Methotrexate combined with Tacrolimus

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Polyneuropathy Other Serious 56 Male 1/19/2006 Germany
Primary
Secondary
Concomitant
Respiratory Syncytial Virus Infection Other Serious 12/16/2005 Male 160 lb 1/13/2006 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 20 Male 4/3/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 3/19/2006 Male 141 lb 4/11/2006 United States
Primary
Secondary
Granulocytopenia Required Intervention 59 Male 5/11/2006 Other Health Professional United States
Primary
Concomitant
Urticaria Other Serious 1/1/2003 Male 5/17/2006 Physician Sweden
Primary
Concomitant
Urticaria Other Serious 1/1/2003 Male 5/23/2006 Physician Sweden
Primary
Concomitant
Nephropathy Hospitalization 2/1/2001 54 Male 176 lb 6/1/2006 Consumer United States
Primary
Secondary
Concomitant
Nephropathy Hospitalization 2/1/2001 54 Male 176 lb 6/6/2006 Consumer United States
Primary
Secondary
Concomitant
Streptococcal Infection Hospitalization 6/7/2006 Male 135 lb 6/8/2006 United States
Primary
Secondary
Concomitant
Sepsis Death Female 6/9/2006 Physician Japan
Primary
Concomitant
Skin Exfoliation Other Serious 2 Male 6/29/2006 United States
Primary
Concomitant
Thrombotic Thrombocytopenic Purpura Other Serious 7/3/2006 Consumer United States
Primary
Secondary
Concomitant
Troponin I Increased Hospitalization 8/1/2006 Male 181 lb 8/1/2006 United States
Primary
Secondary
Sepsis Death 4/17/2006 69 Female 8/11/2006 Physician Japan
Primary
Secondary
Concomitant
Septic Shock Life Threatening 7/27/2006 51 Male 181 lb 8/16/2006 Physician United States
Primary
Concomitant
Oral Mucosal Disorder Hospitalization 2/9/2006 10 Male 8/30/2006 Consumer United States
Primary
Secondary
Concomitant
Splenomegaly Hospitalization 8/19/2006 Female 9/11/2006 Physician Japan
Primary
Secondary
Stem Cell Transplant Hospitalization 8/25/2006 Male 138 lb 9/7/2006 United States
Primary
Secondary
Trichosporon Infection Death 42 Male 10/9/2006 Japan
Primary
Secondary
Concomitant
Melaena Other Serious 1/1/2004 41 Female 10/17/2006 Japan
Primary
Secondary
Concomitant
Trichosporon Infection Death 42 Male 10/17/2006 Japan
Primary
Secondary
Concomitant
Skin Exfoliation Other Serious 31 Female 10/31/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Fibrosis Hospitalization 8/25/2006 Male 138 lb 11/15/2006 United States
Primary
Secondary
Hospitalisation Other Serious 1/19/2006 Female 179 lb 11/20/2006 Other Health Professional United States
Primary
Concomitant
Sputum Culture Positive Life Threatening 10/19/2006 35 Female 294 lb 11/9/2006 Other Health Professional United States
Primary
Concomitant
Thrombocytopenia Other Serious 11/1/2005 Female 179 lb 12/12/2006 Other Health Professional United States
Primary
Concomitant
Sputum Culture Positive Life Threatening 10/19/2006 35 Female 294 lb 12/6/2006 Other Health Professional United States
Primary
Concomitant
Tachypnoea Life Threatening 10/25/2006 63 Male 12/13/2006 Other Health Professional United States
Primary
Concomitant
Cystitis Haemorrhagic Hospitalization 16 Male 1/23/2007 Physician Japan
Primary
Concomitant
Restlessness Life Threatening 10/25/2006 63 Male 1/18/2007 Physician United States
Primary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 1/30/2007 Japan
Primary
Concomitant
Colitis Ulcerative Other Serious 12/19/2006 Male 2/1/2007 Physician Czech Republic
Primary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 2/8/2007 Japan
Primary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 2/8/2007 Japan
Primary
Concomitant
