Leflunomide combined with Rituximab

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Respiratory Tract Infection Hospitalization 1/1/2005 Female 132 lb 8/17/2006 Physician Germany
Primary
Secondary
Concomitant
Neoplasm Skin Hospitalization 2/28/2006 Female 5/18/2007 Other Health Professional France
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 12/1/2003 Female 121 lb 5/29/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 4/18/2007 Female 6/1/2007 Physician Germany
Primary
Secondary
Staphylococcal Sepsis Hospitalization 2/21/2007 56 Female 6/12/2007 Physician Germany
Primary
Secondary
Concomitant
Pyrexia Hospitalization 4/18/2007 Female 6/15/2007 Physician Germany
Primary
Secondary
Concomitant
Staphylococcal Sepsis Hospitalization 2/21/2007 56 Female 8/18/2007 Physician Germany
Primary
Secondary
Concomitant
Staphylococcal Sepsis Hospitalization 12/15/2006 56 Female 2/8/2008 Physician Germany
Primary
Secondary
Concomitant
Terminal State Other Serious 3/30/2007 Female 3/4/2008 Germany
Primary
Concomitant
Thrombosis Other Serious 3/30/2007 Female 3/17/2008 Germany
Primary
Concomitant
Hypertension Hospitalization 10/24/2007 Female 154 lb 5/15/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 7/1/2007 Male 5/21/2008 Germany
Primary
Secondary
Concomitant
Septic Shock Hospitalization Male 5/28/2008 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 Male 6/6/2008 Germany
Primary
Secondary
Concomitant
Paraesthesia Hospitalization 2/14/2008 Female 6/9/2008 Germany
Primary
Concomitant
Hodgkin's Disease Stage Ii Other Serious 2/21/2008 Female 43 lb 6/5/2008 Physician United States
Primary
Secondary
Concomitant
Infarction Hospitalization 2/21/2008 Male 6/26/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Pain Other Serious 8/14/2007 59 Female 6/27/2008 Consumer United Kingdom
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 51 Female 6/30/2008 United States
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 2/21/2008 Male 7/11/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Knee Arthroplasty Hospitalization 8/14/2007 50 Female 8/7/2008 Other Health Professional Germany
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 Male 8/8/2008 Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/11/2004 47 Female 8/8/2008 Germany
Primary
Secondary
Concomitant
Septic Shock Other Serious 12/1/2007 78 Male 8/11/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Thrombosis Other Serious 3/30/2007 Female 8/13/2008 Germany
Primary
Concomitant
Hodgkin's Disease Other Serious 10 Female 8/18/2008 Physician United States
Primary
Secondary
Weight Increased Hospitalization 7/1/2007 Male 8/19/2008 Germany
Primary
Secondary
Concomitant
Pyrexia Hospitalization 4/18/2007 Female 8/25/2008 Physician Germany
Primary
Secondary
Concomitant
Hodgkin's Disease Other Serious 10 Female 8/27/2008 Physician United States
Primary
Secondary
Concomitant
Hodgkin's Disease Other Serious 10 Female 8/28/2008 United States
Primary
Secondary
Concomitant
Joint Destruction Other Serious 10 Female 9/22/2008 United States
Primary
Secondary
Concomitant
Hodgkin's Disease Other Serious 10 Female 9/26/2008 Physician United States
Primary
Secondary
Hodgkin's Disease Other Serious 10 Female 10/2/2008 Other Health Professional United States
Primary
Secondary
Wheelchair User Other Serious 10 Female 10/17/2008 Physician United States
Primary
Secondary
Pneumocystis Jiroveci Pneumonia Other Serious 53 Male 11/21/2008
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 12/1/2003 Female 143 lb 11/26/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Rash Life Threatening 47 Female 121 lb 12/3/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 10/3/2008 Female 12/9/2008 Physician United Kingdom
Primary
Secondary
Metastases To Liver Death 4/18/2007 Female 1/5/2009 Physician United Kingdom
Primary
Concomitant
