Melphalan combined with Tacrolimus

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Streptococcal Infection Hospitalization 6/7/2006 Male 135 lb 6/8/2006 United States
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Other Serious 7/3/2006 Consumer United States
Primary
Secondary
Concomitant
Vomiting Other Serious 10 Male 1/9/2007 Consumer Australia
Primary
Secondary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 1/30/2007 Japan
Primary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 2/8/2007 Japan
Primary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 2/8/2007 Japan
Primary
Concomitant
Systemic Candida Other Serious 45 Female 3/5/2007 Japan
Primary
Concomitant
Encephalitis Herpes Other Serious 58 Female 4/27/2007 Physician United States
Primary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 6/22/2007 Japan
Primary
Secondary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 6/22/2007 Japan
Primary
Secondary
Concomitant
Wrong Technique In Drug Usage Process Other Serious 5/30/2007 Female 31 lb 6/28/2007 Pharmacist United States
Primary
Concomitant
Pancreatitis Other Serious 5/30/2007 Female 31 lb 9/17/2007 Pharmacist
Primary
Concomitant
Pneumonia Parainfluenzae Viral Hospitalization 5/30/2007 45 Male 9/18/2007 Japan
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 40 Female 10/24/2007 Physician Japan
Primary
Concomitant
Sepsis Other Serious 58 Female 10/30/2007 Physician United States
Primary
Concomitant
Stem Cell Transplant Death 7/28/2007 65 Male 10/26/2007 Japan
Primary
Concomitant
Venoocclusive Liver Disease Life Threatening 6/24/2007 14 Female 11/16/2007 Japan
Primary
Concomitant
Thrombotic Microangiopathy Life Threatening 10/22/2006 40 Female 12/10/2007 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 12/28/2007 Female 197 lb 1/8/2008 United States
Primary
Secondary
Renal Failure Other Serious 2/22/2008 Other Health Professional United States
Primary
Secondary
Renal Disorder Other Serious 2/29/2008 Other Health Professional United States
Primary
Secondary
Serositis Death 1 3/6/2008 Consumer Japan
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 11 3/11/2008 Consumer Japan
Primary
Concomitant
Venoocclusive Disease Other Serious 13 3/11/2008 Consumer Japan
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 14 3/11/2008 Consumer Japan
Primary
Concomitant
Cytomegalovirus Enteritis Other Serious 12 3/11/2008 Consumer Japan
Primary
Concomitant
Serositis Death 1 3/24/2008 Physician Japan
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 15 3/24/2008 Physician Japan
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 11 3/24/2008 Physician Japan
Primary
Concomitant
Venoocclusive Disease Other Serious 13 3/24/2008 Physician Japan
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 14 3/24/2008 Physician Japan
Primary
Concomitant
Cytomegalovirus Enteritis Other Serious 12 3/24/2008 Physician Japan
Primary
Concomitant
Multi-organ Failure Other Serious 4/2/2008 United States
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 5/22/2008 Japan
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 64 Female 6/13/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Transplant Failure Other Serious 63 Male 7/1/2008 Japan
Primary
Secondary
Concomitant
Staphylococcal Bacteraemia Other Serious 63 Female 7/1/2008 Japan
Primary
Secondary
Concomitant
Transplant Failure Other Serious 61 Male 7/1/2008 Japan
Primary
Secondary
Concomitant
Transplant Failure Other Serious 59 Female 7/1/2008 Japan
Primary
Secondary
Concomitant
Multi-organ Failure Other Serious 57 Female 7/1/2008 Japan
Primary
Secondary
Concomitant
Multi-organ Failure Other Serious 57 Female 8/7/2008 Japan
Primary
Secondary
Concomitant
Staphylococcal Bacteraemia Other Serious 63 Female 8/7/2008 Japan
Primary
Secondary
Concomitant
Transplant Failure Other Serious 59 Female 8/7/2008 Japan
Primary
Secondary
Concomitant
Transplant Failure Other Serious 63 Male 8/7/2008 Japan
Primary
Secondary
Concomitant
Transplant Failure Other Serious 61 Male 8/7/2008 Japan
Primary
Secondary
Concomitant
Caecitis Hospitalization 8/13/2008 Male 9/4/2008 Physician United States
Primary
Concomitant
Caecitis Hospitalization 8/13/2008 Male 9/9/2008 Physician United States
Primary
Concomitant
Infection Other Serious 44 Male 181 lb 9/15/2008 United States
Primary
Concomitant
Septic Shock Other Serious 8/1/2008 58 Male 123 lb 10/16/2008 Physician Spain
Primary
Secondary
Concomitant
Septic Shock Other Serious 8/1/2008 58 Male 123 lb 10/17/2008 Physician Spain
Primary
Secondary
Concomitant
Tachycardia Other Serious 8/1/2008 Male 10/22/2008 Other Health Professional Spain
Primary
Concomitant
