Leflunomide combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Therapeutic Agent Toxicity Hospitalization 12/1/2005 Male 2/22/2006 Pharmacist United States
Primary
Secondary
Concomitant
Coronary Artery Thrombosis Death 4/4/2006 Male 185 lb 7/17/2006 Other Health Professional United Kingdom
Primary
Concomitant
Metastasis Other Serious 6/20/2006 75 Female 8/17/2006 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 54 Female 11/13/2006 Other Health Professional United Kingdom
Primary
Concomitant
Ventricular Fibrillation Hospitalization Male 12/15/2006 Other Health Professional United Kingdom
Primary
Concomitant
Coronary Artery Thrombosis Death 4/4/2006 Male 185 lb 1/19/2007 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 54 Female 5/30/2007 Other Health Professional United Kingdom
Primary
Concomitant
Venous Pressure Jugular Increased Other Serious 3/15/2006 Female 146 lb 6/19/2007 Physician United Kingdom
Primary
Concomitant
Hospitalisation Hospitalization Female 7/13/2007 Canada
Primary
Concomitant
Inflammation Hospitalization 6/1/2007 73 Male 8/9/2007 Germany
Primary
Concomitant
Chest Pain Hospitalization 7/7/2007 Female 155 lb 8/29/2007 Canada
Primary
Concomitant
Septic Shock Hospitalization 8/15/2007 Female 170 lb 9/6/2007 United Kingdom
Primary
Concomitant
Inflammation Hospitalization 5/1/2007 Male 192 lb 9/13/2007 Germany
Primary
Concomitant
Pulmonary Oedema Other Serious 1/1/2007 76 Female 197 lb 10/29/2007 Other Health Professional United Kingdom
Primary
Concomitant
Syncope Other Serious 2/1/2007 Male 141 lb 11/15/2007 Other Health Professional United Kingdom
Primary
Concomitant
Rash Other Serious 8/1/2007 74 Female 11/21/2007
Primary
Concomitant
Necrotising Retinitis Other Serious 9/1/2007 54 Female 11/26/2007
Primary
Secondary
Concomitant
Septic Shock Hospitalization 8/15/2007 Female 170 lb 11/29/2007 United Kingdom
Primary
Concomitant
Retinal Infarction Other Serious 9/1/2007 54 Female 12/2/2007 United Kingdom
Primary
Secondary
Concomitant
Lower Respiratory Tract Infection Other Serious 5/6/2007 Male 154 lb 12/3/2007 Other Health Professional United Kingdom
Primary
Concomitant
Death Other Serious Male 121 lb 12/3/2007 Other Health Professional United Kingdom
Primary
Concomitant
Necrotising Retinitis Hospitalization 9/1/2007 54 Female 11/30/2007 United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/3/2008 Male 220 lb 2/22/2008 Pharmacist Netherlands
Primary
Concomitant
Hypothermia Other Serious 10/16/2007 Male 121 lb 2/25/2008 Other Health Professional United Kingdom
Primary
Concomitant
Speech Disorder Hospitalization Male 168 lb 2/29/2008 Brazil
Primary
Concomitant
Weight Increased Hospitalization 1/3/2008 Male 220 lb 3/12/2008 Pharmacist Netherlands
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 11/1/2007 Female 3/15/2008 Consumer United States
Primary
Concomitant
Polyuria Other Serious 1/1/2008 Female 4/10/2008 Physician Belgium
Primary
Concomitant
Hypertension Hospitalization 10/24/2007 Female 154 lb 5/15/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Atrial Fibrillation Hospitalization 6/12/2008 73 Female 163 lb 7/24/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 3/28/2008 Female 8/6/2008 Germany
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 4/29/2008 8/15/2008 United Kingdom
Primary
Concomitant
Hyperglycaemia Hospitalization 8/1/2004 75 Female 8/25/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Hyperglycaemia Hospitalization Female 8/27/2008 United States
Primary
Secondary
Concomitant
Peripheral Vascular Disorder Hospitalization 1/1/2008 67 Female 146 lb 8/28/2008 Germany
Primary
Concomitant
Weight Decreased Other Serious 7/11/2008 Male 150 lb 8/28/2008 Other Health Professional United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Death 1/9/2008 Male 223 lb 8/28/2008 United Kingdom
