Leflunomide combined with Vitamin D

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Hip Surgery Hospitalization 12/7/2005 51 Female 3/13/2006 Consumer Canada
Primary
Concomitant
Death Death 12/7/2006 70 Female 12/15/2006 Consumer Canada
Primary
Concomitant
Death Death 12/6/2006 70 Female 12/19/2006 Physician Canada
Primary
Concomitant
Erythema Multiforme Other Serious 11/5/2000 70 Female 3/30/2007 Physician Spain
Primary
Concomitant
Urinary Tract Infection Other Serious 5/19/2002 Female 7/11/2007 Other Health Professional United Kingdom
Primary
Concomitant
Seroma Hospitalization 8/15/2006 45 Female 7/30/2007 Physician Germany
Primary
Secondary
Concomitant
Thoracic Vertebral Fracture Hospitalization 53 Female 12/3/2007 Japan
Primary
Secondary
Concomitant
Hepatocellular Damage 1/1/2007 Female 143 lb 12/12/2007 Physician United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2007 Female 168 lb 5/2/2008 Physician United States
Primary
Concomitant
Atrial Fibrillation Hospitalization 6/12/2008 73 Female 163 lb 7/24/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Alopecia 10/1/2008 Female 3/14/2009 Consumer United States
Primary
Secondary
Concomitant
Tonsillitis 3/1/2007 Female 225 lb 6/12/2009 United States
Primary
Concomitant
Wrong Drug Administered Other Serious 6/10/2009 80 Female 95 lb 6/18/2009 Consumer United States
Primary
Concomitant
Myocardial Infarction Life Threatening 6/12/2008 73 7/28/2009 Physician Peru
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 10/10/2009 81 Female 10/17/2009 Consumer Canada
Primary
Concomitant
Venous Thrombosis Other Serious 4/1/2007 Female 11/3/2009 Physician France
Primary
Secondary
Concomitant
Toothache Other Serious 9/29/2009 Female 204 lb 11/4/2009 Canada
Primary
Concomitant
Myocardial Infarction Life Threatening 6/12/2008 73 Female 163 lb 11/9/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Rash 7/19/2009 Female 11/25/2009 Physician United States
Primary
Concomitant
Unresponsive To Stimuli Other Serious 10/10/2009 81 Female 11/25/2009 Consumer Canada
Primary
Concomitant
Rash Generalised 11/1/2009 46 Female 170 lb 1/30/2010 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased 9/1/2009 Female 147 lb 1/30/2010 Consumer United States
Primary
Secondary
Concomitant
Myocardial Infarction Life Threatening 6/12/2008 73 Female 163 lb 3/3/2010 Physician Peru
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 6/12/2008 73 Female 163 lb 4/6/2010 Physician Peru
Primary
Secondary
Concomitant
Myocardial Infarction Death 2/19/2010 67 Female 130 lb 6/7/2010 Consumer Canada
Primary
Concomitant
Vomiting Other Serious 5/1/2010 61 Female 140 lb 6/8/2010 Consumer Canada
Primary
Concomitant
Withdrawal Syndrome Hospitalization 11/1/2006 70 Female 98 lb 6/16/2010 Consumer United States
Primary
Concomitant
Withdrawal Syndrome Hospitalization 11/1/2006 70 Female 98 lb 7/8/2010 Consumer United States
Primary
Concomitant
Procedural Site Reaction Other Serious Female 143 lb 7/8/2010 Consumer Brazil
Primary
Concomitant
Vomiting Other Serious 5/1/2010 61 Female 7/9/2010 Consumer United States
Primary
Concomitant
Squamous Cell Carcinoma Other Serious Female 9/10/2010 Consumer United States
Primary
Concomitant
Pain 8/1/2009 65 Female 150 lb 9/14/2010 Other Health Professional United States
Primary
Concomitant
Haematoma Other Serious Female 9/17/2010 Consumer United States
Primary
Concomitant
Vomiting Other Serious 5/1/2010 61 Female 9/20/2010 Consumer United States
Primary
Concomitant
Pleural Effusion Other Serious 6/17/2010 62 Female 160 lb 9/22/2010 Physician United States
Primary
Concomitant
Impaired Healing Other Serious Female 200 lb 9/22/2010 Consumer Canada
Primary
Concomitant
Impaired Healing Other Serious Female 200 lb 10/6/2010 Physician Canada
