Humira combined with Leflunomide

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Rheumatoid Arthritis Other Serious 6/17/2005 Female 170 lb 1/6/2006 United States
Primary
Concomitant
Depression Hospitalization 12/19/2005 Female 140 lb 1/13/2006 United States
Primary
Concomitant
Hepatotoxicity Hospitalization 3/20/2005 Male 209 lb 1/16/2006 United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Other Serious 5/1/2005 Male 181 lb 1/18/2006 United Kingdom
Primary
Concomitant
Synovectomy Hospitalization 47 Female 1/20/2006 Germany
Primary
Concomitant
Toe Amputation Other Serious 8/1/2003 Female 199 lb 1/20/2006 United States
Primary
Concomitant
Rash Other Serious 9/5/2005 Male 1/23/2006 Czech Republic
Primary
Concomitant
Respiratory Failure Hospitalization 6/30/2005 Female 1/23/2006 Germany
Primary
Concomitant
Hepatotoxicity Hospitalization 3/20/2005 Male 209 lb 1/24/2006 United Kingdom
Primary
Concomitant
Pharyngeal Oedema Other Serious 1/10/2006 Female 280 lb 1/26/2006 Canada
Primary
Concomitant
Pregnancy Other Serious 11/23/2005 29 Female 1/26/2006 Greece
Primary
Concomitant
Skin Ulcer Hospitalization 1/1/2005 Female 1/26/2006 Hungary
Primary
Concomitant
Polyarthritis Hospitalization 4/19/2005 41 Female 1/27/2006 France
Primary
Secondary
Concomitant
Vertigo Hospitalization 8/11/2005 Female 1/27/2006 Italy
Primary
Concomitant
Visual Disturbance Disability 7/19/2005 Female 130 lb 1/27/2006 United States
Primary
Concomitant
Osteoarthritis Other Serious 8/1/2005 Female 135 lb 1/27/2006 United States
Primary
Concomitant
Pneumonia Hospitalization 6/13/2005 Female 1/30/2006 Germany
Primary
Concomitant
Sudden Death Death 7/27/2004 Female 2/1/2006 United States
Primary
Concomitant
Sudden Death Death 7/27/2004 Female 2/1/2006 United States
Primary
Concomitant
Bronchitis Chronic Hospitalization 8/4/2005 Female 154 lb 2/1/2006 Italy
Primary
Concomitant
Diverticulitis Hospitalization 1/1/2006 Female 155 lb 2/1/2006 Canada
Primary
Concomitant
Muscle Spasms Hospitalization 12/9/2005 Female 176 lb 2/2/2006 Canada
Primary
Secondary
Concomitant
Throat Tightness Other Serious 1/10/2006 Female 280 lb 2/3/2006 Canada
Primary
Concomitant
Respiratory Failure Hospitalization 6/30/2005 Female 2/3/2006 Germany
Primary
Concomitant
Psoriasis Other Serious 8/4/2005 Female 120 lb 2/6/2006 Canada
Primary
Concomitant
Polyarthritis Hospitalization 4/19/2005 41 Female 2/7/2006 France
Primary
Secondary
Concomitant
Sepsis Hospitalization 12/12/2005 Male 220 lb 2/9/2006 Canada
Primary
Concomitant
Dyspnoea Other Serious 2/28/2005 Male 2/9/2006 Australia
Primary
Concomitant
Vasculitis Life Threatening 3/7/2005 Male 190 lb 2/9/2006 United Kingdom
Primary
Concomitant
Joint Swelling Hospitalization 6/7/2005 Female 231 lb 2/9/2006 Germany
Primary
Concomitant
Temporomandibular Joint Syndrome Hospitalization Male 2/9/2006 Germany
Primary
Concomitant
Transaminases Increased Hospitalization 6/7/2005 53 Female 2/10/2006 Germany
Primary
Secondary
Concomitant
Tendon Rupture Hospitalization 11/26/2003 52 Male 2/10/2006 Germany
Primary
Concomitant
Osteomalacia Hospitalization 4/15/2004 Female 2/10/2006 Germany
Primary
Concomitant
Cerebrovascular Accident Death 11/1/2005 Female 2/10/2006 United States
Primary
Concomitant
Joint Arthroplasty Hospitalization 58 Female 2/14/2006 Physician Germany
Primary
Concomitant
Cerebral Toxoplasmosis Death 9/1/2005 70 2/14/2006 Physician Australia
Primary
Secondary
Osteitis Hospitalization 8/23/2004 Female 163 lb 2/15/2006 Netherlands
Primary
Concomitant
Peridiverticular Abscess Hospitalization 1/1/2006 Female 155 lb 2/17/2006 Physician Canada
Primary
Concomitant
Pneumonia Hospitalization 12/30/2005 Female 128 lb 3/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Facial Palsy Hospitalization 2/13/2006 Female 152 lb 3/3/2006 Greece
