Fosamax combined with Leflunomide

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Tooth Extraction Disability 12/22/2005 52 Female 5/23/2006 Other Health Professional Australia
Primary
Secondary
Concomitant
Osteonecrosis Hospitalization 9/15/2003 67 Female 5/31/2006 Other Health Professional Australia
Primary
Concomitant
Osteonecrosis Hospitalization 9/15/2003 67 Female 6/5/2006 Physician Australia
Primary
Concomitant
Tooth Infection Other Serious 5/14/2004 54 Male 229 lb 6/28/2006 Physician United States
Primary
Concomitant
Thrombosis Hospitalization 1/1/2003 62 Female 7/13/2006 Consumer Australia
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 5/14/2004 54 Male 229 lb 8/11/2006 Physician United States
Primary
Concomitant
Tooth Avulsion Other Serious 4/1/2005 69 Female 12/27/2006 Other Health Professional France
Primary
Concomitant
Osteonecrosis Hospitalization 2/1/2004 64 Female 110 lb 1/19/2007 Physician Spain
Primary
Concomitant
Osteonecrosis Hospitalization 9/15/2003 67 Female 3/5/2007 Physician Australia
Primary
Concomitant
Pulmonary Embolism Life Threatening 3/1/2007 68 Female 146 lb 8/9/2007
Primary
Secondary
Concomitant
Foot Amputation Hospitalization 10/11/2006 34 Male 154 lb 9/18/2007 Physician United States
Primary
Concomitant
Basal Cell Carcinoma Other Serious 4/25/2007 75 Female 132 lb 9/28/2007 Other Health Professional United Kingdom
Primary
Concomitant
Respiratory Disorder Female 10/25/2007 Consumer United States
Primary
Concomitant
Underdose Hospitalization 1/1/1996 50 Female 11/15/2007 Lawyer United States
Primary
Concomitant
Staphylococcal Infection Other Serious 9/19/2006 Male 11/28/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Vomiting Other Serious 11/30/2007 Male 12/5/2007 Pharmacist United States
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 1/1/1996 50 Female 12/17/2007 Physician United States
Primary
Concomitant
Osteonecrosis Other Serious 6/1/2004 45 Female 152 lb 11/28/2007 Other Health Professional United States
Primary
Concomitant
Wrist Fracture Other Serious 2/1/2000 67 Female 93 lb 11/28/2007 United States
Primary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/1996 50 Female 1/9/2008 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 10/1/2007 Female 1/28/2008 Physician Germany
Primary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/1996 50 Female 1/29/2008 Physician United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/1996 50 Female 2/4/2008 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 1/1/1996 50 Female 126 lb 2/18/2008 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 1/1/1996 50 Female 126 lb 2/21/2008 Physician United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 4/1/2005 69 Female 2/22/2008 Other Health Professional France
Primary
Concomitant
Vomiting Required Intervention 1/1/2007 62 Male 12/5/2007 Other Health Professional United States
Primary
Concomitant
Benign Intracranial Hypertension Other Serious 8 Male 1/9/2008 Physician United States
Primary
Concomitant
Osteonecrosis Hospitalization 2/1/2004 64 Female 110 lb 6/6/2008 Physician Spain
Primary
Concomitant
Femur Fracture Other Serious 10/1/2004 63 Female 6/25/2008 Physician Australia
Primary
Concomitant
Wrist Fracture Other Serious 2/1/2000 67 Female 93 lb 7/3/2008 Physician United States
Primary
Concomitant
Wrist Fracture Other Serious 2/1/2000 67 Female 93 lb 8/21/2008 Physician United States
Primary
Concomitant
Wrist Fracture Other Serious 2/1/2000 67 Female 93 lb 8/29/2008 Physician United States
Primary
Concomitant
Urinary Tract Infection Other Serious 1/1/1996 50 Female 126 lb 12/11/2008 Physician United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 4/4/2007 Female 126 lb 2/2/2009 United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 4/4/2007 Female 126 lb 2/5/2009 United Kingdom
Primary
Concomitant
Synovitis Hospitalization 5/8/2008 Female 170 lb 2/20/2009 United Kingdom
