| Primary |
| Factor Viii Deficiency |
64.9% |
| Haemophilia |
7.6% |
| Prophylaxis |
4.9% |
| Haemorrhage |
2.7% |
| Pain |
2.7% |
| Haemorrhage Prophylaxis |
2.0% |
| Knee Arthroplasty |
2.0% |
| Viral Infection |
2.0% |
| Constipation |
1.3% |
| Hypertension |
1.1% |
| Off Label Use |
1.1% |
| Post Procedural Haemorrhage |
1.1% |
| Anti Factor Viii Antibody Positive |
0.9% |
| Central Venous Catheterisation |
0.9% |
| Cerebral Haemorrhage |
0.9% |
| Migraine |
0.9% |
| Surgery |
0.9% |
| Candidiasis |
0.7% |
| Convulsion |
0.7% |
| Traumatic Haemorrhage |
0.7% |
|
| Factor Viii Inhibition |
39.7% |
| Haemarthrosis |
10.3% |
| Haemorrhage |
7.8% |
| Drug Ineffective |
6.6% |
| Muscle Haemorrhage |
4.9% |
| Anti Factor Viii Antibody Positive |
4.6% |
| Pain In Extremity |
4.3% |
| Haematoma |
3.4% |
| Therapy Non-responder |
3.2% |
| No Therapeutic Response |
2.3% |
| Spontaneous Haematoma |
2.3% |
| Infection |
1.7% |
| Drug Specific Antibody Present |
1.1% |
| Ecchymosis |
1.1% |
| Free Haemoglobin Present |
1.1% |
| Hypersensitivity |
1.1% |
| Incorrect Product Storage |
1.1% |
| Post Procedural Haemorrhage |
1.1% |
| Weight Increased |
1.1% |
| Central Venous Catheter Removal |
0.9% |
|
| Secondary |
| Factor Viii Deficiency |
60.3% |
| Haemorrhage Prophylaxis |
6.1% |
| Pain |
4.8% |
| Prophylaxis |
4.2% |
| Anti Factor Viii Antibody Positive |
3.2% |
| Bronchitis Chronic |
2.9% |
| Constipation |
2.3% |
| Haemophilia |
1.9% |
| Central Venous Catheterisation |
1.4% |
| Cerebral Haemorrhage |
1.4% |
| Hypertension |
1.4% |
| Knee Arthroplasty |
1.4% |
| Migraine |
1.4% |
| Haemorrhage |
1.3% |
| Candidiasis |
1.1% |
| Convulsion |
1.1% |
| Hiv Infection |
1.0% |
| Viral Infection |
1.0% |
| Arthralgia |
0.8% |
| Arthritis |
0.8% |
|
| Factor Viii Inhibition |
36.0% |
| Pain In Extremity |
10.0% |
| Free Haemoglobin Present |
6.6% |
| Haemorrhage |
6.2% |
| Drug Ineffective |
5.2% |
| Haemarthrosis |
4.5% |
| Spontaneous Haematoma |
4.5% |
| Haematoma |
4.3% |
| Anti Factor Viii Antibody Positive |
3.6% |
| Ecchymosis |
3.1% |
| Post Procedural Haemorrhage |
3.1% |
| Drug Specific Antibody Present |
2.8% |
| Traumatic Brain Injury |
2.1% |
| Infection |
1.4% |
| Muscle Haemorrhage |
1.4% |
| No Therapeutic Response |
1.2% |
| Synovitis |
1.2% |
| Hypersensitivity |
0.9% |
| Oesophageal Varices Haemorrhage |
0.9% |
| Pleurisy |
0.9% |
|
| Concomitant |
| Hepatitis C |
35.3% |
| Chronic Hepatitis C |
17.6% |
| Haemophilia |
17.6% |
| Hypertension |
17.6% |
| Prophylaxis |
11.8% |
|
| Photosensitivity Reaction |
60.0% |
| Haemarthrosis |
40.0% |
|
