Tacrolimus



Indications and Reactions:

Role Indications Reactions
Primary
Renal Transplant 19.3%
Liver Transplant 13.3%
Immunosuppression 11.3%
Dermatitis Atopic 9.0%
Lupus Nephritis 7.7%
Immunosuppressant Drug Therapy 6.2%
Prophylaxis Against Transplant Rejection 5.8%
Rheumatoid Arthritis 4.5%
Colitis Ulcerative 3.3%
Product Used For Unknown Indication 3.0%
Prophylaxis 2.6%
Lung Transplant 2.2%
Heart Transplant 2.1%
Stem Cell Transplant 2.0%
Prophylaxis Against Graft Versus Host Disease 1.9%
Hypertension 1.8%
Myasthenia Gravis 1.3%
Nephrotic Syndrome 1.1%
Graft Versus Host Disease 0.9%
Asthma 0.8%
Death 44.5%
Lymphadenopathy 6.0%
Thrombotic Microangiopathy 5.4%
Off Label Use 4.4%
Transplant Rejection 3.8%
Vomiting 3.8%
Tremor 3.5%
Sepsis 3.2%
Drug Interaction 2.9%
Pneumonia 2.4%
Drug Ineffective 2.3%
Weight Decreased 2.3%
Renal Impairment 2.3%
Neutrophil Pelger-huet Anomaly Present 2.1%
Septic Shock 2.1%
Toxicity To Various Agents 2.1%
White Blood Cell Count Increased 1.9%
Pyrexia 1.7%
Drug Level Increased 1.6%
Kidney Fibrosis 1.6%
Secondary
Immunosuppression 14.9%
Renal Transplant 14.7%
Prophylaxis Against Transplant Rejection 12.0%
Product Used For Unknown Indication 7.7%
Liver Transplant 6.8%
Prophylaxis 6.6%
Colitis Ulcerative 5.2%
Immunosuppressant Drug Therapy 4.9%
Rheumatoid Arthritis 4.0%
Drug Use For Unknown Indication 3.9%
Prophylaxis Against Graft Versus Host Disease 2.8%
Infection Prophylaxis 2.7%
Hypertension 2.7%
Prophylaxis Against Renal Transplant Rejection 2.3%
Burkitt's Lymphoma 2.0%
Graft Versus Host Disease 1.6%
Heart Transplant 1.6%
Bone Marrow Conditioning Regimen 1.5%
Antifungal Prophylaxis 1.3%
Transplant Rejection 1.0%
Transplant Rejection 16.6%
Urinary Tract Infection 8.1%
Renal Impairment 7.3%
Vomiting 6.0%
Thrombotic Microangiopathy 5.6%
Sepsis 5.3%
Liver Transplant Rejection 5.1%
Pyrexia 4.7%
Renal Disorder 4.5%
Upper Respiratory Tract Infection 4.5%
Diarrhoea 3.8%
Renal Failure Acute 3.8%
Kidney Transplant Rejection 3.4%
Pneumonia 3.3%
Renal Failure 3.2%
Cytomegalovirus Infection 3.1%
Urosepsis 3.1%
Respiratory Failure 2.9%
Neutrophil Pelger-huet Anomaly Present 2.8%
Diabetes Mellitus 2.7%
Concomitant
Product Used For Unknown Indication 24.6%
Prophylaxis Against Graft Versus Host Disease 8.2%
Infection Prophylaxis 7.7%
Prophylaxis 7.7%
Bone Marrow Conditioning Regimen 7.4%
Prophylaxis Against Transplant Rejection 5.7%
Immunosuppression 5.2%
Renal Transplant 4.9%
Drug Use For Unknown Indication 4.2%
Rheumatoid Arthritis 3.7%
Premedication 3.1%
Antifungal Prophylaxis 3.0%
Stem Cell Transplant 2.5%
Acute Myeloid Leukaemia 2.5%
Antiviral Prophylaxis 2.2%
Graft Versus Host Disease 1.9%
Antibiotic Prophylaxis 1.6%
Hypertension 1.5%
Immunosuppressant Drug Therapy 1.4%
Acute Graft Versus Host Disease 1.1%
Vomiting 10.4%
Transplant Rejection 10.3%
Urinary Tract Infection 8.4%
Venoocclusive Liver Disease 6.9%
Pyrexia 6.8%
Sepsis 5.7%
Thrombotic Microangiopathy 4.8%
White Blood Cell Count Decreased 4.6%
Renal Impairment 4.4%
Renal Failure 4.1%
Thrombocytopenia 3.9%
Graft Versus Host Disease 3.8%
Renal Failure Acute 3.8%
Acute Graft Versus Host Disease 3.7%
Off Label Use 3.3%
Respiratory Failure 3.3%
Stomatitis 3.1%
Diarrhoea 3.0%
Multi-organ Failure 2.8%
Death 2.8%
Interacting
Immunosuppression 18.2%
Immunosuppressant Drug Therapy 12.3%
Renal Transplant 9.7%
Product Used For Unknown Indication 9.6%
Hiv Infection 7.4%
Drug Use For Unknown Indication 7.0%
Hypertension 5.0%
Prophylaxis Against Transplant Rejection 4.8%
Pneumonia 4.0%
Tuberculosis 3.5%
Prophylaxis 3.1%
Renal Failure Chronic 2.8%
Lung Transplant 2.6%
Liver Transplant 2.2%
Aspergillosis 1.8%
Antiretroviral Therapy 1.4%
Upper Respiratory Tract Infection 1.4%
Hepatitis C 1.2%
Pulmonary Tuberculosis 1.2%
Fungal Oesophagitis 1.1%
Drug Interaction 19.9%
Drug Level Increased 12.6%
Transplant Rejection 10.1%
Immunosuppressant Drug Level Increased 8.7%
Hyperglycaemia 6.3%
Renal Failure Acute 6.3%
Nephropathy Toxic 4.9%
Haemolytic Uraemic Syndrome 4.2%
Electrocardiogram Qt Prolonged 3.5%
Vomiting 3.5%
Toxicity To Various Agents 3.1%
Pyrexia 2.8%
Overdose 2.1%
Renal Impairment 2.1%
Rhabdomyolysis 2.1%
Wrong Technique In Drug Usage Process 2.1%
Kidney Transplant Rejection 1.4%
Liver Transplant Rejection 1.4%
Stomatitis 1.4%
Treatment Noncompliance 1.4%