Primary
Secondary
Concomitant
Death Other Serious 74 Male 143 lb 2/23/2009 Other Health Professional United Kingdom
Primary
Concomitant
Synovitis Hospitalization 5/8/2008 Female 170 lb 2/25/2009 United Kingdom
Primary
Secondary
Concomitant
Benign Intracranial Hypertension Other Serious 8 Male 1/7/2009 Physician United States
Primary
Concomitant
Wrist Fracture Other Serious 2/1/2000 67 Female 93 lb 3/10/2009 Physician United States
Primary
Concomitant
Renal Failure Other Serious 10/7/2008 74 Male 143 lb 3/11/2009 Other Health Professional United Kingdom
Primary
Concomitant
Rheumatoid Arthritis 7/1/2008 Male 3/14/2009 United States
Primary
Secondary
Concomitant
Wrist Fracture Other Serious 2/1/2000 67 Female 93 lb 4/8/2009 Physician United States
Primary
Concomitant
Wrist Fracture Other Serious 2/1/2000 67 Female 93 lb 4/30/2009 Physician United States
Primary
Concomitant
Renal Failure Other Serious 10/7/2008 74 Male 143 lb 5/12/2009 Other Health Professional United Kingdom
Primary
Concomitant
Crohn's Disease Other Serious 1/1/2009 52 Female 5/15/2009 Consumer United Kingdom
Primary
Concomitant
Renal Failure Other Serious 10/7/2008 74 Male 143 lb 5/18/2009 Other Health Professional United Kingdom
Primary
Concomitant
Intestinal Stoma Other Serious 6/15/2008 Male 168 lb 6/10/2009 United Kingdom
Primary
Concomitant
Tuberculosis Of Central Nervous System Hospitalization 5/8/2008 Female 170 lb 7/31/2009 United Kingdom
Primary
Secondary
Concomitant
Pulmonary Embolism Life Threatening 6/20/2009 74 Female 8/13/2009 Other Health Professional France
Primary
Secondary
Exostosis Hospitalization 1/1/2009 46 Female 8/21/2009 Consumer Germany
Primary
Secondary
Concomitant
Tubulointerstitial Nephritis Other Serious 9/1/2008 60 Female 117 lb 8/24/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 1/1/1996 50 Female 126 lb 9/8/2009 Physician United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization Female 9/11/2009 Physician United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization Female 9/22/2009 Physician United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization Female 9/30/2009 Physician United States
Primary
Concomitant
Wrist Fracture Other Serious 2/1/2000 67 Female 93 lb 10/2/2009 Physician United States
Primary
Concomitant
Oral Lichen Planus Other Serious 4/14/2008 Female 110 lb 10/5/2009 Physician Canada
Primary
Concomitant
Wrist Fracture Other Serious 2/1/2000 67 Female 93 lb 10/6/2009 Physician United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization Female 10/27/2009 Physician United States
Primary
Concomitant
Stress Fracture Hospitalization 6/1/2009 Female 11/2/2009 Other Health Professional United Kingdom
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 6/1/2009 Female 11/19/2009 Physician United States
Primary
Concomitant
Staphylococcal Infection 1/8/2007 Female 140 lb 12/4/2009 Physician United States
Primary
Concomitant
Urinary Tract Infection 3/4/2009 Female 162 lb 12/8/2009 Physician United States
Primary
Concomitant
Haemorrhage Intracranial Death Female 80 lb 2/2/2010 Consumer United States
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 4/7/2009 Female 2/3/2010 United Kingdom
Primary
Concomitant
Haemorrhage Intracranial Death 12/24/2009 Female 88 lb 2/11/2010 Physician United States
Primary
Concomitant
Bursa Disorder Other Serious 12/12/2005 Male 2/25/2010 United Kingdom
Primary
Concomitant
Haemorrhage Intracranial Death 12/24/2009 Female 88 lb 3/4/2010 Physician United States
Primary
Concomitant
Intestinal Stoma Other Serious 6/15/2008 Male 168 lb 3/17/2010 United Kingdom
Primary
Concomitant
Pulmonary Embolism Other Serious 3/25/2009 Female 3/22/2010 United Kingdom
Primary
Concomitant
Pathological Fracture Other Serious 12/2/2009 78 Female 5/7/2010 Other Health Professional Spain
Primary
Concomitant
Pathological Fracture Other Serious 12/2/2009 78 Female 6/2/2010 Other Health Professional Spain