Primary
Concomitant
Pneumonia Death 12/13/2005 75 143 lb 3/7/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 6/30/2005 Female 3/9/2006 Physician Germany
Primary
Concomitant
Bronchitis Chronic Hospitalization 8/4/2005 Female 154 lb 3/9/2006 Physician Italy
Primary
Concomitant
Lethargy Hospitalization 5/21/2005 Female 137 lb 3/10/2006 Other Health Professional United Kingdom
Primary
Concomitant
Cerebrovascular Accident Hospitalization 9/6/2005 Female 99 lb 3/14/2006 Germany
Primary
Concomitant
Pregnancy Hospitalization 12/19/2005 Female 143 lb 3/14/2006 Physician Italy
Primary
Concomitant
Tinnitus Hospitalization 9/10/2005 Female 172 lb 3/15/2006 Germany
Primary
Concomitant
Osteomyelitis Hospitalization 1/1/2006 Female 163 lb 3/16/2006 Netherlands
Primary
Concomitant
Osteomyelitis Hospitalization 1/1/2006 Female 163 lb 3/16/2006 Netherlands
Primary
Concomitant
Tooth Infection Other Serious 2/1/2006 Female 130 lb 3/16/2006 Consumer Canada
Primary
Concomitant
Visual Disturbance Disability 7/1/2005 39 Female 3/22/2006 Consumer United States
Primary
Concomitant
Facial Palsy Hospitalization 2/13/2006 Female 152 lb 3/22/2006 Greece
Primary
Concomitant
Eosinophilia Other Serious 7/1/2001 55 Female 3/23/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious 7/5/2004 Female 3/27/2006 Pharmacist United Kingdom
Primary
Concomitant
Thrombocytopenia Hospitalization 9/3/2004 Male 161 lb 3/29/2006 France
Primary
Concomitant
Vomiting Hospitalization 7/20/2005 Female 99 lb 3/30/2006 Germany
Primary
Concomitant
Acute Febrile Neutrophilic Dermatosis Other Serious 9/5/2005 Female 148 lb 3/30/2006 France
Primary
Concomitant
Pulmonary Embolism Other Serious 11/1/2005 Female 3/30/2006 France
Primary
Concomitant
Secondary Amyloidosis Hospitalization 11/27/2005 73 Female 3/30/2006 Physician Greece
Primary
Concomitant
Facial Palsy Hospitalization 2/13/2006 Female 152 lb 3/30/2006 Greece
Primary
Concomitant
Pustular Psoriasis Other Serious 1/25/2006 Female 3/31/2006 Physician Belgium
Primary
Concomitant
Pneumonia Hospitalization 12/30/2005 Female 128 lb 4/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Respiratory Failure Hospitalization 6/30/2005 Female 4/4/2006 Physician Germany
Primary
Concomitant
Radiation Oesophagitis Hospitalization 5/1/2005 Male 4/5/2006 Physician Germany
Primary
Concomitant
Acquired Bronchial Cyst Other Serious 9/1/2004 Female 108 lb 4/6/2006 Consumer United States
Primary
Concomitant
Streptococcal Sepsis Hospitalization 12/12/2005 Male 220 lb 4/6/2006 Physician Canada
Primary
Concomitant
Wound Dehiscence Other Serious 7/29/2005 Female 117 lb 4/7/2006 Consumer Canada
Primary
Concomitant
Sepsis Hospitalization Female 4/10/2006 Physician Germany
Primary
Concomitant
Osteitis Hospitalization 8/23/2004 Female 163 lb 4/11/2006 Netherlands
Primary
Concomitant
Toe Amputation Hospitalization 8/23/2004 Female 163 lb 4/11/2006 Netherlands
Primary
Concomitant
Skin Disorder Hospitalization 1/1/2006 Female 163 lb 4/12/2006 Netherlands
Primary
Concomitant
Sepsis Hospitalization 12/30/2005 Female 128 lb 4/13/2006 Other Health Professional United Kingdom
Primary
Concomitant
Urticaria Hospitalization 1/1/2005 Female 123 lb 4/13/2006 Other Health Professional France
Primary
Concomitant
Venous Thrombosis Other Serious 8/28/2005 Female 185 lb 4/13/2006 Physician France
Primary
Concomitant
Facial Palsy Hospitalization 2/13/2006 Female 152 lb 4/13/2006 Greece
Primary
Concomitant
Sepsis Hospitalization Female 4/17/2006 Physician Germany
Primary
Concomitant
Respiratory Tract Infection Hospitalization 11/15/2005 Male 122 lb 4/21/2006 Other Health Professional United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Hospitalization Male 4/21/2006 Physician Belgium
