Afinitor combined with Zometa

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vomiting Other Serious 7/9/2009 Male 160 lb 8/17/2009 Physician United States
Primary
Concomitant
Troponin T Increased Other Serious Male 10/22/2009 Physician Austria
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 11/1/2008 Male 152 lb 12/22/2009 Physician Germany
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/1/2009 Male 12/24/2009 Consumer Germany
Primary
Secondary
Urine Output Decreased Life Threatening Male 165 lb 2/3/2010 Physician France
Primary
Secondary
Renal Failure Hospitalization 11/18/2009 Male 2/19/2010 Physician Belgium
Primary
Secondary
Concomitant
Swelling Hospitalization 2/17/2010 Female 106 lb 2/24/2010 Physician Japan
Primary
Secondary
Concomitant
Influenza Like Illness Other Serious 12/14/2009 Female 222 lb 3/2/2010 Physician United States
Primary
Secondary
Concomitant
Tooth Extraction Hospitalization 12/29/2009 Female 106 lb 3/5/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious Male 3/18/2010 Physician Belgium
Primary
Secondary
Concomitant
Pain In Jaw Other Serious 67 Male 5/4/2010 Other Health Professional United States
Primary
Concomitant
Mental Status Changes Other Serious 2/1/2010 69 Male 5/4/2010 Physician Switzerland
Primary
Concomitant
Tooth Extraction Other Serious 1/1/2009 Male 5/11/2010 Consumer Germany
Primary
Secondary
Red Cell Distribution Width Increased Other Serious 3/18/2010 59 Male 5/13/2010 Other Health Professional Canada
Primary
Secondary
Renal Tubular Necrosis Hospitalization Male 5/14/2010 United States
Primary
Secondary
Concomitant
Renal Tubular Necrosis Hospitalization 1/5/2010 50 Male 205 lb 5/19/2010 United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 11/1/2008 49 Male 152 lb 5/28/2010 Physician Germany
Primary
Secondary
Concomitant
Tooth Extraction Hospitalization 12/29/2009 63 Female 106 lb 6/3/2010 Physician Japan
Primary
Secondary
Concomitant
Tremor Other Serious 9/7/2009 72 Female 6/24/2010 Other Health Professional Germany
Primary
Concomitant
Oedema Other Serious 11/1/2009 72 Female 6/28/2010 Other Health Professional Germany
Primary
Concomitant
Malaise Other Serious 6/15/2010 77 Male 139 lb 7/13/2010 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 6/15/2010 77 Male 139 lb 7/14/2010 Physician Japan
Primary
Concomitant
Venous Pressure Jugular Increased Hospitalization 4/19/2010 55 Male 207 lb 7/14/2010 Physician United Kingdom
Primary
Concomitant
Pyrexia Other Serious 6/15/2010 77 Male 139 lb 7/16/2010 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 6/15/2010 77 Male 139 lb 7/28/2010 Physician Japan
Primary
Concomitant
Venous Pressure Jugular Increased Hospitalization 1/21/2010 55 Male 207 lb 8/11/2010 Physician United Kingdom
Primary
Concomitant
Pyrexia Other Serious 6/15/2010 77 Male 139 lb 8/13/2010 Physician Japan
Primary
Concomitant
Thrombocytopenia Hospitalization 8/10/2010 58 Female 138 lb 8/20/2010 Physician United States
Primary
Secondary
Concomitant
Venous Pressure Jugular Increased Hospitalization 1/21/2010 55 Male 207 lb 8/26/2010 Physician United Kingdom
Primary
Concomitant
