Sirolimus combined with Tacrolimus

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Thrombotic Microangiopathy Hospitalization 1/8/2004 68 Male 176 lb 2/7/2006 Physician Spain
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 20 Male 4/3/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Glomerular Filtration Rate Decreased Other Serious 50 Female 5/30/2006 Physician Australia
Primary
Concomitant
Skin Exfoliation Other Serious 2 Male 6/29/2006 United States
Primary
Concomitant
Renal Failure Other Serious 1/1/1996 43 Female 7/17/2006 Other Health Professional Italy
Primary
Secondary
Concomitant
Proteinuria Hospitalization Male 7/10/2006 Other Health Professional Belgium
Primary
Concomitant
Renal Impairment Other Serious 2 Female 9/15/2006 Canada
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2 Female 9/29/2006 Canada
Primary
Secondary
Concomitant
Ventricular Tachycardia Other Serious 2 Female 10/24/2006 Canada
Primary
Secondary
Concomitant
Transaminases Increased Death 3/17/2006 66 Male 168 lb 11/2/2006 Consumer Germany
Primary
Secondary
Concomitant
Basal Cell Carcinoma Other Serious 9/1/2006 52 Male 11/6/2006 Physician Australia
Primary
Secondary
Concomitant
Gastroenteritis Hospitalization 9/3/2006 52 Male 11/7/2006 Physician Australia
Primary
Secondary
Gastroenteritis Hospitalization 9/3/2006 52 Male 12/12/2006 Physician Australia
Primary
Secondary
Thrombotic Thrombocytopenic Purpura Disability 7/24/2006 43 Male 148 lb 12/6/2006 Pharmacist United States
Primary
Secondary
Concomitant
Lymphoproliferative Disorder Other Serious 1/31/2007 Physician United Kingdom
Primary
Concomitant
Small For Dates Baby Congenital Anomaly 3 lb 2/7/2007 Other Health Professional United States
Primary
Concomitant
Venoocclusive Disease Other Serious 2/16/2007 Physician United States
Primary
Concomitant
Venoocclusive Disease Other Serious 2/16/2007 Physician United States
Primary
Concomitant
Venoocclusive Disease Other Serious 2/16/2007 Physician United States
Primary
Concomitant
Sebaceous Adenoma Other Serious 55 Male 2/16/2007
Primary
Secondary
Pyrexia Hospitalization 1/13/2005 37 Male 2/13/2007 Other Health Professional France
Primary
Secondary
Concomitant
Pyelonephritis Hospitalization 5/29/2006 Female 2/9/2007 Other Health Professional France
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/5/2006 43 Male 2/8/2007 Other Health Professional France
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 12/9/2005 46 Male 2/15/2007 Other Health Professional France
Primary
Secondary
Concomitant
Septic Shock Hospitalization 5/19/2005 39 Male 2/8/2007 Other Health Professional France
Primary
Secondary
Concomitant
Ascites Hospitalization 11/2/2004 46 Female 2/8/2007 Physician France
Primary
Secondary
Concomitant
Hernial Eventration Hospitalization 8/31/2006 50 Male 2/14/2007 Physician France
Primary
Secondary
Concomitant
Wound Evisceration Hospitalization 3/7/2006 44 Male 2/13/2007 Physician France
Primary
Secondary
Concomitant
Proteinuria Hospitalization 10/18/2004 41 Female 2/8/2007 Physician France
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 10/20/2005 46 Male 2/8/2007 Physician France
Primary
Secondary
Concomitant
Wound Evisceration Hospitalization 3/16/2005 37 Male 2/8/2007 Physician France
Primary
Secondary
Concomitant
Hydronephrosis Hospitalization 10/8/2004 45 Male 2/8/2007 Physician France
Primary
Secondary
Concomitant
Wound Evisceration Other Serious 10/29/2004 45 Male 2/8/2007 Physician France
Primary
Secondary
Concomitant
Premature Baby Other Serious Female 3/16/2007 Physician United States
Primary
Concomitant
Drug Exposure During Pregnancy Other Serious Female 3/16/2007 Physician United States
Primary
Concomitant
Drug Exposure During Pregnancy Other Serious Female 3/16/2007 Physician United States
Primary
Concomitant
Drug Exposure During Pregnancy Other Serious Female 3/16/2007 Physician United States
Primary