Primary
Concomitant
Hyperglycaemia Hospitalization 8/1/2004 Female 9/4/2008 United States
Primary
Secondary
Concomitant
Bronchial Carcinoma Death 8/10/2008 Male 150 lb 9/30/2008 United Kingdom
Primary
Concomitant
Tooth Extraction Other Serious 4/29/2008 64 Female 9/30/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Bronchial Carcinoma Death 8/10/2008 Male 150 lb 10/2/2008 United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 7/11/2008 Male 150 lb 10/6/2008 Other Health Professional United Kingdom
Primary
Concomitant
Tooth Extraction Other Serious 4/29/2008 64 Female 10/6/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 4/29/2008 10/6/2008 United Kingdom
Primary
Concomitant
Phantom Pain Other Serious 1/1/2008 67 Female 146 lb 10/22/2008 Germany
Primary
Concomitant
Tooth Extraction Other Serious 4/29/2008 Female 10/24/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 4/29/2008 Female 10/28/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hyperglycaemia Hospitalization 8/1/2004 Female 149 lb 11/20/2008 United States
Primary
Secondary
Concomitant
Staphylococcal Skin Infection 7/1/2008 Female 220 lb 12/12/2008 Consumer United States
Primary
Concomitant
Injection Site Haemorrhage 11/18/2008 Male 185 lb 12/12/2008 Consumer United States
Primary
Concomitant
Pain 11/1/2008 Female 150 lb 12/12/2008 Other Health Professional United States
Primary
Concomitant
Respiratory Tract Congestion Hospitalization 11/17/2008 Male 165 lb 12/17/2008 United States
Primary
Concomitant
Subdural Haematoma Hospitalization Female 12/17/2008 Germany
Primary
Concomitant
Vomiting Hospitalization 6/30/2008 Female 170 lb 1/12/2009 United Kingdom
Primary
Concomitant
Myocardial Infarction Other Serious 10/1/2008 Male 152 lb 1/20/2009 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 6/30/2008 Female 155 lb 1/23/2009 United Kingdom
Primary
Concomitant
Subdural Haematoma Hospitalization 7/26/2008 Female 2/4/2009 Germany
Primary
Secondary
Concomitant
Weight Decreased Other Serious 7/11/2008 Male 150 lb 2/13/2009 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Infarction Other Serious Male 152 lb 2/13/2009 Other Health Professional United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Death 1/9/2008 Male 223 lb 2/18/2009 United Kingdom
Primary
Concomitant
Atrial Flutter Other Serious 1/22/2009 66 Female 3/12/2009 Other Health Professional United Kingdom
Primary
Concomitant
Oropharyngeal Pain 11/27/2008 Male 185 lb 3/14/2009 United States
Primary
Concomitant
Epilepsy Other Serious 4/28/2009 74 Male 6/5/2009
Primary
Concomitant
Productive Cough Hospitalization 4/22/2009 Female 227 lb 6/19/2009 United Kingdom
Primary
Concomitant
Urinary Tract Infection Hospitalization 4/1/2009 Female 7/1/2009 Physician United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 11/1/2005 69 Male 7/2/2009
Primary
Concomitant
Urinary Tract Infection Other Serious 4/1/2009 Female 240 lb 7/17/2009 United Kingdom
Primary
Concomitant
Myocardial Infarction Life Threatening 6/12/2008 73 7/28/2009 Physician Peru
Primary
Secondary
Concomitant
Lip Neoplasm Malignant Stage Unspecified Other Serious 12/7/2007 Female 137 lb 7/31/2009 Other Health Professional United Kingdom
Primary
Concomitant
Lumbar Radiculopathy Death 11/13/2008 Male 174 lb 8/10/2009 Physician United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 2/9/2008 Female 209 lb 8/19/2009 United Kingdom
Primary
Concomitant
Basal Cell Carcinoma Other Serious 7/12/2007 Female 137 lb 8/31/2009 Other Health Professional United Kingdom
Primary
Concomitant
Nodule Other Serious Female 176 lb 9/11/2009 Brazil
Primary
Concomitant
Wrong Technique In Drug Usage Process 7/1/2008 Female 220 lb 9/12/2009 Consumer United States
Primary
Concomitant
Basal Cell Carcinoma Other Serious 12/7/2007 Female 137 lb 9/18/2009 Other Health Professional United Kingdom