Venoocclusive Disease Other Serious 2/16/2007 Physician United States
Primary
Concomitant
Venoocclusive Disease Other Serious 2/16/2007 Physician United States
Primary
Concomitant
Venoocclusive Disease Other Serious 2/16/2007 Physician United States
Primary
Concomitant
Viral Myocarditis Other Serious 56 Male 2/22/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Ventricular Tachycardia Hospitalization 56 Male 2/26/2007
Primary
Secondary
Postrenal Failure Other Serious 35 Male 2/27/2007 Japan
Primary
Concomitant
Postrenal Failure Other Serious 35 Male 2/27/2007 Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 12/22/2006 Female 110 lb 3/2/2007 Physician Japan
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Other Serious 48 Male 3/3/2007 Japan
Primary
Concomitant
Weight Decreased Other Serious 48 Male 3/10/2007 Japan
Primary
Secondary
Concomitant
Ureteric Stenosis Other Serious 35 Male 3/14/2007 Japan
Primary
Secondary
Concomitant
Vomiting Disability 1/30/2007 7 Female 3/13/2007 Japan
Primary
Concomitant
Ureteric Stenosis Other Serious 35 Male 3/28/2007 Japan
Primary
Secondary
Concomitant
Stress Other Serious 12/21/2006 80 Female 81 lb 3/15/2007 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 52 Male 4/4/2007 Other Health Professional United States
Primary
Secondary
Staphylococcal Sepsis Other Serious 31 Male 4/4/2007 Other Health Professional United States
Primary
Secondary
Varicella Hospitalization 12/20/2006 52 Male 4/19/2007 Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/16/2006 54 Female 4/19/2007 Japan
Primary
Secondary
Concomitant
Vomiting Death 12/20/2006 52 Male 5/7/2007 Japan
Primary
Secondary
Concomitant
Thyroid Cancer Other Serious 2/1/2006 56 Female 5/23/2007 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 12/16/2006 54 Female 6/11/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Mucous Membrane Disorder Other Serious 57 Female 6/13/2007 Japan
Primary
Secondary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 6/22/2007 Japan
Primary
Secondary
Concomitant
Vomiting Death 12/20/2006 52 Male 6/20/2007 Japan
Primary
Secondary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 6/22/2007 Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 10 Male 7/6/2007 Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 10 Male 7/6/2007 Japan
Primary
Secondary
Concomitant
Vomiting Life Threatening 1/28/2007 34 Female 7/16/2007 Japan
Primary
Concomitant
Staphylococcal Sepsis Life Threatening 4/13/2007 49 Male 7/16/2007 Japan
Primary
Secondary
Concomitant
Septic Shock Life Threatening 2/20/2007 Female 8/17/2007 Other Health Professional France
Primary
Secondary
Concomitant
Vomiting Other Serious 1/30/2007 7 Female 8/16/2007 Japan
Primary
Concomitant
Trigeminal Neuralgia Hospitalization 2/26/2007 Female 8/22/2007 Physician Japan
Primary
Concomitant
Epstein-barr Virus Infection Hospitalization 5/2/2006 62 Male 218 lb 1/15/2007 Other Health Professional United States
Primary
Concomitant
Cystitis Hospitalization 8/27/2006 44 Female 173 lb 1/15/2007 Other Health Professional United States
Primary
Concomitant
Death Life Threatening 50 Male 8/30/2007 Consumer United States
Primary
Secondary
Concomitant
Keratoconjunctivitis Sicca Other Serious 6/1/2007 54 Female 9/11/2007 Netherlands
Primary
Secondary
Concomitant
Stomatitis Life Threatening 5/6/2007 56 Female 9/18/2007 Japan
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Life Threatening 3/21/2007 20 Male 9/18/2007 Japan
Primary
Concomitant
Stenotrophomonas Infection Death 4/12/2007 33 Male 9/18/2007 Japan
Primary
Concomitant