Concomitant
Peritoneal Effusion Hospitalization 11/2/2004 46 Female 3/6/2007 Physician France
Primary
Secondary
Concomitant
Focal Glomerulosclerosis Other Serious 4/3/2007 Physician United States
Primary
Concomitant
Drug Exposure During Pregnancy Other Serious Female 4/4/2007 Physician United States
Primary
Concomitant
Drug Exposure During Pregnancy Other Serious Female 4/4/2007 Physician United States
Primary
Concomitant
Drug Exposure During Pregnancy Other Serious Female 4/4/2007 Physician United States
Primary
Concomitant
Premature Baby Other Serious Female 4/4/2007 Physician United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 9/9/2006 Male 294 lb 1/22/2007 Pharmacist United States
Primary
Concomitant
Pulmonary Alveolar Haemorrhage Hospitalization 9/9/2006 Male 294 lb 1/22/2007 Pharmacist United States
Primary
Secondary
Concomitant
Lung Neoplasm Hospitalization 3/27/2007 Male 205 lb 4/23/2007 Physician United States
Primary
Secondary
Lymphoproliferative Disorder Other Serious 61 4/24/2007 Other Health Professional United Kingdom
Primary
Concomitant
Polyneuropathy Other Serious 7/5/2006 Male 4/26/2007 Physician United States
Primary
Secondary
Concomitant
Lymphoproliferative Disorder Other Serious 11/1/2005 61 Male 174 lb 5/2/2007 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Hospitalization 10/12/2005 Female 165 lb 5/7/2007 Physician Belgium
Primary
Concomitant
Diabetes Mellitus Hospitalization 11/20/2004 Female 5/8/2007 Physician Belgium
Primary
Secondary
Concomitant
Transplant Rejection Hospitalization 10/20/2004 43 Male 172 lb 5/9/2007 Physician Belgium
Primary
Concomitant
Urinary Tract Infection Hospitalization 2/3/2005 Male 5/9/2007 Physician Belgium
Primary
Concomitant
Neck Pain Hospitalization 4/17/2007 Male 5/10/2007 Physician United States
Primary
Secondary
Concomitant
Transplant Rejection Hospitalization 10/20/2004 43 Male 172 lb 5/22/2007 Physician Belgium
Primary
Concomitant
Polyneuropathy Other Serious 7/5/2006 Male 5/23/2007 Physician United States
Primary
Secondary
Concomitant
Liver Transplant Rejection Other Serious 37 6/19/2007 Other Health Professional Germany
Primary
Concomitant
Proteinuria Other Serious 19 Male 6/28/2007 Physician United States
Primary
Secondary
Condition Aggravated Hospitalization Male 123 lb 7/3/2007 Physician France
Primary
Concomitant
Condition Aggravated Hospitalization Male 123 lb 7/6/2007 Physician France
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 12/14/2005 Male 7/16/2007 Physician United States
Primary
Secondary
Concomitant
Liver Transplant Rejection Other Serious 4/16/2007 Male 7/16/2007 Physician United States
Primary
Secondary
Concomitant
Lung Infiltration Hospitalization 4/17/2007 Male 185 lb 8/3/2007 Physician Austria
Primary
Concomitant
Pneumonia Hospitalization 6/25/2006 Female 8/15/2007 Physician United States
Primary
Secondary
Concomitant
Lung Infiltration Other Serious 4/17/2007 Male 185 lb 8/17/2007 Physician Austria
Primary
Concomitant
Urinary Tract Infection Hospitalization 10/12/2005 65 Female 165 lb 8/28/2007 Physician Belgium
Primary
Concomitant
Urinary Tract Infection Hospitalization 2/3/2005 Male 8/29/2007 Physician Belgium
Primary
Concomitant
Lung Infiltration Other Serious 4/17/2007 Male 185 lb 8/30/2007 Physician Austria
Primary
Concomitant
Vomiting Other Serious 5/29/2006 44 Male 9/4/2007 United States
Primary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Life Threatening 8/5/2007 10 Male 66 lb 9/7/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Life Threatening 8/5/2007 10 Male 66 lb 9/12/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Complications Of Transplanted Liver Hospitalization 1/17/2007 Male 9/13/2007 Physician United States
Primary
Secondary
Concomitant
Rash Erythematous Other Serious 8/15/2007 1 Female 26 lb 9/13/2007 Other Health Professional United Kingdom
Primary
Concomitant
