacist Canada
Primary
Secondary
Concomitant
Treatment Noncompliance Death 3/1/2006 33 Female 170 lb 10/12/2006 Physician France
Primary
Concomitant
Septic Shock Death 9/9/2006 28 Male 11/3/2006 United States
Primary
Concomitant
Troponin Increased Hospitalization 12/13/2006 51 Male 297 lb 12/29/2006 Pharmacist United States
Primary
Concomitant
Tachycardia Hospitalization 8/3/2006 78 Male 12/29/2006 Switzerland
Primary
Secondary
Concomitant
Septic Shock Death 9/9/2006 28 Male 1/2/2007 United States
Primary
Concomitant
Salivary Hypersecretion Other Serious 48 Male 172 lb 1/15/2007 Other Health Professional Italy
Primary
Secondary
Concomitant
Posture Abnormal Other Serious 52 Female 1/19/2007 Other Health Professional Spain
Primary
Secondary
Tardive Dyskinesia Other Serious 3/1/2005 42 Male 1/24/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Tardive Dyskinesia Other Serious 1/1/2003 40 Male 2/12/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Glomerulonephritis Death 1/1/2006 50 Male 3/8/2007 Physician Austria
Primary
Concomitant
Sopor Hospitalization 8/1/2006 50 3/2/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Sedation Hospitalization 12/21/2006 63 Female 146 lb 3/6/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Death Other Serious 1/15/2007 49 Male 5/1/2007 Pharmacist United States
Primary
Concomitant
Overdose Other Serious 10/12/2006 51 Male 5/23/2007 Physician Switzerland
Primary
Concomitant
White Blood Cells Urine Positive Other Serious 4/23/2007 54 Female 99 lb 6/1/2007 Physician Japan
Primary
Concomitant
Pseudophaeochromocytoma Other Serious 39 Male 5/30/2007 Germany
Primary
Concomitant
Drug Toxicity Hospitalization 36 Male 6/12/2007 Physician United States
Primary
Concomitant
Treatment Noncompliance Hospitalization 36 Male 6/21/2007 Physician United States
Primary
Concomitant
Tachycardia Life Threatening 2/18/2007 Female 6/30/2007 Physician Germany
Primary
Secondary
Concomitant
Waldenstrom's Macroglobulinaemia Other Serious 1/1/2005 51 Male 7/4/2007 Physician Switzerland
Primary
Concomitant
Skin Exfoliation Other Serious 36 Male 7/6/2007 Other Health Professional Italy
Primary
Concomitant
Testicular Swelling Other Serious 47 Male 8/7/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 7/6/2007 47 Male 154 lb 8/7/2007 Pharmacist United States
Primary
Concomitant
No Adverse Reaction Other Serious 47 Male 8/27/2007 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Tachycardia Other Serious 47 Male 8/24/2007 United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Other Serious 47 Male 8/31/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Orchitis Other Serious 47 Male 9/7/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Other Serious 47 Male 8/29/2007 United Kingdom
Primary
Secondary
Concomitant
Orchitis Other Serious 47 Male 9/18/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Gait Disturbance Hospitalization 9/12/2007 41 Female 106 lb 9/29/2007 Physician Japan
Primary
Secondary
Concomitant
Syncope Other Serious 56 Female 10/9/2007 Other Health Professional Denmark
Primary
Secondary
Concomitant
Suicidal Ideation Hospitalization 9/12/2007 41 Female 106 lb 10/26/2007 Physician Japan
Primary
Secondary
Concomitant
Skin Exfoliation Other Serious 36 Male 10/23/2007 Physician Italy
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 3/1/2006 41 Female 11/8/2007 Physician United States
Primary
Secondary
Concomitant
Syncope Other Serious 56 Female 11/7/2007 Other Health Professional Canada
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/1/2007 17 Male 166 lb 11/12/2007 Pharmacist United States
Primary
Secondary
Concomitant