Primary
Concomitant
Sinusitis Other Serious 8/30/2010 61 Female 10/27/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Tooth Injury 64 Female 10/13/2010 Consumer United States
Primary
Concomitant
Sinusitis Other Serious 8/30/2010 61 Female 10/30/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 11/30/2009 68 Female 10/28/2010 Consumer Canada
Primary
Concomitant
Sudden Death Death 2/19/2010 67 Female 130 lb 11/19/2010 Physician Canada
Primary
Concomitant
Impaired Healing Other Serious Female 200 lb 11/22/2010 Physician Canada
Primary
Concomitant
Rotator Cuff Syndrome Hospitalization 1/1/2010 56 Female 11/24/2010 Consumer United States
Primary
Concomitant
Myocardial Infarction Death 2/19/2010 67 Female 130 lb 12/1/2010 Physician Canada
Primary
Concomitant
Myocardial Infarction Death 2/19/2010 67 Female 130 lb 12/1/2010 Physician Canada
Primary
Concomitant
Weight Decreased Other Serious 11/30/2009 68 Female 12/7/2010 Consumer Canada
Primary
Concomitant
Vomiting Other Serious 4/1/2010 61 Female 12/21/2010 Physician United States
Primary
Concomitant
Arthralgia 11/30/2009 68 Female 121 lb 1/18/2011 Consumer Canada
Primary
Concomitant
Ingrowing Nail Other Serious 12/15/2010 46 Female 1/24/2011 Consumer United States
Primary
Concomitant
Injection Site Pain 8/6/2010 60 Female 1/29/2011 Consumer United States
Primary
Concomitant
Laceration 11/23/2010 55 Female 180 lb 1/30/2011 Consumer United States
Primary
Concomitant
Muscular Weakness 9/1/2010 60 Female 1/30/2011 Consumer United States
Primary
Concomitant
Fatigue 1/1/2005 46 Female 260 lb 1/30/2011 Consumer United States
Primary
Concomitant
Injection Site Erythema 11/26/2010 63 Female 150 lb 1/30/2011 Consumer United States
Primary
Concomitant
Drug Ineffective Female 1/30/2011 Consumer United States
Primary
Concomitant
Arthralgia 11/4/2010 56 Female 1/30/2011 Consumer United States
Primary
Concomitant
No Adverse Event 11/7/2010 70 Female 175 lb 2/18/2011 Consumer United States
Primary
Concomitant
Hypoglycaemia Other Serious 3/1/2011 66 Female 102 lb 5/2/2011 Other Health Professional United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 11/1/2010 68 Female 5/4/2011 Consumer Canada
Primary
Concomitant
Pathological Fracture Hospitalization 11/1/2010 48 Male 227 lb 5/17/2011 Consumer Canada
Primary
Secondary
Concomitant
Nasopharyngitis Other Serious 3/1/2010 71 Female 5/19/2011 Consumer United States
Primary
Concomitant
Bladder Tamponade Hospitalization 4/11/2011 68 Male 152 lb 6/3/2011 Physician United Kingdom
Primary
Concomitant
Pancytopenia Hospitalization 10/1/2010 69 Female 6/14/2011 Physician Germany
Primary
Concomitant
Haemoglobin Decreased Life Threatening 77 Female 88 lb United States
Primary
Concomitant
Oropharyngeal Pain Other Serious 3/1/2010 71 Female 6/30/2011 Consumer United States
Primary
Concomitant
Prostatic Acid Phosphatase Increased Hospitalization 4/11/2011 68 Male 152 lb 7/5/2011 Physician Germany
Primary
Concomitant
Blindness Unilateral Hospitalization 6/27/2011 66 Female 88 lb 7/12/2011 Physician Colombia
Primary
Concomitant
Dyspnoea Exertional Other Serious 10/1/2010 55 Female 7/20/2011 Physician Germany
Primary
Secondary
Optic Neuritis Hospitalization 6/27/2011 66 Female 88 lb 7/29/2011 Physician Colombia
Primary
Concomitant
Death Death Female 7/29/2011 Physician United States
Primary
Concomitant
Anaemia Hospitalization 62 Male 7/22/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Heart Valve Incompetence Death Female 8/5/2011 Consumer United States
Primary
Concomitant
Pain In Extremity Other Serious 8/1/2010 87 Female 8/16/2011 Physician United States
Primary
Concomitant
Mobility Decreased Hospitalization 9/1/2010 71 Female 133 lb 9/7/2011 Physician United States
Primary
Concomitant
