Heparin combined with Tacrolimus

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Liver Function Test Abnormal 11/1/2004 61 9/12/2005 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased 4/30/2004 60 9/12/2005 Physician United States
Primary
Concomitant
International Normalised Ratio Increased 2/2/2005 59 9/12/2005 Physician United States
Primary
Concomitant
Urticaria Required Intervention 6/28/2005 Male 168 lb Pharmacist United States
Primary
Concomitant
Respiratory Distress Life Threatening 8/19/2005 66 Male 3/1/2006 Physician Switzerland
Primary
Secondary
Concomitant
Urine Output Decreased Required Intervention 11/15/2005 64 Female 118 lb 1/3/2006 United States
Primary
Concomitant
Glomerular Filtration Rate Decreased Other Serious 50 Female 5/30/2006 Physician Australia
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 4/7/2005 65 Male 6/26/2006 Physician Germany
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 7/2/2006 66 198 lb 7/11/2006 Pharmacist United States
Primary
Concomitant
Respiratory Depression Life Threatening 2/25/2005 44 Female 7/24/2006 Physician Germany
Primary
Secondary
Concomitant
Pulmonary Oedema Other Serious 1/1/2006 Male 7/19/2006 Pharmacist United States
Primary
Concomitant
Respiratory Failure Hospitalization 10/31/2005 45 Female 7/28/2006 Physician Germany
Primary
Secondary
Concomitant
Pyelonephritis Hospitalization 8/21/2005 47 Female 8/22/2006 Physician France
Primary
Secondary
Concomitant
Wound Secretion Hospitalization 8/21/2005 59 Female 9/29/2006 Physician Germany
Primary
Secondary
Concomitant
Wound Dehiscence Hospitalization 8/21/2005 59 Female 10/19/2006 Physician Germany
Primary
Secondary
Concomitant
Vaginal Candidiasis Hospitalization 11/6/2005 56 Female 10/26/2006 Physician France
Primary
Secondary
Concomitant
Weight Decreased Other Serious 6/1/2006 44 Male 10/30/2006 Physician France
Primary
Secondary
Concomitant
Lymphadenopathy Other Serious 6/1/2006 44 Male 11/7/2006 Physician France
Primary
Secondary
Concomitant
Wound Dehiscence Hospitalization 8/21/2005 59 Female 11/13/2006 Physician Germany
Primary
Secondary
Concomitant
Kaposi's Sarcoma Other Serious 6/1/2006 44 Male 11/17/2006 Physician France
Primary
Secondary
Concomitant
Pulmonary Oedema Required Intervention 7/2/2006 66 Male 8/1/2006 Pharmacist United States
Primary
Concomitant
Rash Maculo-papular Other Serious 12/12/2006 65 Male 229 lb 1/13/2007 Other Health Professional United States
Primary
Concomitant
Human Herpesvirus 8 Infection Other Serious 6/1/2006 44 Male 2/1/2007 Physician France
Primary
Secondary
Concomitant
Escherichia Urinary Tract Infection Hospitalization 4/23/2006 53 Male 2/1/2007 Physician France
Primary
Secondary
Concomitant
Klebsiella Infection Hospitalization 12/14/2006 53 Male 2/2/2007 Physician France
Primary
Secondary
Concomitant
Human Herpesvirus 8 Infection Other Serious 6/1/2006 44 Male 2/5/2007 Physician France
Primary
Secondary
Concomitant
Human Herpesvirus 8 Infection Other Serious 6/1/2006 44 Male 2/5/2007 Physician France
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/7/2007 50 Female 2/6/2007 Pharmacist Canada
Primary
Concomitant
Pyrexia Hospitalization 1/13/2005 37 Male 2/13/2007 Other Health Professional France
Primary
Secondary
Concomitant
B-cell Lymphoma Hospitalization 3/31/2006 48 Male 2/9/2007 Other Health Professional France
Primary
Secondary
Concomitant
Blood Creatinine Increased Hospitalization 2/3/2006 44 Male 2/12/2007 Other Health Professional France
Primary
Secondary
Concomitant
Pyelonephritis Hospitalization 5/29/2006 Female 2/9/2007 Other Health Professional France
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/5/2006 43 Male 2/8/2007 Other Health Professional France
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 12/9/2005 46 Male 2/15/2007 Other Health Professional France
Primary
Secondary
Concomitant
Septic Shock Hospitalization 5/19/2005 39 Male 2/8/2007 Other Health Professional France
Primary
Secondary
Concomitant
Pancreatitis Hospitalization 3/4/2005 32 Male 2/8/2007 Physician France
Primary
Secondary
Concomitant
