Metoprolol combined with Tacrolimus

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
International Normalised Ratio Increased 6/30/2004 53 9/12/2005 Pharmacist United States
Primary
Concomitant
Liver Function Test Abnormal 12/18/2004 38 9/12/2005 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased 4/30/2004 60 9/12/2005 Physician United States
Primary
Concomitant
Ventricular Fibrillation Hospitalization 11/10/2001 60 Male 1/20/2006 Physician United States
Primary
Secondary
Concomitant
Asthenia Hospitalization 7/9/2005 68 Female 196 lb 1/25/2006 Physician United States
Primary
Secondary
Concomitant
Urticaria 9/14/2005 78 Male 240 lb United States
Primary
Concomitant
Subcutaneous Abscess Hospitalization 10/29/2004 53 Male 176 lb 2/9/2006 Physician Germany
Primary
Secondary
Concomitant
Systemic Inflammatory Response Syndrome 11/20/2005 49 Male 1/23/2006 Pharmacist United States
Primary
Concomitant
Respiratory Distress Life Threatening 8/19/2005 66 Male 3/1/2006 Physician Switzerland
Primary
Secondary
Concomitant
Foot Amputation Hospitalization 10/31/2005 67 Male 4/28/2006 Physician Germany
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 7/2/2006 66 198 lb 7/11/2006 Pharmacist United States
Primary
Concomitant
Pulmonary Oedema Other Serious 1/1/2006 Male 7/19/2006 Pharmacist United States
Primary
Concomitant
Infusion Related Reaction Other Serious 7/1/2006 Male 9/20/2006 Pharmacist United States
Primary
Concomitant
Blood Creatinine Increased Hospitalization 4/13/2006 53 Male 167 lb 10/31/2006 Pharmacist United States
Primary
Secondary
Concomitant
Muscular Weakness Hospitalization 7/9/2005 68 Female 196 lb 9/25/2007 Physician United States
Primary
Secondary
Concomitant
Polyomavirus-associated Nephropathy Hospitalization 3/27/2007 Male 184 lb 10/19/2007 Consumer Sweden
Primary
Secondary
Concomitant
Retroperitoneal Haemorrhage Required Intervention 9/8/2007 77 Female 165 lb 10/2/2007 United States
Primary
Concomitant
Pleural Effusion Required Intervention 6/25/2007 44 Female 86 lb 7/30/2007 United States
Primary
Concomitant
Troponin Increased Death 1/28/2007 Female 10/22/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Multiple Myeloma Hospitalization 5/4/2006 67 Male 172 lb 10/29/2007 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Enterococcal Other Serious 5/15/2007 61 Female 132 lb 11/30/2007 Physician United States
Primary
Concomitant
Vascular Injury Other Serious 5/21/2007 65 Female 101 lb 11/30/2007 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 10/16/2007 60 Female 140 lb 12/13/2007 Physician United States
Primary
Secondary
Concomitant
Polyomavirus-associated Nephropathy Hospitalization 3/27/2007 Male 184 lb 12/21/2007 Consumer Sweden
Primary
Secondary
Concomitant
Vomiting Other Serious 10/16/2007 60 Female 140 lb 1/3/2008 Physician United States
Primary
Secondary
Concomitant
Sinusitis Hospitalization 11/1/2007 Female 138 lb 1/11/2008 Physician United States
Primary
Concomitant
Swelling Other Serious 1/1/2007 Female 155 lb 6/12/2008 Consumer United States
Primary
Concomitant
Urinary Tract Infection Other Serious 1/1/2007 Female 182 lb 6/17/2008 Physician United States
Primary
Concomitant
Vomiting Hospitalization 3/19/2008 3/26/2008 Pharmacist United States
Primary
Concomitant
Pyrexia Other Serious 7/22/2005 53 Female 271 lb 6/25/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Lethargy Hospitalization 10/20/2008 48 Female 10/20/2008 Pharmacist United States
Primary
Concomitant
Transplant Rejection Other Serious 10/21/2008 Male 228 lb 12/3/2008 Physician Canada
Primary
Concomitant
Kidney Transplant Rejection Other Serious 10/7/2008 Male 260 lb 12/3/2008 Physician Canada
Primary
Secondary
Concomitant
Pneumonia Hospitalization 9/26/2004 Female 12/15/2008 Physician United States
Primary
Secondary
Concomitant
Pain Other Serious 1/1/2007 Male 110 lb 12/23/2008 Physician United States
Primary
Secondary
Concomitant
Myositis Hospitalization 7/15/2008 59 Male 2/13/2009 Other Health Professional United States
Primary
Concomitant
Myositis Hospitalization 7/15/2008 59 Male 3/11/2009 Other Health Professional United States
