Simvastatin combined with Tacrolimus

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Nephropathy Toxic Required Intervention 7/28/2005 66 Male 157 lb 10/25/2005 Pharmacist United States
Primary
Concomitant
Retinal Oedema Hospitalization 11/12/2005 49 Male 207 lb 7/12/2006 Consumer Australia
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 9/12/2006 58 Female 205 lb 11/20/2006 Physician United States
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Disability 7/24/2006 43 Male 148 lb 12/6/2006 Pharmacist United States
Primary
Secondary
Concomitant
Pyelonephritis Hospitalization 10/28/2006 44 Female 185 lb 12/14/2006 Physician Australia
Primary
Secondary
Concomitant
Rash Maculo-papular Other Serious 12/12/2006 65 Male 229 lb 1/13/2007 Other Health Professional United States
Primary
Concomitant
Lymphoproliferative Disorder Other Serious 11/1/2005 61 Male 174 lb 5/2/2007 Other Health Professional United Kingdom
Primary
Concomitant
Thrombocytopenia Life Threatening 6/4/2007 31 Female 139 lb 8/9/2007 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/17/2007 55 Female 133 lb 5/29/2007 United States
Primary
Concomitant
Kidney Transplant Rejection Hospitalization 12/14/2006 26 Female 205 lb 12/18/2006 Pharmacist United States
Primary
Concomitant
Thrombocytopenia Life Threatening 6/11/2007 31 Female 139 lb 9/18/2007 Physician Japan
Primary
Secondary
Concomitant
Polyomavirus-associated Nephropathy Hospitalization 5/15/2007 Male 192 lb 10/18/2007 Consumer Sweden
Primary
Concomitant
Thrombocytopenia Other Serious 3/15/2005 Male 183 lb 11/7/2007 Physician Canada
Primary
Secondary
Concomitant
Nephrotic Syndrome Other Serious 24 Male 12/19/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Disorder Other Serious 24 Male 12/20/2007 Other Health Professional United Kingdom
Primary
Secondary
Polyomavirus-associated Nephropathy Hospitalization 5/15/2007 Male 192 lb 12/21/2007 Consumer Sweden
Primary
Secondary
Concomitant
Renal Failure Chronic Other Serious 24 Male 12/21/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Polyomavirus-associated Nephropathy Hospitalization 3/22/2007 Male 192 lb 1/3/2008 Consumer Sweden
Primary
Secondary
Concomitant
Renal Disorder Hospitalization 24 Male 12/28/2007
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 4/13/2007 Male 123 lb 1/17/2008 Physician Spain
Primary
Concomitant
Interacting
Rash Erythematous Other Serious 10/4/2007 Male 2/1/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Splenomegaly Hospitalization 7/6/2007 Male 2/5/2008 Physician United Kingdom
Primary
Concomitant
Splenomegaly Hospitalization 7/6/2007 Male 2/28/2008 Physician United Kingdom
Primary
Concomitant
Rash Erythematous Other Serious 10/4/2007 Male 2/29/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 66 Male 4/11/2008 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased 5/2/2007 75 Female 101 lb 4/21/2008 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 6/11/2007 31 Female 139 lb 4/28/2008 Physician Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 1/1/2007 Female 182 lb 6/17/2008 Physician United States
Primary
Concomitant
Neurotoxicity Other Serious 6/11/2008 6/30/2008 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Other Serious 1/1/2007 Female 182 lb 7/10/2008 Physician United States
Primary
Concomitant
Neurotoxicity Other Serious 6/11/2008 72 Male 7/10/2008 Consumer United Kingdom
Primary
Concomitant
Cardiac Failure Life Threatening 8/3/2008 63 Male 8/8/2008 Sweden
Primary
Concomitant
Presyncope Other Serious 6/1/2008 63 Male 131 lb 8/11/2008 Sweden
Primary
Concomitant
Systemic Inflammatory Response Syndrome Life Threatening Male 10/13/2008 Physician Germany
Primary
Concomitant
Nausea Other Serious Female 11/19/2008 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 8/5/2003 Female 123 lb 4/3/2009 Physician Germany
Primary
Secondary
Concomitant
Atrial Fibrillation Other Serious 5/28/2004 Male 201 lb 4/3/2009 Physician Israel
Primary
Secondary
