Clozapine combined with Valproic Acid

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Neutropenia Other Serious 8/25/2005 57 Female 1/31/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 2/9/2006
Primary
Secondary
Concomitant
Pneumonia Hospitalization 44 Female 2/17/2006 Other Health Professional United Kingdom
Primary
Secondary
Loss Of Consciousness Hospitalization 51 Female 2/13/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 2/16/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 51 Male 2/28/2006
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 2/28/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Male 3/1/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 51 Male 3/8/2006
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/7/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/7/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/3/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Unknown 3/3/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 51 Male 3/2/2006 United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/16/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/2/2006 United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/10/2006 United Kingdom
Primary
Secondary
Concomitant
Agranulocytosis Required Intervention 2/24/2005 49 Male 169 lb 3/22/2005 Pharmacist United States
Primary
Concomitant
Neutropenia Other Serious 2/22/2005 38 Male 245 lb 4/1/2005 Pharmacist United States
Primary
Concomitant
Agranulocytosis Required Intervention 4/20/2005 51 Male 194 lb 6/27/2005 Physician United States
Primary
Concomitant
Death Death 3/1/2005 41 Male 5/10/2005 Pharmacist United States
Primary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/16/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pyrexia Other Serious 17 Female 3/28/2006 Physician Chile
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 51 Female 3/27/2006 United Kingdom
Primary
Secondary
Concomitant
Pharmaceutical Product Complaint Hospitalization 51 Female 3/29/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 61 Male 4/6/2006 Canada
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 4/6/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Neutropenia Required Intervention 11/16/2004 38 Female 211 lb 12/20/2004 Physician United States
Primary
Concomitant
Schizophrenia Other Serious 1/1/2005 Female 5/1/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 1/21/2000 40 Female 6/1/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/25/2006 34 Male 5/25/2006 United Kingdom
Primary
Concomitant
Vomiting Hospitalization 34 Male 7/17/2006 France
Primary
Secondary
Concomitant
Interacting
Hepatotoxicity Other Serious 7/21/2006 France
Primary
Interacting
Rash Macular Other Serious 34 Male 7/21/2006 France
Primary
Concomitant
Granulocytopenia Required Intervention 10/18/2005 67 Male 202 lb 3/9/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/7/2005 40 Female 220 lb 5/16/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/26/2006 40 Female 3/20/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 2/7/2006 45 Male 6/1/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/26/2005 36 Male 259 lb 1/17/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 8/19/2005 22 Male 1/24/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/22/2005 35 Male 269 lb 1/30/2006 United States
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 11/28/2005 32 Male 3/20/2006 United States
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 9/26/2005 53 Female 132 lb 2/8/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/17/2005 47 Male 3/21/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 10/24/2005 51 Male 1/31/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/20/2005 31 Male 190 lb 2/14/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 4/17/2006 24 Female 221 lb 6/21/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 4/13/2006 31 Male 5/23/2006 Consumer United States
Primary
Concomitant
Leukopenia Required Intervention 4/10/2006 64 Female 5/22/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/13/2005 48 Female 5/17/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/6/2005 44 Male 180 lb 1/24/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/8/2005 33 Male 153 lb 3/14/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/1/2005 35 Male 190 lb 1/6/2006 Consumer United States
Primary
Concomitant
Hepatotoxicity Other Serious 8/9/2006 France
Primary
Interacting
Granulocytopenia Required Intervention 2/13/2006 48 Female 203 lb 5/18/2006 Consumer United States
Primary
Concomitant
