Avastin combined with Zometa

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pain In Jaw Other Serious 12/1/2005 59 Female 1/19/2006 United States
Primary
Concomitant
Wound Dehiscence Other Serious 1/3/2006 47 Male 185 lb 1/18/2006 Physician United States
Primary
Concomitant
Wound Debridement Other Serious 5/23/2005 55 Female 2/2/2006 United States
Primary
Concomitant
Skin Fissures 4/19/2005 85 Female 12/7/2005 Other Health Professional United States
Primary
Concomitant
Pain In Jaw Other Serious 6/1/2005 60 Male 2/7/2006 United States
Primary
Concomitant
Vascular Calcification Required Intervention 8/19/2005 53 Female 2/14/2006 Other Health Professional United States
Primary
Concomitant
Tooth Loss Other Serious 2/17/2006 70 Female 3/3/2006 Other Health Professional United States
Primary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 3/25/2005 52 Male 154 lb 3/3/2006 Physician United States
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Hospitalization 1/31/2006 59 Female 118 lb 3/3/2006 Physician United States
Primary
Secondary
Concomitant
Tooth Loss Other Serious 2/11/2006 70 Female 3/14/2006 United States
Primary
Concomitant
Vomiting Projectile Hospitalization 2/12/2006 59 Female 3/6/2006 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 6/1/2005 59 Female 3/23/2006 United States
Primary
Concomitant
Vomiting Projectile Hospitalization 1/31/2006 59 Female 118 lb 3/20/2006 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 6/30/2005 59 Female 3/28/2006 United States
Primary
Concomitant
Wound Secretion Other Serious 1/3/2006 47 Male 185 lb 3/24/2006 Physician United States
Primary
Concomitant
Staphylococcal Infection Other Serious 6/30/2005 59 Female 4/4/2006 United States
Primary
Concomitant
Ulcer Haemorrhage Hospitalization 70 Female 5/1/2006 United States
Primary
Concomitant
Escherichia Urinary Tract Infection Required Intervention 4/4/2006 84 Female 149 lb 5/1/2006 Physician United States
Primary
Secondary
Concomitant
Red Blood Cell Sedimentation Rate Increased Required Intervention 8/19/2005 53 Female 5/8/2006 Other Health Professional United States
Primary
Concomitant
Wound Debridement Other Serious 1/1/2004 55 Female 5/11/2006 Physician United States
Primary
Concomitant
Enterovesical Fistula Required Intervention 4/4/2006 84 Female 149 lb 5/8/2006 Physician United States
Primary
Secondary
Concomitant
Proctalgia Hospitalization 4/28/2006 60 Male 127 lb 5/11/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Pain In Jaw Other Serious 6/1/2005 60 Male 5/17/2006 United States
Primary
Concomitant
Pain Other Serious 4/14/2006 Male 5/17/2006 Other Health Professional United States
Primary
Concomitant
Ejection Fraction Decreased Other Serious 10/20/2005 36 Female 3/1/2006 Physician United States
Primary
Secondary
Concomitant
Dyspepsia Other Serious 12/15/2005 47 Female 3/1/2006 Consumer United States
Primary
Secondary
Concomitant
Swelling Other Serious 6/1/2005 60 Male 5/24/2006 Physician United States
Primary
Concomitant
Pain Other Serious 4/14/2006 45 Male 5/24/2006 United States
Primary
Concomitant
Ulcer Haemorrhage Hospitalization 70 Female 5/24/2006 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 5/17/2006 71 Male 150 lb 6/2/2006 Physician Germany
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 6/30/2005 59 Female 6/4/2006 United States
Primary
Concomitant
Purulent Discharge Other Serious 9/1/2005 45 Male 6/8/2006 United States
Primary
Concomitant
Tooth Extraction Other Serious 3/23/2006 Female 6/12/2006 Physician United States
Primary
Concomitant
Tooth Loss Other Serious 12/11/2005 68 Male 165 lb 6/21/2006 Physician France
Primary
Secondary
Concomitant
Gliosis Hospitalization 5/17/2006 71 Male 150 lb 7/11/2006 Physician Germany
Primary
Secondary
Concomitant
Radiation Injury Hospitalization 5/17/2006 71 Male 150 lb 7/18/2006 Physician Germany
Primary
Secondary
Concomitant
Somnolence 66 Female 5/31/2006 Consumer United States
