Leflunomide combined with Naproxen

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Respiratory Failure Life Threatening 5/30/2005 Male 168 lb 1/27/2006 Physician United Kingdom
Primary
Concomitant
Vasculitis Life Threatening 3/7/2005 Male 190 lb 2/9/2006 United Kingdom
Primary
Concomitant
Nausea Other Serious 4/20/2006 Male 247 lb 6/20/2006 Other Health Professional United Kingdom
Primary
Concomitant
Chronic Lymphocytic Leukaemia Other Serious 3/14/2006 Female 139 lb 7/5/2006 Greece
Primary
Concomitant
Osteitis Hospitalization 9/11/2006 Physician Belgium
Primary
Concomitant
Diarrhoea Hospitalization 8/29/2006 Female 121 lb 12/13/2006 Other Health Professional United Kingdom
Primary
Concomitant
Epstein-barr Virus Infection Other Serious 11/1/2004 Female 2/5/2007 Netherlands
Primary
Concomitant
Osteitis Hospitalization 10/28/2005 Female 2/7/2007 Physician Belgium
Primary
Concomitant
Wound Drainage Other Serious 10/28/2005 Female 2/16/2007 Physician Belgium
Primary
Secondary
Concomitant
Neutropenia Hospitalization 11/13/2006 56 Male 2/16/2007 Pharmacist United States
Primary
Secondary
Concomitant
Wound Drainage Other Serious 10/18/2005 Female 2/21/2007 Physician Belgium
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/1/2007 Female 127 lb 2/28/2007 Consumer Canada
Primary
Concomitant
Pustular Psoriasis Other Serious 19 Female 3/9/2007 Physician Canada
Primary
Concomitant
Vomiting Hospitalization 1/1/2007 Female 127 lb 3/22/2007 Consumer Canada
Primary
Concomitant
Epstein-barr Virus Infection 11/1/2004 Female 4/5/2007 Netherlands
Primary
Concomitant
Lung Disorder Hospitalization 4/1/2007 Female 4/19/2007 Physician Canada
Primary
Concomitant
Pulmonary Fibrosis Life Threatening 6/1/2005 Male 187 lb 4/23/2007 Physician Canada
Primary
Concomitant
Hypergammaglobulinaemia Benign Monoclonal Other Serious 4/10/2007 Female 110 lb 4/24/2007 Other Health Professional United Kingdom
Primary
Concomitant
Pancreatitis Acute Hospitalization 12/17/2006 42 Female 128 lb 4/25/2007 Physician Spain
Primary
Secondary
Lung Disorder Hospitalization 4/1/2007 Female 6/5/2007 Physician Canada
Primary
Concomitant
Hypergammaglobulinaemia Benign Monoclonal Other Serious 4/10/2007 Female 110 lb 6/11/2007 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 8/31/2006 Female 216 lb 6/19/2007 Other Health Professional United Kingdom
Primary
Concomitant
Chronic Lymphocytic Leukaemia Other Serious 3/14/2006 Female 139 lb 6/21/2007 Greece
Primary
Concomitant
Tendon Injury Hospitalization Female 251 lb 9/24/2007 Canada
Primary
Concomitant
Aspartate Aminotransferase Increased Other Serious 4/20/2006 Female 165 lb 11/15/2007 Physician United States
Primary
Concomitant
Underdose Hospitalization 1/1/1996 50 Female 11/15/2007 Lawyer United States
Primary
Concomitant
Necrotising Retinitis Other Serious 9/1/2007 54 Female 11/26/2007
Primary
Secondary
Concomitant
Retinal Infarction Other Serious 9/1/2007 54 Female 12/2/2007 United Kingdom
Primary
Secondary
Concomitant
Necrotising Retinitis Hospitalization 9/1/2007 54 Female 11/30/2007 United Kingdom
Primary
Secondary
Concomitant
Fatigue 6/1/2007 Female 130 lb 12/14/2007 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 1/1/1996 50 Female 12/17/2007 Physician United States
Primary
Concomitant
Joint Stiffness 10/8/2007 Female 12/14/2007 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/1996 50 Female 1/9/2008 Physician United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/1996 50 Female 1/29/2008 Physician United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/1996 50 Female 2/4/2008 Physician United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 4/20/2006 Female 165 lb 2/6/2008 Physician United States
Primary
Concomitant