Paraesthesia Hospitalization 2/14/2008 Female 2/4/2009 Germany
Primary
Secondary
Concomitant
Arthrodesis Other Serious 8/7/2008 50 Female 2/12/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Conjunctival Haemorrhage Hospitalization 3/2/2008 64 Female 2/12/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Vestibular Neuronitis Other Serious 4/1/2008 68 Male 2/12/2009 Consumer United Kingdom
Primary
Concomitant
Knee Arthroplasty Hospitalization 2/15/2008 56 Female 2/12/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Cerebrovascular Accident Life Threatening 4/18/2008 72 Female 2/12/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Visual Field Defect Hospitalization 2/21/2008 Male 2/12/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Thrombosis Hospitalization 2/16/2008 Male 3/9/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pregnancy Other Serious Female 102 lb 3/18/2009 Consumer United States
Primary
Concomitant
Joint Effusion Other Serious 10/30/2007 Male 4/3/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pyelonephritis Hospitalization 7/19/2008 Male 4/9/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pregnancy Other Serious Female 102 lb 4/17/2009 Consumer United States
Primary
Concomitant
Pregnancy Other Serious Female 102 lb 4/24/2009 Consumer United States
Primary
Concomitant
Serum Sickness Other Serious 1/26/2009 15 Female 277 lb 4/28/2009 Physician United States
Primary
Concomitant
Hodgkin's Disease Other Serious 2 Female 5/8/2009 Other Health Professional United States
Primary
Secondary
Pregnancy Other Serious Female 102 lb 5/8/2009 Consumer United States
Primary
Concomitant
Respiratory Tract Infection Viral Hospitalization 4/3/2009 Female 5/12/2009 Physician United Kingdom
Primary
Concomitant
Respiratory Tract Infection Viral Hospitalization 4/3/2009 Female 5/20/2009 Physician United Kingdom
Primary
Concomitant
Fall Hospitalization 2/6/2009 Male 6/25/2009 Physician United Kingdom
Primary
Concomitant
Coronary Artery Disease Hospitalization 11/4/2008 71 Female 7/9/2009 Physician United Kingdom
Primary
Concomitant
Fall Hospitalization 2/6/2009 Female 7/10/2009 Physician United Kingdom
Primary
Concomitant
Respiratory Tract Infection Viral Hospitalization 4/3/2009 Female 8/18/2009 Physician United Kingdom
Primary
Concomitant
Deep Vein Thrombosis Hospitalization 7/4/2009 Female 8/27/2009 Physician United Kingdom
Primary
Concomitant
Skin Cancer Hospitalization 8/7/2009 Female 10/22/2009 Physician United Kingdom
Primary
Concomitant
Intestinal Operation Hospitalization 4/20/2009 Female 10/23/2009 Physician United Kingdom
Primary
Concomitant
Vestibular Neuronitis Other Serious 4/1/2008 68 Male 10/29/2009 Physician United Kingdom
Primary
Concomitant
Skin Infection Other Serious 8/7/2008 50 Female 10/29/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pregnancy Other Serious 4/18/2008 Female 102 lb 11/6/2009 Consumer United States
Primary
Concomitant
Skin Cancer Other Serious 10/1/2007 Female 159 lb 11/24/2009 Consumer United Kingdom
Primary
Concomitant
Intestinal Prolapse Hospitalization 4/20/2009 Female 119 lb 12/4/2009 Physician United Kingdom
Primary
Concomitant
Cerebrovascular Accident Life Threatening 4/18/2008 72 Female 12/4/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Liver Function Test Abnormal Other Serious 11/11/2008 12/10/2009 Consumer United Kingdom
Primary
Secondary
Liver Function Test Abnormal 11/11/2008 12/21/2009 Consumer United Kingdom
Primary
Secondary
Pneumonia Aspiration Other Serious 3/23/2007 42 Male 1/7/2010 Germany
Primary
Concomitant
Myocardial Infarction Hospitalization 7/27/2009 Male 216 lb 1/8/2010 Consumer United Kingdom
Primary
Secondary
Pneumonia Aspiration Other Serious 3/23/2007 42 Male 1/8/2010 Germany
Primary
Concomitant
Lower Respiratory Tract Infection Hospitalization 8/14/2009 Female 1/12/2010 Physician United Kingdom