Post Procedural Complication Hospitalization 14 Male 9/19/2007 Japan
Primary
Secondary
Concomitant
Transplant Rejection Life Threatening 5/23/2007 60 Male 9/20/2007 Other Health Professional Japan
Primary
Concomitant
Stomatitis Other Serious 12/15/2006 6 Female 9/20/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Staphylococcal Sepsis Life Threatening 12/18/2006 50 Male 9/20/2007 Other Health Professional Japan
Primary
Concomitant
Pericardial Disease Other Serious 54 Female 9/24/2007 Netherlands
Primary
Secondary
Concomitant
Malaise Hospitalization 5/29/2007 Female 110 lb 10/17/2007 United Kingdom
Primary
Concomitant
Vomiting Life Threatening 1/28/2007 34 Female 10/22/2007 Japan
Primary
Concomitant
Thrombotic Microangiopathy Life Threatening 4/13/2007 49 Male 10/22/2007 Japan
Primary
Secondary
Concomitant
Status Epilepticus Life Threatening 2/10/2005 39 Male 10/26/2007 Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease 7/30/2007 51 Male 10/26/2007 Japan
Primary
Concomitant
Stomatitis 6/10/2007 21 Female 10/26/2007 Japan
Primary
Concomitant
Somnolence Other Serious 52 Male 10/31/2007 Physician Japan
Primary
Secondary
Concomitant
Cerebral Toxoplasmosis Other Serious 52 Male 11/16/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Stomatitis Hospitalization 1/25/2007 4 Male 11/16/2007 Japan
Primary
Secondary
Concomitant
Vomiting Life Threatening 4/19/2007 18 Female 11/16/2007 Japan
Primary
Concomitant
Vomiting Hospitalization 6/3/2007 60 Male 11/16/2007 Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 6/24/2007 14 Female 11/16/2007 Japan
Primary
Concomitant
Streptococcal Sepsis Other Serious 5/3/2007 54 Female 11/16/2007 Japan
Primary
Concomitant
Vomiting Other Serious 10/5/2006 9 Female 41 lb 11/24/2007 United Kingdom
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 65 Female 11/26/2007 Other Health Professional United States
Primary
Secondary
Virus Serology Test Positive Other Serious 56 Male 11/20/2007 Japan
Primary
Secondary
Vomiting Other Serious 10/5/2006 9 Female 40 lb 12/2/2007 United Kingdom
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 1/1/2005 65 Female 11/20/2007 Consumer United States
Primary
Secondary
Oral Herpes Other Serious 1/1/2005 65 Female 11/29/2007 Consumer
Primary
Secondary
Vomiting Hospitalization 10/5/2006 9 Female 41 lb 11/29/2007 United Kingdom
Primary
Concomitant
Vomiting Other Serious 10/5/2006 9 Female 41 lb 12/1/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 10/5/2006 9 Female 41 lb 11/30/2007 United Kingdom
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Other Serious 2/1/2001 52 Male 12/10/2007 Japan
Primary
Concomitant
Cytomegalovirus Viraemia Hospitalization 6/11/2007 60 Male 12/10/2007 Japan
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Other Serious 2/1/2001 52 Male 12/21/2007 Japan
Primary
Concomitant
Lymphocyte Count Decreased Death 2/9/2006 66 Female 108 lb 12/7/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Death 6/7/2006 77 Male 143 lb 12/27/2007 Physician Japan
Primary
Concomitant
Lymphocyte Count Decreased Other Serious 2/9/2006 66 Female 108 lb 12/27/2007 Physician Japan
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Life Threatening 3/21/2007 20 Male 1/3/2008 Japan
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 4/25/2007 64 Male 1/3/2008 Japan
Primary
Secondary
Concomitant
Nuclear Magnetic Resonance Imaging Brain Abnormal Death 11 Female 1/22/2008 Other Health Professional Saudi Arabia
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 1/1/2005 65 Female 1/15/2008 Consumer United States
