Topiramate combined with Zonisamide

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vanishing Bile Duct Syndrome Other Serious 35 Male 1/23/2007
Primary
Secondary
Vanishing Bile Duct Syndrome Other Serious 35 Male 5/15/2007 Physician United States
Primary
Concomitant
Restless Legs Syndrome Other Serious 50 Female 8/20/2007
Primary
Secondary
Weight Decreased Life Threatening 6/1/2002 49 Female 127 lb 1/14/2008 Consumer United Kingdom
Primary
Concomitant
Weight Decreased Life Threatening 6/1/2002 49 Female 127 lb 2/25/2008 Consumer United Kingdom
Primary
Concomitant
Self Injurious Behaviour Other Serious Female 3/5/2008 Physician Japan
Primary
Concomitant
Pco2 Decreased Required Intervention 2/1/2008 47 Female 120 lb 10/7/2008 United States
Primary
Concomitant
Intra-uterine Death Other Serious 3/1/2008 40 Female 3/10/2009 Other Health Professional Netherlands
Primary
Secondary
Epilepsy Other Serious 6/2/2005 1 Male 22 lb 3/6/2009 Italy
Primary
Concomitant
Respiratory Arrest Required Intervention 2/1/2008 47 Female 120 lb 4/15/2009 United States
Primary
Concomitant
Muscle Spasms Other Serious 7/16/2007 31 Female 5/12/2009 Consumer United States
Primary
Concomitant
Death Death 6/10/2009 59 Female 157 lb 6/24/2009 Physician United States
Primary
Concomitant
Weight Decreased Life Threatening 6/1/2002 49 Female 127 lb 10/19/2009 United Kingdom
Primary
Concomitant
Weight Decreased Life Threatening 6/1/2002 49 Female 127 lb 10/27/2009 Consumer United Kingdom
Primary
Concomitant
Stomatitis Hospitalization 8/7/2009 35 Female 11/25/2009 Physician Japan
Primary
Concomitant
Weight Decreased Other Serious 6/1/2002 Female 127 lb 1/18/2010 Consumer United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Life Threatening 1/16/2006 Female 172 lb 3/11/2010 Germany
Primary
Secondary
Concomitant
Vomiting Other Serious 4/1/2006 27 Female 172 lb 3/18/2010 Physician
Primary
Secondary
Toxic Epidermal Necrolysis Life Threatening 5/1/2009 48 Male 4/5/2010 Physician Japan
Primary
Concomitant
Hallucination, Visual Hospitalization 9/26/2009 10 Male 4/16/2010 Other Health Professional Japan
Primary
Concomitant
Drug Exposure During Pregnancy Other Serious Female 4/23/2010 Other Health Professional United Kingdom
Primary
Secondary
Intra-uterine Death Other Serious 3/1/2008 35 Female 4/26/2010 Other Health Professional United Kingdom
Primary
Secondary
Maternal Drugs Affecting Foetus Death 35 4/26/2010 Other Health Professional United Kingdom
Primary
Secondary
Vertigo Other Serious 39 Female 4/27/2010 Austria
Primary
Concomitant
Myocardial Infarction Death 64 Male 6/11/2010 Germany
Primary
Secondary
Concomitant
Thrombophlebitis Hospitalization 6/7/2010 21 Female 7/23/2010 Pharmacist Ireland
Primary
Concomitant
Vomiting Hospitalization 27 Female 8/2/2010 Other Health Professional Germany
Primary
Secondary
Vomiting Hospitalization 27 Female 8/2/2010 Other Health Professional Germany
Primary
Secondary
Vomiting Hospitalization 27 Female 8/2/2010 Other Health Professional Germany
Primary
Secondary
Vomiting Hospitalization 27 Female 8/2/2010 Other Health Professional Germany
Primary
Secondary
Overdose Hospitalization 4/1/2006 27 Female 8/3/2010 Other Health Professional Germany
Primary
Secondary
Vomiting Hospitalization 4/1/2006 27 Female 7/30/2010 Other Health Professional Germany
Primary
Secondary
Vomiting Hospitalization 4/1/2006 27 Female 172 lb 8/25/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/16/2010 43 Male 9/1/2010 Other Health Professional Japan
Primary
Secondary
Nephrolithiasis Other Serious 6 Male 9/1/2010
Primary
Secondary
Calculus Urinary Other Serious 6 Male 9/8/2010 Other Health Professional United States
Primary
Secondary
Calculus Urinary Other Serious 6 Male 9/8/2010 Other Health Professional United States
Primary
Secondary
Calculus Urinary Other Serious 6 Male 9/8/2010 Other Health Professional United States
Primary
Secondary
Hyperammonaemic Encephalopathy Other Serious 5 Male 9/9/2010
Primary
Secondary
Myocardial Infarction 64 Male 9/7/2010 Physician Germany
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/16/2010 43 Male 9/22/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Respiratory Disorder Other Serious 14 Male 10/1/2010 Other Health Professional Japan
Primary
Secondary
Paranoia Other Serious 22 Female 10/21/2010 Other Health Professional Japan
Primary
Concomitant
Paranoia Other Serious 22 Female 11/8/2010 Other Health Professional Japan
Primary
Concomitant
Status Epilepticus Other Serious 38 Female 11/4/2010 Italy
Primary
Concomitant
Lennox-gastaut Syndrome Other Serious 38 Female 11/4/2010 Italy
Primary
Concomitant
Encephalopathy Hospitalization 8/21/2007 37 Female 154 lb 1/14/2011 Other Health Professional Korea, Republic Of