Primary
Concomitant
Respiratory Failure Other Serious 3/23/2007 42 Male 1/15/2010 Germany
Primary
Concomitant
Pneumonia Other Serious 3/23/2007 Male 1/15/2010 Germany
Primary
Secondary
Concomitant
Pneumonia Other Serious 3/23/2007 Male 1/25/2010 Germany
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Of Skin Hospitalization 8/7/2009 Female 1/26/2010 Physician United Kingdom
Primary
Concomitant
Death Death 12/23/2009 Female 163 lb 2/2/2010 Physician United Kingdom
Primary
Concomitant
Myocardial Infarction Life Threatening 7/27/2009 Male 216 lb 2/11/2010 Consumer Germany
Primary
Secondary
Inclusion Body Myositis Other Serious 57 Female 2/12/2010 Germany
Primary
Secondary
Concomitant
Subcutaneous Abscess Hospitalization 3/16/2008 73 Female 2/17/2010 Physician United Kingdom
Primary
Concomitant
Peritonitis Hospitalization 5/5/2008 79 Female 2/17/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Coronary Artery Disease Other Serious 78 Male 3/19/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Skin Cancer Other Serious 10/1/2007 Female 159 lb 3/24/2010 Consumer United Kingdom
Primary
Concomitant
Skin Ulcer Death 11/1/2008 78 Female 163 lb 4/1/2010 Physician United Kingdom
Primary
Concomitant
Myocardial Infarction Hospitalization 3/16/2008 73 Female 4/19/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Cholecystitis Hospitalization 11/9/2008 74 Female 4/20/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Impaired Healing Hospitalization 8/1/2009 60 Male 5/6/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Chest Pain Hospitalization 11/8/2009 68 Male 170 lb 5/7/2010 Physician United Kingdom
Primary
Concomitant
Prostate Cancer Other Serious 1/21/2010 63 Male 130 lb 5/18/2010 Consumer United Kingdom
Primary
Concomitant
Squamous Cell Carcinoma Other Serious 2/1/2006 48 Female 5/27/2010 Physician United States
Primary
Secondary
Psoriasis Other Serious 52 Male 6/17/2010 Other Health Professional Italy
Primary
Secondary
Skin Ulcer Other Serious 11/1/2008 78 Female 163 lb 6/24/2010 Physician United Kingdom
Primary
Concomitant
Pain Disability 8/8/2007 58 Female 7/7/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Pain Hospitalization 6/24/2010 67 Male 196 lb 8/3/2010 Physician United Kingdom
Primary
Concomitant
Urinary Tract Infection Hospitalization 1/21/2009 64 Female 143 lb 8/4/2010 Physician Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/24/2010 67 Female 9/28/2010 Consumer United Kingdom
Primary
Concomitant
Urinary Tract Infection Other Serious Female 141 lb 11/2/2010 Physician United Kingdom
Primary
Concomitant
Atrial Fibrillation Hospitalization 9/15/2007 64 Male 11/3/2010 Physician United Kingdom
Primary
Concomitant
Vomiting Hospitalization 10/26/2010 60 Male 130 lb 11/5/2010 Physician United Kingdom
Primary
Concomitant
Pain Hospitalization 6/22/2010 67 Male 196 lb 11/29/2010 Physician United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 11/4/2010 64 Male 12/6/2010 Consumer United Kingdom
Primary
Concomitant
Vomiting Hospitalization 10/26/2010 60 Male 130 lb 12/10/2010 Physician Germany
Primary
Concomitant
Periodontal Disease Hospitalization 8/13/2010 69 Female 150 lb 1/7/2011 Consumer United Kingdom
Primary
Secondary
Anaphylactic Reaction Other Serious 10 Female 1/13/2011 Physician
Primary
Secondary
Concomitant
Hodgkin's Disease Stage Ii Other Serious 10 Female 1/28/2011 Physician United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 1/1/2010 65 Female 2/24/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Neck Pain Hospitalization 1/1/2010 65 Female 2/25/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Bladder Cancer Hospitalization 71 Male 3/1/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Sepsis Hospitalization 1/1/2010 65 Female 3/1/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Drug Resistance Hospitalization 1/1/2010 65 Female 3/3/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Rash Hospitalization 1/1/2010 65 Female 3/8/2011 Physician United Kingdom