Focal Glomerulosclerosis Other Serious 32 Male 9/20/2007 Other Health Professional Egypt
Primary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Life Threatening 4/5/2007 10 Male 66 lb 9/24/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Transplant Rejection Hospitalization 5/26/2005 Male 192 lb 9/24/2007 Physician United Kingdom
Primary
Concomitant
Renal Tubular Disorder Hospitalization 8/3/2005 31 Male 150 lb 9/26/2007 Other Health Professional India
Primary
Concomitant
Transplant Rejection Hospitalization 5/26/2005 Male 192 lb 9/26/2007 Physician United Kingdom
Primary
Concomitant
Lung Infiltration Other Serious 4/17/2007 Male 185 lb 10/1/2007 Physician Austria
Primary
Concomitant
Large Intestinal Ulcer Other Serious 42 Female 146 lb 10/3/2007 Physician United States
Primary
Concomitant
Splenomegaly Hospitalization 3/1/2003 24 Male 10/23/2007
Primary
Secondary
Concomitant
Klebsiella Sepsis Hospitalization 9/1/2006 Male 10/26/2007 Physician Israel
Primary
Secondary
Pathogen Resistance Death 45 Male 11/1/2007 Other Health Professional Austria
Primary
Concomitant
Pathogen Resistance Death 45 Male 11/2/2007 Other Health Professional Austria
Primary
Concomitant
Pathogen Resistance Death 45 Male 11/2/2007 Other Health Professional Austria
Primary
Concomitant
Thrombocytopenia Other Serious 3/15/2005 Male 183 lb 11/7/2007 Physician Canada
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 8/22/2004 51 Male 152 lb 11/19/2007 Physician Germany
Primary
Secondary
Concomitant
Myopathy Hospitalization 11/28/2007 Other Health Professional Turkey
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 8/22/2004 51 Male 152 lb 12/12/2007 Physician Germany
Primary
Secondary
Concomitant
Nephrotic Syndrome Other Serious 24 Male 12/19/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Nephrotic Syndrome Other Serious 24 Male 12/20/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Disorder Other Serious 24 Male 12/20/2007 Other Health Professional United Kingdom
Primary
Secondary
Urinary Tract Infection Hospitalization 10/12/2005 65 Female 165 lb 12/21/2007 Physician Belgium
Primary
Concomitant
Focal Segmental Glomerulosclerosis Hospitalization 10/20/2004 43 Male 172 lb 12/21/2007 Physician Belgium
Primary
Concomitant
Vomiting Hospitalization 1/28/2005 Female 201 lb 12/21/2007 Physician Canada
Primary
Concomitant
Nephrotic Syndrome Other Serious 24 Male 12/26/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Nephrotic Syndrome Other Serious 12/27/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Focal Segmental Glomerulosclerosis Hospitalization 10/20/2004 43 Male 172 lb 12/27/2007 Physician Belgium
Primary
Concomitant
Hepatic Artery Thrombosis Hospitalization 1/17/2007 Male 1/7/2008 Physician United States
Primary
Secondary
Concomitant
Urinary Retention Life Threatening 7/5/2004 66 Male 1/10/2008 Physician Germany
Primary
Secondary
Concomitant
Renal Disorder Hospitalization 24 Male 12/28/2007
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 12/23/2007 34 Male 177 lb 1/3/2008 Physician United States
Primary
Concomitant
Urinary Tract Infection Life Threatening 7/5/2004 66 Male 1/15/2008 Physician Germany
Primary
Secondary
Concomitant
Transplant Rejection Hospitalization 11/8/2007 Male 203 lb 1/18/2008 Physician Canada
Primary
Secondary
Concomitant
Deep Vein Thrombosis Hospitalization 1/31/2005 Male 185 lb 1/17/2008 Physician Canada
Primary
Concomitant
Thrombocytopenia Hospitalization 12/23/2007 34 Male 177 lb 1/19/2008 Physician United States
Primary
Concomitant
Vomiting Hospitalization 1/28/2005 Female 201 lb 1/21/2008 Physician Canada
Primary
Concomitant
Transplant Rejection Hospitalization 11/8/2007 Male 203 lb 1/21/2008 Physician Canada
Primary
Secondary
Concomitant
Transplant Rejection Hospitalization 11/8/2007 Male 203 lb 1/22/2008 Physician Canada
Primary
Secondary
Concomitant
Urinary Retention Life Threatening 7/5/2004 66 Male 1/25/2008 Physician Germany