Primary
Concomitant
Tongue Ulceration Other Serious 6/5/2009 69 Female 132 lb 9/18/2009 Consumer United States
Primary
Concomitant
Weight Decreased 1/1/2009 Female 165 lb 9/18/2009 Consumer United States
Primary
Concomitant
Speech Disorder Other Serious Male 168 lb 9/21/2009 Brazil
Primary
Concomitant
Speech Disorder Other Serious Male 168 lb 9/22/2009 Brazil
Primary
Concomitant
Basal Cell Carcinoma Other Serious 12/7/2007 Female 137 lb 10/1/2009 Other Health Professional United Kingdom
Primary
Concomitant
Loss Of Consciousness Other Serious 7/1/2008 55 Female 174 lb 10/9/2009 Consumer United States
Primary
Concomitant
Loss Of Consciousness Other Serious 7/1/2008 55 Female 174 lb 10/14/2009 Consumer United States
Primary
Concomitant
Spinal Fracture Hospitalization 11/1/2008 Female 10/14/2009 United Kingdom
Primary
Concomitant
Urosepsis Hospitalization 8/25/2007 Female 10/27/2009 Germany
Primary
Concomitant
Nodule Other Serious Female 176 lb 10/27/2009 Brazil
Primary
Concomitant
Myocardial Infarction Life Threatening 6/12/2008 73 Female 163 lb 11/9/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pancreatic Necrosis Hospitalization 12/1/2008 63 Female 11/18/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Myocardial Infarction Life Threatening 12/11/2008 57 Female 165 lb 12/14/2009 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Embolism Hospitalization 2/9/2008 Female 209 lb 12/23/2009 United Kingdom
Primary
Concomitant
Atrial Flutter Other Serious 1/22/2009 66 Female 1/7/2010 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 6/1/2009 62 Female 103 lb 1/28/2010 Other Health Professional United Kingdom
Primary
Concomitant
Death Death 12/23/2009 Female 163 lb 2/2/2010 Physician United Kingdom
Primary
Concomitant
Myocardial Infarction Life Threatening 6/12/2008 73 Female 163 lb 3/3/2010 Physician Peru
Primary
Secondary
Concomitant
Skin Ulcer Death 11/1/2008 78 Female 163 lb 4/1/2010 Physician United Kingdom
Primary
Concomitant
Myocardial Infarction Hospitalization 6/12/2008 73 Female 163 lb 4/6/2010 Physician Peru
Primary
Secondary
Concomitant
Productive Cough Other Serious 4/22/2009 51 Female 227 lb 5/6/2010 United Kingdom
Primary
Concomitant
Poor Quality Drug Administered Other Serious 1/1/2009 57 Male 235 lb 5/13/2010 United States
Primary
Concomitant
Oedema Peripheral Other Serious 71 Male 5/14/2010 Consumer United States
Primary
Concomitant
Rheumatoid Lung Other Serious 9/1/2009 72 Female 5/14/2010 Physician Germany
Primary
Concomitant
Weight Decreased Other Serious 1/1/2010 52 Male 400 lb 6/2/2010 Consumer United States
Primary
Secondary
Concomitant
Skin Ulcer Other Serious 11/1/2008 78 Female 163 lb 6/24/2010 Physician United Kingdom
Primary
Concomitant
Pulmonary Mass Hospitalization 6/3/2010 55 Female 8/3/2010 Physician Thailand
Primary
Secondary
Concomitant
Rheumatoid Lung Other Serious 9/1/2009 72 Female 8/11/2010 Physician Germany
Primary
Concomitant
Pneumonia Hospitalization 7/29/2010 55 Female 8/17/2010 Physician Thailand
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 71 Male 8/18/2010 Consumer United States
Primary
Concomitant
Oedema Peripheral Other Serious Male 8/19/2010 Consumer Germany
Primary
Concomitant
Gait Disturbance Life Threatening 3/15/2009 62 Female 154 lb 10/20/2010 Physician Germany
Primary
Secondary
Concomitant
Urticaria Other Serious 9/1/2008 10/21/2010 Physician United States
Primary
Concomitant
Sinusitis Other Serious 8/30/2010 61 Female 10/27/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sinusitis Other Serious 8/30/2010 61 Female 10/30/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious Female 141 lb 11/2/2010 Physician United Kingdom
Primary
Concomitant
Lung Squamous Cell Carcinoma Stage Unspecified Death 1/8/2010 11/16/2010 United Kingdom