Primary
Concomitant
Rheumatoid Arthritis Hospitalization Male 4/26/2006 Physician Belgium
Primary
Concomitant
Vasculitic Rash Hospitalization 1/1/2006 65 Female 4/26/2006 Physician Greece
Primary
Concomitant
Knee Arthroplasty Other Serious Male 138 lb 5/2/2006 Consumer Canada
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 11/7/2005 Female 126 lb 5/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Pustular Psoriasis Other Serious 1/25/2006 Female 5/4/2006 Physician Belgium
Primary
Concomitant
Lung Consolidation Hospitalization 12/15/2005 Female 123 lb 5/5/2006 Other Health Professional United Kingdom
Primary
Concomitant
Autoimmune Hepatitis Other Serious 1/23/2006 Female 198 lb 5/5/2006 Physician Germany
Primary
Concomitant
Nodule Other Serious 4/3/2005 Female 170 lb 5/5/2006 Consumer Canada
Primary
Concomitant
Eosinophilia Other Serious 7/1/2001 55 Female 5/8/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Psoriasis Other Serious 12/1/2005 Female 120 lb 5/8/2006 Consumer Canada
Primary
Concomitant
Streptococcal Infection Hospitalization Female 5/9/2006 Physician Germany
Primary
Concomitant
Meniscus Operation Hospitalization 3/27/2006 58 Female 5/11/2006 Physician Austria
Primary
Concomitant
Toxic Skin Eruption Other Serious 4/4/2006 42 Male 183 lb 5/11/2006 Physician France
Primary
Concomitant
Hospitalisation Hospitalization Female 170 lb 5/12/2006 Consumer Canada
Primary
Concomitant
Mobility Decreased Hospitalization 8/1/2005 67 Female 168 lb 1/11/2006 Physician United States
Primary
Concomitant
Renal Disorder Other Serious 4/6/2006 54 Female 135 lb 5/19/2006 Other Health Professional Canada
Primary
Concomitant
Weight Decreased Hospitalization 12/12/2005 Male 225 lb 5/19/2006 Physician Canada
Primary
Concomitant
Osteomyelitis Hospitalization 1/1/2006 Female 163 lb 5/19/2006 Netherlands
Primary
Concomitant
Transaminases Increased Other Serious 11/1/2005 Female 198 lb 5/22/2006 Physician Germany
Primary
Concomitant
Synovectomy Hospitalization 11/10/2005 34 Female 5/24/2006 Physician Germany
Primary
Secondary
Concomitant
Sepsis Hospitalization 4/5/2005 Female 148 lb 5/25/2006 Greece
Primary
Concomitant
Wound Dehiscence Other Serious 7/29/2005 Female 117 lb 5/30/2006 Consumer Canada
Primary
Concomitant
Nervousness Hospitalization 4/27/2006 Male 5/31/2006 Physician Belgium
Primary
Concomitant
Visual Disturbance Disability 7/19/2005 Female 130 lb 6/2/2006 Physician United States
Primary
Concomitant
Renal Colic Hospitalization 10/28/2005 Male 209 lb 6/2/2006 Italy
Primary
Concomitant
Transaminases Increased Other Serious 11/1/2005 Female 198 lb 6/2/2006 Physician Germany
Primary
Concomitant
Rheumatoid Nodule Removal Other Serious 4/1/2006 Female 150 lb 6/5/2006 Consumer United States
Primary
Concomitant
Hip Arthroplasty Hospitalization 5/5/2006 Female 140 lb 6/7/2006 Consumer Canada
Primary
Concomitant
Sepsis Hospitalization 12/30/2005 Female 128 lb 6/8/2006 Other Health Professional United Kingdom
Primary
Concomitant
Rheumatoid Nodule Removal Other Serious 4/1/2006 Female 150 lb 6/13/2006 Physician United States
Primary
Concomitant
Staphylococcal Infection Other Serious 60 Female 6/20/2006 Physician Brazil
Primary
Concomitant
Nausea Other Serious 4/20/2006 Male 247 lb 6/20/2006 Other Health Professional United Kingdom
Primary
Concomitant
Staphylococcal Infection Hospitalization 4/21/2006 Female 170 lb 6/21/2006 Consumer Canada
Primary
Concomitant
Visual Disturbance Disability 7/19/2005 Female 130 lb 6/23/2006 Physician United States
Primary
Concomitant
Malabsorption Hospitalization 4/7/2006 Female 128 lb 6/26/2006 Other Health Professional United Kingdom
Primary
Concomitant
Chronic Lymphocytic Leukaemia Other Serious 3/14/2006 Female 139 lb 7/5/2006 Greece
Primary
