Leflunomide



Indications and Reactions:

Role Indications Reactions
Primary
Rheumatoid Arthritis 71.5%
Hypertension 4.9%
Drug Use For Unknown Indication 3.9%
Product Used For Unknown Indication 2.4%
Psoriatic Arthropathy 2.4%
Prophylaxis 2.0%
Pain 1.8%
Arthritis 1.7%
Hypercholesterolaemia 1.0%
Immunosuppression 0.9%
Juvenile Arthritis 0.9%
Asthma 0.8%
Osteoporosis 0.8%
Wound Infection 0.8%
Atrial Fibrillation 0.7%
Hypothyroidism 0.7%
Constipation 0.7%
Duodenal Ulcer 0.7%
Seronegative Arthritis 0.7%
Angina Pectoris 0.6%
Drug Exposure During Pregnancy 15.3%
Maternal Exposure During Pregnancy 10.2%
Weight Decreased 8.3%
Ischaemic Stroke 5.6%
Progressive Multifocal Leukoencephalopathy 5.6%
Dyspnoea 5.1%
Vomiting 5.1%
Hepatic Enzyme Increased 4.6%
Renal Failure Acute 4.2%
Hypertension 3.7%
Liver Function Test Abnormal 3.7%
Pyrexia 3.7%
Off Label Use 3.2%
Pancytopenia 3.2%
Posterior Reversible Encephalopathy Syndrome 3.2%
Pregnancy 3.2%
Respiratory Failure 3.2%
Sepsis 3.2%
Hepatic Function Abnormal 2.8%
Rash 2.8%
Secondary
Rheumatoid Arthritis 36.0%
Drug Use For Unknown Indication 10.5%
Pain 8.4%
Osteoporosis 8.0%
Myalgia 7.5%
Hypermobility Syndrome 7.3%
Osteoarthritis 7.3%
Product Used For Unknown Indication 5.5%
Juvenile Arthritis 2.3%
Psoriatic Arthropathy 1.5%
Hypertension 1.5%
Asthma 0.7%
Arthritis 0.6%
Juvenile Idiopathic Arthritis 0.5%
Prophylaxis 0.5%
Renal Transplant 0.5%
Type 2 Diabetes Mellitus 0.4%
Diabetes Mellitus 0.4%
Ankylosing Spondylitis 0.3%
Cytomegalovirus Viraemia 0.3%
Suicidal Ideation 34.0%
Weight Decreased 5.8%
Wound Infection Staphylococcal 4.9%
Pneumonia 4.5%
Rheumatoid Arthritis 4.5%
Vomiting 4.5%
Tubulointerstitial Nephritis 3.9%
Thrombocytopenia 3.6%
Drug Hypersensitivity 3.2%
Myocardial Infarction 3.2%
Overdose 3.2%
Sepsis 3.2%
Hodgkin's Disease 2.9%
Weight Increased 2.9%
White Blood Cell Count Decreased 2.9%
Wound Infection 2.9%
Pyrexia 2.6%
Respiratory Failure 2.6%
Hypertension 2.3%
Joint Instability 2.3%
Concomitant
Rheumatoid Arthritis 40.4%
Drug Use For Unknown Indication 21.6%
Product Used For Unknown Indication 18.8%
Hypertension 4.4%
Pain 2.5%
Psoriatic Arthropathy 2.0%
Osteoporosis 1.8%
Arthritis 1.3%
Diabetes Mellitus 1.1%
Depression 0.9%
Vitamin Supplementation 0.7%
Hypothyroidism 0.6%
Asthma 0.6%
Gastrooesophageal Reflux Disease 0.6%
Psoriasis 0.5%
Blood Pressure 0.5%
Insomnia 0.5%
Prophylaxis 0.4%
Blood Cholesterol Increased 0.4%
Ankylosing Spondylitis 0.4%
Rheumatoid Arthritis 12.8%
Injection Site Pain 10.9%
Vomiting 7.5%
Weight Decreased 5.9%
Urinary Tract Infection 5.7%
Pneumonia 5.1%
Pain 5.0%
Pain In Extremity 4.4%
Injection Site Swelling 4.4%
Sinusitis 4.4%
Drug Ineffective 4.3%
Rash 4.1%
Pyrexia 3.8%
Sepsis 3.7%
Myocardial Infarction 3.5%
Arthralgia 3.2%
Staphylococcal Infection 3.2%
Death 3.1%
Diarrhoea 2.7%
Weight Increased 2.6%
Interacting
Rheumatoid Arthritis 37.9%
Drug Use For Unknown Indication 27.2%
Juvenile Arthritis 6.8%
Hypertension 4.9%
Atrial Fibrillation 2.9%
Embolism Arterial 2.9%
Product Used For Unknown Indication 2.9%
Obstructive Airways Disorder 1.9%
Osteoporosis 1.9%
Pain 1.9%
Blood Cholesterol 1.0%
Colitis Ulcerative 1.0%
Crohn's Disease 1.0%
Depression 1.0%
Hyperchlorhydria 1.0%
Prophylaxis Against Gastrointestinal Ulcer 1.0%
Pulmonary Fibrosis 1.0%
Thyroid Disorder 1.0%
Vitamin D Decreased 1.0%
Respiratory Tract Infection 19.2%
Drug Interaction 15.4%
Pneumonia Legionella 11.5%
Tardive Dyskinesia 11.5%
Pain 7.7%
Red Blood Cell Count Decreased 7.7%
Abdominal Distension 3.8%
Arthritis 3.8%
Meningitis 3.8%
Neuropathy Peripheral 3.8%
Sensory Disturbance 3.8%
Transaminases Increased 3.8%
Urticaria 3.8%