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 9/1/2005 70 Female 5/31/2006 Other Health Professional United States
Primary
Concomitant
Deep Vein Thrombosis Hospitalization 10/1/2005 70 Female 5/31/2006 Other Health Professional United States
Primary
Concomitant
Skin Ulcer 70 Female 5/31/2006 Physician United States
Primary
Concomitant
Disease Progression Death 38 Female 6/30/2006 United States
Primary
Concomitant
Pain In Jaw Other Serious 54 Female 199 lb 7/28/2006 Other Health Professional United States
Primary
Concomitant
Rash 12/1/2004 Female 5/24/2006 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 5/17/2006 71 Male 150 lb 8/11/2006 Physician Germany
Primary
Secondary
Concomitant
Parophthalmia Other Serious 3/16/2006 48 Female 8/9/2006 Pharmacist United States
Primary
Concomitant
Ejection Fraction Decreased Other Serious 10/20/2005 36 Female 6/6/2006 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 5/17/2006 71 Male 150 lb 9/13/2006 Physician Germany
Primary
Secondary
Concomitant
Wound Dehiscence Other Serious 11/1/2005 47 Male 185 lb 9/20/2006 Physician United States
Primary
Concomitant
Osteonecrosis Other Serious 6/23/2006 48 Male 9/20/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 9/1/2006 56 Male 9/28/2006 Physician United States
Primary
Concomitant
Ulcer Haemorrhage Hospitalization 70 Female 9/22/2006 Consumer United States
Primary
Concomitant
Osteonecrosis Other Serious 4/1/2006 Female 10/5/2006 Physician United States
Primary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Required Intervention 83 Female 123 lb 10/17/2006 Physician United States
Primary
Concomitant
Pain Other Serious 4/1/2006 75 Male 205 lb 10/31/2006 Other Health Professional United States
Primary
Concomitant
Tooth Extraction Other Serious 3/23/2006 48 Female 11/1/2006 Physician United States
Primary
Concomitant
Tooth Disorder Other Serious 1/1/2006 55 Female 11/6/2006 Physician United States
Primary
Concomitant
Primary Sequestrum Other Serious 8/1/2006 56 Male 11/10/2006 Physician United States
Primary
Concomitant
Vomiting Projectile Hospitalization 2/12/2006 59 Female 11/15/2006 Physician United States
Primary
Secondary
Concomitant
Wound Dehiscence Other Serious 11/1/2005 47 Male 185 lb 11/28/2006 Physician United States
Primary
Concomitant
Wound Secretion Other Serious 11/21/2005 47 Male 185 lb 12/6/2006 Physician United States
Primary
Concomitant
Toothache Other Serious 8/2/2006 55 Female 189 lb 12/7/2006 Other Health Professional United States
Primary
Concomitant
Osteonecrosis Other Serious 4/1/2006 Female 142 lb 12/12/2006 Physician United States
Primary
Concomitant
Osteonecrosis Other Serious 4/1/2006 68 Female 12/12/2006 United States
Primary
Concomitant
Surgical Procedure Repeated Other Serious 3/16/2006 48 Female 12/8/2006 Pharmacist United States
Primary
Concomitant
Urticaria Required Intervention 11/19/2006 58 Female 366 lb 12/29/2006 Other Health Professional United States
Primary
Concomitant
Renal Failure Acute Life Threatening 3/24/2005 70 Male 8/29/2006 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 12/1/2004 62 Female 8/29/2006 Physician United States
Primary
Concomitant
Osteonecrosis Other Serious 4/1/2006 68 Female 1/12/2007 United States
Primary
Concomitant
Swelling Other Serious 54 Female 199 lb 1/17/2007 United States
Primary
Concomitant
Urticaria Required Intervention 11/19/2006 58 Female 366 lb 1/10/2007 Other Health Professional United States
Primary
Concomitant
Osteonecrosis Other Serious 7/1/2006 54 Female 1/19/2007 Other Health Professional United States
Primary
Concomitant
Tooth Extraction Disability 10/1/2002 50 Female 1/27/2007 France
Primary
Concomitant
Osteonecrosis Other Serious 1/29/2006 Male 140 lb 1/31/2007 Pharmacist United States
Primary
Concomitant
Tooth Extraction Disability 10/1/2002 50 Female 2/15/2007 France
Primary
Concomitant
Abdominal Tenderness 1/10/2007 43 Female 2/8/2007 Pharmacist United States
Primary
Concomitant