Blindness Unilateral Other Serious 9/1/2010 Male 9/8/2011 Consumer Canada
Primary
Concomitant
Blindness Unilateral Other Serious 9/1/2010 Male 9/21/2011 Consumer Canada
Primary
Concomitant
Limb Deformity Other Serious 1/1/2006 48 Female 167 lb 9/26/2011 Physician Canada
Primary
Concomitant
Hip Fracture Hospitalization 5/15/2011 77 Female 9/30/2011 Consumer Canada
Primary
Concomitant
Pain Other Serious 1/1/2006 48 Female 167 lb 10/14/2011 Physician Canada
Primary
Concomitant
Infection Other Serious 7/28/2011 70 Female 146 lb 10/25/2011 Physician Germany
Primary
Secondary
Concomitant
Injection Site Haematoma Other Serious 10/1/2010 86 Female 103 lb 10/14/2011 Consumer United States
Primary
Concomitant
Diarrhoea Other Serious 1/1/2006 48 Female 167 lb 10/28/2011 Physician Canada
Primary
Concomitant
Dental Caries 64 Female 10/24/2011 Lawyer United States
Primary
Concomitant
Drug Ineffective 3/7/2011 48 Female 185 lb 10/29/2011 Pharmacist United States
Primary
Concomitant
Femur Fracture Hospitalization 1/3/2010 44 Female 185 lb 10/31/2011 Physician United States
Primary
Concomitant
Musculoskeletal Pain Hospitalization 1/1/2010 71 Female 133 lb 11/15/2011 Physician United States
Primary
Concomitant
Gallbladder Operation Hospitalization 11/3/2011 75 Female 11/18/2011 Consumer United States
Primary
Concomitant
Femur Fracture Other Serious 6/1/2011 66 Female 11/22/2011 Consumer Canada
Primary
Concomitant
Arthritis Other Serious 7/1/2011 49 Male 204 lb 11/23/2011 Physician United States
Primary
Concomitant
Pain Other Serious 6/1/2011 66 Female 11/30/2011 Consumer Canada
Primary
Concomitant
Asthenia Other Serious 1/1/2010 71 Female 133 lb 12/1/2011 Physician United States
Primary
Concomitant
Hypoaesthesia Oral Hospitalization 11/1/2011 46 Female 12/6/2011 Physician Germany
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 11/1/2010 48 Male 227 lb 12/7/2011 Consumer Canada
Primary
Secondary
Concomitant
Nasopharyngitis Other Serious Female 133 lb 12/8/2011 Physician United States
Primary
Concomitant
Joint Lock Female 12/13/2011 Physician United States
Primary
Concomitant
Hypocalcaemia Hospitalization 11/19/2011 73 Female 12/15/2011 Physician Netherlands
Primary
Concomitant
Ingrowing Nail Other Serious 12/15/2010 64 Female 12/20/2011 Consumer United States
Primary
Concomitant
Insomnia Hospitalization 11/3/2011 75 Female 12/26/2011 Consumer United States
Primary
Concomitant
Arthralgia Hospitalization 1/17/2012 40 Male 200 lb 1/26/2012 Pharmacist Canada
Primary
Concomitant
Injection Site Pain 11/26/2010 63 Female 150 lb 1/27/2012 Consumer United States
Primary
Concomitant
Nausea 5/1/2011 63 Female 1/28/2012 Consumer United States
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection 10/1/2010 57 Female 150 lb 1/27/2012 Consumer United States
Primary
Concomitant
Injection Site Erythema 1/30/2011 59 Male 1/27/2012 Consumer United States
Primary
Concomitant
Staphylococcal Infection 2/1/2010 65 Male 1/28/2012 Consumer United States
Primary
Concomitant
Injection Site Haematoma 1/1/2007 85 Female 95 lb 1/28/2012 Consumer United States
Primary
Concomitant
Injection Site Pain 12/1/2010 52 Female 1/28/2012 Consumer United States
Primary
Concomitant
Arthralgia 1/30/2011 59 Male 1/29/2012 Consumer United States
Primary
Concomitant
Injection Site Erythema 9/1/2011 38 Female 1/28/2012 Consumer United States
Primary
Concomitant
Lung Infiltration Other Serious 3/14/2011 56 Male 172 lb 2/3/2012 Physician Germany
Primary
Concomitant
Hypoaesthesia Hospitalization 11/1/2011 46 Female 2/15/2012 Physician Germany
Primary
Concomitant
Death Death 7/6/2011 47 Female 143 lb 2/16/2012 Physician Netherlands
Primary
Concomitant
Dizziness Other Serious 11/12/2011 64 Female 2/23/2012 Consumer France
Primary
Secondary
