Methylprednisolone Sodium Succinate combined with Tacrolimus

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
International Normalised Ratio Increased 7/22/2004 9/12/2005 Physician United States
Primary
Concomitant
Sinus Tachycardia Other Serious 3/8/2007 11 Female 53 lb 3/30/2007 Physician United States
Primary
Concomitant
Depression Other Serious 54 Female 12/11/2007 Other Health Professional United States
Primary
Secondary
Haemoglobin Decreased Other Serious 59 Female 12/11/2007 Other Health Professional United States
Primary
Secondary
Weight Decreased Other Serious 55 Male 12/11/2007 Other Health Professional United States
Primary
Secondary
Pulmonary Alveolar Haemorrhage Other Serious 9/1/2006 Male 10/20/2008 Physician Japan
Primary
Secondary
Concomitant
Necrotising Fasciitis Other Serious 39 Male 11/21/2008 Canada
Primary
Secondary
Vomiting Other Serious 57 Female 4/22/2009 Pharmacist Japan
Primary
Concomitant
Vomiting Other Serious 57 Female 5/1/2009 Pharmacist Japan
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 59 Male 5/11/2009 Physician Japan
Primary
Concomitant
Respiratory Failure Other Serious 4/5/2009 Male 183 lb 5/25/2009 Other Health Professional United States
Primary
Concomitant
Respiratory Failure Other Serious 4/5/2009 Male 183 lb 6/8/2009 Other Health Professional United States
Primary
Concomitant
Hepatic Neoplasm Malignant Recurrent Death 47 Male 6/17/2009 Physician Japan
Primary
Concomitant
Urinoma Hospitalization 11/13/2004 Male 163 lb 6/23/2009 Physician Canada
Primary
Secondary
Concomitant
Ureteric Stenosis Hospitalization 11/29/2004 Male 187 lb 6/23/2009 Physician Canada
Primary
Secondary
Concomitant
Sepsis Hospitalization 9/3/2004 Male 194 lb 6/23/2009 Physician Czech Republic
Primary
Secondary
Concomitant
Pseudomonal Sepsis Other Serious 3/4/2009 60 Male 150 lb 6/15/2009 Physician Japan
Primary
Concomitant
Focal Segmental Glomerulosclerosis Other Serious 6 Female 10/23/2009 Physician Japan
Primary
Concomitant
Multi-organ Failure Death 4/20/2009 33 Male 121 lb 10/28/2009 Physician Japan
Primary
Concomitant
Precursor T-lymphoblastic Lymphoma/leukaemia Other Serious 2/1/2009 12 Male 12/2/2009 Other Health Professional Japan
Primary
Concomitant
Transplant Rejection Required Intervention 22 Male 12/9/2009 Physician United Kingdom
Primary
Secondary
Nephrolithiasis Other Serious 44 Male 12/22/2009 Other Health Professional Japan
Primary
Concomitant
Urine Output Decreased Hospitalization 49 Female 1/25/2010 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Concomitant
Pyrexia Other Serious 3/22/2009 15 Male 110 lb 2/26/2010 Physician Japan
Primary
Concomitant
Systemic Mycosis Other Serious 4 Female 2/26/2010 Physician Japan
Primary
Secondary
Hepatic Function Abnormal Life Threatening 6/28/2009 Male 3/30/2010 Physician Japan
Primary
Concomitant
Staphylococcal Infection Life Threatening 5/1/2007 65 Male 99 lb 5/26/2010 Consumer Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 10/19/2009 54 Male 132 lb 6/21/2010 Other Health Professional Japan
Primary
Concomitant
Bronchopulmonary Aspergillosis Death 55 Male 6/29/2010 Other Health Professional Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/26/2009 11 Male 77 lb 7/21/2010 Physician Japan
Primary
Concomitant
Multi-organ Failure Death 5/6/2009 33 Male 194 lb 7/28/2010 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 9/21/2009 37 Female 93 lb 8/9/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/26/2009 11 Male 77 lb 8/11/2010 Physician Japan
Primary
Concomitant
Bacterial Sepsis Other Serious 33 Male 8/13/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 31 Female 8/13/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Herpes Zoster Other Serious 19 Male 8/13/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Mycobacterium Kansasii Pneumonia Death 53 Male 8/13/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 28 Female 8/13/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Disease Recurrence Hospitalization 2/22/2010 49 Female 97 lb 8/13/2010 Physician Japan
