Imatinib



Indications and Reactions:

Role Indications Reactions
Primary
Chronic Myeloid Leukaemia 49.3%
Gastrointestinal Stromal Tumour 20.2%
Acute Lymphocytic Leukaemia 14.8%
Leukaemia 1.8%
Prophylaxis 1.6%
Diabetes Mellitus 1.2%
Hypereosinophilic Syndrome 1.2%
Metastatic Neoplasm 1.0%
Prophylaxis Against Graft Versus Host Disease 1.0%
Suicide Attempt 1.0%
Acute Myeloid Leukaemia 0.8%
Deep Vein Thrombosis 0.8%
Dermatofibrosarcoma 0.8%
Graft Versus Host Disease 0.8%
Antibiotic Therapy 0.6%
Blast Crisis In Myelogenous Leukaemia 0.6%
Corneal Transplant 0.6%
Dyspnoea 0.6%
Hypertension 0.6%
Immunosuppression 0.6%
Death 17.7%
Second Primary Malignancy 7.0%
Thrombocytopenia 6.5%
Treatment Failure 6.5%
Premature Baby 6.0%
Vomiting 6.0%
Complications Of Transplant Surgery 4.7%
Pancytopenia 4.7%
Pneumonia 4.2%
Sepsis 4.2%
Therapeutic Response Decreased 4.2%
Weight Increased 4.2%
Pyrexia 3.7%
White Blood Cell Count Decreased 3.7%
Cardiac Failure 3.3%
Drug Resistance 2.8%
Malignant Neoplasm Progression 2.8%
Splenomegaly 2.8%
White Blood Cell Count Increased 2.8%
Maternal Exposure During Pregnancy 2.3%
Secondary
Acute Lymphocytic Leukaemia 44.9%
Chromosome Analysis Abnormal 22.5%
Chronic Myeloid Leukaemia 7.5%
Prophylaxis 5.3%
Gastrointestinal Stromal Tumour 3.5%
Antifungal Prophylaxis 3.5%
Product Used For Unknown Indication 2.9%
Prophylaxis Against Graft Versus Host Disease 2.4%
Colorectal Cancer 0.9%
Suicide Attempt 0.9%
Hodgkin's Disease 0.9%
Graft Versus Host Disease 0.8%
Pulmonary Arterial Hypertension 0.7%
Acute Undifferentiated Leukaemia 0.6%
Hypereosinophilic Syndrome 0.6%
Leukaemia 0.5%
Non-hodgkin's Lymphoma 0.5%
Bone Marrow Conditioning Regimen 0.4%
Colorectal Cancer Stage Iv 0.4%
Immunosuppression 0.4%
Off Label Use 12.1%
Thrombocytopenia 12.1%
Vomiting 12.1%
White Blood Cell Count Decreased 7.5%
Treatment Failure 6.9%
Rash 5.7%
Pancytopenia 5.2%
Suicide Attempt 5.2%
Pancreatitis 3.4%
Respiratory Failure 3.4%
Weight Increased 3.4%
Pneumonia 2.9%
Thrombocytosis 2.9%
Tumour Lysis Syndrome 2.9%
White Blood Cell Count Increased 2.9%
Hepatic Cirrhosis 2.3%
Hepatotoxicity 2.3%
Pancreatic Carcinoma 2.3%
Sepsis 2.3%
Stem Cell Transplant 2.3%
Concomitant
Product Used For Unknown Indication 38.6%
Drug Use For Unknown Indication 16.4%
Chronic Graft Versus Host Disease 5.5%
Prophylaxis 5.5%
Acute Lymphocytic Leukaemia 4.7%
Hypertension 4.7%
Chronic Myeloid Leukaemia 3.4%
Acute Graft Versus Host Disease 3.1%
Pain 2.9%
Pyoderma Gangrenosum 2.1%
Chemotherapy 1.8%
Infection Prophylaxis 1.6%
Non-small Cell Lung Cancer 1.6%
Cardiac Disorder 1.3%
Her-2 Positive Breast Cancer 1.3%
Stem Cell Transplant 1.3%
Antiviral Prophylaxis 1.0%
B Precursor Type Acute Leukaemia 1.0%
Depression 1.0%
Diabetes Mellitus 1.0%
Renal Failure Acute 12.2%
Palpitations 9.8%
Pancytopenia 7.3%
Septic Shock 7.3%
Vomiting 7.3%
Bronchospasm 4.9%
Cytomegalovirus Viraemia 4.9%
Peripheral Sensory Neuropathy 4.9%
Rash Maculo-papular 4.9%
Therapeutic Response Unexpected 4.9%
Thrombocytopenia 4.9%
Type Iii Immune Complex Mediated Reaction 4.9%
Vertigo 4.9%
Agranulocytosis 2.4%
Bronchopulmonary Aspergillosis 2.4%
Cystitis Haemorrhagic 2.4%
Death 2.4%
Disease Progression 2.4%
Disseminated Intravascular Coagulation 2.4%
Drug Level Above Therapeutic 2.4%
Interacting
Immunosuppression 17.1%
Atrial Fibrillation 14.3%
Chronic Myeloid Leukaemia 11.4%
Eosinophilic Leukaemia 11.4%
Gastrointestinal Stromal Tumour 11.4%
Product Used For Unknown Indication 11.4%
Abdominal Pain 8.6%
Metastases To Peritoneum 5.7%
Primary Hypothyroidism 5.7%
Mineral Supplementation 2.9%
Renal Impairment 31.3%
Transplant Rejection 18.8%
Drug Interaction 12.5%
Vomiting 12.5%
Hepatotoxicity 6.3%
Nausea 6.3%
Periorbital Oedema 6.3%
Tumour Lysis Syndrome 6.3%