Concomitant
Intracranial Aneurysm Hospitalization 12/1/2005 Female 7/7/2006 Physician Ireland
Primary
Concomitant
Pulmonary Fibrosis Death 4/19/2006 Female 325 lb 7/7/2006 Physician Canada
Primary
Concomitant
Pulmonary Embolism Other Serious 11/19/2005 Female 7/11/2006 France
Primary
Concomitant
Propionibacterium Infection Other Serious 48 Female 7/14/2006 Spain
Primary
Secondary
Concomitant
Coronary Artery Thrombosis Death 4/4/2006 Male 185 lb 7/17/2006 Other Health Professional United Kingdom
Primary
Concomitant
Pruritus Other Serious 50 Female 7/19/2006 Physician Brazil
Primary
Concomitant
Acquired Bronchial Cyst Other Serious 9/1/2004 Female 108 lb 7/21/2006 Physician United States
Primary
Concomitant
Streptococcal Infection Life Threatening 7/8/2006 69 Female 7/21/2006 Physician Spain
Primary
Secondary
Concomitant
Tooth Abscess Hospitalization 6/30/2006 51 Female 7/21/2006 Physician Greece
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 5/1/2006 Female 7/24/2006 Physician Belgium
Primary
Concomitant
Staphylococcal Infection Hospitalization 2/1/2003 Female 178 lb 7/26/2006 Consumer United States
Primary
Concomitant
Lung Neoplasm Hospitalization 3/29/2005 Female 146 lb 7/27/2006 Other Health Professional United Kingdom
Primary
Concomitant
Pneumonia Hospitalization 6/13/2005 Female 7/27/2006 Physician Germany
Primary
Concomitant
Tuberculosis Skin Test Positive Hospitalization 7/19/2006 50 Female 187 lb 7/28/2006 Physician Greece
Primary
Concomitant
Nervousness Hospitalization 4/27/2006 Male 7/28/2006 Physician Belgium
Primary
Concomitant
Staphylococcal Infection Hospitalization 10/4/2005 Female 7/28/2006 Physician Belgium
Primary
Concomitant
Pulmonary Tuberculosis Death 7/6/2004 Male 126 lb 8/2/2006 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Mass Other Serious 9/26/2005 Female 123 lb 8/2/2006 Other Health Professional United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Other Serious 5/25/2005 Male 181 lb 8/2/2006 Other Health Professional United Kingdom
Primary
Concomitant
Sepsis Hospitalization 12/25/2005 Female 128 lb 8/2/2006 Other Health Professional United Kingdom
Primary
Concomitant
Hyponatraemia Hospitalization 5/2/2006 Male 188 lb 8/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Wound Infection Staphylococcal Other Serious 11/1/2005 41 Male 8/3/2006 Physician Germany
Primary
Secondary
Concomitant
Thyroid Neoplasm Life Threatening 4/21/2006 Female 167 lb 8/4/2006 Other Health Professional Canada
Primary
Concomitant
Arterial Occlusive Disease Other Serious 6/29/2006 Male 209 lb 8/4/2006 Consumer Canada
Primary
Concomitant
Paraesthesia Hospitalization 5/1/2006 Female 120 lb 8/4/2006 Other Health Professional Canada
Primary
Concomitant
Rheumatoid Arthritis Hospitalization Male 8/7/2006 Physician Belgium
Primary
Concomitant
Hepatotoxicity Other Serious 3/20/2005 Male 209 lb 8/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Lethargy Other Serious 5/17/2005 Female 137 lb 8/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Subarachnoid Haemorrhage Other Serious Female 8/10/2006 Physician Ireland
Primary
Concomitant
Shunt Occlusion Hospitalization 7/18/2006 Female 8/10/2006 Consumer Canada
Primary
Concomitant
Shock Haemorrhagic Other Serious 5/1/2005 Female 104 lb 8/10/2006 Physician Germany
Primary
Secondary
Concomitant
Renal Colic Hospitalization 6/1/2006 50 Male 8/10/2006 Physician Germany
Primary
Concomitant
Visual Disturbance Disability 7/19/2005 Female 130 lb 8/10/2006 Physician United States
Primary
Concomitant
Influenza Like Illness Hospitalization Female 8/17/2006 Physician Germany
Primary
Secondary
Concomitant
Metastasis Other Serious 6/20/2006 75 Female 8/17/2006 Other Health Professional United Kingdom
Primary
Concomitant

Drug Data