Primary
Secondary
Concomitant
Pneumonia Hospitalization 9/26/2004 Female 1/29/2008 Physician United States
Primary
Secondary
Concomitant
Hepatitis C Hospitalization 4/16/2007 Male 2/5/2008 Physician United States
Primary
Concomitant
Pseudomembranous Colitis Hospitalization 37 Female 2/7/2008 United States
Primary
Secondary
Death Death 1/1/2008 73 Female 2/19/2008 Physician United States
Primary
Secondary
Concomitant
Death Death 1/1/2008 Female 2/22/2008 Physician United States
Primary
Secondary
Concomitant
Death Death 10/26/2007 73 Female 99 lb 2/25/2008 Physician United States
Primary
Secondary
Concomitant
Complications Of Transplanted Liver Death 10/26/2007 Female 2/26/2008 Physician United States
Primary
Secondary
Concomitant
Kaposi's Sarcoma Other Serious 65 3/6/2008 Other Health Professional Germany
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/7/2008 Physician Belgium
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/7/2008 Physician Belgium
Primary
Concomitant
Renal Impairment Hospitalization 3/4/2008 Other Health Professional Turkey
Primary
Secondary
Concomitant
Rectal Haemorrhage Hospitalization 3/3/2008 Male 174 lb 3/17/2008 Physician Canada
Primary
Concomitant
Multi-organ Failure Other Serious 4/2/2008 United States
Primary
Secondary
Concomitant
Multi-organ Failure Hospitalization 1/1/2004 50 Female 4/9/2008 Physician Austria
Primary
Concomitant
Pyrexia Hospitalization 4/12/2008 Male 141 lb 4/23/2008 Physician Taiwan, Province Of China
Primary
Concomitant
Thrombotic Microangiopathy Hospitalization 26 Male 5/2/2008 United States
Primary
Secondary
Concomitant
Vomiting Other Serious Male 5/5/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious Male 5/5/2008 Physician United States
Primary
Secondary
Concomitant
Pneumonia Other Serious Female 5/5/2008 Physician United States
Primary
Secondary
Concomitant
Ovarian Cyst Other Serious Female 5/5/2008 Physician United States
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Of Skin Other Serious Male 5/5/2008 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 4/12/2008 Male 141 lb 5/8/2008 Physician Taiwan, Province Of China
Primary
Concomitant
Pyrexia Life Threatening 6/1/2006 Male 5/8/2008 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 3/30/2008 Male 174 lb 5/20/2008 Physician Canada
Primary
Secondary
Concomitant
Rectal Haemorrhage Hospitalization 3/3/2008 Male 140 lb 5/22/2008 Physician Canada
Primary
Concomitant
Pyrexia Hospitalization 4/12/2008 Male 141 lb 5/28/2008 Physician Taiwan, Province Of China
Primary
Concomitant
Wound Infection Staphylococcal Other Serious 5/1/2007 Female 5/29/2008 Physician Canada
Primary
Secondary
Concomitant
Intestinal Obstruction Other Serious 20 Female 6/4/2008 Other Health Professional United States
Primary
Secondary
Sepsis Death 62 Male 6/5/2008 Other Health Professional Austria
Primary
Secondary
Intestinal Obstruction Other Serious 20 Female 6/9/2008 Other Health Professional United States
Primary
Secondary
Sepsis Death 62 Male 6/10/2008 Other Health Professional Austria
Primary
Secondary
Renal Impairment Hospitalization 6/13/2008 Physician United States
Primary
Interacting
Zygomycosis Death 62 Male 6/16/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 12/14/2005 Male 6/18/2008 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 8/25/2006 50 Male 6/19/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Zygomycosis Death 62 Male 6/20/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Clostridial Infection Hospitalization 3/3/2008 Male 159 lb 6/24/2008 Physician Canada
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 12/14/2005 Male 6/25/2008 Physician United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 5/1/2007 Female 6/27/2008 Physician Canada
Primary
Secondary
Concomitant
Pyrexia Life Threatening 1/1/2006 Male 7/9/2008 Physician United States
Primary
Concomitant

Drug Data