Venous Pressure Jugular Increased Hospitalization 1/21/2010 55 Male 207 lb 9/9/2010 Physician United Kingdom
Primary
Concomitant
Thrombocytopenia Hospitalization 8/10/2010 58 Female 138 lb 9/13/2010 Physician United States
Primary
Secondary
Concomitant
Wheezing Other Serious 6/15/2010 77 Male 139 lb 9/14/2010 Physician Japan
Primary
Concomitant
Spinal Fusion Acquired Other Serious 3/13/2010 67 Female 121 lb 9/16/2010 Physician France
Primary
Secondary
Red Cell Distribution Width Increased Other Serious 3/18/2010 59 Male 10/11/2010 Other Health Professional Canada
Primary
Secondary
Urinary Tract Infection Other Serious 59 Female 10/12/2010 Pharmacist Belgium
Primary
Secondary
Osteomyelitis Other Serious 6/2/2010 45 Male 10/20/2010 Physician Japan
Primary
Secondary
Concomitant
Hyperglycaemia Hospitalization 7/29/2010 52 Male 10/21/2010 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 8/21/2010 78 Male 10/26/2010 Physician Japan
Primary
Concomitant
Wheezing Other Serious 6/15/2010 77 Male 139 lb 11/5/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/13/2010 67 Female 121 lb 11/9/2010 Physician France
Primary
Secondary
Radiation Pneumonitis Other Serious 8/6/2010 62 Male 11/17/2010 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 8/21/2010 78 Male 12/8/2010 Physician Japan
Primary
Concomitant
Lymphocyte Count Decreased Other Serious 9/9/2010 67 Male 12/13/2010 Physician Japan
Primary
Concomitant
Radiation Pneumonitis Other Serious 8/6/2010 62 Male 12/13/2010 Physician Japan
Primary
Concomitant
Small Intestinal Haemorrhage Hospitalization 11/21/2010 54 Male 163 lb 12/28/2010 Physician Japan
Primary
Concomitant
Platelet Count Increased Other Serious 7/5/2010 63 Female 126 lb 12/29/2010 Physician Japan
Primary
Concomitant
Hyperkalaemia Other Serious 6/25/2010 69 Male 12/30/2010 Physician Japan
Primary
Concomitant
Neoplasm Malignant Hospitalization 8/21/2010 78 Male 1/7/2011 Physician Japan
Primary
Concomitant
Polyneuropathy Other Serious 10/1/2010 59 Female 1/13/2011 Physician Switzerland
Primary
Secondary
Concomitant
Lymphocyte Count Decreased Other Serious 9/9/2010 67 Male 1/25/2011 Physician Japan
Primary
Concomitant
Neoplasm Malignant Other Serious 10/25/2010 61 Male 143 lb 1/28/2011 Physician Japan
Primary
Concomitant
Metastases To Bone Hospitalization 12/22/2010 61 Male 154 lb 2/4/2011 Physician Germany
Primary
Secondary
Concomitant
Hypokalaemia Other Serious 7/5/2010 63 Female 126 lb 2/15/2011 Physician Japan
Primary
Concomitant
Hypophosphataemia Other Serious 12/1/2010 55 Male 3/4/2011 Physician Slovakia (Slovak Republic)
Primary
Secondary
Blood Urea Increased Death 10/4/2010 Female 146 lb 3/7/2011 Physician Austria
Primary
Secondary
Pyrexia Other Serious 8/6/2010 62 Male 148 lb 3/11/2011 Physician Japan
Primary
Concomitant
Pneumonia Death 8/26/2010 72 Male 3/11/2011 Physician Japan
Primary
Concomitant
Hyperkalaemia Other Serious 12/22/2010 61 Male 154 lb 3/16/2011 Physician Germany
Primary
Secondary
Concomitant
Haemoglobin Decreased Other Serious 11/21/2010 54 Male 163 lb 3/28/2011 Physician Japan
Primary
Concomitant
