Leflunomide combined with Levothyroxine Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vertigo Hospitalization 8/11/2005 Female 1/27/2006 Italy
Primary
Concomitant
Pancreatitis Hospitalization 1/4/2006 31 Female 128 lb 1/25/2006 Physician Mexico
Primary
Concomitant
Tinnitus Hospitalization 9/10/2005 Female 172 lb 3/15/2006 Germany
Primary
Concomitant
Pustular Psoriasis Other Serious 1/25/2006 Female 3/31/2006 Physician Belgium
Primary
Concomitant
Hypertension Hospitalization 7/1/2002 44 Female 4/27/2006 Norway
Primary
Concomitant
Hypertension Hospitalization 7/1/2002 44 Female 5/3/2006 Norway
Primary
Concomitant
Pustular Psoriasis Other Serious 1/25/2006 Female 5/4/2006 Physician Belgium
Primary
Concomitant
Nodule Other Serious 4/3/2005 Female 170 lb 5/5/2006 Consumer Canada
Primary
Concomitant
Pulmonary Fibrosis Death 4/19/2006 Female 325 lb 7/7/2006 Physician Canada
Primary
Concomitant
Shunt Occlusion Hospitalization 7/18/2006 Female 8/10/2006 Consumer Canada
Primary
Concomitant
Shunt Occlusion Hospitalization 7/18/2006 Female 9/8/2006 Consumer Canada
Primary
Concomitant
Volvulus Other Serious 10/29/2005 Male 115 lb 9/27/2006 Consumer United Kingdom
Primary
Concomitant
Volvulus Other Serious 10/29/2005 Male 115 lb 10/4/2006 Consumer United Kingdom
Primary
Concomitant
Staphylococcal Infection Hospitalization 10/4/2005 Female 10/4/2006 Physician Belgium
Primary
Concomitant
Urticaria Disability 1/1/2006 47 Female 10/27/2006 Other Health Professional France
Primary
Concomitant
Shunt Occlusion Hospitalization 7/18/2006 Female 11/7/2006 Consumer Canada
Primary
Concomitant
Coronary Artery Occlusion Other Serious 10/31/2006 Female 123 lb 11/13/2006 Consumer United States
Primary
Concomitant
Coronary Artery Occlusion Other Serious 10/31/2006 Female 123 lb 11/13/2006 Consumer United States
Primary
Concomitant
Subarachnoid Haemorrhage Hospitalization 11/1/2006 Female 236 lb 12/6/2006 Physician United States
Primary
Concomitant
Tinnitus Hospitalization 9/10/2005 Female 172 lb 12/28/2006 Germany
Primary
Concomitant
Musculoskeletal Stiffness Other Serious 6/3/2006 Female 185 lb 1/12/2007 Other Health Professional United Kingdom
Primary
Concomitant
Drug Ineffective Hospitalization 7/24/2006 Female 161 lb 1/17/2007 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Infarction Death 8/18/2006 Male 115 lb 1/27/2007 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased Hospitalization 1/1/2006 Female 163 lb 2/16/2007 Physician Germany
Primary
Secondary
Concomitant
Rash Pustular Hospitalization 6/1/2006 Female 154 lb 2/16/2007 Physician Denmark
Primary
Secondary
Concomitant
Lymphocytosis Hospitalization 11/17/2005 Female 3/28/2007 Other Health Professional United Kingdom
Primary
Concomitant
Gallbladder Operation Other Serious Male 190 lb 4/4/2007 Consumer Canada
Primary
Concomitant
Vibration Test Abnormal Other Serious 10/31/2006 Female 236 lb 5/25/2007 Physician United States
Primary
Concomitant
Venous Pressure Jugular Increased Other Serious 3/15/2006 Female 146 lb 6/19/2007 Physician United Kingdom
Primary
Concomitant
Spinal Decompression Other Serious 1/28/2007 Female 84 lb 6/22/2007 Other Health Professional United Kingdom
Primary
Concomitant
Hospitalisation Hospitalization Female 7/13/2007 Canada
Primary
Concomitant
Spinal Decompression Other Serious 1/28/2007 Female 84 lb 8/6/2007 Other Health Professional United Kingdom
Primary
Concomitant
Chest Pain Hospitalization 7/7/2007 Female 155 lb 8/29/2007 Canada
Primary
Concomitant
Intervertebral Disc Compression Hospitalization 7/1/2007 Female 128 lb 8/30/2007 Physician United States
Primary
Concomitant
Surgery Hospitalization 7/18/2007 Female 130 lb 8/31/2007 Consumer United States
Primary
Secondary
Concomitant