Thrombotic Microangiopathy Hospitalization 70 Male 12/30/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 54 Male 1/15/2009 Physician Japan
Primary
Secondary
Influenza Other Serious 3/1/2007 39 Male 1/23/2009 Other Health Professional Japan
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 70 Male 1/26/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Septic Shock Other Serious 8/18/2008 58 Male 132 lb 3/3/2009 Physician Spain
Primary
Secondary
Concomitant
Septic Shock Other Serious 8/18/2008 58 Male 132 lb 3/5/2009 Physician Spain
Primary
Secondary
Concomitant
Tachycardia Other Serious 8/18/2008 58 Male 3/6/2009 Other Health Professional Spain
Primary
Concomitant
Venoocclusive Liver Disease Life Threatening 7/21/2008 56 Male 132 lb 4/15/2009 Physician Japan
Primary
Concomitant
Renal Failure Acute Other Serious 4/5/2009 Male 183 lb 4/23/2009 Other Health Professional United States
Primary
Concomitant
Renal Failure Acute Other Serious 4/5/2009 Male 183 lb 4/29/2009 Other Health Professional United States
Primary
Concomitant
Renal Failure Acute Other Serious 4/5/2009 Male 183 lb 5/13/2009 Other Health Professional United States
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 5/14/2009 Other Health Professional United States
Primary
Concomitant
Respiratory Failure Other Serious 4/5/2009 Male 183 lb 5/25/2009 Other Health Professional United States
Primary
Concomitant
Respiratory Failure Other Serious 4/5/2009 Male 183 lb 6/8/2009 Other Health Professional United States
Primary
Concomitant
Tuberculosis Other Serious 12/1/2007 19 Male 7/3/2009 Other Health Professional Brazil
Primary
Secondary
Concomitant
Tuberculosis Other Serious 12/1/2007 19 Male 7/7/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 7/11/2008 56 Male 132 lb 9/24/2009 Physician Japan
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 44 Female 10/20/2009 Other Health Professional Japan
Primary
Concomitant
Weight Increased Other Serious 44 Female 10/20/2009 Other Health Professional Japan
Primary
Concomitant
Transplant Rejection Death 47 Female 11/2/2009 Physician United States
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Death 12/1/2009 Other Health Professional Japan
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 44 Female 12/7/2009 Other Health Professional Japan
Primary
Concomitant
Acute Graft Versus Host Disease In Intestine Hospitalization 7/25/2009 32 Male 12/1/2009 Other Health Professional Spain
Primary
Concomitant
Renal Impairment Death 12/1/2008 61 Male 115 lb 2/22/2010 Physician Japan
Primary
Concomitant
Pulmonary Alveolar Haemorrhage Death 3/4/2010 United States
Primary
Secondary
Concomitant
Pulmonary Alveolar Haemorrhage Death 3/8/2010 United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 12/1/2008 50 Male 3/14/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Viral Upper Respiratory Tract Infection Other Serious 31 Female 6/4/2010 United States
Primary
Secondary
Concomitant
Renal Failure Death 45 6/9/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Death 45 6/9/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Death 7/12/2010 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Skin Infection Hospitalization 8 Male 7/28/2010 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 3/11/2009 23 Female 97 lb 8/17/2010 Physician Japan
Primary
Concomitant
Renal Failure Life Threatening 8/1/2010 56 Male 8/20/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Staphylococcal Skin Infection Other Serious 9 Male 8/20/2010 Other Health Professional Netherlands
Primary
Concomitant
Renal Failure Death 45 8/24/2010 United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 3/11/2009 23 Female 97 lb 8/31/2010 Physician Japan
Primary
Concomitant
Acute Myeloid Leukaemia Recurrent Other Serious 12/10/2009 5 Male 53 lb 9/1/2010 Physician Japan
Primary
Concomitant
Thrombotic Thrombocytopenic Purpura Death 9/2/2010 Other Health Professional Japan
Primary
Concomitant
Sepsis Other Serious 4/20/2010 1 Male 15 lb 9/3/2010 Physician Japan
Primary
Concomitant
Venoocclusive Disease Death 9/6/2010 Physician United States
Primary
Secondary
Concomitant
Neoplasm Malignant Death 9/6/2010 Physician United States
Primary
Secondary
Concomitant
Disease Progression Death 9/6/2010 Physician United States
Primary
Secondary
Concomitant
Disease Progression Death 9/6/2010 Physician United States
Primary
Secondary
Concomitant
Disease Progression Death 9/6/2010 Physician United States
Primary
Secondary
Concomitant
Acute Leukaemia Death 9/6/2010 Physician United States
Primary
Secondary
Concomitant
Sepsis Other Serious 4/20/2010 1 Male 15 lb 9/8/2010 Physician United States
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Death 9/8/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/13/2009 4 Female 31 lb 9/9/2010 Physician Japan
