Melphalan combined with Zometa

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Swollen Tongue Other Serious 6/14/2005 Female 163 lb 1/13/2006 Physician Belgium
Primary
Concomitant
Osteonecrosis Other Serious 68 Female 95 lb 1/13/2006 Physician Portugal
Primary
Concomitant
Tooth Extraction Other Serious 1/1/2003 79 Male 1/13/2006 United States
Primary
Concomitant
Tooth Extraction Other Serious 11/17/2005 75 Male 1/19/2006 Physician Spain
Primary
Concomitant
Wound Debridement Other Serious 6/18/1999 51 Male 1/25/2006 United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 5/1/2005 60 Female 2/3/2006 Physician Spain
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/1/2005 Female 2/2/2006 Physician Germany
Primary
Concomitant
Osteonecrosis Other Serious Female 2/17/2006 Physician United States
Primary
Secondary
Concomitant
Osteonecrosis Hospitalization 1/23/2006 71 Female 2/17/2006 Other Health Professional Italy
Primary
Secondary
Concomitant
Osteonecrosis Other Serious Female 2/17/2006 Physician United States
Primary
Secondary
Concomitant
Tooth Extraction Hospitalization 3/18/2005 66 Female 172 lb 2/18/2006 France
Primary
Concomitant
Surgery Other Serious 6/27/2005 Female 2/18/2006 Spain
Primary
Concomitant
Wound Debridement Other Serious 2/1/2003 Male 2/24/2006 United States
Primary
Secondary
Concomitant
Pain In Jaw Disability 3/1/2005 72 Female 157 lb 3/1/2006 United Kingdom
Primary
Concomitant
Tooth Extraction Other Serious 1/1/2004 62 Male 3/2/2006 Other Health Professional United States
Primary
Concomitant
Wound Drainage Other Serious 1/1/2001 52 Male 3/15/2006 United States
Primary
Secondary
Concomitant
Wound Drainage Other Serious 1/1/2001 52 Male 3/24/2006 United States
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 11/9/2005 65 Female 95 lb 4/7/2006 Physician Germany
Primary
Concomitant
Osteonecrosis Other Serious 2/1/2006 67 Female 4/12/2006 United Kingdom
Primary
Concomitant
Plastic Surgery Other Serious 2/26/2004 57 Female 141 lb 4/13/2006 Physician South Africa
Primary
Concomitant
Osteonecrosis Other Serious 5/1/2005 80 Female 132 lb 4/13/2006 Physician Portugal
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 11/17/2005 75 Male 4/20/2006 Physician Spain
Primary
Concomitant
Swelling Other Serious 4/1/2006 83 Female 5/5/2006 United States
Primary
Concomitant
Wound Debridement Other Serious 2/1/2003 Male 5/8/2006 United States
Primary
Secondary
Concomitant
Pain In Jaw Other Serious 1/1/2002 70 Female 5/20/2006 United States
Primary
Secondary
Concomitant
Tooth Disorder Other Serious 9/1/2001 75 Male 5/25/2006 Physician Sweden
Primary
Secondary
Concomitant
Wound Drainage Other Serious 1/1/2001 52 Male 5/31/2006 United States
Primary
Secondary
Concomitant
Wound Debridement Other Serious 2/1/2003 Male 6/1/2006 United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 1/1/2000 69 Male 6/2/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 1/1/2000 69 Male 6/2/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Swelling Other Serious 1/1/2002 70 Female 6/4/2006 Physician United States
Primary
Secondary
Concomitant
Soft Tissue Disorder Other Serious 1/1/2005 68 Male 6/9/2006 Physician United States
Primary
Secondary
Concomitant
Toothache Other Serious 12/1/2004 Male 207 lb 6/17/2006 Physician Germany
Primary
Concomitant
Wound Decomposition Other Serious 9/1/2003 49 Male 6/21/2006 Physician United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 2/1/2003 61 Male 6/22/2006 United States
Primary
Concomitant
Tooth Extraction Other Serious 6/1/2004 Male 153 lb 6/24/2006 Physician Germany
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 2/1/2003 61 Male 6/30/2006 United States
Primary