Primary
Concomitant
Nephrotic Syndrome Other Serious 9/19/2009 69 Female 86 lb 8/13/2010 Physician Japan
Primary
Concomitant
Thrombotic Microangiopathy Hospitalization 1/23/2010 66 Male 130 lb 8/13/2010 Consumer Japan
Primary
Concomitant
Herpes Zoster Other Serious 10/30/2009 31 Male 128 lb 8/16/2010 Physician Japan
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 3/11/2009 23 Female 97 lb 8/17/2010 Physician Japan
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 1/23/2010 67 Male 130 lb 8/19/2010 Physician Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 1/23/2010 67 Male 130 lb 8/24/2010 Physician Japan
Primary
Secondary
Concomitant
Herpes Zoster Other Serious 10/30/2009 31 Male 8/24/2010 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 3/11/2009 23 Female 97 lb 8/31/2010 Physician Japan
Primary
Concomitant
Mycobacterium Kansasii Pneumonia Death 54 Male 8/31/2010 Physician Japan
Primary
Concomitant
Acute Myeloid Leukaemia Recurrent Other Serious 12/10/2009 5 Male 53 lb 9/1/2010 Physician Japan
Primary
Concomitant
Sepsis Other Serious 4/20/2010 1 Male 15 lb 9/3/2010 Physician Japan
Primary
Concomitant
Sepsis Other Serious 4/20/2010 1 Male 15 lb 9/8/2010 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/13/2009 4 Female 31 lb 9/9/2010 Physician Japan
Primary
Concomitant
Therapeutic Response Decreased Hospitalization 2/8/2010 3 Female 31 lb 9/20/2010 Physician Japan
Primary
Concomitant
Febrile Neutropenia Other Serious 8/11/2009 10 Male 86 lb 9/20/2010 Physician Japan
Primary
Concomitant
Multi-organ Failure Hospitalization 6/24/2009 15 Male 126 lb 9/23/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/10/2009 4 Female 31 lb 10/8/2010 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 4/10/2009 4 Female 31 lb 10/11/2010 Physician Japan
Primary
Secondary
Concomitant
Pruritus Hospitalization 9/30/2009 18 Female 137 lb 10/18/2010 Physician Japan
Primary
Concomitant
Herpes Zoster Other Serious 10/30/2009 31 Male 128 lb 10/20/2010 Physician Japan
Primary
Concomitant
Encephalopathy Other Serious 4/10/2010 35 Male 139 lb 10/20/2010 Physician Japan
Primary
Concomitant
Pneumonia Hospitalization 7/2/2010 62 Male 130 lb 10/21/2010 Physician Japan
Primary
Concomitant
Sepsis Other Serious 7/22/2010 14 Female 97 lb 10/22/2010 Physician Japan
Primary
Concomitant
Staphylococcal Sepsis Life Threatening 1/14/2009 67 Male 99 lb 10/26/2010 Consumer Japan
Primary
Concomitant
Transplant Failure Other Serious 12/27/2008 52 Male 152 lb 10/28/2010 Physician Japan
Primary
Secondary
Concomitant
Oedema Life Threatening 2/6/2010 59 Male 176 lb 11/1/2010 Physician Japan
Primary
Concomitant
Thrombotic Microangiopathy Death 9/21/2009 62 Female 126 lb 11/3/2010 Physician Japan
Primary
Concomitant
Epstein-barr Virus Associated Lymphoproliferative Disorder Death 5/6/2010 59 Female 99 lb 11/3/2010 Physician Japan
Primary
Concomitant
Febrile Neutropenia Other Serious 10/23/2009 41 Male 132 lb 11/3/2010 Physician Japan
Primary
Concomitant
Oedema Life Threatening 1/29/2010 59 Male 176 lb 11/3/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Death 2/8/2010 38 Male 146 lb 11/8/2010 Physician Japan
Primary
Concomitant
Sepsis Other Serious 5/26/2009 7 Female 29 lb 11/11/2010 Physician Japan
Primary
Secondary
Concomitant
Failure To Thrive Other Serious 11 Male 11/18/2010 Physician Japan
Primary
Concomitant
Weight Increased Other Serious 1/17/2010 Male 168 lb 11/22/2010 Physician Japan
Primary
Concomitant
Idiopathic Pneumonia Syndrome Other Serious 7/14/2010 Female 99 lb 11/22/2010 Physician Japan
Primary
Concomitant
Thyroid Disorder Other Serious 7/17/2009 28 Male 110 lb 11/23/2010 Physician Japan
Primary
Concomitant
Multi-organ Failure Hospitalization 6/24/2009 15 Male 126 lb 11/23/2010 Physician Japan