Vomiting Hospitalization 8/10/2006 48 Female 131 lb 2/15/2007 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Death 1/19/2007 41 Female 88 lb 2/26/2007 Physician France
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 50 Female 2/26/2007 Consumer United States
Primary
Concomitant
Osteonecrosis Other Serious 2/1/2007 42 Male 3/2/2007 Physician United States
Primary
Secondary
Urinary Tract Infection Other Serious 1/1/2005 52 Female 3/8/2007 United States
Primary
Concomitant
Toothache Other Serious 8/2/2006 55 Female 189 lb 3/14/2007 United States
Primary
Concomitant
Wound Debridement Other Serious 7/1/2006 54 Female 3/14/2007 United States
Primary
Concomitant
Pain In Jaw Other Serious 3/20/2006 Female 3/13/2007 Other Health Professional United States
Primary
Concomitant
Loss Of Consciousness Death 2/8/2007 61 Female 106 lb 3/12/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 3/20/2007 51 Male 174 lb 3/20/2007 Other Health Professional United States
Primary
Concomitant
Toothache Other Serious 12/1/2005 43 Female 243 lb 3/24/2007 France
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 2/1/2007 66 Male 188 lb 3/25/2007 Physician United States
Primary
Concomitant
Osteonecrosis Other Serious 6/23/2006 73 Female 119 lb 3/31/2007 Physician United States
Primary
Concomitant
X-ray Abnormal Other Serious 1/1/2006 59 124 lb 4/5/2007 Physician United States
Primary
Concomitant
Toothache Other Serious 3/1/2007 Female 4/6/2007 Physician Ireland
Primary
Concomitant
Pain Other Serious 4/1/2006 75 Male 205 lb 4/5/2007 Other Health Professional United States
Primary
Concomitant
X-ray Abnormal Other Serious 9/1/2006 59 Female 124 lb 4/18/2007 United States
Primary
Concomitant
Pleural Effusion Other Serious Female 4/20/2007 Consumer United States
Primary
Concomitant
Malignant Ascites Hospitalization 8/7/2006 Female 95 lb 4/12/2007 Physician United States
Primary
Secondary
Concomitant
Oesophageal Perforation Other Serious 3/30/2007 Female 104 lb 5/2/2007 Consumer United States
Primary
Concomitant
Pain Other Serious 3/4/2006 75 Male 205 lb 5/3/2007 Other Health Professional United States
Primary
Concomitant
Hypernatraemia Other Serious 10/13/2006 62 Male 5/9/2007 Other Health Professional United States
Primary
Concomitant
Hypernatraemia Other Serious 10/13/2006 62 Male 5/17/2007 Other Health Professional United States
Primary
Concomitant
Pulmonary Hypertension Other Serious Female 5/18/2007 Physician United States
Primary
Concomitant
Osteonecrosis Other Serious 12/1/2006 Female 5/24/2007 Physician France
Primary
Concomitant
Swelling Other Serious 3/4/2006 75 Male 205 lb 5/26/2007 Other Health Professional United States
Primary
Concomitant
Appendicitis Perforated Other Serious 12/19/2006 46 Female 2/28/2007 Physician United States
Primary
Concomitant
Oral Pain Other Serious 2/26/2007 84 Female 112 lb 5/31/2007 Other Health Professional United States
Primary
Secondary
Venous Stent Insertion Other Serious 11/1/2006 84 Female 112 lb 6/7/2007 United States
Primary
Secondary
Oesophageal Perforation Other Serious 3/30/2007 Female 104 lb 6/7/2007 Consumer United States
Primary
Concomitant
Tooth Extraction Other Serious 12/11/2006 53 Female 6/8/2007 Physician United States
Primary
Concomitant
Tooth Extraction Other Serious 12/11/2006 53 Female 6/8/2007 Physician United States
Primary
Concomitant
Wound Debridement Hospitalization 1/9/2007 74 Female 112 lb 6/20/2007 France
Primary
Secondary
Concomitant
Unevaluable Event Required Intervention 2/14/2007 40 Female 140 lb 6/15/2007 Other Health Professional United States
Primary
Secondary
Tooth Extraction Other Serious 9/1/2005 55 Male 6/24/2007 France
Primary
Concomitant
Wound Debridement Disability 12/1/2006 Female 123 lb 6/29/2007 Physician France
Primary
Secondary
Concomitant
Osteonecrosis Other Serious Female 6/29/2007 Other Health Professional United States
Primary
Concomitant
Weight Increased Other Serious 1/11/2007 52 Female 6/30/2007 France
Primary
