Busulfan (Busulfan)



Indications and Reactions:

Role Indications Reactions
Primary
Stem Cell Transplant 82.5%
Drug Use For Unknown Indication 4.9%
Neuroblastoma 3.1%
Prophylaxis Against Graft Versus Host Disease 3.1%
Bone Marrow Conditioning Regimen 2.2%
Graft Versus Host Disease 1.3%
Ill-defined Disorder 0.9%
Acute Myeloid Leukaemia 0.4%
B-cell Type Acute Leukaemia 0.4%
Chronic Myelomonocytic Leukaemia 0.4%
Hyperbilirubinaemia 0.4%
Vomiting 21.9%
Stomatitis 18.8%
Venoocclusive Liver Disease 14.1%
Weight Increased 6.3%
Thrombotic Microangiopathy 5.5%
Graft Versus Host Disease 3.9%
Stem Cell Transplant 3.9%
Sepsis 3.1%
White Blood Cell Count Decreased 3.1%
Pleural Effusion 2.3%
Staphylococcal Sepsis 2.3%
Viraemia 2.3%
Lymphoproliferative Disorder 1.6%
Pneumonia Staphylococcal 1.6%
Renal Impairment 1.6%
Respiratory Distress 1.6%
Sarcoidosis 1.6%
Shock 1.6%
Streptococcal Sepsis 1.6%
Thrombotic Thrombocytopenic Purpura 1.6%
Secondary
Acute Myeloid Leukaemia 35.0%
Stem Cell Transplant 16.5%
Bone Marrow Conditioning Regimen 15.5%
Graft Versus Host Disease 5.5%
Acute Leukaemia 5.0%
Myeloid Leukaemia 4.5%
Haematological Malignancy 3.0%
Leukaemia 3.0%
Adrenoleukodystrophy 2.0%
Chronic Lymphocytic Leukaemia 2.0%
Medulloblastoma 1.5%
Transplant 1.5%
Acute Lymphocytic Leukaemia 1.0%
Drug Use For Unknown Indication 1.0%
Prophylaxis Against Graft Versus Host Disease 1.0%
Acute Myeloid Leukaemia Recurrent 0.5%
Cord Blood Transplant Therapy 0.5%
Myelodysplastic Syndrome 0.5%
T-cell Depletion 0.5%
Weight Increased 23.6%
Venoocclusive Liver Disease 14.5%
Oesophagitis 5.5%
Unresponsive To Stimuli 5.5%
Venoocclusive Disease 5.5%
White Blood Cell Count Decreased 5.5%
Graft Versus Host Disease 3.6%
Infection 3.6%
Platelet Count Decreased 3.6%
Renal Impairment 3.6%
Stem Cell Transplant 3.6%
Upper Respiratory Tract Infection 3.6%
Vomiting 3.6%
Weight Decreased 3.6%
Acute Graft Versus Host Disease 1.8%
Acute Lymphocytic Leukaemia Recurrent 1.8%
Cytomegalovirus Viraemia 1.8%
Dizziness Postural 1.8%
Epstein-barr Virus Infection 1.8%
Haemorrhage 1.8%
Concomitant
Stem Cell Transplant 31.3%
Bone Marrow Conditioning Regimen 13.5%
Bone Marrow Transplant 10.4%
Chemotherapy 9.4%
Prophylaxis Against Graft Versus Host Disease 8.3%
Graft Versus Host Disease 5.2%
Prophylaxis 5.2%
Haematopoietic Stem Cell Mobilisation 3.1%
Cord Blood Transplant Therapy 2.1%
Allogenic Bone Marrow Transplantation Therapy 1.0%
Antifungal Prophylaxis 1.0%
Chediak-higashi Syndrome 1.0%
Chronic Myeloid Leukaemia 1.0%
Combined Immunodeficiency 1.0%
Confusional State 1.0%
Essential Thrombocythaemia 1.0%
Infection Prophylaxis 1.0%
Mucopolysaccharidosis 1.0%
Mucopolysaccharidosis I 1.0%
Non-hodgkin's Lymphoma 1.0%
Thrombotic Microangiopathy 20.4%
Pancytopenia 7.4%
Pseudomonal Sepsis 7.4%
Pyrexia 5.6%
Renal Failure 5.6%
Stem Cell Transplant 5.6%
Upper Gastrointestinal Haemorrhage 5.6%
Delayed Engraftment 3.7%
Engraft Failure 3.7%
Epstein-barr Virus Infection 3.7%
Headache 3.7%
Infection 3.7%
Multi-organ Failure 3.7%
Pneumocystis Jiroveci Pneumonia 3.7%
Sepsis 3.7%
Septic Shock 3.7%
Serum Ferritin Increased 3.7%
Death 1.9%
Encephalitis Herpes 1.9%
Hypoxia 1.9%