Insomnia Hospitalization 4/23/2010 56 Female 97 lb 3/28/2011 Physician Japan
Primary
Concomitant
Infected Epidermal Cyst Other Serious 11/19/2010 64 Male 4/8/2011 Physician Japan
Primary
Secondary
Concomitant
Neoplasm Malignant Hospitalization 6/27/2010 71 Male 4/12/2011 Physician Japan
Primary
Concomitant
Erythema Multiforme Other Serious 10/9/2010 55 Male 4/13/2011 Physician Japan
Primary
Concomitant
Anaemia Other Serious 8/6/2010 62 Male 148 lb 4/15/2011 Physician Japan
Primary
Concomitant
Lymphocyte Count Decreased Other Serious 7/5/2010 63 Female 126 lb 4/20/2011 Physician Japan
Primary
Concomitant
Neoplasm Malignant Other Serious 6/25/2010 69 Male 101 lb 4/26/2011 Physician Japan
Primary
Concomitant
Cough Hospitalization 8/6/2010 62 Male 148 lb 4/11/2011 Physician Japan
Primary
Concomitant
Blood Creatinine Increased Other Serious 8/26/2010 72 Male 5/2/2011 Other Health Professional Japan
Primary
Concomitant
Lymphocyte Count Decreased Other Serious 9/9/2010 67 Male 5/24/2011 Physician Japan
Primary
Concomitant
Lymphocyte Count Decreased Other Serious 7/5/2010 63 Female 126 lb 5/26/2011 Physician Japan
Primary
Concomitant
Sepsis Death 6/25/2009 72 Male 6/9/2011 Physician Germany
Primary
Secondary
Death Death 5/4/2011 52 Male 6/13/2011 Consumer Canada
Primary
Secondary
Neoplasm Malignant Death 5/4/2011 52 Male 6/16/2011 Consumer Canada
Primary
Secondary
Erysipelas Hospitalization 5/1/2011 57 Male 6/28/2011 Physician Germany
Primary
Concomitant
Interacting
Infected Epidermal Cyst Other Serious 11/19/2010 64 Male 6/30/2011 Physician Japan
Primary
Secondary
Concomitant
Adverse Event Hospitalization 6/28/2011 72 Male 7/8/2011 Consumer United States
Primary
Concomitant
Renal Impairment Other Serious 6/25/2010 69 Male 101 lb 7/12/2011 Physician Japan
Primary
Concomitant
Anaemia Hospitalization 11/19/2010 64 Male 7/7/2011 Physician Japan
Primary
Secondary
Concomitant
Blood Creatine Increased Death 10/4/2010 68 Female 146 lb 7/20/2011 Physician Austria
Primary
Secondary
Pneumonitis Other Serious 5/1/2011 Male 7/21/2011 Physician Slovakia (Slovak Republic)
Primary
Secondary
Haemoglobin Decreased Other Serious 3/26/2011 65 Male 123 lb 7/26/2011 Physician Japan
Primary
Secondary
Concomitant
Anaemia Other Serious 11/19/2010 64 Male 8/2/2011 Physician Japan
Primary
Secondary
Concomitant
Blood Urea Increased Death 8/20/2010 62 Male 112 lb 8/4/2011 Physician Japan
Primary
Concomitant
C-reactive Protein Increased Other Serious 11/21/2010 52 Female 115 lb 8/16/2011 Physician Japan
Primary
Concomitant
Neutrophil Count Increased Other Serious Female 8/17/2011 United States
Primary
Secondary
Concomitant
Haemoglobin Decreased Other Serious Male 123 lb 8/18/2011 Physician Japan
Primary
Secondary
Concomitant
Neoplasm Malignant Hospitalization 8/20/2010 62 Male 112 lb 8/25/2011 Physician Japan
Primary
Concomitant
Lipid Metabolism Disorder Disability 7/9/2009 42 Female 8/30/2011 Lawyer United States
Primary
Concomitant
Metastases To Liver Other Serious 4/22/2011 50 Male 143 lb 8/30/2011 Physician Japan
Primary
Concomitant
Tachycardia Other Serious 7/9/2009 42 Female 8/31/2011 Lawyer United States
Primary
Concomitant