Secondary
Concomitant
Intracranial Pressure Increased Other Serious 1/9/2007 24 Female 7/9/2007 Consumer United States
Primary
Concomitant
Stomatitis Other Serious 4/15/2007 77 Male 178 lb 7/26/2007 Physician United States
Primary
Concomitant
Hyperthyroidism Other Serious 4/1/2007 Female 143 lb 7/31/2007 Physician United Kingdom
Primary
Concomitant
Stomatitis Other Serious 4/15/2007 77 Male 178 lb 8/2/2007 Physician United States
Primary
Concomitant
Venous Stent Insertion Other Serious 11/1/2006 84 Female 112 lb 8/11/2007 United States
Primary
Secondary
Pulmonary Embolism Other Serious 6/22/2007 Female 8/16/2007 Physician United Kingdom
Primary
Concomitant
Urinary Incontinence Hospitalization 8/27/2007 Male 185 lb 8/28/2007 Other Health Professional United States
Primary
Concomitant
Periodontal Infection Hospitalization 8/7/2007 Male 163 lb 9/6/2007 Other Health Professional United States
Primary
Concomitant
Macular Oedema Other Serious 47 Female 9/18/2007 Physician United States
Primary
Concomitant
Cerebral Infarction Other Serious 9/6/2007 Male 201 lb 9/24/2007 Consumer United States
Primary
Secondary
Concomitant
Peripheral Motor Neuropathy Hospitalization 8/14/2007 57 Male 164 lb 9/20/2007 Other Health Professional United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 8/29/2007 57 Male 164 lb 9/20/2007 Other Health Professional United States
Primary
Concomitant
Gingival Ulceration Other Serious 60 Female 9/26/2007 Physician United Kingdom
Primary
Secondary
Cerebral Infarction Other Serious 9/6/2007 Male 201 lb 10/1/2007 Consumer United States
Primary
Secondary
Concomitant
Liver Disorder Other Serious 6/11/2007 Male 129 lb 10/8/2007 Consumer United States
Primary
Concomitant
Osteonecrosis Other Serious 55 Female 340 lb 10/30/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Macular Oedema Other Serious Female 11/26/2007 Physician United States
Primary
Concomitant
Epistaxis Other Serious 11/5/2007 Female 170 lb 12/3/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Wound Debridement Hospitalization 1/9/2007 74 Female 112 lb 12/6/2007 France
Primary
Secondary
Concomitant
Epistaxis Other Serious 11/2/2007 69 Female 170 lb 12/17/2007 Physician Germany
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 12/19/2007 Physician United States
Primary
Concomitant
Osteonecrosis Other Serious 12/1/2007 Female 139 lb 1/17/2008 Other Health Professional United States
Primary
Concomitant
Pain In Jaw Other Serious 11/1/2007 63 Female 166 lb 1/24/2008 United States
Primary
Concomitant
Osteonecrosis Other Serious 12/14/2007 Female 2/13/2008 Physician United States
Primary
Concomitant
Pain In Jaw Other Serious 1/1/2007 49 Male 2/26/2008 United States
Primary
Concomitant
Tooth Extraction Other Serious 12/12/2000 42 Female 3/27/2008 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 10/9/2001 69 Female 169 lb 3/27/2008 United States
Primary
Secondary
Concomitant
Tooth Disorder Other Serious 11/19/2004 4/11/2008 Physician United States
Primary
Concomitant
Herpes Simplex Hospitalization 3/3/2008 Female 192 lb 4/18/2008 Physician United States
Primary
Secondary
Concomitant
Poor Personal Hygiene Hospitalization 2/1/2008 56 Female 4/22/2008 France
Primary
Secondary
Concomitant
Poor Personal Hygiene Hospitalization 2/1/2008 56 Female 4/22/2008 France
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 12/14/2007 46 Female 4/24/2008 Pharmacist United States
Primary
Concomitant
Dyspnoea Other Serious 11/10/2006 60 Female 2/28/2008 Other Health Professional United States
Primary
Concomitant
Osteonecrosis Other Serious 2/15/2008 60 Female 4/26/2008 France
Primary
Secondary
Concomitant
Deep Vein Thrombosis Other Serious 1/9/2007 24 Female 2/28/2008 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 8/14/2007 Female 106 lb 2/28/2008 Physician United States
Primary
Concomitant
Osteonecrosis Other Serious 4/21/2008 52 Female 148 lb 5/1/2008 Physician United States
Primary
Concomitant

Drug Data