Leukopenia Required Intervention 9/12/2005 60 Male 156 lb 1/9/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 3/13/2006 56 Female 180 lb 5/11/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 3/23/2006 25 Female 5/16/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/21/2005 57 Male 5/24/2006 United States
Primary
Secondary
Leukopenia Required Intervention 9/29/2005 55 Male 174 lb 3/24/2006 United States
Primary
Concomitant
Confusional State Hospitalization 2/22/2005 45 Female 7/17/2006 Physician United States
Primary
Secondary
Concomitant
Ventricular Extrasystoles Other Serious 3/24/2006 57 Male 8/28/2006 United Kingdom
Primary
Secondary
Concomitant
Pneumonia Hospitalization 44 Female 10/3/2006 Other Health Professional United Kingdom
Primary
Secondary
Prothrombin Time Prolonged Other Serious 1/1/2004 23 Female 10/6/2006 France
Primary
Interacting
Thrombocytopenia Other Serious 7/18/2006 34 Female 10/17/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Tachycardia Hospitalization 34 Female 10/27/2006 Consumer France
Primary
Secondary
Concomitant
Neutrophil Count Decreased Life Threatening 12/7/2006 Male 12/28/2006 Pharmacist United States
Primary
Concomitant
Postictal State Other Serious 7/13/2006 42 Female 1/3/2007 United Kingdom
Primary
Concomitant
Salivary Hypersecretion Other Serious 48 Male 172 lb 1/15/2007 Other Health Professional Italy
Primary
Secondary
Concomitant
Tachycardia Hospitalization 7/26/2006 34 Female 1/31/2007 Consumer France
Primary
Secondary
Concomitant
Polycystic Ovaries Hospitalization 3/1/2006 27 Female 2/8/2007 Physician Philippines
Primary
Concomitant
Pleurisy Other Serious 1/1/2005 53 Male 2/16/2007 Physician Germany
Primary
Secondary
Weight Increased Other Serious 33 Female 168 lb 3/14/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Wheezing Other Serious 1/4/2007 36 Male 3/21/2007 Physician Italy
Primary
Concomitant
Tachycardia Life Threatening 7/28/2006 33 Female 3/21/2007 Other Health Professional France
Primary
Concomitant
Weight Increased Other Serious 33 Female 168 lb 4/6/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Tachycardia Hospitalization 7/26/2006 34 Female 4/16/2007 Consumer France
Primary
Secondary
Concomitant
Tachycardia Required Intervention 7/26/2006 33 Female 4/6/2007 United Kingdom
Primary
Secondary
Concomitant
Stupor Hospitalization 38 Male 5/11/2007 Other Health Professional United States
Primary
Concomitant
Stupor Hospitalization 38 Male 5/11/2007 Other Health Professional United States
Primary
Concomitant
Tachycardia Life Threatening 7/28/2006 33 Female 5/21/2007 Other Health Professional France
Primary
Concomitant
Vomiting Hospitalization 34 Male 6/22/2007 France
Primary
Secondary
Concomitant
Interacting
Tachycardia Other Serious 64 Female 9/22/2007 Other Health Professional United States
Primary
Concomitant
Weight Increased Other Serious 25 Female 10/3/2007 Physician Netherlands
Primary
Secondary
Concomitant
Weight Increased Other Serious 25 Female 10/5/2007 Netherlands
Primary
Secondary
Concomitant
Tachycardia Hospitalization 7/28/2007 33 Female 10/9/2007 United Kingdom
Primary
Secondary
Weight Increased Other Serious 32 Male 10/23/2007 Physician Germany
Primary
Secondary
Concomitant
Weight Increased Other Serious 25 Female 10/24/2007 Netherlands
Primary
Secondary
Concomitant
Small Intestinal Obstruction Death 64 Female 11/2/2007
Primary
Secondary
Weight Increased Other Serious 25 Female 11/1/2007 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Weight Increased Other Serious 25 Female 11/6/2007 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Weight Increased Hospitalization 25 Female 11/20/2007
Primary
Secondary
Concomitant
Pleurothotonus Other Serious 39 Female 12/13/2007 Other Health Professional Taiwan, Province Of China
Primary
Concomitant
Weight Increased Other Serious 25 Female 12/18/2007 Netherlands
Primary
Secondary
Concomitant
Pleurothotonus Other Serious 39 Female 1/7/2008 France
Primary
Secondary
Interacting
Toxic Encephalopathy Other Serious 43 Female 1/10/2008 Other Health Professional United Kingdom
Primary
Secondary
Thrombocytopenia Hospitalization 6/1/2007 27 Male 1/15/2008 Other Health Professional United Kingdom
Primary
Secondary
Thrombocytopenia Life Threatening 7/26/2006 33 Female 5/13/2008 United Kingdom
Primary
Secondary
Concomitant
Pyrexia Life Threatening 4/2/2008 20 Male 5/29/2008
Primary
Secondary
Drug Interaction Death 7/21/2006 64 Male 6/5/2008 Physician United Kingdom
Primary
Concomitant
Drug Interaction Other Serious 7/21/2006 6/12/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Death 7/21/2006 64 Male 6/13/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Interacting