Suicide Attempt Other Serious 11/2/2007 50 Female 11/20/2007 Germany
Primary
Secondary
Skin Exfoliation Hospitalization 36 Male 11/27/2007 Other Health Professional Italy
Primary
Secondary
Concomitant
Syncope Other Serious 56 Female 152 lb 11/27/2007 Other Health Professional Denmark
Primary
Secondary
Concomitant
Skin Exfoliation Other Serious 36 Male 12/4/2007 Other Health Professional Italy
Primary
Concomitant
Immune System Disorder Hospitalization 5/1/2007 17 Male 166 lb 12/6/2007 Pharmacist United States
Primary
Secondary
Concomitant
Tic 10/17/2006 49 Female 189 lb 11/6/2006 Pharmacist United States
Primary
Concomitant
Speech Disorder 61 Male 173 lb 10/30/2006 Pharmacist United States
Primary
Concomitant
Renal Disorder Hospitalization 36 Male 12/21/2007 Physician Italy
Primary
Concomitant
Tremor Required Intervention 5/18/2007 28 Male 170 lb 5/18/2007 Pharmacist United States
Primary
Secondary
Concomitant
Cytomegalovirus Infection Hospitalization 5/1/2007 17 Male 166 lb 12/19/2007 Pharmacist United States
Primary
Secondary
Concomitant
Suicidal Ideation Hospitalization 9/12/2007 41 Female 106 lb 12/28/2007 Physician Japan
Primary
Secondary
Concomitant
Suicidal Ideation Hospitalization 9/12/2007 41 Female 106 lb 12/28/2007 Physician Japan
Primary
Secondary
Concomitant
Renal Disorder Other Serious 36 Male 12/31/2007 Italy
Primary
Interacting
Somnolence Hospitalization 1/16/2008 Other Health Professional China
Primary
Secondary
Renal Disorder Hospitalization 36 Male 1/25/2008 Physician Italy
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/1/2006 41 Female 2/8/2008 Physician United States
Primary
Secondary
Concomitant
Atrial Fibrillation Hospitalization 1/30/2008 60 Female 213 lb 2/12/2008 Physician United States
Primary
Concomitant
Atrial Fibrillation Hospitalization 1/30/2008 60 Female 213 lb 2/13/2008 Physician United States
Primary
Concomitant
Agranulocytosis Other Serious 1/8/2008 51 Male 138 lb 3/5/2008 Pharmacist United States
Primary
Concomitant
Waxy Flexibility Other Serious 31 Male 3/24/2008 Other Health Professional Canada
Primary
Concomitant
White Blood Cell Count Increased Other Serious 2/1/2008 46 Male 5/5/2008 Physician Belgium
Primary
Secondary
Concomitant
Drug Interaction Other Serious 47 Male 5/28/2008 United Kingdom
Primary
Secondary
Concomitant
Platelet Count Increased Other Serious 10/1/2006 51 Male 6/5/2008 Other Health Professional United Kingdom
Primary
Secondary
Psychomotor Retardation Other Serious 8/10/2007 Male 6/24/2008 Germany
Primary
Secondary
Concomitant
Cerebral Haemorrhage Hospitalization 8/10/2007 54 Male 6/18/2008 Physician Germany
Primary
Concomitant
Somnolence Hospitalization 5/21/2008 58 Male 6/24/2008 Other Health Professional United States
Primary
Secondary
Overdose Hospitalization 6/6/2007 Male 148 lb 7/3/2008 Physician Germany
Primary
Concomitant
Pickwickian Syndrome Death 4/15/2008 Male 7/21/2008 Physician United States
Primary
Concomitant
Sinus Tachycardia Hospitalization 7/8/2008 23 Male 227 lb 7/15/2008 Pharmacist United States
Primary
Concomitant
Respiratory Depression Other Serious 8/2/2008 Female 8/12/2008 Pharmacist Germany
Primary
Secondary
Tachycardia Hospitalization 5/6/2008 Female 8/12/2008 Other Health Professional Germany
Primary
Secondary
Tachycardia Other Serious 47 Male 8/15/2008 United Kingdom
Primary
Secondary
Concomitant
Memory Impairment Life Threatening 6/24/2008 37 Male 8/27/2008 Physician Italy
Primary
Secondary
Neutropenia Other Serious 6/17/2008 Female 165 lb 8/27/2008 Physician Germany
Primary
Concomitant
Tachycardia Other Serious 47 Male 8/22/2008 Physician United Kingdom
Primary
Secondary
Concomitant

Drug Data