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 5/16/2004 Male 194 lb 4/3/2009 Physician Israel
Primary
Secondary
Concomitant
Small Intestinal Obstruction Hospitalization 5/16/2004 Male 4/9/2009 Physician Israel
Primary
Secondary
Concomitant
Coronary Artery Stenosis Hospitalization 1/13/2009 51 Male 198 lb 4/28/2009 Physician Canada
Primary
Concomitant
Cardio-respiratory Arrest Required Intervention 3/8/2009 58 Female 4/2/2009 Pharmacist United States
Primary
Concomitant
Subarachnoid Haemorrhage Life Threatening 1/19/2009 25 Female 94 lb 2/3/2009 Pharmacist United States
Primary
Concomitant
Kidney Transplant Rejection Other Serious 1/19/2009 Male 168 lb 5/7/2009 Physician Canada
Primary
Secondary
Concomitant
Respiratory Distress Other Serious 1/29/2009 Male 186 lb 6/26/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Distress Hospitalization 4/20/2009 59 Male 196 lb 4/22/2009 Pharmacist United States
Primary
Concomitant
Ventricular Septal Defect Other Serious Female 5 lb 7/6/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Haemoglobin Decreased Other Serious 7/27/2009 Male 7/29/2009 Physician United States
Primary
Concomitant
Flushing 11/1/2008 Female 8/22/2009 United States
Primary
Concomitant
Ureteric Anastomosis Complication Hospitalization 4/9/2008 34 Male 8/24/2009 Physician Germany
Primary
Secondary
Concomitant
Ureteric Anastomosis Complication Hospitalization 4/9/2008 34 Male 8/25/2009 Physician Germany
Primary
Secondary
Concomitant
Transplant Rejection Other Serious 12/15/2008 Male 163 lb 8/28/2009 Physician United States
Primary
Secondary
Concomitant
Ureteric Anastomosis Complication Hospitalization 4/9/2008 34 Male 9/8/2009 Physician Germany
Primary
Concomitant
Prostate Cancer Other Serious 8/13/2009 Male 188 lb 9/8/2009 Physician United States
Primary
Concomitant
Prostate Cancer Other Serious 8/13/2009 Male 188 lb 9/9/2009 Physician United States
Primary
Concomitant
Transplant Rejection Other Serious 12/15/2008 Male 163 lb 9/25/2009 Physician United States
Primary
Secondary
Concomitant
Vomiting Required Intervention 11/4/2008 39 Male 11/6/2008 Pharmacist United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 6/20/2009 67 Female 135 lb 7/17/2009 Pharmacist United States
Primary
Concomitant
Prostate Cancer Other Serious 8/13/2009 Male 188 lb 10/2/2009 Physician United States
Primary
Secondary
Concomitant
Wound Infection Hospitalization 29 Female 276 lb 9/29/2009 United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 5/29/2009 Male 120 lb 10/16/2009 Physician United States
Primary
Concomitant
Malaise Life Threatening 8/15/2009 68 Male 178 lb 8/17/2009 Pharmacist United States
Primary
Concomitant
Product Quality Issue Other Serious 8/26/2009 53 Male 128 lb 10/2/2009 United States
Primary
Concomitant
Product Quality Issue Other Serious 9/27/2009 44 Male 148 lb 10/2/2009 United States
Primary
Concomitant
Product Quality Issue Other Serious 9/27/2009 52 Male 201 lb 10/7/2009 United States
Primary
Concomitant
Vomiting Hospitalization 10/19/2009 Female 162 lb 11/11/2009 Physician Australia
Primary
Concomitant
Sudden Death Death 10/22/2009 Male 11/12/2009 Physician Germany
Primary
Secondary
Concomitant
Intravascular Haemolysis Hospitalization 6/10/2008 65 Male 88 lb 11/6/2008 Physician United States
Primary
Concomitant
Vomiting Hospitalization 10/19/2009 Female 162 lb 11/16/2009 Physician Australia
Primary
Concomitant
Transplant Failure Other Serious 1/1/2009 Male 155 lb 12/4/2009 Physician Germany
Primary
Concomitant
Skin Tightness Other Serious 8/1/2005 51 Male 181 lb 12/7/2009 Physician United States
Primary
Concomitant
Tricuspid Valve Incompetence Other Serious 12/8/2009 Other Health Professional Germany
Primary
Secondary
Urosepsis Hospitalization 5/20/2009 Male 212 lb 12/11/2009 Physician Germany
Primary
Secondary
Concomitant
Transplant Failure Other Serious 1/1/2009 Male 155 lb 12/14/2009 Physician Germany
Primary
Concomitant
Urosepsis Other Serious 12/1/2009 Male 157 lb 1/11/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Urosepsis Other Serious 11/27/2009 Male 157 lb 1/15/2010 Physician Netherlands