Cerebrovascular Accident Life Threatening 11/1/2007 Male 251 lb 2/15/2008 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Other Serious 1/1/1996 50 Female 126 lb 2/18/2008 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 1/1/1996 50 Female 126 lb 2/21/2008 Physician United States
Primary
Secondary
Concomitant
Dyspnoea Life Threatening 11/7/2007 Male 251 lb 2/29/2008 United Kingdom
Primary
Concomitant
Injection Site Pain 1/1/2007 Female 168 lb 3/14/2008 Consumer United States
Primary
Concomitant
Peripheral Embolism Life Threatening 11/7/2007 Male 251 lb 4/4/2008 United Kingdom
Primary
Secondary
Concomitant
Pneumonia Legionella Death 4/17/2008 Male 5/1/2008 Physician New Zealand
Primary
Secondary
Concomitant
Pleuritic Pain Hospitalization 9/15/2006 Male 225 lb 5/12/2008 Physician United Kingdom
Primary
Concomitant
Pleuritic Pain Hospitalization 9/15/2006 Male 225 lb 5/19/2008 Physician United Kingdom
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Death 1/9/2008 Male 223 lb 6/4/2008 United Kingdom
Primary
Concomitant
Accidental Exposure 3/31/2008 Male 240 lb 6/12/2008 United States
Primary
Concomitant
Disseminated Tuberculosis Other Serious 5/14/2008 19 Female 8/15/2008 Physician Colombia
Primary
Concomitant
Hodgkin's Disease Other Serious 10 Female 8/27/2008 Physician United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis Death 1/9/2008 Male 223 lb 8/28/2008 United Kingdom
Primary
Concomitant
Skin Reaction 7/2/2008 Female 160 lb 9/12/2008 United States
Primary
Concomitant
Upper Respiratory Tract Infection Female 250 lb 9/13/2008 United States
Primary
Concomitant
Weight Decreased Other Serious 3/1/2007 Female 148 lb 9/17/2008 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2007 Female 148 lb 9/24/2008 Physician United States
Primary
Secondary
Concomitant
Hodgkin's Disease Other Serious 10 Female 9/26/2008 Physician United States
Primary
Secondary
Hodgkin's Disease Other Serious 10 Female 9/30/2008 Physician United Kingdom
Primary
Secondary
Hodgkin's Disease Other Serious 10 Female 10/2/2008 Other Health Professional United States
Primary
Secondary
Wheelchair User Other Serious 10 Female 10/17/2008 Physician United States
Primary
Secondary
Pneumonia Death 7/14/2008 Female 154 lb 10/27/2008 United Kingdom
Primary
Concomitant
Surgery Hospitalization 2/22/2008 Female 163 lb 10/29/2008 United Kingdom
Primary
Concomitant
Vascular Operation Hospitalization 2/22/2008 Female 163 lb 10/31/2008 United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 1/1/2007 79 Female 148 lb 10/29/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2007 75 Female 148 lb 10/29/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 3/1/2007 Female 148 lb 11/10/2008 Physician United States
Primary
Secondary
Concomitant
Ovarian Cancer Other Serious 1/30/2007 Female 154 lb 12/9/2008 United Kingdom
Primary
Concomitant
Tremor 1/1/2006 Female 148 lb 12/11/2008 Physician United States
Primary
Concomitant
Urinary Tract Infection Other Serious 1/1/1996 50 Female 126 lb 12/11/2008 Physician United States
Primary
Secondary
Concomitant
Hospitalisation Hospitalization Female 118 lb 12/18/2008
Primary
Concomitant
Subarachnoid Haemorrhage Other Serious 10/27/2008 Female 110 lb 12/29/2008 Physician United States
Primary
Secondary
Concomitant
Lower Respiratory Tract Infection Other Serious 8/25/2008 2/11/2009 Physician Colombia
Primary
Secondary
Concomitant
Rheumatoid Arthritis Death 1/9/2008 Male 223 lb 2/18/2009 United Kingdom
Primary
Concomitant
Lower Respiratory Tract Infection Other Serious 8/25/2008 2/18/2009 Physician Colombia
Primary
Secondary
Concomitant
Vomiting Other Serious 12/5/2008 57 Female 126 lb 3/6/2009 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Infarction Life Threatening 12/11/2008 57 Female 3/25/2009 Other Health Professional United Kingdom
Primary
Concomitant
Sepsis Death 4/10/2009 Physician New Zealand
Primary
Secondary
Sepsis Death 4/17/2009 Other Health Professional United Kingdom
Primary
Secondary