Septic Shock Hospitalization 8/15/2007 Female 170 lb 9/6/2007 United Kingdom
Primary
Concomitant
Supraventricular Tachycardia Other Serious 4/27/2007 Female 159 lb 9/26/2007
Primary
Concomitant
Supraventricular Tachycardia Other Serious 4/27/2007 Female 159 lb 10/8/2007
Primary
Concomitant
Tuberculosis Test Positive Other Serious 9/1/2005 Female 143 lb 11/2/2007 Physician Argentina
Primary
Concomitant
Tinnitus Disability 1/1/2007 Female 267 lb 11/7/2007 Other Health Professional United Kingdom
Primary
Concomitant
General Physical Health Deterioration Other Serious 4/1/2007 Female 161 lb 11/21/2007 Germany
Primary
Concomitant
Speech Disorder Hospitalization 5/25/2007 Female 108 lb 11/21/2007 United Kingdom
Primary
Concomitant
Necrotising Retinitis Other Serious 9/1/2007 54 Female 11/26/2007
Primary
Secondary
Concomitant
General Physical Health Deterioration Other Serious 4/1/2007 Female 161 lb 11/26/2007 Germany
Primary
Concomitant
Septic Shock Hospitalization 8/15/2007 Female 170 lb 11/29/2007 United Kingdom
Primary
Concomitant
Cholecystectomy Hospitalization Female 11/30/2007 Belgium
Primary
Concomitant
Retinal Infarction Other Serious 9/1/2007 54 Female 12/2/2007 United Kingdom
Primary
Secondary
Concomitant
Somnolence 8/24/2007 49 Male 255 lb 11/8/2007 Consumer United States
Primary
Concomitant
Tuberculosis Test Positive Other Serious 9/1/2005 Female 143 lb 12/4/2007 Physician Argentina
Primary
Concomitant
Necrotising Retinitis Hospitalization 9/1/2007 54 Female 11/30/2007 United Kingdom
Primary
Secondary
Concomitant
Injection Site Pain 1/1/2004 Female 185 lb 12/14/2007 Consumer United States
Primary
Concomitant
Arthritis Bacterial Hospitalization 9/15/2004 Female 134 lb 12/19/2007 Germany
Primary
Concomitant
Tinnitus Hospitalization 1/7/2008 Female 110 lb 1/16/2008 Physician Brazil
Primary
Concomitant
Tinnitus Hospitalization 1/7/2008 Female 110 lb 1/22/2008 Physician Brazil
Primary
Concomitant
Tinnitus Hospitalization 1/7/2008 Female 110 lb 1/28/2008 Physician Brazil
Primary
Concomitant
Tinnitus Hospitalization 1/7/2008 Female 110 lb 1/29/2008 Physician Brazil
Primary
Concomitant
Drug Ineffective 11/1/2007 Female 180 lb 3/14/2008 Consumer United States
Primary
Concomitant
White Blood Cell Count Decreased 1/7/2007 Female 100 lb 3/14/2008 Physician United States
Primary
Concomitant
Sinusitis 2/5/2008 Female 150 lb 3/15/2008 United States
Primary
Concomitant
Knee Arthroplasty Other Serious 1/7/2008 24 Female 3/19/2008 Brazil
Primary
Concomitant
Uterine Leiomyoma Other Serious 3/1/2007 Female 152 lb 3/27/2008 United States
Primary
Concomitant
Vertigo Hospitalization 8/11/2005 Female 4/10/2008 Physician Italy
Primary
Concomitant
Drug Toxicity Death 5/9/2007 Female 134 lb 4/28/2008 Physician United States
Primary
Secondary
Concomitant
Hypertension Hospitalization 10/24/2007 Female 154 lb 5/15/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Spinal Osteoarthritis Hospitalization 1/1/2004 Female 110 lb 5/16/2008 United States
Primary
Concomitant
Peripheral Embolism Hospitalization 5/16/2008 Male 210 lb 6/2/2008 United States
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Death 1/9/2008 Male 223 lb 6/4/2008 United Kingdom
Primary
Concomitant
Peripheral Embolism Hospitalization 5/16/2008 Male 210 lb 6/6/2008 United States
Primary
Concomitant
Pharyngolaryngeal Pain 3/30/2008 Female 192 lb 6/12/2008 United States
Primary
Concomitant
Skin Warm 3/25/2008 Female 115 lb 6/12/2008 Physician United States
Primary
Concomitant
Hepatic Enzyme Increased 4/10/2008 Female 140 lb 6/12/2008 Consumer United States
Primary
Secondary
Concomitant
Injection Site Rash 5/2/2008 Female 148 lb 6/13/2008 United States
Primary
Concomitant
Arrhythmia Death 5/22/2006 Female 6/18/2008 Germany