Primary
Secondary
Concomitant
Urosepsis Other Serious 11/27/2009 Male 157 lb 1/19/2010 Physician Netherlands
Primary
Secondary
Concomitant
Urosepsis Other Serious 12/11/2009 Male 157 lb 1/19/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Urosepsis Other Serious 11/27/2009 Male 157 lb 1/20/2010 Physician Netherlands
Primary
Secondary
Concomitant
Urosepsis Other Serious 11/27/2009 Male 157 lb 1/26/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Urosepsis Other Serious 11/27/2009 Male 157 lb 1/28/2010 Physician Netherlands
Primary
Secondary
Concomitant
Galactorrhoea Other Serious 19 Female 3/12/2010 Other Health Professional India
Primary
Secondary
Concomitant
Cytomegalovirus Infection Hospitalization 4/11/2010 66 Male 4/29/2010 Physician Netherlands
Primary
Secondary
Concomitant
Weight Increased Other Serious 2/1/2008 51 Male 5/25/2010 Physician United States
Primary
Secondary
Concomitant
Mental Status Changes Hospitalization 5/1/2010 55 Male 5/26/2010 Physician United States
Primary
Secondary
Concomitant
Tubulointerstitial Nephritis Other Serious 55 Female 6/17/2010 Other Health Professional Austria
Primary
Secondary
Concomitant
Granulocytopenia Other Serious 9/27/2009 34 Male 240 lb 6/24/2010 United States
Primary
Secondary
Concomitant
Transplant Rejection Other Serious 12/15/2008 42 Male 163 lb 7/12/2010 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 3/7/2010 46 Female 176 lb 7/12/2010 Pharmacist United States
Primary
Concomitant
Toxic Encephalopathy Hospitalization 3/10/2010 57 Female 149 lb 7/19/2010 Physician Canada
Primary
Secondary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 65 Male 7/21/2010 Pharmacist Canada
Primary
Concomitant
Interacting
Bone Marrow Oedema Other Serious 52 Female 8/19/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Urosepsis Hospitalization 5/20/2009 52 Male 212 lb 9/22/2010 Physician Germany
Primary
Secondary
Concomitant
Musculoskeletal Chest Pain Other Serious 5/18/2009 63 Female 110 lb 10/21/2010 Physician United States
Primary
Concomitant
Skin Nodule Hospitalization 17 Female 10/21/2010 Physician United States
Primary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 65 Male 10/28/2010 Other Health Professional France
Primary
Concomitant
Interacting
Vomiting Other Serious 1/1/2010 10/29/2010 Physician United States
Primary
Secondary
Concomitant
Renal Cell Carcinoma Hospitalization 11/2/2010 61 Female 137 lb 12/1/2010 Physician Germany
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2010 12/8/2010 Physician United States
Primary
Secondary
Concomitant
Transplant Failure Hospitalization 2/1/2010 51 Female 12/9/2010 Physician Germany
Primary
Concomitant
Vomiting Other Serious 1/1/2010 12/15/2010 Physician United States
Primary
Concomitant
Abortion Spontaneous Other Serious Female 2/15/2011 Other Health Professional United States
Primary
Concomitant
Alopecia Other Serious 1/1/2010 29 Male 143 lb 1/6/2010 Other Health Professional United States
Primary
Concomitant
Aplasia Pure Red Cell Other Serious 1/1/2010 51 Female 3/3/2011 Pharmacist United States
Primary
Concomitant
Blood Parathyroid Hormone Increased Other Serious 1/1/2009 38 Female 3/31/2011 Other Health Professional United States
Primary
Concomitant
Fear Hospitalization 11/28/2004 55 Male 4/6/2011 Consumer United States
Primary
Concomitant
Blood Parathyroid Hormone Increased Other Serious 1/1/2009 38 Female 4/18/2011 Physician United States
Primary
Concomitant
Bone Marrow Oedema Other Serious 52 Female 4/25/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Agitation Hospitalization 54 Male 5/17/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Muscle Contractions Involuntary Life Threatening 54 Male 5/18/2011 Other Health Professional United States
Primary
Concomitant
Interacting
Agitation Hospitalization 54 Male 6/2/2011 Other Health Professional United States
Primary
Concomitant
Interacting
Nephrogenic Anaemia Hospitalization 4/14/2009 72 Male 5/25/2011 Physician United States
Primary
Secondary
Concomitant