Primary
Concomitant
Cytomegalovirus Infection Other Serious 7/17/2009 28 Male 110 lb 11/24/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Life Threatening Male 112 lb 11/24/2010 Physician Japan
Primary
Concomitant
Venoocclusive Liver Disease Hospitalization 5/26/2010 Male 18 lb 11/24/2010 Physician Japan
Primary
Concomitant
Therapeutic Response Decreased Death 1/27/2010 55 Female 128 lb 11/29/2010 Physician Japan
Primary
Concomitant
Fall Other Serious 12/9/2009 11/29/2010 Physician Japan
Primary
Concomitant
Pseudomonal Sepsis Other Serious 5/21/2010 Male 154 lb 12/3/2010 Physician Japan
Primary
Concomitant
Staphylococcal Sepsis Other Serious 8/21/2009 13 Male 97 lb 12/8/2010 Physician Japan
Primary
Concomitant
Staphylococcal Sepsis Other Serious 8/18/2009 13 Male 97 lb 12/10/2010 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 4/20/2010 1 Male 15 lb 12/10/2010 Physician Japan
Primary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Life Threatening 2/19/2010 7 Male 51 lb 12/13/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/13/2009 4 Female 31 lb 12/20/2010 Physician Japan
Primary
Concomitant
Vomiting Other Serious 3/15/2010 54 Female 95 lb 12/22/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Cytomegaloviral Death 5/6/2009 33 Male 194 lb 12/23/2010 Physician Japan
Primary
Concomitant
Liver Disorder Hospitalization 3/26/2010 54 Female 95 lb 12/28/2010 Physician Japan
Primary
Secondary
Concomitant
Pseudomonal Sepsis Life Threatening 11/7/2010 49 Female 97 lb 12/30/2010 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 2/23/2010 69 Male 130 lb 12/30/2010 Physician Japan
Primary
Concomitant
Bacterial Infection Death 8/20/2009 46 Male 161 lb 1/3/2011 Other Health Professional Japan
Primary
Concomitant
Urinary Tract Infection Fungal Hospitalization 7/26/2010 51 Male 198 lb 1/3/2011 Physician Japan
Primary
Secondary
Concomitant
Enterococcal Sepsis Death 5/5/2010 48 Male 137 lb 1/6/2011 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Death 10/23/2009 62 Male 130 lb 1/6/2011 Physician Japan
Primary
Concomitant
Haemorrhage Death 4/13/2009 4 Female 31 lb 1/7/2011 Physician Japan
Primary
Concomitant
Pneumonia Cytomegaloviral Death 5/6/2009 33 Male 194 lb 1/7/2011 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Death 10/23/2009 62 Male 130 lb 1/7/2011 Physician Japan
Primary
Secondary
Concomitant
Febrile Neutropenia Death 5/5/2010 48 Male 137 lb 1/7/2011 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Sepsis Death 1/1/2010 1/7/2011 Physician Japan
Primary
Concomitant
Febrile Neutropenia Death 8/11/2010 24 Male 141 lb 1/7/2011 Physician Japan
Primary
Concomitant
Cytomegalovirus Test Positive Death 5/1/2010 54 Female 119 lb 1/10/2011 Physician Japan
Primary
Concomitant
Infection Life Threatening 7/4/2010 73 Female 97 lb 1/10/2011 Physician Japan
Primary
Concomitant
Acute Myeloid Leukaemia Recurrent Other Serious 2/26/2010 56 Male 134 lb 1/10/2011 Physician Japan
Primary
Concomitant
Acute Myeloid Leukaemia Recurrent Other Serious 5/12/2009 56 Male 139 lb 1/10/2011 Physician Japan
Primary
Concomitant
Cystitis Haemorrhagic Hospitalization 5/17/2010 43 Female 1/10/2011 Physician Japan
Primary
Concomitant
Acute Myeloid Leukaemia Death 5/12/2009 56 Male 139 lb 1/10/2011 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Death 8/6/2010 35 Female 71 lb 1/10/2011 Physician Japan
Primary
Concomitant
Infection Life Threatening 7/4/2010 73 Female 97 lb 1/11/2011 Physician Japan
Primary
Secondary
Concomitant
Cytomegalovirus Test Positive Hospitalization 5/1/2010 54 Female 119 lb 1/11/2011 Physician Japan
Primary
Secondary
Concomitant
Viral Haemorrhagic Cystitis Life Threatening 11/7/2009 66 Male 128 lb 1/11/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Skin Hospitalization 2/26/2010 56 Male 134 lb 1/11/2011 Physician Japan
Primary
Secondary
Concomitant
Infection Life Threatening 7/4/2010 73 Female 97 lb 1/13/2011 Physician Japan