Concomitant
Pallor Required Intervention 3/13/2009 59 Female 3/16/2009 Pharmacist United States
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 4/13/2007 Male 123 lb 5/18/2009 Physician Spain
Primary
Concomitant
Interacting
Ventricular Fibrillation Hospitalization 4/1/2007 56 Male 5/19/2009 Physician Spain
Primary
Secondary
Concomitant
Ventricular Fibrillation Other Serious 6/1/2007 56 Male 5/26/2009 Other Health Professional Spain
Primary
Secondary
Ventricular Fibrillation Death 56 Male 6/2/2009 Other Health Professional Spain
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 56 Male 6/5/2009 Other Health Professional Spain
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 4/13/2007 Male 123 lb 6/19/2009 Physician Spain
Primary
Concomitant
Interacting
Urosepsis Hospitalization 5/26/2004 Female 134 lb 6/23/2009 Physician Germany
Primary
Secondary
Concomitant
Wound Infection Hospitalization 4/2/2004 Female 220 lb 6/23/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Shock Haemorrhagic Life Threatening 1/13/2004 Female 196 lb 6/23/2009 Physician Israel
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 11/10/2003 Male 154 lb 6/23/2009 Physician Turkey
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 12/12/2003 Female 6/23/2009 Physician Austria
Primary
Secondary
Concomitant
Bronchopneumonia Hospitalization 11/26/2003 Female 133 lb 6/23/2009 Physician Czech Republic
Primary
Secondary
Concomitant
Shock Haemorrhagic Other Serious 1/13/2004 Female 6/24/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Unresponsive To Stimuli Required Intervention 4/2/2009 39 Female 110 lb 4/28/2009 Pharmacist United States
Primary
Concomitant
Ventricular Extrasystoles Death 3/7/2006 74 Male 146 lb 6/22/2009 Physician Japan
Primary
Concomitant
Pollakiuria Disability 2/28/2009 57 Male 148 lb 6/30/2009 Physician United States
Primary
Concomitant
Urosepsis Hospitalization 5/26/2004 Female 7/1/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pollakiuria Disability 2/28/2009 57 Male 148 lb 7/7/2009 Other Health Professional United States
Primary
Concomitant
Myalgia 5/15/2009 73 Male 7/13/2009 Pharmacist United States
Primary
Secondary
Rhabdomyolysis Other Serious 7/2/2007 Male 123 lb 7/29/2009 Physician Spain
Primary
Concomitant
Interacting
Rhabdomyolysis Other Serious 7/2/2007 Male 123 lb 8/5/2009 Physician Spain
Primary
Concomitant
Interacting
Rhabdomyolysis Other Serious 7/2/2007 Male 123 lb 8/6/2009 Physician Spain
Primary
Concomitant
Interacting
Shock Haemorrhagic Life Threatening 1/13/2004 50 Female 7/31/2009 Physician Israel
Primary
Secondary
Concomitant
Ventricular Fibrillation Other Serious 4/1/2007 56 Male 8/10/2009 Other Health Professional Spain
Primary
Secondary
Interacting
Prostate Cancer Other Serious 8/13/2009 Male 188 lb 9/8/2009 Physician United States
Primary
Concomitant
Liver Transplant Rejection Life Threatening 5/7/2009 Male 260 lb 9/8/2009 Physician Netherlands
Primary
Secondary
Concomitant
Ventricular Fibrillation Hospitalization 8/1/2007 56 Male 8/31/2009 United States
Primary
Secondary
Prostate Cancer Other Serious 8/13/2009 Male 188 lb 9/9/2009 Physician United States
Primary
Concomitant
Prostate Cancer Other Serious 8/13/2009 Male 188 lb 10/2/2009 Physician United States
Primary
Secondary
Concomitant
Liver Transplant Rejection Life Threatening 5/7/2009 Male 260 lb 10/2/2009 Physician Netherlands
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 8/1/2007 56 Male 10/12/2009 Other Health Professional Spain
Primary
Secondary
Concomitant
Somnambulism Other Serious 10/3/2009 53 Male 160 lb 10/7/2009 Pharmacist United States
Primary
Concomitant
Hyperhidrosis Hospitalization 8/28/2009 67 Male 123 lb 8/31/2009 Pharmacist United States
Primary
Concomitant
Renal Failure Chronic Other Serious 24 Male 10/23/2009 United Kingdom
Primary
Concomitant
Vomiting Hospitalization 10/19/2009 Female 162 lb 11/11/2009 Physician Australia
Primary
Concomitant