Primary
Concomitant
Sensory Loss Other Serious 5/23/2007 Male 251 lb 6/20/2008 Lawyer United States
Primary
Concomitant
Hyperplasia Hospitalization 8/21/2007 58 Female 6/30/2008 Germany
Primary
Secondary
Concomitant
Hyperplasia Hospitalization 8/21/2007 58 Female 7/11/2008 Germany
Primary
Secondary
Concomitant
Influenza Like Illness Hospitalization 7/25/2007 Female 143 lb 7/17/2008 United Kingdom
Primary
Concomitant
Thyroid Function Test Abnormal Other Serious 3/1/2007 87 Female 139 lb 7/18/2008 Physician United States
Primary
Secondary
Concomitant
Arthritis Bacterial Hospitalization 9/15/2004 Female 134 lb 7/25/2008 Germany
Primary
Concomitant
Arrhythmia Death 5/22/2006 Female 8/7/2008 Germany
Primary
Concomitant
Rash Pruritic 6/24/2008 Male 186 lb 8/8/2008 Physician United States
Primary
Concomitant
Deafness Hospitalization 1/7/2008 Female 110 lb 8/11/2008 Physician Brazil
Primary
Concomitant
Spinal Fusion Surgery Other Serious 1/1/2006 152 lb 8/11/2008 Other Health Professional United States
Primary
Concomitant
Hyperglycaemia Hospitalization 8/1/2004 75 Female 8/25/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Hyperglycaemia Hospitalization Female 8/27/2008 United States
Primary
Secondary
Concomitant
Hyperglycaemia Hospitalization 8/1/2004 Female 9/4/2008 United States
Primary
Secondary
Concomitant
Colitis Hospitalization 55 Female 128 lb 9/8/2008 Germany
Primary
Concomitant
Pneumonia Other Serious 1/24/2007 60 Female 190 lb 9/10/2008 Physician Finland
Primary
Secondary
Concomitant
Sneezing 3/19/2008 Female 123 lb 9/12/2008 United States
Primary
Concomitant
Pruritus Generalised 5/1/2008 Female 165 lb 9/12/2008 United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis 4/1/2008 Female 226 lb 9/12/2008 Other Health Professional United States
Primary
Concomitant
Injection Site Irritation 5/15/2008 Female 114 lb 9/12/2008 United States
Primary
Concomitant
Road Traffic Accident 11/28/2007 Female 180 lb 9/13/2008 Consumer United States
Primary
Concomitant
Injection Site Pain 5/1/2008 Female 131 lb 9/13/2008 Consumer United States
Primary
Concomitant
Interstitial Lung Disease Hospitalization 4/1/2007 Female 156 lb 9/13/2008 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 3/1/2007 Female 148 lb 9/17/2008 Physician United States
Primary
Secondary
Concomitant
Arthritis Bacterial Hospitalization 9/15/2004 Female 134 lb 9/18/2008 Germany
Primary
Concomitant
Weight Decreased Other Serious 1/1/2007 Female 148 lb 9/24/2008 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 8/1/2007 Female 9/26/2008 Physician United States
Primary
Secondary
Concomitant
Spinal Disorder Hospitalization 1/1/2007 Female 126 lb 10/16/2008 Brazil
Primary
Concomitant
Death Other Serious Male 179 lb 10/20/2008 Other Health Professional United Kingdom
Primary
Concomitant
Sepsis Other Serious 8/9/2008 Male 179 lb 10/28/2008 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 1/1/2007 79 Female 148 lb 10/29/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2007 75 Female 148 lb 10/29/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 3/1/2007 Female 148 lb 11/10/2008 Physician United States
Primary
Secondary
Concomitant
Hyperglycaemia Hospitalization 8/1/2004 Female 149 lb 11/20/2008 United States
Primary
Secondary
Concomitant
Oedema Peripheral 8/1/2008 Female 12/12/2008 United States
Primary
Concomitant
Underdose Male 180 lb 12/12/2008 Consumer United States
Primary
Concomitant
Pain 8/1/2008 Female 190 lb 12/12/2008 Consumer United States
Primary
Concomitant
Drug Ineffective 8/29/2008 Female 162 lb 12/12/2008 Consumer United States
Primary
Concomitant
Pain 9/1/2007 Female 155 lb 12/12/2008 United States
Primary
Concomitant
Nasopharyngitis 10/21/2008 Female 182 lb 12/12/2008 United States