Fall Other Serious 1/1/2011 66 Male 8/31/2011 United States
Primary
Secondary
Concomitant
Hypertension Other Serious 6/27/2010 71 Male 9/5/2011 Physician Japan
Primary
Concomitant
Upper Respiratory Tract Infection Disability 7/9/2009 42 Female 9/27/2011 Physician United States
Primary
Concomitant
Impaired Gastric Emptying Disability 7/9/2009 42 Female 10/3/2011 Physician United States
Primary
Concomitant
Neoplasm Malignant Other Serious 8/2/2010 60 Male 143 lb 10/3/2011 Physician Japan
Primary
Concomitant
Bone Pain Hospitalization 6/27/2010 71 Male 10/6/2011 Japan
Primary
Concomitant
Nasal Congestion Other Serious 7/9/2009 42 Female 10/7/2011 Lawyer United States
Primary
Concomitant
Rhinorrhoea Hospitalization 7/9/2009 42 Female 10/20/2011 Physician United States
Primary
Concomitant
Osteomyelitis Other Serious 7/1/2011 59 Male 10/25/2011 Physician Japan
Primary
Secondary
Concomitant
Jaundice Hospitalization 10/1/2011 66 Female 10/26/2011 Physician Germany
Primary
Concomitant
Asthenia Hospitalization 9/12/2011 70 Male 10/28/2011 Physician Germany
Primary
Secondary
Concomitant
Decreased Appetite Other Serious 10/9/2010 55 Male 11/16/2011 Physician Japan
Primary
Concomitant
Skin Disorder Other Serious 11/21/2010 52 Female 115 lb 11/23/2011 Physician Japan
Primary
Secondary
Concomitant
Nasal Congestion Hospitalization 7/9/2009 42 Female 11/23/2011 Lawyer United States
Primary
Concomitant
Neoplasm Malignant Other Serious 7/9/2010 51 Male 11/29/2011 Physician Japan
Primary
Concomitant
Neoplasm Progression Other Serious 5/1/2011 46 Male 12/13/2011 Physician Japan
Primary
Secondary
Concomitant
C-reactive Protein Increased Other Serious 9/25/2011 78 Male 110 lb 12/21/2011 Physician Japan
Primary
Secondary
Concomitant
Osteonecrosis Of Jaw Other Serious 7/1/2011 59 Male 12/26/2011 Physician Japan
Primary
Secondary
Concomitant
Liver Function Test Abnormal Other Serious 12/8/2011 54 Male 165 lb 12/26/2011 Other Health Professional United States
Primary
Concomitant
Rhinorrhoea Hospitalization 7/9/2009 42 Female 1/1/2012 Lawyer United States
Primary
Concomitant
Oedema Peripheral Other Serious 6/30/2010 66 Female 1/4/2012 Physician United States
Primary
Secondary
Concomitant
Carcinoma In Situ Death 7/9/2009 42 Female 1/6/2012 Lawyer United States
Primary
Concomitant
Death Death Male 1/12/2012 Canada
Primary
Secondary
Neoplasm Progression Death 12/1/2010 55 Male 1/17/2012 Physician Slovakia (Slovak Republic)
Primary
Secondary
Concomitant
Death Death 10/20/2011 48 Male 1/31/2012 United States
Primary
Secondary
Pleural Effusion Other Serious 12/16/2011 63 Male 139 lb 2/6/2012 Physician Japan
Primary
Concomitant
Cough Other Serious 8/3/2011 59 Female 2/7/2012 Physician United States
Primary
Secondary
Concomitant
Pericardial Effusion Other Serious 12/16/2011 63 Male 139 lb 2/24/2012 Physician Japan
Primary
Concomitant
Subcutaneous Abscess Other Serious 1/17/2012 69 Male 3/5/2012 Physician Japan
Primary
Secondary
Concomitant
Sleep Disorder Other Serious 6/30/2010 66 Female 3/5/2012 Consumer United States
Primary
Secondary
Concomitant
Subcutaneous Abscess Other Serious 1/17/2012 69 Male 3/8/2012 Physician Japan