Concomitant
Wound Treatment Other Serious 1/23/2006 71 Female 7/5/2006 Italy
Primary
Secondary
Concomitant
Osteomyelitis Hospitalization 6/5/2005 72 Male 7/18/2006 Italy
Primary
Concomitant
Tooth Extraction Other Serious 10/1/2003 60 Female 7/21/2006 Physician Germany
Primary
Concomitant
Osteomyelitis Hospitalization 5/9/2005 60 Male 7/21/2006 Italy
Primary
Concomitant
Wound Debridement Other Serious 1/1/2003 61 Male 187 lb 7/21/2006 Physician Germany
Primary
Concomitant
Osteomyelitis Hospitalization 8/23/2005 79 Female 7/21/2006 Italy
Primary
Concomitant
Surgery Hospitalization 2/28/2006 68 Male 7/24/2006 Other Health Professional Italy
Primary
Concomitant
Surgery Hospitalization 12/5/2005 75 Male 7/24/2006 Other Health Professional Italy
Primary
Concomitant
Tooth Extraction Other Serious 2/1/2003 61 Male 7/25/2006 United States
Primary
Concomitant
Tooth Extraction Other Serious 6/1/2004 Male 153 lb 8/8/2006 Physician Germany
Primary
Secondary
Concomitant
Therapeutic Response Decreased Life Threatening 2/9/2006 Female 184 lb 8/8/2006 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 10/14/2005 72 Female 176 lb 8/31/2006 France
Primary
Secondary
Toothache Other Serious 10/1/2004 Male 9/20/2006 United States
Primary
Concomitant
Vision Blurred Other Serious 3/5/2002 72 Male 190 lb 9/27/2006 Consumer United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 3/5/2002 72 Male 190 lb 9/27/2006 Consumer United States
Primary
Secondary
Concomitant
Osteonecrosis Hospitalization 5/5/2005 61 Female 10/3/2006 Other Health Professional Italy
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 5/1/2005 62 Male 152 lb 10/4/2006 Physician United States
Primary
Concomitant
Toothache Other Serious 10/1/2004 72 Male 10/11/2006 United States
Primary
Concomitant
Tooth Injury Other Serious 1/1/2002 65 Female 10/13/2006 Consumer United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/1/2000 69 Male 10/23/2006 United States
Primary
Secondary
Concomitant
Wound Decomposition Other Serious 9/1/2003 49 Male 10/25/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 10/1/2005 72 Female 176 lb 11/3/2006 France
Primary
Secondary
Plastic Surgery Hospitalization 7/1/2004 59 Male 11/4/2006 Spain
Primary
Concomitant
Osteonecrosis Other Serious 10/23/2006 78 Male 125 lb 11/15/2006 United States
Primary
Concomitant
Osteonecrosis Other Serious 1/1/2006 66 Female 187 lb 11/15/2006 Physician Germany
Primary
Concomitant
Swelling Other Serious 4/1/2006 83 Female 11/21/2006 United States
Primary
Concomitant
Wound Debridement Other Serious 2/1/2003 Male 11/22/2006 United States
Primary
Secondary
Concomitant
Tachyarrhythmia Other Serious 5/1/2006 79 Female 170 lb 11/23/2006 Pharmacist Germany
Primary
Secondary
Concomitant
Tooth Disorder Other Serious 1/18/2006 75 Female 12/5/2006 Physician Spain
Primary
Concomitant
Wound Debridement Other Serious 2/1/2005 74 Female 12/7/2006 Physician Belgium
Primary
Concomitant
Tooth Extraction Other Serious 2/1/2005 68 Female 12/7/2006 Physician Belgium
Primary
Concomitant
Tooth Injury Other Serious 1/1/2002 65 Female 12/18/2006 Consumer United States
Primary
Secondary
Concomitant
Purulent Discharge Other Serious 5/31/2002 70 Female 161 lb 12/22/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Wound Debridement Disability 12/1/2005 63 Female 1/3/2007 Switzerland
Primary
Secondary
Concomitant
Wound Debridement Other Serious 2/1/2003 54 Male 1/12/2007 United States
Primary
Secondary
Concomitant
Osteonecrosis Disability 9/1/2006 83 Female 1/12/2007 Switzerland
Primary
Secondary
Concomitant
Wound Decomposition Other Serious 9/1/2003 49 Male 130 lb 1/15/2007 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 12/13/2006 65 Male 1/23/2007 Switzerland