Primary
Concomitant
Skin Cancer Other Serious 3/25/2008 11/29/2010 Physician United Kingdom
Primary
Concomitant
Rash 12/13/2010 Consumer United States
Primary
Concomitant
Skin Lesion 12/14/2010 Consumer United States
Primary
Concomitant
Nodule On Extremity Other Serious 4/1/2005 12/16/2010 Physician United States
Primary
Concomitant
Rheumatoid Arthritis 11/1/2009 12/19/2010 Physician United States
Primary
Concomitant
Nausea 2/1/2010 12/22/2010 Other Health Professional United States
Primary
Concomitant
Injection Site Reaction 4/30/2010 12/22/2010 Consumer United States
Primary
Concomitant
Injection Site Reaction 2/1/2010 12/22/2010 Consumer United States
Primary
Concomitant
Exostosis Hospitalization 9/15/2010 50 Male 175 lb 12/27/2010 Consumer United States
Primary
Concomitant
Wheezing Disability 12/20/2010 64 Male 225 lb 1/6/2011 Physician United Kingdom
Primary
Concomitant
Polyarthritis Disability 2/1/2010 53 Female 1/17/2011 Other Health Professional United Kingdom
Primary
Concomitant
Angina Pectoris Other Serious 11/1/2007 68 Female 117 lb 1/17/2011 Physician Brazil
Primary
Concomitant
Incorrect Dose Administered 3/12/2010 56 Female 235 lb 1/28/2011 United States
Primary
Concomitant
Localised Infection Hospitalization 12/1/2009 77 Female 128 lb 1/28/2011 Physician United States
Primary
Concomitant
Injection Site Haematoma 7/8/2010 73 Male 1/29/2011 Consumer United States
Primary
Concomitant
Urinary Tract Infection 3/1/2010 53 Female 160 lb 1/29/2011 Consumer United States
Primary
Concomitant
Rash Erythematous 4/1/2010 70 Female 1/29/2011 Consumer United States
Primary
Concomitant
Injection Site Erythema 11/26/2010 63 Female 150 lb 1/30/2011 Consumer United States
Primary
Concomitant
Oropharyngeal Pain 8/9/2010 61 Female 1/30/2011 Consumer United States
Primary
Concomitant
Arthralgia 11/4/2010 56 Female 1/30/2011 Consumer United States
Primary
Concomitant
No Adverse Event 11/7/2010 70 Female 175 lb 2/18/2011 Consumer United States
Primary
Concomitant
Myocardial Infarction Life Threatening 48 Male 2/28/2011 Other Health Professional United Kingdom
Primary
Concomitant
Sepsis Hospitalization 1/1/2010 65 Female 3/16/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Neck Pain Hospitalization 1/1/2010 65 Female 3/23/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 66 Male 4/1/2011 Physician United Kingdom
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Disability 66 Male 3/31/2011 Other Health Professional United Kingdom
Primary
Concomitant
Pain In Extremity Other Serious 11/1/2010 53 Female 161 lb 4/15/2011 Consumer Brazil
Primary
Concomitant
Pharyngeal Oedema Hospitalization 1/1/2011 33 Female 154 lb 4/25/2011 Consumer Brazil
Primary
Secondary
Concomitant
Hypoglycaemia Other Serious 3/1/2011 66 Female 102 lb 5/2/2011 Other Health Professional United States
Primary
Concomitant
Skin Disorder Other Serious 12/1/2010 79 Male 176 lb 5/4/2011 Other Health Professional United Kingdom
Primary
Concomitant
Skin Disorder Other Serious 12/1/2010 79 Male 176 lb 5/6/2011 Other Health Professional United Kingdom
Primary
Concomitant
Diabetic Foot Other Serious 12/1/2010 79 Male 5/7/2011 United Kingdom
Primary
Concomitant
Renal Disorder Death 5/9/2011 44 Male 5/13/2011 Other Health Professional United States
Primary
Concomitant
Haemoglobin Decreased Life Threatening 77 Female 88 lb United States
Primary
Concomitant
Ageusia Other Serious 5/11/2011 59 Female 165 lb 7/8/2011 United States
Primary
Concomitant
Pain In Extremity Other Serious 8/1/2010 87 Female 8/16/2011 Physician United States
Primary
Concomitant
Pulmonary Congestion Other Serious 11/15/2008 71 Male 8/22/2011 Physician Germany
Primary
Concomitant
Joint Swelling Hospitalization 2/11/2011 76 Female 130 lb 8/17/2011 Physician United States
Primary
Concomitant

Drug Data