Clofarabine



Indications and Reactions:

Role Indications Reactions
Primary
Acute Myeloid Leukaemia 23.4%
Product Used For Unknown Indication 20.0%
Acute Lymphocytic Leukaemia 16.5%
Prophylaxis 8.6%
Drug Use For Unknown Indication 4.0%
Pain 3.2%
Nausea 2.9%
Myeloid Leukaemia 2.8%
Acute Lymphocytic Leukaemia Recurrent 2.5%
Sedation 2.4%
Acute Leukaemia 2.3%
Myelodysplastic Syndrome 1.7%
Premedication 1.7%
Bone Marrow Conditioning Regimen 1.4%
Pyrexia 1.4%
Infection 1.2%
Dry Skin 1.1%
Non-hodgkin's Lymphoma 1.0%
Anti-infective Therapy 0.9%
Acute Myeloid Leukaemia Recurrent 0.9%
Sepsis 12.9%
Vomiting 8.7%
Death 7.1%
Septic Shock 6.6%
White Blood Cell Count Decreased 5.8%
Pneumonia 5.4%
Renal Failure 5.4%
Thrombocytopenia 5.0%
Pancytopenia 4.6%
Tachycardia 4.6%
Staphylococcal Infection 4.1%
Febrile Neutropenia 3.7%
Rash 3.7%
Syncope 3.7%
Pyrexia 3.3%
Renal Failure Acute 3.3%
Therapy Non-responder 3.3%
Lipase Increased 2.9%
Neutropenia 2.9%
Palmar-plantar Erythrodysaesthesia Syndrome 2.9%
Secondary
Acute Myeloid Leukaemia 26.2%
Product Used For Unknown Indication 15.2%
Acute Lymphocytic Leukaemia 14.0%
Bone Marrow Conditioning Regimen 6.1%
Myelodysplastic Syndrome 6.1%
Prophylaxis Against Graft Versus Host Disease 4.0%
Prophylaxis 3.2%
Acute Lymphocytic Leukaemia Recurrent 3.0%
Antibiotic Prophylaxis 2.9%
Chemotherapy 2.8%
Myeloid Leukaemia 2.4%
Acute Leukaemia 2.2%
Antifungal Prophylaxis 2.2%
Stem Cell Transplant 1.9%
Nausea 1.6%
Febrile Neutropenia 1.5%
Antiviral Prophylaxis 1.4%
Hypertension 1.2%
Leukaemia Recurrent 1.1%
Blood Product Transfusion Dependent 0.9%
Sepsis 10.7%
Vomiting 9.1%
Septic Shock 7.5%
Death 7.0%
Pyrexia 6.4%
Cerebral Haemorrhage 5.3%
Neutropenic Sepsis 5.3%
Tachycardia 5.3%
Neutropenia 4.3%
Toxicity To Various Agents 4.3%
Renal Failure 3.7%
Renal Failure Acute 3.7%
Respiratory Failure 3.7%
Thrombocytopenia 3.7%
Venoocclusive Liver Disease 3.7%
Mucosal Inflammation 3.2%
Nephropathy Toxic 3.2%
Pseudomonal Sepsis 3.2%
Renal Impairment 3.2%
Staphylococcal Sepsis 3.2%
Concomitant
Product Used For Unknown Indication 35.1%
Drug Use For Unknown Indication 18.2%
Bone Marrow Conditioning Regimen 12.1%
Acute Myeloid Leukaemia 5.9%
Stem Cell Transplant 5.4%
Acute Lymphocytic Leukaemia 4.1%
Prophylaxis Against Graft Versus Host Disease 2.8%
Immunosuppression 2.6%
Prophylaxis 2.3%
Acute Lymphocytic Leukaemia Recurrent 2.1%
Non-hodgkin's Lymphoma 2.1%
Acute Graft Versus Host Disease 1.0%
Surgical Preconditioning 1.0%
Antibiotic Prophylaxis 0.8%
Antifungal Prophylaxis 0.8%
B Precursor Type Acute Leukemia 0.8%
Bone Marrow Transplant 0.8%
Nausea 0.8%
Neutropenia 0.8%
Pain 0.8%
Hypoxia 10.5%
Pneumonia 10.5%
Drug Ineffective 7.9%
Drug Interaction 7.9%
Pseudomonas Infection 7.9%
Death 5.3%
Disease Progression 5.3%
Encephalitis 5.3%
Hepatotoxicity 5.3%
Multi-organ Failure 5.3%
Neuropathy Peripheral 5.3%
Acute Graft Versus Host Disease In Skin 2.6%
Acute Myeloid Leukaemia 2.6%
Aspergillosis 2.6%
Cardiac Failure 2.6%
Cystitis Haemorrhagic 2.6%
Epistaxis 2.6%
Hypersensitivity 2.6%
Hyponatraemia 2.6%
Infection 2.6%
Interacting
Product Used For Unknown Indication 28.1%
Prophylaxis 21.1%
Acute Lymphocytic Leukaemia 10.5%
Pain 7.0%
Pyrexia 7.0%
Vomiting 7.0%
Analgesic Therapy 4.1%
Hypertension 3.5%
Nausea 3.5%
Neuralgia 3.5%
Pain Management 3.5%
Drug Use For Unknown Indication 1.2%
Tumour Lysis Syndrome 85.7%
Agranulocytosis 14.3%