Alendronate Sodium combined with Leflunomide

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Rheumatoid Arthritis Other Serious 5/1/2005 Male 181 lb 1/18/2006 United Kingdom
Primary
Concomitant
Toe Amputation Other Serious 8/1/2003 Female 199 lb 1/20/2006 United States
Primary
Concomitant
Skin Ulcer Hospitalization 1/1/2005 Female 1/26/2006 Hungary
Primary
Concomitant
Vertigo Hospitalization 8/11/2005 Female 1/27/2006 Italy
Primary
Concomitant
Osteoarthritis Other Serious 8/1/2005 Female 135 lb 1/27/2006 United States
Primary
Concomitant
Psoriasis Other Serious 8/4/2005 Female 120 lb 2/6/2006 Canada
Primary
Concomitant
Pneumonia Hospitalization 12/30/2005 Female 128 lb 3/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Tinnitus Hospitalization 9/10/2005 Female 172 lb 3/15/2006 Germany
Primary
Concomitant
Renal Impairment Other Serious 7/5/2004 Female 3/27/2006 Pharmacist United Kingdom
Primary
Concomitant
Pneumonia Hospitalization 12/30/2005 Female 128 lb 4/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Wound Dehiscence Other Serious 7/29/2005 Female 117 lb 4/7/2006 Consumer Canada
Primary
Concomitant
Sepsis Hospitalization 12/30/2005 Female 128 lb 4/13/2006 Other Health Professional United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Hospitalization Male 4/21/2006 Physician Belgium
Primary
Concomitant
Rheumatoid Arthritis Hospitalization Male 4/26/2006 Physician Belgium
Primary
Concomitant
Psoriasis Other Serious 12/1/2005 Female 120 lb 5/8/2006 Consumer Canada
Primary
Concomitant
Wound Dehiscence Other Serious 7/29/2005 Female 117 lb 5/30/2006 Consumer Canada
Primary
Concomitant
Sepsis Hospitalization 12/30/2005 Female 128 lb 6/8/2006 Other Health Professional United Kingdom
Primary
Concomitant
Cerebrovascular Accident Hospitalization 5/1/2006 Female 7/24/2006 Physician Belgium
Primary
Concomitant
Staphylococcal Infection Hospitalization 2/1/2003 Female 178 lb 7/26/2006 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis Other Serious 5/25/2005 Male 181 lb 8/2/2006 Other Health Professional United Kingdom
Primary
Concomitant
Sepsis Hospitalization 12/25/2005 Female 128 lb 8/2/2006 Other Health Professional United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Hospitalization Male 8/7/2006 Physician Belgium
Primary
Concomitant
Subarachnoid Haemorrhage Other Serious Female 8/10/2006 Physician Ireland
Primary
Concomitant
Spinal Fracture Other Serious 6/1/2006 Female 118 lb 8/28/2006 Consumer United States
Primary
Concomitant
Pancreatic Carcinoma Life Threatening 5/19/2006 65 Female 8/28/2006 Other Health Professional United Kingdom
Primary
Concomitant
Depression Hospitalization 7/4/2006 22 Female 8/30/2006 Other Health Professional United Kingdom
Primary
Concomitant
Panic Attack Hospitalization 4/11/2005 Female 128 lb 9/11/2006 Consumer Canada
Primary
Concomitant
Panic Attack Hospitalization 4/11/2005 Female 128 lb 9/14/2006 Consumer Canada
Primary
Concomitant
Ventricular Arrhythmia Life Threatening 2/22/2006 Female 9/21/2006 Physician Germany
Primary
Concomitant
Vomiting Hospitalization 61 Female 9/25/2006
Primary
Secondary
Concomitant
Vision Blurred Hospitalization 4/5/2006 Female 146 lb 9/28/2006 Consumer United Kingdom
Primary
Concomitant
Wound Dehiscence Other Serious 7/29/2005 Female 117 lb 10/3/2006 Consumer Canada
Primary
Concomitant
Infection Other Serious 12/7/2004 Female 140 lb 11/3/2006 Physician United States
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 54 Female 11/13/2006 Other Health Professional United Kingdom
Primary
Concomitant
Spinal Fracture Other Serious 6/1/2006 Female 120 lb 11/21/2006 Physician United States
Primary
Concomitant
Unevaluable Event Hospitalization 11/14/2006 75 Female 154 lb 12/1/2006 Physician Greece
Primary
Secondary
Concomitant
Rectal Haemorrhage Death 9/13/2006 Female 163 lb 12/7/2006 Other Health Professional United Kingdom