Hodgkin's Disease Other Serious 2 Female 5/8/2009 Other Health Professional United States
Primary
Secondary
Drug Exposure During Pregnancy Other Serious 38 Female 6/5/2009 Other Health Professional United Kingdom
Primary
Secondary
Abortion Spontaneous Other Serious 38 Female 6/8/2009 Other Health Professional United Kingdom
Primary
Secondary
Tooth Fracture Other Serious 9/28/2005 68 Female 123 lb 4/20/2009 Physician United States
Primary
Secondary
Concomitant
Sepsis Other Serious 4/17/2008 49 Male 6/29/2009
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 4/1/2009 Female 7/1/2009 Physician United Kingdom
Primary
Concomitant
Renal Failure Life Threatening 12/3/2004 65 Female 7/2/2009
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 4/1/2009 Female 240 lb 7/17/2009 United Kingdom
Primary
Concomitant
Myocardial Infarction Life Threatening 6/12/2008 73 7/28/2009 Physician Peru
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 1/1/1996 50 Female 126 lb 9/8/2009 Physician United States
Primary
Secondary
Concomitant
Injection Site Extravasation 9/11/2006 Male 185 lb 9/11/2009 Consumer United States
Primary
Concomitant
Incorrect Dose Administered 3/31/2008 Male 240 lb 9/12/2009 United States
Primary
Concomitant
Rash Pruritic Other Serious 7/1/2009 Female 10/26/2009 Consumer United States
Primary
Concomitant
Toothache Other Serious 9/29/2009 Female 204 lb 11/4/2009 Canada
Primary
Concomitant
Myocardial Infarction Life Threatening 12/11/2008 57 Female 165 lb 12/14/2009 Other Health Professional United Kingdom
Primary
Concomitant
Sepsis Death 4/17/2008 Male 1/7/2010 Physician New Zealand
Primary
Secondary
Concomitant
Skin Tightness Other Serious 1/1/2009 Female 158 lb 2/3/2010 Physician United States
Primary
Secondary
Concomitant
Postoperative Wound Infection Other Serious 12/1/2009 Female 128 lb 2/17/2010 Brazil
Primary
Concomitant
Myocardial Infarction Life Threatening 6/12/2008 73 Female 163 lb 3/3/2010 Physician Peru
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 6/12/2008 73 Female 163 lb 4/6/2010 Physician Peru
Primary
Secondary
Concomitant
Tooth Fracture Other Serious 9/28/2005 68 Female 123 lb 4/13/2010 Physician United States
Primary
Secondary
Concomitant
Pulmonary Mass Hospitalization 6/3/2010 55 Female 8/3/2010 Physician Thailand
Primary
Secondary
Concomitant
Vertigo Hospitalization 1/1/2009 51 Female 203 lb 8/9/2010 Consumer Brazil
Primary
Concomitant
Pneumonia Hospitalization 7/29/2010 55 Female 8/17/2010 Physician Thailand
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 6/1/2010 65 Female 10/22/2010 Physician Canada
Primary
Secondary
Concomitant
Tooth Disorder Other Serious 10/11/2010 59 Female 217 lb 11/5/2010 Other Health Professional Canada
Primary
Concomitant
Lung Disorder Other Serious 9/1/2010 53 Female 11/16/2010 Other Health Professional Canada
Primary
Concomitant
Pain In Extremity 10/30/2009 12/14/2010 Physician United States
Primary
Concomitant
Pneumonia Life Threatening 12/6/2010 52 Female 165 lb 12/17/2010 Physician Argentina
Primary
Secondary
Concomitant
Injection Site Reaction 2/1/2010 12/22/2010 Consumer United States
Primary
Concomitant
Pneumonia Life Threatening 12/6/2010 52 Female 165 lb 12/30/2010 Physician Argentina
Primary
Secondary
Concomitant
Death Other Serious 77 Female 137 lb 1/3/2011 Physician
Primary
Secondary
Tooth Fracture Other Serious 9/28/2005 68 Female 123 lb 10/28/2010 Physician United States
Primary
Secondary
Concomitant
Infection Hospitalization 12/1/2010 77 Male 1/7/2011 Consumer Canada
Primary
Concomitant
Pneumonia Life Threatening 12/6/2010 52 Female 165 lb 1/10/2011 Physician Argentina
Primary
Secondary
Concomitant
Anaphylactic Reaction Other Serious 10 Female 1/13/2011 Physician
Primary
Secondary
Concomitant
Acinetobacter Test Positive Hospitalization 12/6/2010 52 Female 165 lb 1/17/2011 Physician Argentina
Primary
Secondary
Concomitant