Primary
Concomitant
Wound Debridement Other Serious 2/1/2003 54 Male 1/25/2007 United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 6/1/2003 53 Male 167 lb 2/20/2007 United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 6/1/2003 53 Male 167 lb 2/20/2007 United States
Primary
Secondary
Concomitant
Tooth Disorder Other Serious 1/18/2006 75 Female 2/27/2007 Physician Spain
Primary
Concomitant
Tooth Extraction Disability 2/1/2005 84 Male 3/19/2007 France
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 10/23/2006 78 Male 125 lb 3/23/2007 United States
Primary
Concomitant
Tooth Extraction Other Serious 12/1/2004 84 Male 4/17/2007 France
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 10/3/2005 78 Male 125 lb 4/18/2007 United States
Primary
Concomitant
Osteonecrosis Other Serious 8/31/2006 80 Female 79 lb 4/19/2007 Pharmacist Germany
Primary
Concomitant
Osteonecrosis Other Serious 5/3/2007 Physician Cyprus
Primary
Concomitant
Tooth Extraction Other Serious 12/1/2004 54 Female 166 lb 5/7/2007 United States
Primary
Concomitant
Tooth Loss Other Serious 8/31/2006 80 Female 79 lb 5/9/2007 Pharmacist Germany
Primary
Concomitant
Osteonecrosis Other Serious 8/31/2006 80 Female 79 lb 5/10/2007 Pharmacist Germany
Primary
Concomitant
Osteonecrosis Other Serious 8/31/2006 80 Female 79 lb 5/10/2007 Pharmacist Germany
Primary
Concomitant
Osteonecrosis Other Serious 10/1/2006 Male 5/14/2007 Physician Germany
Primary
Concomitant
Osteonecrosis Other Serious 10/1/2006 Male 5/14/2007 Physician Germany
Primary
Concomitant
Tooth Extraction Other Serious 1/1/2006 70 Female 5/15/2007 Physician Belgium
Primary
Concomitant
Osteonecrosis Other Serious 68 Male 5/15/2007 Other Health Professional Spain
Primary
Concomitant
Wound Drainage Other Serious 1/1/2005 73 Male 239 lb 5/16/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 3/1/2007 80 Male 5/26/2007 Physician Germany
Primary
Concomitant
Tooth Extraction 2/1/2007 47 Male 154 lb 5/31/2007 Physician Germany
Primary
Concomitant
Tooth Extraction 2/1/2007 47 Male 154 lb 5/31/2007 Physician Germany
Primary
Concomitant
Wound Debridement Other Serious 4/1/2007 70 Male 6/2/2007 Physician Belgium
Primary
Concomitant
Wound Drainage Other Serious 2/1/2005 73 Male 239 lb 6/7/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/1/2004 47 Female 6/8/2007 Physician Australia
Primary
Secondary
Concomitant
Surgery Hospitalization 11/1/2006 65 Male 6/8/2007 Physician Australia
Primary
Secondary
Concomitant
Renal Tubular Atrophy Hospitalization 12/13/2006 65 Male 6/12/2007 Switzerland
Primary
Concomitant
Wound Debridement Other Serious 2/1/2003 56 Male 6/15/2007 United States
Primary
Secondary
Concomitant
Primary Sequestrum Other Serious 10/12/2006 78 Male 6/23/2007 Physician Japan
Primary
Secondary
Concomitant
X-ray Abnormal Other Serious 11/2/2004 75 Female 6/30/2007 Physician Germany
Primary
Secondary
Concomitant
Swelling Other Serious 1/1/2005 60 Female 7/20/2007 United States
Primary
Secondary
Concomitant
Swelling Other Serious 1/1/2005 60 Female 7/20/2007 United States
Primary
Secondary
Concomitant
Sinusitis Other Serious 10/12/2006 78 Male 128 lb 7/24/2007 Physician Japan
Primary
Secondary
Concomitant
Sinusitis Other Serious 10/12/2006 78 Male 128 lb 7/28/2007 Physician Japan
Primary
Secondary
Concomitant
Wound Treatment Other Serious 3/21/2007 80 Female 7/30/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Stomatitis Other Serious 4/1/2007 77 Female 139 lb 8/4/2007 Physician Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 1/1/1997 64 Female 9/4/2007 United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 1/1/1997 64 Female 9/4/2007 United States