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 4 Female 10/19/2010 Physician Japan
Primary
Concomitant
Rash Other Serious 5/20/2010 7 Male 42 lb 12/7/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/13/2009 4 Female 31 lb 12/20/2010 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Hospitalization 2/23/2010 69 Male 130 lb 12/30/2010 Physician Japan
Primary
Concomitant
Bacterial Infection Death 8/20/2009 46 Male 161 lb 1/3/2011 Other Health Professional Japan
Primary
Concomitant
Staphylococcal Infection Death 20 Male 1/3/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Fungal Hospitalization 7/26/2010 51 Male 198 lb 1/3/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Fungal Death 1/4/2011 Physician United States
Primary
Secondary
Concomitant
Nausea Other Serious 15 Male 12/20/2010 Physician Japan
Primary
Concomitant
Nervous System Disorder Death 12 Male 12/26/2010 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Death 10/23/2009 62 Male 130 lb 1/6/2011 Physician Japan
Primary
Concomitant
Haemorrhage Death 4/13/2009 4 Female 31 lb 1/7/2011 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Death 10/23/2009 62 Male 130 lb 1/7/2011 Physician Japan
Primary
Secondary
Concomitant
Cytomegalovirus Test Positive Death 5/1/2010 54 Female 119 lb 1/10/2011 Physician Japan
Primary
Concomitant
Infection Life Threatening 7/4/2010 73 Female 97 lb 1/10/2011 Physician Japan
Primary
Concomitant
Sepsis Death Female 170 lb 1/10/2011 Physician Japan
Primary
Concomitant
Cystitis Haemorrhagic Hospitalization 5/17/2010 43 Female 1/10/2011 Physician Japan
Primary
Concomitant
Cardiac Failure Death 8/6/2010 35 Female 71 lb 1/10/2011 Physician Japan
Primary
Concomitant
Infection Life Threatening 7/4/2010 73 Female 97 lb 1/11/2011 Physician Japan
Primary
Secondary
Concomitant
Cytomegalovirus Test Positive Hospitalization 5/1/2010 54 Female 119 lb 1/11/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Death 10/26/2009 59 Male 121 lb 1/11/2011 Physician Japan
Primary
Secondary
Concomitant
Infection Life Threatening 7/4/2010 73 Female 97 lb 1/13/2011 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Other Serious 8/6/2010 35 Female 71 lb 1/14/2011 Physician Japan
Primary
Secondary
Concomitant
Neutropenia Death 1/18/2011 Other Health Professional United States
Primary
Concomitant
Acute Graft Versus Host Disease In Liver Other Serious 3 Male 1/19/2011 Physician Japan
Primary
Secondary
Concomitant
Multi-organ Failure Death 1/25/2011 Physician United States
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Death 1/25/2011 Physician United States
Primary
Secondary
Thrombotic Microangiopathy Death 9/21/2009 62 Female 126 lb 1/26/2011 Physician Japan
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 5/17/2010 43 Female 119 lb 1/26/2011 Physician Japan
Primary
Concomitant
Graft Versus Host Disease Hospitalization 9/30/2009 18 Female 137 lb 1/28/2011 Physician Japan
Primary
Concomitant
Acute Myeloid Leukaemia Death 57 Female 2/3/2011 Other Health Professional Japan
Primary
Concomitant
Disease Progression Death Male 2/4/2011 Physician United States
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Death 66 Male 2/7/2011 Physician Japan
Primary
Concomitant
Infection Other Serious 2/7/2011 Physician United States
Primary
Secondary
Concomitant
Neoplasm Malignant Death Male 2/8/2011 Physician United States
Primary
Secondary
Concomitant
Neoplasm Malignant Death 2/8/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Multi-organ Failure Death 67 Female 2/8/2011 Physician Japan
Primary
Concomitant
Subarachnoid Haemorrhage Other Serious 16 Female 2/9/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Other Serious 3 Female 2/9/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Death 61 Female 2/9/2011 Physician Japan
Primary
Concomitant
Subarachnoid Haemorrhage Other Serious 16 Female 2/10/2011 Physician Japan
Primary
Secondary
Concomitant
Transplant Failure Other Serious 9 Female 2/10/2011 Physician Japan
Primary
Secondary
Concomitant
Disease Progression Death 2/10/2011 Physician United States
Primary
Secondary
Concomitant
Neoplasm Malignant Death 2/10/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Other Serious 12 Male 2/10/2011 Physician Japan
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Other Serious 2 Female 2/10/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Other Serious 7 Male 2/10/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Death 66 Male 2/11/2011 Physician Japan
Primary
Concomitant
Multi-organ Failure Death 67 Female 2/11/2011 Physician Japan
Primary
Concomitant
Acute Myeloid Leukaemia Death 61 Female 2/11/2011 Physician Japan
Primary
Concomitant

Drug Data