Concomitant
White Blood Cells Urine Positive Hospitalization 11/1/2010 68 Female 2/29/2012 Physician Canada
Primary
Concomitant
Cholelithiasis Other Serious Female 168 lb 3/1/2012 Physician New Zealand
Primary
Concomitant
Bone Pain Other Serious 1/1/2011 64 Female 3/6/2012 Other Health Professional Australia
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 11/1/2010 68 Female 3/6/2012 Physician Canada
Primary
Concomitant
Influenza Hospitalization 2/1/2012 66 Female 114 lb 2/28/2012 Physician United States
Primary
Concomitant
Tenderness Hospitalization 2/1/2012 66 Female 114 lb 2/22/2012 Pharmacist United States
Primary
Concomitant
Arthralgia Hospitalization 11/1/2008 70 Female 3/16/2012 Physician Germany
Primary
Concomitant
Cardiac Arrest Death 6/4/2011 72 Female 3/28/2012 Physician Germany
Primary
Concomitant
Night Sweats Other Serious 3/14/2012 23 Female 142 lb 4/27/2012 Physician United States
Primary
Concomitant
Paraesthesia Other Serious 1/1/2011 48 Male 204 lb 5/1/2012 Physician United States
Primary
Concomitant
Small Cell Lung Cancer Stage Unspecified Life Threatening 2/15/2012 64 Male 5/2/2012 Physician Australia
Primary
Secondary
Concomitant
Headache 67 Female 123 lb 5/2/2012 Consumer United States
Primary
Concomitant
Vision Blurred 4/1/2012 45 Female 5/2/2012 Other Health Professional United States
Primary
Concomitant
Femur Fracture Other Serious 6/1/2011 67 Female 5/14/2012 Consumer Canada
Primary
Concomitant
Arthritis Other Serious 1/1/2010 57 Male 172 lb 5/25/2012 Consumer United States
Primary
Concomitant
Pneumonia Hospitalization 5/14/2012 70 Female 148 lb 5/29/2012 Consumer Canada
Primary
Concomitant
Blood Cholesterol Decreased Other Serious 10/1/2010 86 Female 103 lb 6/12/2012 Physician United States
Primary
Concomitant
Dizziness Other Serious 3/14/2012 23 Female 142 lb 6/13/2012 Physician United States
Primary
Concomitant
Weight Increased Female 273 lb 6/13/2012 Consumer United States
Primary
Concomitant
Small Cell Lung Cancer Stage Unspecified Life Threatening 2/15/2012 65 Male 6/14/2012 Physician Australia
Primary
Secondary
Concomitant
Malaise Other Serious 1/1/2012 65 Female 6/15/2012 Physician United States
Primary
Concomitant
Hypertension Hospitalization 1/1/2011 65 Female 6/28/2012 Physician Canada
Primary
Concomitant
Cholecystitis Infective Hospitalization 6/5/2012 55 Female 180 lb 7/3/2012 Physician United States
Primary
Concomitant
Visual Impairment Other Serious 1/1/2007 53 Female 204 lb 7/10/2012 Consumer United States
Primary
Secondary
Concomitant
Arthralgia Other Serious 1/1/2007 53 Female 204 lb 7/11/2012 Consumer United States
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 7 Male 7/19/2012 Physician Brazil
Primary
Secondary
Concomitant
Interacting
Dizziness Other Serious 2/1/2011 66 Female 7/21/2011 Consumer United States
Primary
Secondary
Concomitant
Dementia 1/1/2009 81 Male 140 lb 8/2/2012 United States
Primary
Concomitant
Dizziness Other Serious Female 8/2/2012 Consumer Germany
Primary
Concomitant
Euphoric Mood Other Serious 7/2/2012 47 Male 8/9/2012 Other Health Professional Australia
Primary
Concomitant
Bladder Tamponade Other Serious 1/6/2011 68 Male 152 lb 8/13/2012 Physician Germany
Primary
Concomitant
Hypoaesthesia Hospitalization 11/1/2011 46 Female 8/20/2012 Physician Germany
Primary
Concomitant
Dementia 1/1/2009 81 Male 140 lb 8/20/2012 United States
Primary
Concomitant
Pulmonary Oedema Hospitalization 5/14/2012 71 Female 148 lb 9/18/2012 Consumer Ca
Primary
Concomitant
Dementia Death 2009 81 Male 140 lb 10/20/2012 Us
Primary
Concomitant
Septic Shock Other Serious 69 Female 8/30/2012 Physician Ca
Primary
Concomitant
Nausea Other Serious 8/14/2012 70 Female 2/19/2013 Consumer Us
Primary
Secondary
Concomitant

Drug Data