Primary
Secondary
Concomitant
Septic Shock Other Serious 12/22/2011 65 Male 154 lb 3/14/2012 Physician France
Primary
Secondary
Concomitant
Pyrexia Other Serious 10/3/2011 78 Male 110 lb 3/15/2012 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 3/6/2012 61 Female 121 lb 3/19/2012 Physician Japan
Primary
Secondary
Concomitant
Haemoglobin Decreased Hospitalization 1/27/2011 69 Female 7/5/2011 Physician United States
Primary
Secondary
Concomitant
Fatigue Disability 3/1/2011 81 Male 7/5/2011 Physician United States
Primary
Concomitant
Haematocrit Decreased Hospitalization 1/27/2011 69 Female 7/5/2011 Physician United States
Primary
Secondary
Concomitant
Anaemia Other Serious 12/16/2011 63 Male 139 lb 3/20/2012 Physician Japan
Primary
Concomitant
Febrile Neutropenia Hospitalization 3/12/2012 58 Male 226 lb 3/21/2012 Physician United States
Primary
Concomitant
Chest Pain Hospitalization 3/2/2012 3/21/2012 Consumer Italy
Primary
Concomitant
Renal Failure Other Serious 9/3/2009 Male 10/9/2009 Physician United States
Primary
Concomitant
Weight Decreased Disability 3/1/2011 81 Male 7/5/2011 Physician United States
Primary
Concomitant
Dyspnoea Hospitalization 1/27/2011 69 Female 4/7/2011 Consumer United States
Primary
Secondary
Concomitant
Neoplasm Progression Death 9/12/2011 70 Male 3/26/2012 Physician Germany
Primary
Secondary
Concomitant
Mean Cell Haemoglobin Decreased Other Serious Female 3/28/2012 Consumer United States
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 3/6/2012 61 Female 121 lb 3/28/2012 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 3/8/2012 48 Female 137 lb 4/2/2012 Physician Lebanon
Primary
Secondary
Concomitant
Blood Pressure Increased Other Serious 6/30/2010 66 Female 4/4/2012 Consumer United States
Primary
Secondary
Concomitant
Inflammation Other Serious 6/30/2010 66 Female 4/4/2012 Physician United States
Primary
Secondary
Concomitant
Septic Shock Other Serious 12/22/2011 65 Male 154 lb 4/5/2012 Physician France
Primary
Secondary
Concomitant
Liver Disorder Other Serious 6/2/2010 45 Male 4/5/2012 Physician Japan
Primary
Secondary
Concomitant
Haemoglobin Decreased Death 5/1/2011 46 Male 4/4/2012 Physician Japan
Primary
Secondary
Concomitant
Neoplasm Malignant Life Threatening 5/1/2011 46 Male 4/4/2012 Physician Japan
Primary
Secondary
Concomitant
Diarrhoea Other Serious 2/22/2012 61 Female 145 lb 4/11/2012 Consumer United States
Primary
Concomitant
Renal Failure Acute Hospitalization 3/8/2012 48 Female 137 lb 4/12/2012 Physician Lebanon
Primary
Secondary
Concomitant
Gait Disturbance Other Serious 2/22/2012 61 Female 145 lb 4/19/2012 Consumer United States
Primary
Concomitant
Neutropenia Other Serious 2/22/2012 61 Female 145 lb 4/24/2012 Consumer United States
Primary
Concomitant
Jaw Fracture Other Serious 3/1/2012 53 Female 5/14/2012 Physician United States
Primary
Secondary
Concomitant
Blood Phosphorus Decreased Other Serious 6/9/2010 39 Male 5/15/2012 Other Health Professional Canada
Primary
Secondary
Mucosal Inflammation Other Serious 1/1/2011 Female 5/15/2012 Physician Germany
Primary
Secondary

Drug Data