Primary
Concomitant
Vomiting 6/22/2010 66 Female 130 lb 7/6/2010 Consumer United States
Primary
Concomitant
Sinusitis Other Serious 10/7/2008 44 Female 146 lb 7/8/2010 Lawyer Italy
Primary
Concomitant
Diarrhoea Hospitalization Female 161 lb 7/8/2010 Physician Germany
Primary
Concomitant
Sinusitis Other Serious 10/7/2008 44 Female 146 lb 7/9/2010 Lawyer Italy
Primary
Concomitant
Vomiting 6/22/2010 66 Female 130 lb 7/26/2010 Consumer United States
Primary
Concomitant
Vomiting 6/22/2010 66 Female 130 lb 8/12/2010 Physician United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 6/1/2009 72 Female 8/23/2010 Physician United States
Primary
Concomitant
Wrist Fracture Other Serious 2/1/2000 67 Female 93 lb 9/10/2010 Physician United States
Primary
Concomitant
Tooth Disorder Other Serious 3/1/2007 44 Female 146 lb 11/16/2010 Physician Italy
Primary
Concomitant
Pulmonary Fibrosis Death 3/19/2010 53 Female 128 lb 11/23/2010 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Fibrosis Death 3/19/2010 53 Female 128 lb 12/10/2010 Other Health Professional United Kingdom
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 1/1/2008 64 Female 103 lb 1/11/2011 Other Health Professional Canada
Primary
Concomitant
Sinusitis Other Serious 1/1/2008 47 Female 175 lb 1/28/2011 Physician United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Death 6/1/2009 72 Female 2/3/2011 Physician United States
Primary
Concomitant
Femur Fracture Other Serious 11/17/2010 66 Female 2/23/2011 Physician Ireland
Primary
Concomitant
Femur Fracture Hospitalization 11/16/2010 67 Female 3/16/2011 Physician Ireland
Primary
Concomitant
Systemic Lupus Erythematosus Other Serious 12/1/2010 56 Female 141 lb 4/1/2011 Other Health Professional Slovenia
Primary
Concomitant
Aneurysm Hospitalization 3/1/2011 59 Female 5/6/2011 Consumer Australia
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 6/1/2009 72 Female 5/16/2011 Physician United States
Primary
Concomitant
Pathological Fracture Hospitalization 11/1/2010 48 Male 227 lb 5/17/2011 Consumer Canada
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Death 6/1/2009 72 Female 5/18/2011 Consumer United States
Primary
Concomitant
Fracture Hospitalization 6/13/2010 63 Female 5/19/2011 Other Health Professional Australia
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Other Serious 7/25/2007 59 Female 6/23/2011 Other Health Professional United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Death 6/1/2009 72 Female 8/5/2011 Physician United States
Primary
Concomitant
Respiratory Failure Death 5/1/2011 67 Male 161 lb 8/9/2011 Physician United Kingdom
Primary
Concomitant
Osteonecrosis Of Jaw Other Serious 9/9/2011 Other Health Professional United Kingdom
Primary
Secondary
Appendicitis Perforated Hospitalization 7/1/2007 Female 9/23/2011 Lawyer United States
Primary
Concomitant
Arthropathy Other Serious 7/1/2007 64 Female 9/28/2011 Physician United States
Primary
Concomitant
Osteomyelitis Other Serious 7/1/2007 64 Female 10/6/2011 Physician United States
Primary
Secondary
Concomitant
Femur Fracture Hospitalization 9/12/2011 67 Female 10/10/2011 Other Health Professional United Kingdom
Primary
Concomitant
Edentulous Other Serious 4/5/2007 64 Female 10/17/2011 Physician United States
Primary
Secondary
Concomitant
Femur Fracture Hospitalization 9/12/2011 67 Female 10/20/2011 Other Health Professional United Kingdom
Primary
Concomitant
Pathological Fracture Other Serious 12/2/2009 78 Female 10/24/2011 Other Health Professional Spain
Primary
Secondary
Concomitant
Hypertension Other Serious 4/5/2007 64 Female 10/27/2011 Physician United States
Primary
Secondary
Concomitant
Tooth Extraction Hospitalization 4/5/2007 64 Female 11/1/2011 Physician United States
Primary
Secondary
Concomitant
Oral Infection Other Serious 4/5/2007 64 Female 12/5/2011 Physician United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 11/1/2010 48 Male 227 lb 12/7/2011 Consumer Canada
