Metopirone



Indications and Reactions:

Role Indications Reactions
Primary
Cushing's Syndrome 20.0%
Pituitary-dependent Cushing's Syndrome 11.5%
Hypertension 9.1%
Hypokalaemia 9.1%
Ectopic Acth Syndrome 4.2%
Gastritis 4.2%
Hypothyroidism 4.2%
Prophylaxis 4.2%
Acth-producing Pituitary Tumour 3.6%
Diabetes Mellitus 3.6%
Hypercorticoidism 3.6%
Infection Prophylaxis 3.6%
Mental Disorder 3.6%
Pneumonia 3.6%
Nephrogenic Diabetes Insipidus 3.0%
Adrenocortical Insufficiency Acute 2.4%
Infection 2.4%
Acth Stimulation Test 1.2%
Gastric Ulcer 1.2%
Hyperadrenocorticism 1.2%
Respiratory Failure 16.4%
Death 8.2%
Nausea 8.2%
Pneumocystis Jiroveci Pneumonia 8.2%
White Blood Cell Count Increased 6.6%
Drug Interaction Potentiation 4.9%
Pyrexia 4.9%
Septic Shock 4.9%
Vomiting 4.9%
Alanine Aminotransferase Increased 3.3%
Fatigue 3.3%
Mental Status Changes 3.3%
Pituitary Tumour 3.3%
Po2 Decreased 3.3%
Potentiating Drug Interaction 3.3%
Stupor 3.3%
Surgery 3.3%
Thrombocytopenia 3.3%
Adrenal Carcinoma 1.6%
Aspartate Aminotransferase Increased 1.6%
Secondary
Hypercorticoidism 19.9%
Hypertension 15.6%
Pituitary-dependent Cushing's Syndrome 13.4%
Cushing's Syndrome 9.1%
Adrenocortical Insufficiency Acute 7.5%
Hypokalaemia 7.0%
Gastritis 3.8%
Hypothyroidism 3.2%
Mental Disorder 3.2%
Pneumonia 3.2%
Prophylaxis 3.2%
Diabetes Mellitus 2.2%
Ectopic Acth Syndrome 2.2%
Nephrogenic Diabetes Insipidus 2.2%
Infection 1.1%
Neoplasm 1.1%
Acth Stimulation Test 0.5%
Acth-producing Pituitary Tumour 0.5%
Adrenal Insufficiency 0.5%
Anticoagulant Therapy 0.5%
Myoclonus 14.1%
Off Label Use 14.1%
Fatigue 12.5%
Alanine Aminotransferase Increased 10.9%
Hepatitis Acute 9.4%
Nausea 4.7%
Vomiting 4.7%
Drug Interaction Potentiation 3.1%
Hepatitis 3.1%
Mental Status Changes 3.1%
Potentiating Drug Interaction 3.1%
Septic Shock 3.1%
Surgery 3.1%
Aspartate Aminotransferase Increased 1.6%
Headache 1.6%
Hypercholesterolaemia 1.6%
Hypertension 1.6%
Incorrect Route Of Drug Administration 1.6%
Liver Function Test Abnormal 1.6%
Multi-organ Failure 1.6%
Concomitant
Product Used For Unknown Indication 20.6%
Hypertension 14.7%
Pituitary-dependent Cushing's Syndrome 10.3%
Cushing's Syndrome 7.4%
Hypercorticoidism 5.9%
Carcinoid Tumour 4.4%
Haemochromatosis 4.4%
Haemolytic Anaemia 4.4%
Multiple Myeloma 4.4%
Adrenocortical Carcinoma 2.9%
Hypokalaemia 2.9%
Hypomagnesaemia 2.9%
Hypothyroidism 2.9%
Neoplasm Malignant 2.9%
Gastritis 1.5%
Hepatitis B 1.5%
Myelodysplastic Syndrome 1.5%
Pain 1.5%
Pulmonary Arterial Hypertension 1.5%
Steroid Therapy 1.5%
Mitral Valve Incompetence 14.3%
Vomiting 14.3%
Hypoglycaemia 9.5%
Pulmonary Embolism 9.5%
Therapeutic Embolisation 9.5%
Cardiovascular Disorder 4.8%
Dyspnoea 4.8%
Hyperglycaemia 4.8%
Mixed Liver Injury 4.8%
Off Label Use 4.8%
Renal Failure 4.8%
Somnolence 4.8%
Transaminases Increased 4.8%
Urinary Retention 4.8%