Transplant Failure Other Serious 1/1/2009 Male 155 lb 12/4/2009 Physician Germany
Primary
Concomitant
Transplant Failure Other Serious 1/1/2009 Male 155 lb 12/14/2009 Physician Germany
Primary
Concomitant
Vomiting Hospitalization 10/19/2009 Female 162 lb 12/28/2009 Physician Australia
Primary
Concomitant
Transplant Failure Other Serious 1/1/2009 Male 155 lb 12/29/2009 Physician Germany
Primary
Concomitant
Vomiting Hospitalization 10/19/2009 Female 162 lb 1/5/2010 Physician Australia
Primary
Secondary
Concomitant
Stress Other Serious 10/11/2007 56 Female 98 lb 12/31/2009 Physician Japan
Primary
Secondary
Concomitant
Skin Ulcer Other Serious 43 Female 190 lb 1/22/2010
Primary
Secondary
Pulmonary Alveolar Haemorrhage Other Serious 10/11/2007 56 Female 98 lb 1/20/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Disorder Other Serious 1/8/2010 66 Female 116 lb 1/10/2010 Pharmacist United States
Primary
Concomitant
Incorrect Dose Administered Hospitalization 1/11/2010 46 Male 269 lb 1/11/2010 Pharmacist United States
Primary
Concomitant
Pericardial Haemorrhage Other Serious 1/11/2010 55 Male 185 lb 3/30/2010 Pharmacist United States
Primary
Secondary
Concomitant
Myoclonus Other Serious 12/17/2009 51 Male 154 lb 5/4/2010 Other Health Professional United Kingdom
Primary
Concomitant
Wound Complication Hospitalization 6/5/2009 77 Male 211 lb 4/29/2010 Other Health Professional Norway
Primary
Secondary
Concomitant
Vomiting Other Serious 9/1/2009 20 Female 5/20/2010 United States
Primary
Concomitant
Pain In Extremity Other Serious 52 Female 6/2/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Intestinal Obstruction Hospitalization Male 133 lb 6/25/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Other Serious 9/1/2009 20 Female 7/1/2010 United States
Primary
Concomitant
Respiratory Failure Other Serious 4/10/2010 67 Male 155 lb 6/25/2010 United Kingdom
Primary
Concomitant
Respiratory Failure Other Serious 4/10/2010 67 Male 155 lb 7/8/2010 United Kingdom
Primary
Concomitant
Renal Transplant Other Serious 65 Male 7/12/2010 Canada
Primary
Secondary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 65 Male 7/21/2010 Pharmacist Canada
Primary
Concomitant
Interacting
Intestinal Obstruction Hospitalization Male 133 lb 8/3/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Bone Marrow Oedema Other Serious 52 Female 8/19/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Bone Marrow Oedema Syndrome Other Serious 52 Female 8/13/2010 United Kingdom
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 52 Female 8/13/2010 United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 7/27/2010 71 Female 119 lb 9/7/2010 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 6/5/2010 78 Male 133 lb 9/10/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Other Serious 9/1/2009 20 Female 9/13/2010 United States
Primary
Concomitant
Hypoglycaemia Hospitalization 78 Female 9/13/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Pleurisy Hospitalization 78 Female 9/23/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 7/27/2010 71 Female 119 lb 10/8/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Skin Nodule Hospitalization 17 Female 10/21/2010 Physician United States
Primary
Concomitant
Vomiting Other Serious 9/1/2009 20 Female 223 lb 10/28/2010 United States
Primary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 65 Male 10/28/2010 Other Health Professional France
Primary
Concomitant
Interacting
Drug Interaction Other Serious 64 Female 11/2/2010 United States
Primary
Concomitant
Sluggishness Hospitalization Female 115 lb 11/4/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 9/1/2009 20 Female 223 lb 12/29/2010 United States
Primary
Concomitant
Pneumonitis Other Serious 11/1/2009 65 Female 99 lb 1/5/2011 Physician Germany
Primary
Secondary
Concomitant
Disease Progression Other Serious 57 Male 1/19/2011
Primary
Secondary
Mitral Valve Incompetence Other Serious 11/1/2009 65 Female 99 lb 1/21/2011 Physician Germany