Pyelonephritis Hospitalization 3/7/2005 45 Male 2/8/2007 Physician France
Primary
Secondary
Concomitant
Hernial Eventration Hospitalization 8/31/2006 50 Male 2/14/2007 Physician France
Primary
Secondary
Concomitant
Wound Evisceration Hospitalization 3/7/2006 44 Male 2/13/2007 Physician France
Primary
Secondary
Concomitant
Proteinuria Hospitalization 10/18/2004 41 Female 2/8/2007 Physician France
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 10/20/2005 46 Male 2/8/2007 Physician France
Primary
Secondary
Concomitant
Wound Evisceration Hospitalization 3/16/2005 37 Male 2/8/2007 Physician France
Primary
Secondary
Concomitant
Hydronephrosis Hospitalization 10/8/2004 45 Male 2/8/2007 Physician France
Primary
Secondary
Concomitant
Wound Evisceration Other Serious 10/29/2004 45 Male 2/8/2007 Physician France
Primary
Secondary
Concomitant
Shock Life Threatening 12/17/2005 24 Male 3/13/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 5/12/2006 69 Male 3/19/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Peritoneal Effusion Hospitalization 11/2/2004 46 Female 3/6/2007 Physician France
Primary
Secondary
Concomitant
Septic Shock Life Threatening 10/20/2005 34 Male 4/3/2007 Physician France
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Life Threatening 5/10/2006 62 Male 3/19/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vena Cava Thrombosis Life Threatening 2/23/2004 41 Female 4/9/2007 Physician Sweden
Primary
Secondary
Concomitant
Cytomegalovirus Infection Hospitalization 10/25/2005 56 Female 4/16/2007 Physician France
Primary
Secondary
Concomitant
Drug Level Increased 3/26/2007 41 Male 4/26/2007 Pharmacist Canada
Primary
Secondary
Concomitant
Vena Cava Thrombosis Life Threatening 2/23/2004 41 Female 5/11/2007 Physician Sweden
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/20/2006 53 Female 5/4/2007 Other Health Professional France
Primary
Secondary
Concomitant
Human Herpesvirus 8 Infection Other Serious 6/1/2006 44 Male 5/17/2007 Physician France
Primary
Secondary
Concomitant
Wound Dehiscence Hospitalization 8/21/2005 59 Female 5/18/2007 Physician Germany
Primary
Secondary
Concomitant
Soft Tissue Disorder Hospitalization 1/9/2006 45 Female 154 lb 5/17/2007 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious 6/1/2006 44 Male 5/24/2007 Physician France
Primary
Secondary
Concomitant
Retroperitoneal Haemorrhage Life Threatening 11/25/2006 33 Female 6/6/2007 Pharmacist United States
Primary
Concomitant
Wound Dehiscence Hospitalization 8/21/2005 59 Female 6/15/2007 Physician Germany
Primary
Secondary
Concomitant
Renal Failure Acute Required Intervention 3/12/2007 58 Male 225 lb 3/22/2007 Pharmacist United States
Primary
Secondary
Concomitant
Retroperitoneal Haemorrhage Required Intervention 9/8/2007 77 Female 165 lb 10/2/2007 United States
Primary
Concomitant
Multiple Myeloma Hospitalization 5/4/2006 67 Male 172 lb 10/29/2007 Physician United States
Primary
Secondary
Concomitant
Thrombosis Life Threatening 1/27/2004 57 Female 11/28/2007 Physician Germany
Primary
Secondary
Vascular Injury Other Serious 5/21/2007 65 Female 101 lb 11/30/2007 Physician United States
Primary
Concomitant
Platelet Count Decreased Life Threatening 11/6/2007 Female 115 lb 11/15/2007 Pharmacist United States
Primary
Concomitant
Heparin-induced Thrombocytopenia Life Threatening 23 Female 1/17/2008 Other Health Professional Greece
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 10/22/2004 54 Male 2/10/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hepatic Failure Death 19 Male 6/27/2008 Other Health Professional Germany
Primary
Concomitant
Ovarian Cyst Ruptured Other Serious 64 Female 7/21/2008 Physician United States
Primary
Secondary
Concomitant
Transplant Rejection Other Serious Female 7/21/2008 Physician United States
Primary
Secondary
Concomitant
Wound Evisceration Hospitalization 10/12/2004 45 Male 8/20/2008 Other Health Professional France
Primary
Secondary
Concomitant
Wound Evisceration Hospitalization 3/16/2005 37 Male 8/20/2008 Other Health Professional France
Primary
Secondary
Concomitant