Bone Marrow Oedema Other Serious 52 Female 7/5/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Diabetes Mellitus Hospitalization 11/6/2006 49 9/22/2011 United States
Primary
Concomitant
Death Death Female 99 lb 9/30/2011 Pharmacist Australia
Primary
Concomitant
Periostitis Other Serious 30 Female 11/16/2011 Other Health Professional United States
Primary
Concomitant
Dyspnoea Hospitalization 3/12/2010 63 Male 179 lb 2/3/2012 Physician Greece
Primary
Concomitant
Nausea Female 115 lb 5/7/2012 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 11/22/2010 67 Female 145 lb 5/8/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Enterococcal Infection Hospitalization 5/16/2011 66 Male 198 lb 5/22/2012 Physician Germany
Primary
Concomitant
Diarrhoea Hospitalization 5/16/2011 66 Male 198 lb 6/22/2012 Physician Germany
Primary
Concomitant
Transplant Rejection Other Serious 10/13/2009 44 Female 4/9/2013 Consumer Au
Primary
Concomitant
Deep Vein Thrombosis Hospitalization 9/26/2011 58 Female 219 lb 2/1/2013 Physician Us
Primary
Secondary
Concomitant
Hyperkalaemia Other Serious 52 Male 2/28/2013 Other Health Professional Country Not Specified
Primary
Secondary
Concomitant
Kidney Transplant Rejection Other Serious 12/30/2011 53 Female 141 lb 12/14/2012 Pharmacist Us
Primary
Concomitant
Pyrexia Hospitalization 10/13/2011 40 Male 218 lb 12/19/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Oesophageal Candidiasis Other Serious 11/30/2009 45 Female 12/12/2012 Consumer Us
Primary
Secondary
Concomitant
Bk Virus Infection Other Serious 6/17/2009 47 Male 10/24/2012 Physician Us
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 7/31/2012 59 Male 9/7/2012 Physician Us
Primary
Concomitant
Haemoglobin Decreased Other Serious 6/2011 Female 12/18/2012 Consumer Us
Primary
Secondary
Concomitant
Epstein-barr Viraemia Other Serious 8/6/2012 32 Female 10/1/2012 Physician Us
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 5/26/2011 32 Female 5/2/2013 Lawyer Ca
Primary
Secondary
Concomitant
Pruritus Hospitalization 2009 Female 216 lb 4/12/2013 Consumer Us
Primary
Secondary
Concomitant
Vomiting Life Threatening 10/24/2012 66 Female 175 lb 11/5/2012 Pharmacist Us
Primary
Concomitant
Small Cell Lung Cancer Metastatic Death 9/12/2012 62 Female 119 lb 11/20/2012 Consumer Us
Primary
Secondary
Concomitant
Diabetes Mellitus Hospitalization 5/14/2003 56 Male 172 lb 12/14/2012 Physician Se
Primary
Secondary
Concomitant
Ureteric Stenosis Hospitalization 7/10/2003 69 Male 152 lb 12/14/2012 Physician De
Primary
Secondary
Concomitant
Vascular Graft Hospitalization 9/12/2003 62 Male 181 lb 12/17/2012 Physician Se
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 12/12/2003 69 Female 12/20/2012 Physician At
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 12/3/2003 41 Female 152 lb 12/21/2012 Physician Se
Primary
Secondary
Concomitant
Gastritis Hospitalization 2/2004 59 Male 12/21/2012 Physician De
Primary
Secondary
Concomitant
Systemic Inflammatory Response Syndrome Hospitalization 5/8/2008 65 Male 187 lb 12/25/2012 Physician Nl
Primary
Secondary
Concomitant
Sudden Cardiac Death Death 10/22/2009 51 Male 12/24/2012 Other Health Professional De
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 9/12/2011 58 Female 143 lb 1/23/2013 Consumer Gb
Primary
Secondary
Concomitant
Skin Ulcer Hospitalization 69 Male 2/17/2013 Other Health Professional De
Primary
Secondary
Concomitant
Hypomagnesaemia Hospitalization 2/11/2013 17 Female 135 lb 3/7/2013 Physician Us
Primary
Secondary
Concomitant
Henoch-schonlein Purpura Hospitalization 69 Male 2/22/2013 Physician De
Primary
Secondary
Concomitant
Henoch-schonlein Purpura Hospitalization 69 Male 3/5/2013 Physician De
Primary
Secondary
Concomitant
Renal Failure Chronic Other Serious 69 Male 3/1/2013 Other Health Professional Country Not Specified
Primary
Secondary
Blood Alkaline Phosphatase Increased Other Serious 12/1/2004 5 Female 40 lb 3/15/2013 Physician Ca
Primary
Secondary
Concomitant
Somnolence Other Serious 76 Female 239 lb 10/29/2012 Pharmacist Ca
Primary
Concomitant

Drug Data