Primary
Secondary
Concomitant
No Therapeutic Response Other Serious 10 Female 3/16/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 1/1/2010 65 Female 3/16/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Drug Resistance Hospitalization 1/1/2010 65 Female 3/16/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Neck Pain Hospitalization 1/1/2010 65 Female 3/23/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Electrocardiogram Qt Prolonged Hospitalization 9/15/2009 68 Male 3/30/2011 Physician Germany
Primary
Concomitant
Visual Acuity Reduced Hospitalization Male 198 lb 4/1/2011 Consumer United Kingdom
Primary
Secondary
Abortion Spontaneous Other Serious Female 102 lb 4/15/2011 Physician United States
Primary
Concomitant
Gastroenteritis Hospitalization 8/13/2010 69 Female 150 lb 4/18/2011 Physician United Kingdom
Primary
Secondary
Transient Ischaemic Attack Other Serious 3/1/2011 72 Male 4/22/2011 Consumer United Kingdom
Primary
Concomitant
Acute Myocardial Infarction Hospitalization 4/2/2011 59 Male 5/16/2011 Consumer United Kingdom
Primary
Concomitant
Hepatitis B Hospitalization 3/1/2011 55 Female 6/1/2011 Physician United Kingdom
Primary
Concomitant
Leukoencephalopathy Disability Male 198 lb 6/2/2011 Consumer United Kingdom
Primary
Secondary
Bladder Tamponade Hospitalization 4/11/2011 68 Male 152 lb 6/3/2011 Physician United Kingdom
Primary
Concomitant
Hodgkin's Disease Stage Ii Other Serious 10 Female 7/1/2011 Physician United States
Primary
Secondary
Concomitant
Prostatic Acid Phosphatase Increased Hospitalization 4/11/2011 68 Male 152 lb 7/5/2011 Physician Germany
Primary
Concomitant
Squamous Cell Carcinoma Of The Cervix Hospitalization 5/27/2011 29 Female 132 lb 7/13/2011 Consumer United Kingdom
Primary
Secondary
Pelvic Pain Hospitalization 5/19/2011 29 Female 132 lb 7/26/2011 Consumer Italy
Primary
Secondary
Concomitant
Erysipeloid Hospitalization 80 Female 8/2/2011 Physician France
Primary
Secondary
Hodgkin's Disease Other Serious 10 Female 8/5/2011 Physician United States
Primary
Secondary
Chest Pain Other Serious 6/1/2011 65 Female 8/9/2011 Physician France
Primary
Secondary
Concomitant
Pelvic Pain Hospitalization 5/19/2011 29 Female 132 lb 8/11/2011 Consumer Italy
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 1/12/2011 75 Female 128 lb 8/30/2011 Physician Germany
Primary
Secondary
Concomitant
Pneumonia Hospitalization 1/12/2011 Female 8/31/2011 Physician Germany
Primary
Secondary
Concomitant
Pneumonia Hospitalization 1/12/2011 Female 8/31/2011 Physician Germany
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Death 9/2/2011 Physician United Kingdom
Primary
Secondary
Pelvic Pain Hospitalization 5/19/2011 29 Female 132 lb 9/6/2011 Consumer United States
Primary
Secondary
Concomitant
Fatigue Other Serious 7/1/2011 47 Female 141 lb 9/16/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Nasopharyngitis Other Serious 6/30/2011 53 Female 93 lb 9/20/2011 Consumer United Kingdom
Primary
Concomitant
Septic Shock Hospitalization 1/9/2008 60 Female 9/21/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 1/12/2011 75 Female 128 lb 9/28/2011 Physician Germany
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Death 73 Female 11/3/2011 Physician United States
Primary
Secondary
Progressive Multifocal Leukoencephalopathy Other Serious 72 Female 11/3/2011 Physician United States
Primary
Secondary
Neutropenia Hospitalization 2/1/2011 47 Female 11/3/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Neutropenia Hospitalization 2/1/2011 47 Female 11/7/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Aphasia Death 73 Female 11/14/2011 Physician United States
Primary
Secondary
Concomitant

Drug Data