Primary
Secondary
Concomitant
Blood Creatinine Increased Hospitalization 12/31/2010 65 Male 165 lb 3/23/2011 Pharmacist United States
Primary
Concomitant
Hypertension Other Serious 1/1/2004 4/4/2011 Consumer United States
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 1/1/2004 4/22/2011 Consumer United States
Primary
Secondary
Concomitant
Bone Marrow Oedema Other Serious 52 Female 4/25/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Blood Pressure Increased Hospitalization 1/1/2011 51 Female 174 lb 5/5/2011 Consumer United States
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 64 Female 5/20/2011 Pharmacist United States
Primary
Concomitant
Interacting
Tremor Hospitalization 57 Male 161 lb 5/31/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Fall Hospitalization 1/25/2011 82 Male 130 lb 6/14/2011 Other Health Professional United Kingdom
Primary
Concomitant
Blood Thyroid Stimulating Hormone Decreased Hospitalization 1/25/2011 82 Male 6/13/2011 Other Health Professional United Kingdom
Primary
Concomitant
Foot Fracture Other Serious 52 Female 6/27/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Skin Induration Death 1/1/2004 39 Female 117 lb 6/30/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Muscle Contracture Other Serious Female 7/2/2011 Physician United States
Primary
Secondary
Concomitant
Pulmonary Oedema Death Female 7/2/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Bone Marrow Oedema Other Serious 52 Female 7/5/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Bone Marrow Oedema Other Serious 52 Female 7/12/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pain Other Serious 52 Female 7/12/2011 United Kingdom
Primary
Secondary
Concomitant
Bone Marrow Oedema Other Serious 52 Female 7/12/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Bone Marrow Oedema Other Serious 52 Female 7/5/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pain Other Serious 52 Female 8/1/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Anger Hospitalization 7/10/2011 65 Female 7/22/2011 Pharmacist United States
Primary
Concomitant
Blood Pressure Decreased Hospitalization 8/7/2011 64 Female 139 lb 8/10/2011 Pharmacist United States
Primary
Concomitant
Complex Regional Pain Syndrome Other Serious 52 Female 8/5/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Immune System Disorder Hospitalization 7/10/2011 65 Female 8/26/2011 Pharmacist United States
Primary
Concomitant
Upper Limb Fracture Other Serious 9/1/2010 71 Female 9/7/2011 Consumer United States
Primary
Concomitant
Induration Other Serious 3/1/2007 67 Female 230 lb 9/27/2011 Physician United States
Primary
Secondary
Concomitant
Blood Creatinine Increased Other Serious 9/1/2011 36 Female 165 lb 11/22/2011 Other Health Professional United Kingdom
Primary
Concomitant
Wrist Fracture Other Serious 9/1/2010 71 Female 11/22/2011 Consumer United States
Primary
Concomitant
Renal Disorder Hospitalization Male 11/29/2011 Consumer United States
Primary
Concomitant
Renal Disorder Other Serious Male 12/8/2011 Consumer United States
Primary
Concomitant
Kidney Transplant Rejection Other Serious 57 Male 161 lb 1/23/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Ill-defined Disorder 1/23/2011 54 Male 1/27/2012 Consumer United States
Primary
Concomitant
Lupus Nephritis Other Serious 3/11/2009 25 Female 88 lb 2/29/2012 Physician Japan
Primary
Secondary
Concomitant
Transplant Failure Life Threatening 5/16/2011 66 Male 201 lb 3/16/2012 Physician Germany
Primary
Concomitant
Diverticulitis Hospitalization 8/20/2007 38 Male 1/6/2012 Consumer United States
Primary
Concomitant
Platelet Count Decreased Hospitalization 1/1/2011 63 Female 3/19/2012 Physician Spain
Primary
Secondary
Concomitant
Asthenia Hospitalization 1/1/2011 63 Female 3/19/2012 Other Health Professional Spain
Primary
Secondary
Concomitant
Endocarditis Hospitalization 5/16/2011 66 Male 201 lb 3/29/2012 Physician Germany
Primary
Concomitant

Drug Data