Primary
Secondary
Concomitant
Stomatitis Other Serious 4/1/2007 77 Female 139 lb 9/6/2007 Physician Japan
Primary
Secondary
Concomitant
Surgery Hospitalization 11/1/2006 62 Male 10/19/2007 Physician Australia
Primary
Secondary
Concomitant
X-ray Abnormal Other Serious 10/7/2002 61 Female 11/1/2007 Physician
Primary
Concomitant
Sinusitis Other Serious 10/12/2006 78 Male 128 lb 10/31/2007 Japan
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 7/31/2007 63 Male 157 lb 11/2/2007 Physician Japan
Primary
Concomitant
Tooth Extraction Other Serious 6/1/2002 42 Male 173 lb 11/6/2007 United States
Primary
Concomitant
Sinusitis Other Serious 10/12/2006 78 Male 128 lb 11/12/2007 Japan
Primary
Secondary
Concomitant
Bone Infarction Other Serious 11/21/2007 Physician Japan
Primary
Concomitant
Bone Infarction Other Serious 12/7/2007 Physician Japan
Primary
Concomitant
Tooth Extraction Other Serious 6/1/2002 42 Male 173 lb 12/8/2007 United States
Primary
Concomitant
Wound Haemorrhage Other Serious 1/1/2005 68 Male 201 lb 12/11/2007 United States
Primary
Secondary
Concomitant
Wound Debridement Other Serious 2/1/2003 56 Male 12/18/2007 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 8/1/2006 64 Male 12/19/2007 Physician United States
Primary
Secondary
Concomitant
Wound Decomposition Other Serious 9/1/2003 49 Male 130 lb 12/26/2007 Physician United States
Primary
Secondary
Concomitant
Ventricular Tachycardia Other Serious 6/1/2002 41 Male 170 lb 1/18/2008 United States
Primary
Concomitant
Tooth Extraction Other Serious 9/4/2007 60 Male 2/6/2008 Physician Japan
Primary
Secondary
Concomitant
Tooth Abscess Other Serious 1/1/2007 55 Male 2/6/2008 United States
Primary
Concomitant
Tooth Fracture Other Serious 7/1/2007 Male 2/18/2008 United States
Primary
Concomitant
Wound Complication Other Serious 8/11/2000 48 Female 192 lb 2/26/2008 United States
Primary
Secondary
Concomitant
Wound Haemorrhage Other Serious 1/1/2005 67 Male 201 lb 2/26/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 10/14/2007 85 Male 146 lb 2/28/2008 Physician Japan
Primary
Concomitant
Visual Disturbance Other Serious 11/25/1998 43 Female 170 lb 2/29/2008 United States
Primary
Secondary
Concomitant
Tooth Fracture Other Serious 7/1/2007 Male 3/4/2008 United States
Primary
Secondary
Concomitant
Wound Complication Other Serious 8/11/2000 48 Female 192 lb 3/5/2008 United States
Primary
Secondary
Concomitant
Wound Complication Other Serious 8/11/2000 48 Female 192 lb 3/14/2008 United States
Primary
Secondary
Concomitant
Visual Disturbance Other Serious 11/25/1998 43 Female 170 lb 3/18/2008 United States
Primary
Secondary
Concomitant
X-ray Abnormal Other Serious 10/1/2007 69 Male 3/24/2008 Physician Japan
Primary
Concomitant
Osteonecrosis Other Serious 7/31/2007 63 Male 157 lb 3/27/2008 Physician Japan
Primary
Concomitant
Tenderness Other Serious 1/1/2003 60 Male 4/2/2008 United States
Primary
Concomitant
Wound Secretion Other Serious 8/11/2000 48 Female 192 lb 4/3/2008 United States
Primary
Secondary
Concomitant
X-ray Abnormal Other Serious 3/9/2007 71 Male 4/8/2008 Physician Australia
Primary
Concomitant
Surgery Hospitalization 10/5/2007 66 Female 4/12/2008 Italy
Primary
Concomitant
Osteomyelitis Hospitalization 9/15/2007 73 Female 4/11/2008 Italy
Primary
Concomitant
X-ray Dental Other Serious 6/21/2005 74 Male 4/12/2008 Other Health Professional Italy
Primary
Concomitant
Tooth Extraction Other Serious 3/7/2005 Male 4/18/2008 Physician United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/16/2008 67 Male 4/22/2008 Consumer Austria
Primary
Concomitant
Tooth Extraction Other Serious 1/16/2008 67 Male 4/23/2008 Consumer Austria
Primary
Concomitant

Drug Data