Primary
Concomitant
Weight Decreased 1/1/2008 Female 149 lb 12/12/2008 United States
Primary
Secondary
Concomitant
Metastases To Liver Death 4/18/2007 Female 1/5/2009 Physician United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 7/1/2007 Female 1/20/2009 Germany
Primary
Concomitant
Immunodeficiency Hospitalization Female 1/20/2009 Brazil
Primary
Concomitant
Immune System Disorder Hospitalization Female 1/21/2009 Brazil
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 7/1/2007 Female 2/4/2009 Germany
Primary
Concomitant
Rheumatoid Arthritis Death 1/9/2008 Male 223 lb 2/18/2009 United Kingdom
Primary
Concomitant
Drug Exposure During Pregnancy 6/29/2008 39 Female 121 lb 4/30/2009 Argentina
Primary
Secondary
Thrombosis Mesenteric Vessel Hospitalization 5/24/2002 41 Female 7/10/2009
Primary
Secondary
Concomitant
Pyrexia Hospitalization 6/26/2009 Female 189 lb 7/16/2009 Canada
Primary
Concomitant
Rash Other Serious 7/16/2009 58 Female 187 lb 7/17/2009 Physician United States
Primary
Concomitant
Injection Site Extravasation 9/11/2006 Male 185 lb 9/11/2009 Consumer United States
Primary
Concomitant
Musculoskeletal Stiffness 12/1/2006 Female 170 lb 9/11/2009 Consumer United States
Primary
Concomitant
Injection Site Irritation 1/1/2004 Female 97 lb 9/11/2009 Consumer United States
Primary
Concomitant
Incorrect Dose Administered 8/1/2007 Female 180 lb 9/12/2009 Consumer United States
Primary
Concomitant
Incorrect Dose Administered 4/10/2008 Female 140 lb 9/12/2009 Consumer United States
Primary
Secondary
Concomitant
Injection Site Pain 5/1/2008 Female 131 lb 9/12/2009 Consumer United States
Primary
Concomitant
Pain 8/1/2008 Female 190 lb 9/12/2009 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis 4/1/2008 Female 226 lb 9/12/2009 Other Health Professional United States
Primary
Concomitant
Headache 6/11/2009 Female 9/19/2009 Consumer United States
Primary
Concomitant
Rhinorrhoea 7/12/2009 Female 162 lb 9/19/2009 United States
Primary
Concomitant
Loss Of Consciousness Other Serious 7/1/2008 55 Female 174 lb 10/9/2009 Consumer United States
Primary
Concomitant
Loss Of Consciousness Other Serious 7/1/2008 55 Female 174 lb 10/14/2009 Consumer United States
Primary
Concomitant
Temperature Intolerance Death 6/30/2009 Female 10/15/2009 Germany
Primary
Concomitant
Vaginal Infection Other Serious 5/8/2009 46 Female 233 lb 10/20/2009 Other Health Professional United States
Primary
Concomitant
Osteopenia Other Serious 1/1/2007 Female 150 lb 11/25/2009 Brazil
Primary
Concomitant
Pain Management Other Serious 1/1/2007 Female 150 lb 12/1/2009 Brazil
Primary
Concomitant
Dizziness Exertional 3/31/2009 Female 12/8/2009 Physician United States
Primary
Concomitant
Rhinorrhoea 7/12/2009 Female 162 lb 12/10/2009 Consumer United States
Primary
Secondary
Concomitant
Metastatic Neoplasm Other Serious 5/15/2009 Female 146 lb 12/18/2009 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Embolism Hospitalization 2/9/2008 Female 209 lb 12/23/2009 United Kingdom
Primary
Concomitant
Hypoglycaemia Other Serious 12/18/2009 Female 154 lb 1/28/2010 Brazil
Primary
Concomitant
Death Death 12/23/2009 Female 163 lb 2/2/2010 Physician United Kingdom
Primary
Concomitant
Metastatic Neoplasm Other Serious 5/15/2009 Female 146 lb 2/8/2010 Other Health Professional United Kingdom
Primary
Concomitant
Postoperative Wound Infection Other Serious 12/1/2009 Female 128 lb 2/17/2010 Brazil
Primary
Concomitant
Myocardial Infarction Hospitalization 3/16/2008 73 Female 4/19/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Cholecystitis Hospitalization 11/9/2008 74 Female 4/20/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious Female 4/30/2010 Physician Belgium
Primary
Concomitant

Drug Data