| Primary |
| Metastases To Bone |
29.2% |
| Multiple Myeloma |
15.7% |
| Breast Cancer |
11.9% |
| Prostate Cancer |
7.5% |
| Breast Cancer Metastatic |
7.2% |
| Prostate Cancer Metastatic |
5.4% |
| Pain |
4.3% |
| Osteoporosis |
3.7% |
| Hypertension |
3.0% |
| Neoplasm Malignant |
2.0% |
| Depression |
1.3% |
| Prophylaxis |
1.3% |
| Hypercalcaemia |
1.2% |
| Lung Neoplasm Malignant |
1.0% |
| Bone Disorder |
1.0% |
| Diabetes Mellitus |
1.0% |
| Hypercalcaemia Of Malignancy |
0.9% |
| Renal Cell Carcinoma |
0.8% |
| Plasma Cell Myeloma |
0.8% |
| Metastatic Renal Cell Carcinoma |
0.8% |
|
| Osteonecrosis |
21.9% |
| Tooth Extraction |
13.2% |
| Death |
12.4% |
| Osteonecrosis Of Jaw |
12.3% |
| Pain |
5.7% |
| Weight Decreased |
4.7% |
| Toothache |
4.1% |
| Pain In Jaw |
3.0% |
| Vomiting |
2.9% |
| White Blood Cell Count Decreased |
2.4% |
| Osteomyelitis |
2.2% |
| Terminal State |
2.1% |
| Neoplasm Malignant |
1.9% |
| Swelling |
1.8% |
| Tooth Loss |
1.8% |
| Pyrexia |
1.7% |
| Wound Debridement |
1.6% |
| General Physical Health Deterioration |
1.5% |
| Tooth Disorder |
1.5% |
| Surgery |
1.3% |
|
| Secondary |
| Metastases To Bone |
19.2% |
| Multiple Myeloma |
15.5% |
| Breast Cancer |
13.1% |
| Prostate Cancer Metastatic |
8.2% |
| Breast Cancer Metastatic |
7.4% |
| Osteoporosis |
5.8% |
| Pain |
4.8% |
| Prostate Cancer |
4.0% |
| Product Used For Unknown Indication |
3.7% |
| Hypertension |
3.0% |
| Depression |
2.8% |
| Prophylaxis |
2.4% |
| Drug Use For Unknown Indication |
1.9% |
| Neoplasm Malignant |
1.7% |
| Hypercalcaemia |
1.5% |
| Plasma Cell Myeloma |
1.1% |
| Bone Loss |
1.1% |
| Bone Disorder |
1.0% |
| Anaemia |
0.9% |
| Anxiety |
0.9% |
|
| Tooth Extraction |
11.6% |
| Weight Decreased |
10.7% |
| Death |
9.8% |
| Osteonecrosis |
9.0% |
| Terminal State |
8.5% |
| Pain |
7.7% |
| Osteonecrosis Of Jaw |
6.3% |
| Vomiting |
6.0% |
| Toothache |
4.4% |
| General Physical Health Deterioration |
3.8% |
| Neoplasm Malignant |
2.8% |
| Wound Drainage |
2.5% |
| Wound Debridement |
2.4% |
| X-ray Abnormal |
2.2% |
| Wound Dehiscence |
2.1% |
| Pain In Jaw |
2.1% |
| Fatigue |
2.1% |
| Pneumonia |
2.1% |
| Weight Increased |
2.0% |
| Pyrexia |
1.9% |
|
| Concomitant |
| Product Used For Unknown Indication |
19.7% |
| Multiple Myeloma |
15.4% |
| Drug Use For Unknown Indication |
13.9% |
| Prophylaxis |
9.8% |
| Prostate Cancer |
4.2% |
| Breast Cancer |
4.0% |
| Hypertension |
3.9% |
| Pain |
3.9% |
| Plasma Cell Myeloma |
3.6% |
| Metastases To Bone |
3.4% |
| Breast Cancer Metastatic |
2.9% |
| Constipation |
2.2% |
| Metastatic Renal Cell Carcinoma |
2.2% |
| Cancer Pain |
2.1% |
| Non-small Cell Lung Cancer |
1.8% |
| Nausea |
1.8% |
| Prostate Cancer Metastatic |
1.4% |
| Renal Cell Carcinoma |
1.4% |
| Diabetes Mellitus |
1.2% |
| Insomnia |
1.0% |
|
| White Blood Cell Count Decreased |
9.2% |
| Death |
9.0% |
| Vomiting |
8.7% |
| Pneumonia |
7.7% |
| Weight Decreased |
7.6% |
| Pyrexia |
6.5% |
| Thrombocytopenia |
6.4% |
| Sepsis |
4.7% |
| Rash |
4.3% |
| Renal Failure |
4.2% |
| Pain |
3.8% |
| Multiple Myeloma |
3.5% |
| Renal Failure Acute |
3.4% |
| Stomatitis |
3.3% |
| Neutropenia |
3.1% |
| Diarrhoea |
3.1% |
| Neuropathy Peripheral |
3.1% |
| Pancytopenia |
2.9% |
| Disease Progression |
2.8% |
| Osteonecrosis |
2.8% |
|
| Interacting |
| Metastases To Bone |
12.2% |
| Rectal Cancer |
12.2% |
| Prostate Cancer |
10.2% |
| Adenocarcinoma |
6.1% |
| Breast Cancer |
6.1% |
| Breast Cancer Metastatic |
6.1% |
| Hypertension |
6.1% |
| Bone Disorder |
4.1% |
| Bone Lesion |
4.1% |
| Cardiac Failure |
4.1% |
| Hypercalcaemia |
4.1% |
| Multiple Myeloma |
4.1% |
| Nausea |
4.1% |
| Renal Cell Carcinoma |
4.1% |
| Autoimmune Thyroiditis |
2.0% |
| Breast Cancer Female |
2.0% |
| Fracture |
2.0% |
| Hyperuricaemia |
2.0% |
| Hypothyroidism |
2.0% |
| Lung Neoplasm Malignant |
2.0% |
|
| Thrombocytopenia |
14.3% |
| Hepatitis Toxic |
9.5% |
| Osteonecrosis Of Jaw |
9.5% |
| Blood Creatinine Increased |
4.8% |
| Drug Interaction |
4.8% |
| Fatigue |
4.8% |
| Hair Metal Test Abnormal |
4.8% |
| Hepatitis |
4.8% |
| Hypokalaemia |
4.8% |
| Nausea |
4.8% |
| Potentiating Drug Interaction |
4.8% |
| Renal Failure Acute |
4.8% |
| Renal Impairment |
4.8% |
| Swelling |
4.8% |
| Tooth Extraction |
4.8% |
| Vomiting |
4.8% |
| Waist Circumference Increased |
4.8% |
|