Primary
Secondary
Concomitant
Synovitis Other Serious 11/1/2001 Female 12/9/2011 Physician Brazil
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 6/1/2009 72 Female 1/4/2012 Other Health Professional United States
Primary
Concomitant
Cellulitis Hospitalization 70 Female 1/24/2012 Physician Spain
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection 10/1/2010 57 Female 150 lb 1/27/2012 Consumer United States
Primary
Concomitant
Rash Pruritic 10/1/2011 65 Female 1/29/2012 Consumer United States
Primary
Concomitant
Cellulitis Hospitalization 70 Female 2/17/2012 Physician Spain
Primary
Secondary
Concomitant
Bone Disorder Hospitalization 4/5/2007 64 Female 2/23/2012 Physician United States
Primary
Secondary
Concomitant
Hypertension Hospitalization 4/5/2007 64 Female 2/27/2012 Physician United States
Primary
Secondary
Concomitant
Pneumonia Death 5/1/2009 52 Female 146 lb 3/19/2012 Other Health Professional United Kingdom
Primary
Concomitant
Drug Ineffective Other Serious 1/1/2005 62 Female 5/4/2012 Physician United States
Primary
Concomitant
Back Pain Other Serious 4/1/2002 55 Female 121 lb 5/29/2012 Physician United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 5/14/2012 70 Female 148 lb 5/29/2012 Consumer Canada
Primary
Concomitant
Tonsillar Disorder Other Serious 1/1/2003 72 Female 170 lb 6/1/2012 Physician United States
Primary
Concomitant
Dysaesthesia Hospitalization 1/1/2005 63 Female 6/4/2012 Physician United States
Primary
Concomitant
Drug Interaction Other Serious 1/1/2005 63 Female 6/20/2012 Physician United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Other Serious 7/25/2007 59 Female 6/22/2012 Other Health Professional United States
Primary
Concomitant
Klebsiella Infection Other Serious 1/1/2003 72 Female 170 lb 6/22/2012 Physician United States
Primary
Concomitant
Osteonecrosis Of Jaw Hospitalization 56 Female 7/17/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Gastrooesophageal Reflux Disease Disability 1/1/2005 7/27/2012 Consumer United States
Primary
Concomitant
Asthenia Hospitalization 5/17/2012 55 Male 5/21/2012 Pharmacist United States
Primary
Secondary
Concomitant
Rash Disability 1/1/2005 8/7/2012 Consumer United States
Primary
Concomitant
Osteopenia Other Serious 4/1/2002 8/7/2012 Physician United States
Primary
Secondary
Concomitant
Osteoporosis Other Serious 3/1/2012 56 Female 7/25/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Osteopenia Other Serious 4/1/2002 8/13/2012 Consumer United States
Primary
Secondary
Concomitant
Cardiac Valve Vegetation Other Serious 1/1/2003 8/16/2012 Consumer United States
Primary
Concomitant
Somnolence Hospitalization 1/1/2003 8/24/2012 Consumer United States
Primary
Secondary
Concomitant
Diarrhoea Haemorrhagic Death 12/29/2010 Male 154 lb 6/24/2013 Physician De
Primary
Concomitant
Vulvovaginal Dryness Other Serious 4/2002 10/24/2012 Lawyer Us
Primary
Secondary
Concomitant
Viral Infection Other Serious 2005 9/26/2012 Consumer Us
Primary
Concomitant
Pulmonary Oedema Hospitalization 5/14/2012 71 Female 148 lb 9/18/2012 Consumer Ca
Primary
Concomitant
Urinary Tract Infection Hospitalization 5/2002 12/20/2012 Consumer Us
Primary
Concomitant
Urticaria Other Serious 1997 9/17/2012 Physician Us
Primary
Secondary
Concomitant
Nephrolithiasis 4/2/2012 39 Female 107 lb 11/8/2012 Physician Us
Primary
Concomitant
Weight Bearing Difficulty Hospitalization 11/1/2012 77 Female 154 lb 3/19/2013 Physician Nz
Primary
Concomitant
Sinusitis Hospitalization 7/2011 60 Male 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Pain 11/12/2012 60 Male 271 lb 4/22/2013 Other Health Professional Us
Primary
Concomitant
Therapeutic Response Decreased Female 175 lb 10/1/2013 Physician Us
Primary
Concomitant
Sinus Congestion 2/16/2013 56 Female 165 lb 10/1/2013 Physician Us
Primary
Concomitant
Nausea 3/10/2013 60 Female 10/1/2013 Consumer Us
Primary
Concomitant

Drug Data