Renal Tubular Disorder Hospitalization 10/18/2004 41 Female 8/20/2008 Other Health Professional France
Primary
Secondary
Concomitant
Ascites Hospitalization 11/2/2004 46 Female 8/20/2008 Physician France
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/13/2005 37 Male 8/20/2008 Physician France
Primary
Secondary
Concomitant
Wound Evisceration Hospitalization 3/7/2006 44 Male 8/20/2008 Physician France
Primary
Secondary
Concomitant
Wound Evisceration Other Serious 10/29/2004 45 Male 8/20/2008 Physician France
Primary
Secondary
Concomitant
Hydronephrosis Hospitalization 10/8/2004 45 Male 8/20/2008 Physician France
Primary
Secondary
Concomitant
Shock Haemorrhagic Hospitalization 10/20/2005 46 Male 8/20/2008 Physician France
Primary
Secondary
Concomitant
Respiratory Distress Other Serious 8/13/2008 69 Female 9/24/2008 Other Health Professional France
Primary
Secondary
Concomitant
Pyrexia Hospitalization 8/28/2008 9/16/2008 Pharmacist United States
Primary
Concomitant
Thrombosis Hospitalization 8/4/2005 15 Male 159 lb 9/26/2008 Physician United States
Primary
Concomitant
Staphylococcal Sepsis Other Serious 5 Male 10/1/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Streptococcal Sepsis Other Serious 12/19/2001 5 Male 10/1/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Wound Infection Hospitalization 4/26/2008 Female 10/13/2008 Other Health Professional United States
Primary
Concomitant
Transplant Rejection Death 10/4/2007 Female 169 lb 10/8/2008 United States
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 5 Male 10/28/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Transplant Rejection Other Serious 37 Male 11/5/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Transplant Rejection Other Serious 54 Male 11/10/2008 Physician United States
Primary
Secondary
Concomitant
Transplant Rejection Other Serious 36 Male 11/10/2008 Physician United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 8/4/2005 15 Male 159 lb 11/18/2008 Physician United States
Primary
Concomitant
Hypertrophic Cardiomyopathy Other Serious 0 Male 11/19/2008 Japan
Primary
Concomitant
Blood Creatinine Increased Required Intervention 5/31/2008 51 Male 150 lb 6/24/2008 Pharmacist United States
Primary
Concomitant
Pain In Extremity Required Intervention 9/6/2008 58 Female 172 lb 10/3/2008 United States
Primary
Concomitant
Hypertrophic Cardiomyopathy Other Serious 0 Male 12/1/2008 Japan
Primary
Concomitant
Serotonin Syndrome Other Serious 11/25/2008 53 Male 158 lb 12/17/2008 Pharmacist United States
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 5/28/2006 39 Male 1/13/2009 Physician Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 5/28/2006 39 Male 109 lb 1/29/2009 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Hospitalization 8/4/2005 15 Male 159 lb 3/13/2009 Physician United States
Primary
Concomitant
Vomiting Hospitalization 3/18/2009 Other Health Professional Italy
Primary
Secondary
Concomitant
Interacting
Death Death 2/1/2004 Female 4/3/2009 Physician Israel
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/2/2009 Male 186 lb 2/12/2009 Pharmacist United States
Primary
Concomitant
Subarachnoid Haemorrhage Life Threatening 1/19/2009 25 Female 94 lb 2/3/2009 Pharmacist United States
Primary
Concomitant
Leukaemia Recurrent Hospitalization 12/26/2006 20 5/12/2009 Physician France
Primary
Concomitant
Serum Sickness Hospitalization 1/9/2006 45 Female 158 lb 5/18/2009 Physician United States
Primary
Concomitant
Serum Sickness Other Serious 4/30/2007 24 Female 194 lb 5/28/2009 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 5/29/2009 Male 120 lb 6/10/2009 Physician United States
Primary
Concomitant
Hyperkalaemia Other Serious 11/5/2003 Male 265 lb 6/23/2009 Physician Israel
Primary
Secondary
Concomitant
Renal Cyst Life Threatening 1/27/2004 Female 6/23/2009 Physician Germany
Primary
Secondary
Concomitant
Shock Haemorrhagic Life Threatening 1/13/2004 Female 196 lb 6/23/2009 Physician Israel
Primary
Secondary
Concomitant
Gastroenteritis Hospitalization 5/20/2003 Male 6/23/2009 Physician Germany
Primary
Secondary
