Sirolimus



Indications and Reactions:

Role Indications Reactions
Primary
Prophylaxis Against Transplant Rejection 46.4%
Hypertension 12.5%
Immunosuppressant Drug Therapy 7.9%
Immunosuppression 7.3%
Renal Transplant 5.0%
Prophylaxis 3.9%
Prophylaxis Against Renal Transplant Rejection 2.7%
Diabetes Mellitus 2.4%
Hypercholesterolaemia 1.7%
Dyslipidaemia 1.4%
Hyperlipidaemia 1.4%
Infection Prophylaxis 1.4%
Prophylaxis Against Gastrointestinal Ulcer 1.0%
Anaemia 0.8%
Drug Use For Unknown Indication 0.8%
Lymphangioleiomyomatosis 0.8%
Antiviral Prophylaxis 0.7%
Chronic Allograft Nephropathy 0.7%
Depression 0.7%
Lipids Increased 0.7%
Focal Glomerulosclerosis 10.3%
Kidney Transplant Rejection 8.6%
Transplant Rejection 8.6%
Diabetes Mellitus 7.6%
Liver Transplant Rejection 7.3%
Heart Transplant Rejection 7.0%
Death 6.6%
Prostate Cancer 6.0%
Pyrexia 4.3%
Proteinuria 4.0%
Urinary Tract Infection 4.0%
Renal Failure Acute 3.6%
Ovarian Cyst 3.0%
Pulmonary Cavitation 3.0%
Venoocclusive Disease 3.0%
Complications Of Transplant Surgery 2.6%
Deep Vein Thrombosis 2.6%
Gastroenteritis 2.6%
Upper Respiratory Tract Infection 2.6%
Vomiting 2.6%
Secondary
Prophylaxis Against Transplant Rejection 31.3%
Immunosuppression 14.2%
Prophylaxis Against Renal Transplant Rejection 10.9%
Product Used For Unknown Indication 7.6%
Renal Transplant 7.5%
Immunosuppressant Drug Therapy 5.7%
Drug Use For Unknown Indication 2.8%
Stem Cell Transplant 2.7%
Hypertension 2.6%
Prophylaxis Against Graft Versus Host Disease 2.4%
Prophylaxis 2.3%
Graft Versus Host Disease 1.8%
Kidney Transplant Rejection 1.7%
Antiretroviral Therapy 1.3%
Liver Transplant 1.0%
Heart Transplant 1.0%
Histoplasmosis 0.9%
Dyslipidaemia 0.8%
Antibiotic Prophylaxis 0.8%
Multiple Myeloma 0.7%
Urinary Tract Infection 19.1%
Prostate Cancer 8.0%
Urinary Retention 7.7%
Transplant Rejection 7.3%
Thrombotic Microangiopathy 5.8%
Kidney Transplant Rejection 4.7%
Pneumonia 4.7%
Urosepsis 4.6%
Weight Increased 4.3%
Heart Transplant Rejection 3.7%
Sepsis 3.6%
Pancytopenia 3.4%
Diabetes Mellitus 3.1%
Squamous Cell Carcinoma 3.1%
Venoocclusive Disease 3.1%
Death 3.0%
Pyrexia 3.0%
Pleural Effusion 2.8%
Biliary Neoplasm 2.5%
Vomiting 2.5%
Concomitant
Product Used For Unknown Indication 21.6%
Drug Use For Unknown Indication 19.9%
Immunosuppression 12.1%
Renal Transplant 6.4%
Prophylaxis Against Graft Versus Host Disease 5.8%
Prophylaxis Against Transplant Rejection 4.8%
Prophylaxis 4.6%
Immunosuppressant Drug Therapy 3.8%
Heart Transplant 3.5%
Liver Transplant 2.2%
Stem Cell Transplant 2.1%
Hypertension 1.9%
Bone Marrow Conditioning Regimen 1.7%
Chronic Graft Versus Host Disease 1.7%
Nuclear Magnetic Resonance Imaging 1.6%
Graft Versus Host Disease 1.5%
Acute Myeloid Leukaemia 1.5%
Diabetes Mellitus 1.2%
Pneumonia 1.0%
Antiviral Prophylaxis 0.9%
Vomiting 12.4%
Infection 7.9%
Kidney Transplant Rejection 7.3%
Multi-organ Failure 6.7%
Nausea 5.1%
Pyrexia 5.1%
Renal Failure 5.1%
Respiratory Failure 5.1%
Transaminases Increased 5.1%
Kaposi's Sarcoma 4.5%
Pneumonia 4.5%
Renal Impairment 4.5%
Diarrhoea 3.9%
Rectal Haemorrhage 3.4%
Rhabdomyolysis 3.4%
Thrombocytopenia 3.4%
Thrombotic Microangiopathy 3.4%
Transplant Rejection 3.4%
Venoocclusive Liver Disease 3.4%
Blood Creatinine Increased 2.8%
Interacting
Product Used For Unknown Indication 40.8%
Immunosuppression 13.7%
Drug Use For Unknown Indication 9.0%
Immunosuppressant Drug Therapy 6.0%
Myocardial Infarction 3.9%
Renal Transplant 3.9%
Basal Cell Carcinoma 3.0%
Convulsion 2.6%
Grand Mal Convulsion 2.6%
Aspergillus Infection 2.1%
Haemophilus Infection 2.1%
Bone Marrow Failure 1.7%
Convulsion Prophylaxis 1.7%
Lung Adenocarcinoma Stage Iv 1.3%
Zygomycosis 1.3%
Antifungal Prophylaxis 0.9%
Cardiac Failure 0.9%
Chemotherapy 0.9%
Dyslipidaemia 0.9%
Hypertension 0.9%
Drug Interaction 18.8%
Pneumonitis 13.0%
Renal Impairment 10.1%
Renal Failure 7.2%
Drug Level Decreased 5.8%
Pneumonia 5.8%
Off Label Use 4.3%
Rhabdomyolysis 4.3%
Somnolence 4.3%
Vomiting 4.3%
Alveolitis 2.9%
Drug Level Below Therapeutic 2.9%
Hypokalaemia 2.9%
Swelling Face 2.9%
Swollen Tongue 2.9%
Agranulocytosis 1.4%
Dyspnoea Exertional 1.4%
Malabsorption 1.4%
Renal Failure Acute 1.4%
Urinary Tract Infection 1.4%