Drug Interaction Death 7/21/2006 64 Male 6/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Interacting
Drug Interaction Death 7/21/2006 64 Male 6/13/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Death 64 Male 6/18/2008 United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Death 7/21/2006 64 Male 6/18/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Somnolence Other Serious Female 6/30/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Paralysis Other Serious 17 Male 7/2/2008 Physician Colombia
Primary
Concomitant
Somnolence Other Serious Female 7/10/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Left Ventricular Failure Death 54 Male 7/30/2008 Other Health Professional United Kingdom
Primary
Secondary
Brain Neoplasm Other Serious 7/30/2008 Pharmacist Germany
Primary
Concomitant
Syncope Hospitalization 32 Male 8/1/2008 Other Health Professional France
Primary
Secondary
Concomitant
Neutropenia 55 Male 8/19/2008 United States
Primary
Concomitant
Interacting
Organ Failure Other Serious 5/10/2008 Male 184 lb 8/27/2008 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 55 Male 8/25/2008 Physician United States
Primary
Secondary
Concomitant
Red Blood Cell Count Decreased Other Serious 7/16/2008 37 Male 245 lb 9/22/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 10/2/2008 Female 10/21/2008 Consumer Colombia
Primary
Concomitant
Tremor Other Serious 72 Female 11/7/2008 Taiwan, Province Of China
Primary
Secondary
Concomitant
Vomiting Other Serious 6/24/2008 31 Male 12/1/2008 United Kingdom
Primary
Secondary
Concomitant
Post Procedural Complication Other Serious 7/12/2008 31 Male 12/5/2008 Other Health Professional United Kingdom
Primary
Concomitant
Drug Interaction Other Serious 7/21/2006 64 Male 12/24/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 46 Male 12/26/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Liver Disorder Other Serious 58 Male 12/26/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 46 Male 12/26/2008 Other Health Professional Netherlands
Primary
Concomitant
Interacting
Drug Interaction Death 7/21/2006 64 Male 12/29/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 46 Male 12/31/2008 Other Health Professional Netherlands
Primary
Secondary
Interacting
Rhabdomyolysis Hospitalization 46 Male 12/31/2008 Netherlands
Primary
Concomitant
Interacting
Drug Interaction Death 7/21/2008 64 Male 12/29/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 58 Male 1/12/2009 Physician Netherlands
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 46 Male 1/12/2009 Physician Netherlands
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 46 Male 1/20/2009 Other Health Professional Netherlands
Primary
Concomitant
Interacting
Infection Hospitalization 58 Male 1/23/2009 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Pulmonary Oedema Death 38 Male 1/26/2009 Other Health Professional Hong Kong
Primary
Concomitant
Weight Decreased Hospitalization 46 Male 1/28/2009 Consumer Netherlands
Primary
Secondary
Concomitant
Drug Level Increased Hospitalization 58 Male 1/28/2009 Consumer Netherlands
Primary
Secondary
Concomitant
Urinary Tract Infection Required Intervention 58 Male 2/11/2009 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Urosepsis Hospitalization 46 Male 2/11/2009 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Pleurothotonus Disability 67 Male 2/5/2009 Physician Argentina
Primary
Secondary
Concomitant
Liver Disorder Other Serious 58 Male 3/27/2009 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Suicidal Ideation Other Serious 4/6/2009 Other Health Professional United States
Primary
Secondary
Withdrawal Syndrome Hospitalization 45 Female 4/3/2009 Physician United States
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 58 Female 4/9/2009 Other Health Professional Australia
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 58 Female 4/14/2009 Other Health Professional Australia
Primary
Concomitant
Vomiting Other Serious 45 Female 4/30/2009 Other Health Professional Brazil
Primary
Concomitant
Vomiting Other Serious 45 Female 5/14/2009 Other Health Professional Brazil
Primary
Concomitant
Drug Interaction Hospitalization 58 Male 6/23/2009 Netherlands
Primary
Concomitant
Rhabdomyolysis Hospitalization 46 Male 6/23/2009 Netherlands
Primary
Concomitant
Subileus Death 1/11/2009 68 Female 117 lb 7/29/2009 Physician Germany
Primary
Secondary
Subileus Death 1/11/2009 68 Female 117 lb 7/29/2009 Other Health Professional Germany
Primary
Secondary
Subileus Death 1/11/2009 68 Female 117 lb 7/27/2009 Physician Germany
Primary
Secondary

Drug Data