Primary
Concomitant
Metastases To Bone Other Serious Male 12/8/2006 Physician New Zealand
Primary
Concomitant
Tooth Abscess Life Threatening 9/25/2006 Female 12/11/2006 Physician New Zealand
Primary
Secondary
Concomitant
Tooth Abscess Life Threatening 9/25/2006 Female 12/19/2006 Physician New Zealand
Primary
Secondary
Concomitant
Tinnitus Hospitalization 9/10/2005 Female 172 lb 12/28/2006 Germany
Primary
Concomitant
Convulsion Hospitalization 10/15/2006 Male 141 lb 1/9/2007 Other Health Professional United Kingdom
Primary
Concomitant
Vision Blurred Hospitalization 4/5/2006 Female 146 lb 1/19/2007 Consumer United Kingdom
Primary
Concomitant
Psoriasis Hospitalization Female 1/25/2007 Physician Belgium
Primary
Concomitant
Rectal Haemorrhage Death 9/13/2006 Female 163 lb 1/25/2007 Other Health Professional United Kingdom
Primary
Concomitant
Psoriasis Hospitalization Female 2/9/2007 Physician Belgium
Primary
Concomitant
Neutropenia Hospitalization 11/13/2006 56 Male 2/16/2007 Pharmacist United States
Primary
Secondary
Concomitant
Vision Blurred Hospitalization 4/5/2006 72 Female 146 lb 2/23/2007 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 1/1/2007 Female 127 lb 2/28/2007 Consumer Canada
Primary
Concomitant
Joint Swelling Hospitalization 3/14/2006 Female 126 lb 3/8/2007 Consumer United Kingdom
Primary
Concomitant
Vomiting Hospitalization 1/1/2007 Female 127 lb 3/22/2007 Consumer Canada
Primary
Concomitant
Lymphocytosis Hospitalization 11/17/2005 Female 3/28/2007 Other Health Professional United Kingdom
Primary
Concomitant
Erythema Multiforme Other Serious 11/5/2000 70 Female 3/30/2007 Physician Spain
Primary
Concomitant
Wound Dehiscence Other Serious 7/29/2005 Female 117 lb 4/13/2007 Consumer Canada
Primary
Concomitant
Vomiting Other Serious 3/15/2007 75 Female 4/27/2007 Physician Greece
Primary
Concomitant
Urinary Tract Infection Other Serious 11/16/2006 Female 123 lb 5/24/2007 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 54 Female 5/30/2007 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Tuberculosis Other Serious 5/15/2007 Female 108 lb 6/15/2007 Other Health Professional United Kingdom
Primary
Concomitant
Venous Pressure Jugular Increased Other Serious 3/15/2006 Female 146 lb 6/19/2007 Physician United Kingdom
Primary
Concomitant
Urinary Tract Infection Other Serious 5/19/2002 Female 7/11/2007 Other Health Professional United Kingdom
Primary
Concomitant
Joint Swelling Hospitalization 3/14/2006 Female 126 lb 7/25/2007 Consumer United Kingdom
Primary
Concomitant
Vision Blurred Hospitalization 4/5/2006 Female 146 lb 7/30/2007 Other Health Professional United Kingdom
Primary
Concomitant
Staphylococcal Infection Life Threatening 3/1/2007 68 Female 146 lb 8/3/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Acute Respiratory Failure Other Serious 7/31/2007 Female 8/13/2007 Greece
Primary
Concomitant
Respiratory Failure Hospitalization 3/9/2007 70 Male 8/15/2007 Germany
Primary
Concomitant
Pulmonary Tuberculosis Other Serious 5/15/2007 Female 108 lb 9/7/2007 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Embolism Hospitalization 12/15/2006 Female 170 lb 9/10/2007 United Kingdom
Primary
Concomitant
Urinary Tract Infection Other Serious 7/31/2007 Female 9/13/2007 Greece
Primary
Concomitant
Acute Respiratory Failure Other Serious 7/31/2007 Female 9/21/2007 Greece
Primary
Concomitant
Sepsis Other Serious 7/31/2007 Female 9/27/2007 Greece
Primary
Concomitant
Urinary Tract Infection Other Serious 3/1/2007 Female 10/11/2007 Belgium
Primary
Concomitant
Staphylococcal Infection Other Serious 3/1/2007 Female 10/18/2007 Belgium
Primary
Concomitant
Urinary Tract Infection Bacterial Other Serious 3/1/2007 Female 11/16/2007 Belgium
Primary
Concomitant
Respiratory Failure Hospitalization 3/9/2007 70 Male 11/21/2007 Germany
