Denosumab



Combined with:

Indications and Reactions:

Role Indications Reactions
Primary
Metastases To Bone 14.6%
Breast Cancer 12.0%
Osteoporosis Postmenopausal 11.1%
Osteoporosis 10.1%
Prostate Cancer 9.8%
Hypertension 8.6%
Bone Giant Cell Tumour 4.5%
Constipation 4.5%
Nausea 4.1%
Diabetes Mellitus 3.0%
Product Used For Unknown Indication 2.9%
Prophylaxis 2.7%
Pain 2.1%
Back Pain 1.7%
Supplementation Therapy 1.7%
Hypercalcaemia Of Malignancy 1.6%
Bone Density Decreased 1.3%
Hyperlipidaemia 1.3%
Infection 1.2%
Gastrooesophageal Reflux Disease 1.2%
Osteonecrosis Of Jaw 36.5%
Osteomyelitis 7.5%
Osteonecrosis 7.3%
Pain In Jaw 5.8%
Death 5.6%
Exposed Bone In Jaw 3.4%
Pulmonary Embolism 3.4%
Cerebrovascular Accident 3.2%
Pneumothorax 2.9%
Alveolar Osteitis 2.7%
Osteoarthritis 2.7%
Back Pain 2.4%
Neutropenia 2.4%
Periodontal Disease 2.4%
Vomiting 2.2%
Femur Fracture 1.9%
Hypocalcaemia 1.9%
Pyrexia 1.9%
Spinal Compression Fracture 1.9%
Cellulitis 1.7%
Secondary
Product Used For Unknown Indication 21.2%
Metastases To Bone 18.8%
Osteoporosis 13.3%
Breast Cancer 5.9%
Breast Cancer Metastatic 3.9%
Decreased Appetite 3.5%
Hypertension 3.5%
Rheumatoid Arthritis 3.5%
Cancer Pain 3.1%
Prostate Cancer 3.1%
Bone Giant Cell Tumour 2.7%
Mineral Supplementation 2.7%
Prophylaxis 2.4%
Prostate Cancer Metastatic 2.4%
Gastrooesophageal Reflux Disease 2.0%
Pain 2.0%
Cerebrovascular Accident 1.6%
Diabetes Mellitus 1.6%
Sarcoidosis 1.6%
Bone Disorder 1.2%
Osteonecrosis Of Jaw 35.5%
Pneumothorax 11.3%
Blood Parathyroid Hormone Increased 4.8%
Burning Sensation 4.8%
Colonic Polyp 4.8%
B-cell Lymphoma 3.2%
Fatigue 3.2%
Haematuria 3.2%
Malaise 3.2%
Potentiating Drug Interaction 3.2%
Pyrexia 3.2%
Rhabdomyolysis 3.2%
Tachycardia 3.2%
Tongue Disorder 3.2%
Acute Hepatic Failure 1.6%
Anaemia 1.6%
Atrial Fibrillation 1.6%
Back Pain 1.6%
Cerebral Infarction 1.6%
Cholecystitis Acute 1.6%
Concomitant
Product Used For Unknown Indication 29.7%
Metastases To Bone 6.2%
Pain 6.1%
Prostate Cancer 5.6%
Prophylaxis 5.5%
Supplementation Therapy 5.3%
Prostate Cancer Metastatic 4.5%
Constipation 4.2%
Breast Cancer Metastatic 4.0%
Hypertension 3.8%
Nausea 3.5%
Breast Cancer 3.3%
Premedication 3.2%
Non-small Cell Lung Cancer 3.0%
Cough 2.4%
Vitamin Supplementation 2.3%
Rheumatoid Arthritis 1.9%
Back Pain 1.8%
Dyspnoea 1.8%
Insomnia 1.8%
Death 8.7%
Thrombocytopenia 8.7%
Weight Decreased 8.7%
Prostate Cancer 7.2%
Renal Failure 7.2%
Vomiting 7.2%
Deep Vein Thrombosis 4.3%
Disease Progression 4.3%
Interstitial Lung Disease 4.3%
Myocardial Infarction 4.3%
Nausea 4.3%
Pneumonia 4.3%
Pyrexia 4.3%
Sepsis 4.3%
Asthenia 2.9%
C-reactive Protein Decreased 2.9%
Cardiac Failure Congestive 2.9%
Dyspnoea 2.9%
Febrile Neutropenia 2.9%
General Physical Health Deterioration 2.9%