Hodgkin's Disease Other Serious 10 Female 1/24/2011 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 12/1/2010 Female 1/28/2011 Consumer Argentina
Primary
Secondary
Concomitant
Hodgkin's Disease Stage Ii Other Serious 10 Female 1/28/2011 Physician United States
Primary
Secondary
Concomitant
Human Herpesvirus 6 Infection Other Serious 30 Female 1/28/2011 Physician Spain
Primary
Concomitant
Lung Abscess Death 10/8/2009 78 Female 110 lb 1/28/2011 Other Health Professional United Kingdom
Primary
Concomitant
Joint Swelling 1/1/2009 60 Male 1/28/2011 United States
Primary
Concomitant
Pneumonia Death 12/6/2010 52 Female 165 lb 2/2/2011 Physician Argentina
Primary
Secondary
Concomitant
Haemodynamic Instability Hospitalization 12/1/2010 52 Female 165 lb 2/17/2011 Physician Argentina
Primary
Secondary
Concomitant
No Therapeutic Response Other Serious 10 Female 3/16/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 1/1/2010 65 Female 3/16/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Neck Pain Hospitalization 1/1/2010 65 Female 3/23/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Diarrhoea Other Serious 1/1/2008 55 Female 168 lb 4/12/2011 Consumer Argentina
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 1/1/2011 77 Male 5/10/2011 Consumer Canada
Primary
Concomitant
Tuberculosis Death 5/14/2011 52 Female 176 lb 7/1/2011 Physician Hungary
Primary
Concomitant
Hodgkin's Disease Stage Ii Other Serious 10 Female 7/1/2011 Physician United States
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 61 Female 8/10/2011 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Drug Interaction Hospitalization 61 Female 8/11/2011 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Chest Pain Other Serious 3/18/2009 61 Male 220 lb 8/17/2011 Physician United Kingdom
Primary
Concomitant
Haemorrhage Other Serious 1/1/2011 46 Female 8/23/2011 Consumer Argentina
Primary
Concomitant
Ischaemic Stroke Life Threatening 8/22/2011 64 Male 154 lb 9/6/2011 Other Health Professional United Kingdom
Primary
Concomitant
Ischaemic Stroke Life Threatening 8/22/2011 64 Male 154 lb 9/8/2011 Other Health Professional United Kingdom
Primary
Concomitant
Ischaemic Stroke Life Threatening 8/22/2011 64 Male 9/12/2011 United Kingdom
Primary
Concomitant
Limb Deformity Other Serious 1/1/2006 48 Female 167 lb 9/26/2011 Physician Canada
Primary
Concomitant
Pain Other Serious 1/1/2006 48 Female 167 lb 10/14/2011 Physician Canada
Primary
Concomitant
Ischaemic Stroke Life Threatening 8/23/2011 64 Male 154 lb 10/24/2011 Other Health Professional United Kingdom
Primary
Concomitant
Ischaemic Stroke Life Threatening 8/23/2011 64 Male 154 lb 10/25/2011 Other Health Professional United Kingdom
Primary
Concomitant
Diarrhoea Other Serious 1/1/2006 48 Female 167 lb 10/28/2011 Physician Canada
Primary
Concomitant
Ischaemic Stroke Life Threatening 8/23/2011 64 Male 10/27/2011 United Kingdom
Primary
Concomitant
Tuberculosis Death 5/1/2011 52 Female 176 lb 12/5/2011 Physician Hungary
Primary
Concomitant
Disease Progression Other Serious 11/10/2011 78 Female 181 lb 12/5/2011 Physician Argentina
Primary
Secondary
Concomitant
Nodule Other Serious 1/1/2008 53 Female 168 lb 12/13/2011 Consumer Argentina
Primary
Secondary
Concomitant
Dyspnoea 2/1/2011 55 Female 1/27/2012 Consumer United States
Primary
Concomitant
Fall Other Serious 6/1/2011 63 Female 119 lb 1/28/2012 Physician United States
Primary
Concomitant
Retinopathy Other Serious 1/31/2012 56 Male 2/15/2012 Consumer Canada
Primary
Concomitant
Ischaemic Stroke Life Threatening 8/23/2011 64 Male 154 lb 3/22/2012 Other Health Professional United Kingdom
Primary
Concomitant
Nephrolithiasis Other Serious 1/31/2012 53 Female 3/23/2012 Pharmacist United Kingdom
Primary
Concomitant
Ischaemic Stroke Life Threatening 8/23/2011 64 Male 154 lb 3/26/2012 Physician United Kingdom
Primary
Concomitant

Drug Data