Primary
Concomitant
Surgery Other Serious 7/28/2007 Female 174 lb 11/30/2007 United Kingdom
Primary
Concomitant
Multiple Fractures Hospitalization 3/5/2004 Female 146 lb 12/7/2007 United Kingdom
Primary
Concomitant
Viral Infection Hospitalization 12/20/2006 Male 146 lb 12/7/2007 United Kingdom
Primary
Concomitant
Nausea 9/1/2007 Female 160 lb 12/14/2007 United States
Primary
Concomitant
Staphylococcal Infection Other Serious 3/1/2007 Female 12/21/2007 Belgium
Primary
Concomitant
Respiratory Failure Hospitalization 3/9/2007 70 Male 2/8/2008 Germany
Primary
Secondary
Concomitant
Tibia Fracture Other Serious 9/22/2007 Female 150 lb 3/6/2008 Canada
Primary
Concomitant
Knee Arthroplasty Other Serious 1/7/2008 24 Female 3/19/2008 Brazil
Primary
Concomitant
Vertigo Hospitalization 8/11/2005 Female 4/10/2008 Physician Italy
Primary
Concomitant
Urinary Tract Infection 3/27/2007 Female 180 lb 6/12/2008 United States
Primary
Concomitant
Infarction Hospitalization 2/21/2008 Male 6/26/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 2/21/2008 Male 7/11/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Upper Limb Fracture Hospitalization 11/1/2006 Female 7/11/2008 United States
Primary
Concomitant
Thyroid Function Test Abnormal Other Serious 3/1/2007 87 Female 139 lb 7/18/2008 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Surgery Hospitalization 3/31/2008 Female 181 lb 7/23/2008 United Kingdom
Primary
Concomitant
Myocardial Infarction Death 7/30/2008 Female 150 lb 8/15/2008 Canada
Primary
Concomitant
Breast Tenderness 5/1/2008 Female 9/12/2008 United States
Primary
Concomitant
Synovitis 1/1/2005 Female 178 lb 9/12/2008 United States
Primary
Concomitant
Vomiting Hospitalization 7/23/2008 Female 9/12/2008 United States
Primary
Concomitant
Road Traffic Accident 11/28/2007 Female 180 lb 9/13/2008 Consumer United States
Primary
Concomitant
Upper Limb Fracture Hospitalization 11/1/2006 Female 10/6/2008 United States
Primary
Concomitant
Encephalitis Hospitalization 5/13/2008 Female 170 lb 10/8/2008 United Kingdom
Primary
Concomitant
Respiratory Failure Death 6/11/2008 Male 150 lb 10/17/2008 United Kingdom
Primary
Concomitant
Rectal Haemorrhage Death 9/13/2006 Female 163 lb 10/20/2008 Other Health Professional United Kingdom
Primary
Concomitant
Rectal Haemorrhage Death 9/13/2006 Female 163 lb 10/20/2008 United Kingdom
Primary
Concomitant
Renal Failure Other Serious 4/1/2003 Female 10/31/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Nerve Compression Hospitalization 11/4/2004 Female 176 lb 12/2/2008 United Kingdom
Primary
Concomitant
Rhinorrhoea 11/12/2008 Female 116 lb 12/12/2008 Physician United States
Primary
Concomitant
Visual Field Defect Hospitalization 2/21/2008 Male 2/12/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Nephritis Other Serious 9/1/2008 61 Female 110 lb 6/19/2009 Physician United Kingdom
Primary
Concomitant
Tubulointerstitial Nephritis Other Serious 9/1/2008 61 Female 110 lb 6/29/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pulmonary Embolism Life Threatening 6/20/2009 Female 7/22/2009 Other Health Professional France
Primary
Secondary
Exostosis Hospitalization 1/1/2009 46 Female 8/21/2009 Consumer Germany
Primary
Secondary
Concomitant
Weight Increased Other Serious Female 8/31/2009 Brazil
Primary
Secondary
Concomitant
Weight Increased Other Serious Female 9/1/2009 Brazil
Primary
Secondary
Concomitant
Tubulointerstitial Nephritis Other Serious 60 Female 9/3/2009 United Kingdom
Primary
Secondary
Concomitant
Wrong Technique In Drug Usage Process 10/18/2006 Female 9/11/2009 Consumer United States
Primary
Concomitant
Musculoskeletal Stiffness 12/1/2006 Female 170 lb 9/11/2009 Consumer United States
Primary
Concomitant
Incorrect Dose Administered 4/23/2007 Female 98 lb 9/11/2009 Consumer United States
Primary
Concomitant