Concomitant
Urinoma Hospitalization 11/13/2004 Male 163 lb 6/23/2009 Physician Canada
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 11/27/2004 Male 183 lb 6/23/2009 Physician Germany
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 9/12/2004 Female 125 lb 6/23/2009 Physician Canada
Primary
Secondary
Concomitant
Shock Haemorrhagic Other Serious 1/13/2004 Female 6/24/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Unresponsive To Stimuli Required Intervention 4/2/2009 39 Female 110 lb 4/28/2009 Pharmacist United States
Primary
Concomitant
Ventricular Tachycardia Other Serious 10/13/2003 53 Male 7/27/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Shock Haemorrhagic Life Threatening 1/13/2004 50 Female 7/31/2009 Physician Israel
Primary
Secondary
Concomitant
Urinary Fistula Hospitalization 10/18/2004 54 Male 8/21/2009 Spain
Primary
Secondary
Concomitant
Nausea Required Intervention 7/15/2009 64 Female 7/15/2009 Pharmacist United States
Primary
Concomitant
Pyrexia Required Intervention 6/21/2009 55 Male 202 lb 7/14/2009 Pharmacist United States
Primary
Concomitant
Somnolence Life Threatening 8/26/2009 65 Male 8/27/2009 Pharmacist United States
Primary
Concomitant
Wound Infection Hospitalization 29 Female 276 lb 9/29/2009 United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 5/29/2009 Male 120 lb 10/16/2009 Physician United States
Primary
Concomitant
Grand Mal Convulsion Hospitalization 9/14/2009 71 Female 134 lb 10/22/2009 Other Health Professional United States
Primary
Concomitant
Renal Failure Other Serious 9/23/2009 Male 255 lb 10/28/2009 United States
Primary
Secondary
Concomitant
Product Quality Issue Other Serious 9/27/2009 44 Male 148 lb 10/2/2009 United States
Primary
Concomitant
Product Quality Issue Other Serious 9/27/2009 52 Male 201 lb 10/7/2009 United States
Primary
Concomitant
Vomiting Hospitalization 10/19/2009 Female 162 lb 11/16/2009 Physician Australia
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9/23/2009 Male 255 lb 12/2/2009 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9/23/2009 Male 255 lb 12/2/2009 United States
Primary
Secondary
Concomitant
Skin Tightness Other Serious 8/1/2005 51 Male 181 lb 12/7/2009 Physician United States
Primary
Concomitant
Vomiting Hospitalization 10/19/2009 Female 162 lb 12/28/2009 Physician Australia
Primary
Concomitant
Vomiting Hospitalization 10/19/2009 Female 162 lb 1/5/2010 Physician Australia
Primary
Secondary
Concomitant
Hyponatraemia Life Threatening 60 Female 156 lb 3/1/2010 Physician United States
Primary
Concomitant
Urosepsis Other Serious 1/1/2009 60 Male 165 lb 3/8/2010 Physician Germany
Primary
Secondary
Concomitant
Supraventricular Tachycardia Other Serious 58 Female 3/9/2010 Physician United States
Primary
Concomitant
Muscle Spasms Other Serious 12/31/2009 70 Male 196 lb 1/31/2010 Pharmacist United States
Primary
Concomitant
Sepsis Hospitalization 2/1/2010 Female 149 lb 3/19/2010 Physician Canada
Primary
Secondary
Concomitant
Sepsis Hospitalization 3/10/2010 Female 149 lb 3/23/2010 Physician Canada
Primary
Secondary
Concomitant
Pericardial Haemorrhage Other Serious 1/11/2010 55 Male 185 lb 3/30/2010 Pharmacist United States
Primary
Secondary
Concomitant
Urosepsis Other Serious 1/1/2009 60 Male 165 lb 4/15/2010 Physician Germany
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 10/7/2008 71 Male 159 lb 4/16/2010 Physician Germany
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2002 Female 4/22/2010 Physician Japan
Primary
Concomitant
Sepsis Other Serious 1/25/2010 49 Male 147 lb 2/10/2010 Pharmacist United States
Primary
Concomitant
Hyperkalaemia Other Serious 12/16/2009 71 Female 150 lb 5/21/2010 Pharmacist United States
Primary
Concomitant
Urinary Tract Infection Other Serious 1/1/2010 46 Female 176 lb 5/24/2010 Pharmacist United States
Primary
Concomitant
Hepatic Failure Life Threatening 9/4/2009 67 Female 210 lb 6/7/2010 Physician France
Primary
Secondary
Concomitant
Toxic Encephalopathy Hospitalization 3/10/2010 57 Female 149 lb 6/15/2010 Physician Canada
Primary
Secondary
Concomitant

Drug Data