Primary
Secondary
Concomitant
Adult T-cell Lymphoma/leukaemia Death Female 126 lb 1/13/2011 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Other Serious 8/6/2010 35 Female 71 lb 1/14/2011 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 9/10/2009 18 Male 137 lb 1/24/2011 Physician Japan
Primary
Concomitant
Epstein-barr Virus Associated Lymphoproliferative Disorder Death 5/6/2010 59 Female 99 lb 1/26/2011 Physician Japan
Primary
Concomitant
Thrombotic Microangiopathy Death 9/21/2009 62 Female 126 lb 1/26/2011 Physician Japan
Primary
Concomitant
Polyomavirus-associated Nephropathy Hospitalization 38 Male 1/26/2011 Physician Japan
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 5/17/2010 43 Female 119 lb 1/26/2011 Physician Japan
Primary
Concomitant
Graft Versus Host Disease Hospitalization 9/30/2009 18 Female 137 lb 1/28/2011 Physician Japan
Primary
Concomitant
Fungal Infection Hospitalization 6/24/2009 15 Male 126 lb 2/14/2011 Consumer Japan
Primary
Concomitant
Sepsis Hospitalization 7/22/2010 14 Female 97 lb 2/14/2011 Physician Japan
Primary
Concomitant
Sepsis Other Serious 9/10/2009 18 Male 137 lb 2/15/2011 Physician Japan
Primary
Concomitant
Acute Graft Versus Host Disease In Liver Other Serious 9/22/2010 46 Female 64 lb 2/18/2011 Physician Japan
Primary
Secondary
Concomitant
Cytomegalovirus Test Positive Death Male 121 lb 2/18/2011 Physician Japan
Primary
Concomitant
Pneumonia Cytomegaloviral Death 10/15/2010 7 Female 42 lb 2/23/2011 Physician Japan
Primary
Secondary
Concomitant
Epstein-barr Virus Associated Lymphoproliferative Disorder Death 5/6/2010 59 Female 99 lb 3/3/2011 Physician Japan
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Other Serious 3/12/2010 2 Male 22 lb 3/9/2011 Physician Japan
Primary
Concomitant
Liver Disorder Hospitalization 10/24/2010 19 Male 115 lb 3/10/2011 Physician Japan
Primary
Concomitant
Cystitis Haemorrhagic Hospitalization 5/17/2010 43 Female 119 lb 3/10/2011 Physician Japan
Primary
Concomitant
Pneumonia Bacterial Other Serious 1/29/2010 52 Male 132 lb 3/24/2011 Physician Japan
Primary
Secondary
Concomitant
Cystitis Haemorrhagic Hospitalization 5/17/2010 43 Female 119 lb 3/25/2011 Physician Japan
Primary
Concomitant
Haemolysis Life Threatening 10/1/2010 53 Male 146 lb 4/1/2011 Physician Japan
Primary
Concomitant
Delirium Other Serious 6/16/2010 53 Male 154 lb 4/8/2011 Physician Japan
Primary
Concomitant
Toothache Hospitalization 9/21/2009 37 Female 93 lb 4/14/2011 Physician Japan
Primary
Concomitant
Kidney Transplant Rejection Other Serious 7 Female 4/6/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 10/15/2009 57 Female 106 lb 4/19/2011 Physician Japan
Primary
Concomitant
Rash Hospitalization 3/15/2010 54 Female 95 lb 4/20/2011 Physician Japan
Primary
Secondary
Concomitant
Abscess Bacterial Death 11/25/2009 61 Male 141 lb 4/25/2011 Physician Japan
Primary
Secondary
Concomitant
Fungal Infection Other Serious 10/13/2009 36 Male 143 lb 4/27/2011 Physician Japan
Primary
Concomitant
Cardiac Failure Congestive Death 7/14/2010 Female 99 lb 5/5/2011 Physician Japan
Primary
Concomitant
Candida Test Positive Hospitalization 3/12/2010 54 Female 95 lb 5/25/2011 Physician Japan
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/17/2010 55 Male 168 lb 6/7/2011 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Mycosis Other Serious 3/2/2010 63 Male 130 lb 6/7/2011 Physician Japan
Primary
Secondary
Concomitant
Pericardial Effusion Death 10/15/2010 7 Female 42 lb 6/15/2011 Physician Japan
Primary
Secondary
Concomitant
Biopsy Small Intestine Abnormal Hospitalization 1 Male 6/15/2011 Physician Canada
Primary
Secondary
Serum Sickness Death 7/16/2010 68 Male 121 lb 6/16/2011 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Sepsis Life Threatening 1/29/2010 52 Male 132 lb 6/20/2011 Physician Japan
Primary
Secondary
Concomitant

Drug Data