Type 1 Diabetes Mellitus Hospitalization 1/1/2008 Male 11/6/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Type 1 Diabetes Mellitus Other Serious 70 Male 12/8/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Hyponatraemia Disability 11/28/2009 79 Female 12/14/2009 Other Health Professional United Kingdom
Primary
Concomitant
Hyponatraemia Other Serious 11/28/2009 79 Female 12/18/2009 Other Health Professional United Kingdom
Primary
Concomitant
Metastatic Neoplasm Other Serious 5/15/2009 Female 146 lb 12/18/2009 Other Health Professional United Kingdom
Primary
Concomitant
Osteoporosis Other Serious 1/1/2006 Female 183 lb 12/21/2009 Brazil
Primary
Concomitant
Metastatic Neoplasm Other Serious 5/15/2009 Female 146 lb 2/8/2010 Other Health Professional United Kingdom
Primary
Concomitant
Pain Other Serious 1/1/2006 Female 183 lb 2/17/2010 Brazil
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 6/11/2008 51 Female 5/14/2010 Physician Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious Female 141 lb 5/24/2010 Brazil
Primary
Secondary
Concomitant
Pathological Fracture Other Serious 12/2/2009 78 Female 6/11/2010 Other Health Professional Spain
Primary
Concomitant
Tibia Fracture Required Intervention 48 Female 6/10/2010 Physician United States
Primary
Concomitant
Urinary Tract Infection Death Female 146 lb 6/17/2010 Consumer United Kingdom
Primary
Concomitant
Therapeutic Response Decreased Other Serious Female 8/27/2010 Pharmacist Canada
Primary
Concomitant
Wrist Fracture Other Serious 6/1/2006 49 Female 150 lb 9/28/2010 Consumer Brazil
Primary
Concomitant
Lung Squamous Cell Carcinoma Stage Unspecified Death 1/8/2010 11/16/2010 United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 2/19/2009 11/23/2010 Other Health Professional Japan
Primary
Concomitant
Nausea 2/1/2010 12/22/2010 Other Health Professional United States
Primary
Concomitant
Rash 6/22/2010 12/22/2010 Consumer United States
Primary
Concomitant
Feeling Abnormal 12/6/2010 55 Male 1/30/2011 Consumer United States
Primary
Concomitant
Injection Site Haematoma 9/28/2010 73 Female 110 lb 1/30/2011 Consumer United States
Primary
Concomitant
Osteitis Other Serious 1/3/2011 53 Female 137 lb 2/17/2011 Physician Poland
Primary
Concomitant
Weight Decreased Other Serious 3/15/2010 76 Female 4/12/2011 Physician Germany
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Disability 66 Male 3/31/2011 Other Health Professional United Kingdom
Primary
Concomitant
Skin Disorder Other Serious 12/1/2010 79 Male 176 lb 5/4/2011 Other Health Professional United Kingdom
Primary
Concomitant
Skin Disorder Other Serious 12/1/2010 79 Male 176 lb 5/6/2011 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Infarction Hospitalization 1/1/2011 77 Male 5/10/2011 Consumer Canada
Primary
Concomitant
Diabetic Foot Other Serious 12/1/2010 79 Male 5/7/2011 United Kingdom
Primary
Concomitant
Pneumonia Hospitalization 9/27/2009 74 Female 94 lb 5/23/2011 Physician Japan
Primary
Secondary
Concomitant
Dizziness Other Serious 9/27/2009 74 Female 94 lb 5/24/2011 Physician Japan
Primary
Secondary
Concomitant
Rheumatoid Factor Increased Hospitalization 9/27/2009 74 Female 94 lb 6/8/2011 Physician Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 2/19/2009 61 Female 134 lb 6/17/2011 Physician Japan
Primary
Concomitant
Non-small Cell Lung Cancer Other Serious 5/27/2011 66 Female 110 lb 7/27/2011 Other Health Professional United Kingdom
Primary
Concomitant
Pneumonitis Death 1/1/2011 67 Male 8/8/2011 Physician United Kingdom
Primary
Concomitant
Pneumonitis Death 1/1/2011 67 Male 8/9/2011 Physician United Kingdom
Primary
Concomitant
Dizziness Other Serious 6/1/2006 49 Female 150 lb 9/14/2011 Consumer Brazil
Primary
Concomitant
Post Procedural Complication Other Serious 1/1/2008 51 Female 150 lb 9/15/2011 Consumer Brazil
Primary
Concomitant

Drug Data