Primary
Secondary
Septic Shock Death 12/31/2007 65 Male 239 lb 1/16/2008 Physician United States
Primary
Secondary
Concomitant
Spinal Compression Fracture Hospitalization 7/6/2007 74 Female 106 lb 1/13/2008 Physician Japan
Primary
Concomitant
Sepsis Death 12/31/2007 65 Male 239 lb 1/31/2008 Physician United States
Primary
Secondary
Concomitant
Lymphocyte Count Decreased Death 2/9/2006 66 Female 108 lb 1/24/2008 Physician Japan
Primary
Secondary
Concomitant
Sepsis Hospitalization 2/3/2008 Male 167 lb 2/6/2008 United States
Primary
Secondary
Renal Failure Other Serious 2/22/2008 Other Health Professional United States
Primary
Secondary
Weight Increased Death 2/9/2006 66 Female 108 lb 2/20/2008 Physician Japan
Primary
Secondary
Concomitant
Renal Disorder Other Serious 2/29/2008 Other Health Professional United States
Primary
Secondary
Vomiting Death 9 Male 2/25/2008 Other Health Professional Japan
Primary
Concomitant
Serositis Death 1 3/6/2008 Consumer Japan
Primary
Concomitant
Rheumatoid Arthritis Other Serious 65 Male 3/6/2008
Primary
Secondary
Concomitant
Cystitis Haemorrhagic Other Serious 11 3/11/2008 Consumer Japan
Primary
Concomitant
Venoocclusive Disease Other Serious 13 3/11/2008 Consumer Japan
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 14 3/11/2008 Consumer Japan
Primary
Concomitant
Cytomegalovirus Enteritis Other Serious 12 3/11/2008 Consumer Japan
Primary
Concomitant
Vomiting Hospitalization 10/31/2007 65 Female 3/6/2008 Japan
Primary
Concomitant
Pain In Extremity 1/1/2006 Male 150 lb 3/15/2008 Consumer United States
Primary
Concomitant
Nocardiosis Other Serious Female 3/13/2008 Physician United States
Primary
Concomitant
Stem Cell Transplant Death 1 3/13/2008 Japan
Primary
Concomitant
Serositis Death 1 3/24/2008 Physician Japan
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 11 3/24/2008 Physician Japan
Primary
Concomitant
Venoocclusive Disease Other Serious 13 3/24/2008 Physician Japan
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 14 3/24/2008 Physician Japan
Primary
Concomitant
Cytomegalovirus Enteritis Other Serious 12 3/24/2008 Physician Japan
Primary
Concomitant
Venoocclusive Disease Hospitalization 2/12/2008 Male 231 lb 3/17/2008 United States
Primary
Secondary
Obliterative Bronchiolitis Other Serious 10 Female 3/26/2008 Japan
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 12 Male 3/27/2008 Japan
Primary
Concomitant
Pulmonary Haemorrhage Other Serious 80 Female 3/25/2008 Physician Japan
Primary
Secondary
Thrombotic Microangiopathy Other Serious 12 Male 4/7/2008 Japan
Primary
Concomitant
Ureteral Stent Insertion Hospitalization 7/9/2007 56 Male 4/2/2008 Japan
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 5 Male 4/14/2008 Other Health Professional Germany
Primary
Secondary
Venoocclusive Disease Hospitalization 2/12/2008 Male 231 lb 4/16/2008 United States
Primary
Secondary
Stomatitis Life Threatening 10/31/2007 50 Male 4/30/2008 Japan
Primary
Concomitant
Vomiting Hospitalization 10/26/2007 65 Female 4/30/2008 Japan
Primary
Concomitant
Stomatitis Life Threatening 6/12/2007 52 Female 4/30/2008 Japan
Primary
Concomitant
Thrombotic Microangiopathy Life Threatening 2/6/2007 23 Male 4/30/2008 Japan
Primary
Concomitant
Tumour Associated Fever Hospitalization 11/13/2006 58 Male 4/30/2008 Japan
Primary
Secondary
Concomitant
Serositis Hospitalization 12/15/2007 Female 104 lb 5/2/2008 United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 4/25/2008 60 Male 5/8/2008 Other Health Professional United States
Primary
Secondary
Concomitant

Drug Data