Sorafenib (Raf Kinase Inhibitor)



Indications and Reactions:

Role Indications Reactions
Primary
Hepatic Neoplasm Malignant 23.1%
Hypertension 14.5%
Prophylaxis 10.4%
Diabetes Mellitus 5.5%
Diarrhoea 4.9%
Pain 4.2%
Abdominal Pain 3.9%
Surgery 3.5%
Renal Cell Carcinoma 3.0%
Palmar-plantar Erythrodysaesthesia Syndrome 2.9%
Medical Diet 2.8%
Constipation 2.7%
Nausea 2.6%
Hepatocellular Carcinoma 2.6%
Thyroid Cancer 2.6%
Hepatitis B 2.2%
Insomnia 2.2%
Gastric Cancer 2.1%
Supplementation Therapy 2.1%
Ascites 2.1%
Hepatic Encephalopathy 9.5%
Ascites 8.4%
Diarrhoea 8.4%
Hepatic Failure 7.7%
Pulmonary Embolism 6.6%
Death 5.5%
Vomiting 5.5%
Fatigue 5.0%
Pyrexia 5.0%
Hypertension 4.5%
Decreased Appetite 4.3%
Rash 3.9%
Abdominal Pain 3.6%
Asthenia 3.4%
Palmar-plantar Erythrodysaesthesia Syndrome 3.4%
Deep Vein Thrombosis 3.2%
Skin Ulcer 3.2%
Cerebral Ischaemia 3.0%
Cerebrovascular Accident 3.0%
Left Ventricular Dysfunction 3.0%
Secondary
Hepatic Neoplasm Malignant 15.1%
Hypertension 10.2%
Prophylaxis 9.6%
Surgery 8.9%
Hepatocellular Carcinoma 8.3%
Abdominal Pain 5.0%
Medical Diet 4.6%
Diarrhoea 4.4%
Thyroid Cancer 4.3%
Diabetes Mellitus 3.9%
Palmar-plantar Erythrodysaesthesia Syndrome 3.1%
Decreased Appetite 3.1%
Nausea 2.9%
Hepatitis B 2.8%
Computerised Tomogram 2.5%
Oesophagitis 2.3%
Anxiety 2.3%
Insomnia 2.3%
Gastric Ulcer 2.3%
Abdominal Pain Upper 2.1%
Diarrhoea 12.5%
Arthralgia 7.4%
Retinal Vein Occlusion 7.4%
Hepatic Encephalopathy 6.9%
Left Ventricular Dysfunction 6.0%
Abdominal Pain 5.5%
Lung Disorder 5.4%
Duodenal Ulcer 4.4%
Hypertension 4.4%
Hypokalaemia 4.1%
Hepatic Failure 3.9%
Respiratory Failure 3.8%
Upper Gastrointestinal Haemorrhage 3.8%
Abdominal Pain Upper 3.6%
Ascites 3.6%
Myopathy 3.6%
Retinal Vascular Disorder 3.6%
Retinal Vascular Thrombosis 3.6%
Palmar-plantar Erythrodysaesthesia Syndrome 3.4%
Staphylococcal Infection 3.2%
Interacting
Acute Myeloid Leukemia 53.3%
Antifungal Prophylaxis 20.0%
Antiretroviral Therapy 13.3%
Hepatocellular Carcinoma 13.3%
Viral Infection 50.0%
Hypertension 25.0%
Inhibitory Drug Interaction 25.0%