Primary
Secondary
Concomitant
Blood Urine Present Hospitalization 4/16/2010 43 Male 1/28/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Hyperammonaemic Encephalopathy Hospitalization 7/17/2010 79 Male 1/28/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Psychomotor Retardation Hospitalization 7/21/2007 37 Female 129 lb 1/31/2011 Other Health Professional Korea, Republic Of
Primary
Secondary
Concomitant
Speech Disorder Other Serious 21 Female 2/2/2011 Other Health Professional Denmark
Primary
Secondary
Concomitant
Grand Mal Convulsion Other Serious 21 Female 2/4/2011 United Kingdom
Primary
Secondary
Concomitant
Convulsion Hospitalization Female 134 lb Physician United States
Primary
Concomitant
Convulsion Other Serious Male 187 lb 3/4/2011 Physician United States
Primary
Concomitant
Fall Hospitalization Female 134 lb 2/25/2011 Physician United States
Primary
Concomitant
Quadriparesis Other Serious 74 Female 3/14/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious 1/1/2009 39 Male 3/7/2011 Physician Germany
Primary
Secondary
Concomitant
Balance Disorder Other Serious 37 Female 3/21/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Incorrect Route Of Drug Administration Death 52 Female 4/12/2011 Other Health Professional United Kingdom
Primary
Secondary
Abortion Spontaneous Other Serious Female 4/13/2011 Other Health Professional United Kingdom
Primary
Concomitant
Convulsion Other Serious 4/18/2011 72 Male 4/26/2011 Pharmacist Japan
Primary
Concomitant
Death Death 52 Female 4/15/2011 Physician United Kingdom
Primary
Secondary
Epilepsy Other Serious 4/18/2011 70 Male 4/26/2011 Physician Japan
Primary
Concomitant
Epilepsy Other Serious 4/18/2011 72 Male 5/3/2011 Physician Japan
Primary
Concomitant
Convulsion Other Serious 4/18/2011 72 Male 5/3/2011 Pharmacist Japan
Primary
Concomitant
Drug Ineffective Other Serious 27 Female 5/4/2011 Other Health Professional United Kingdom
Primary
Secondary
Brain Herniation Other Serious 27 Female 4/20/2011 Other Health Professional United Kingdom
Primary
Secondary
Encephalocele Other Serious 27 Female 4/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Drug Ineffective Other Serious 27 Female 4/27/2011 Other Health Professional United Kingdom
Primary
Secondary
Encephalocele Other Serious 27 Female 5/3/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cervical Vertebral Fracture Hospitalization 2/9/2011 27 Female 140 lb 5/6/2011 Physician United States
Primary
Concomitant
Drug Ineffective Other Serious 27 Female 5/11/2011 Other Health Professional United Kingdom
Primary
Concomitant
Drug Ineffective 27 Female 5/3/2011 Other Health Professional United Kingdom
Primary
Secondary
Vomiting Other Serious 6/15/2010 27 Male 196 lb 5/20/2011 Physician Japan
Primary
Concomitant
Status Epilepticus Hospitalization 8/26/2010 73 Male 5/23/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Pancytopenia Other Serious 5/1/2009 13 Female 5/24/2011 Other Health Professional Japan
Primary
Secondary
Grand Mal Convulsion Hospitalization 5/7/2011 27 Female 140 lb 5/16/2011 Physician United States
Primary
Concomitant
Epilepsy Other Serious 4/20/2011 72 Male 5/31/2011 Physician Japan
Primary
Concomitant
Drug Eruption Hospitalization 1/9/2010 35 Male 6/10/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Suicidal Ideation Other Serious 27 Female 172 lb 6/6/2011 Other Health Professional Germany
Primary
Concomitant
Epilepsy Other Serious 4/20/2011 72 Male 6/16/2011 Physician Japan
Primary
Concomitant
Fall Hospitalization Female 165 lb 6/24/2011 Physician United States
Primary
Secondary
Concomitant
Agranulocytosis Other Serious 50 Male 7/5/2011 Other Health Professional Japan
Primary
Secondary
Fall Hospitalization Female 165 lb 7/11/2011 Physician United States
Primary
Secondary
Concomitant
Hallucination Other Serious 4/1/2011 21 Female 7/22/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9/6/2001 4 Female 40 lb 7/26/2011 Other Health Professional Japan
Primary
Secondary
Multiple Sclerosis Other Serious Female 165 lb 7/28/2011 Physician United States
Primary
Secondary
Concomitant
Fall Other Serious Female 165 lb 7/28/2011 Physician United States
Primary
Secondary
Concomitant
Acute Tonsillitis Hospitalization 7/19/2011 3 Male 8/5/2011 Physician Japan
Primary
Secondary
Concomitant
Fall Hospitalization Female 165 lb 8/12/2011 Physician United States
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 1 Male 8/12/2011 Physician Japan
Primary
Concomitant
Convulsion Other Serious 67 Male 8/15/2011 Other Health Professional Japan
Primary
Concomitant
Oculomucocutaneous Syndrome Hospitalization 51 Female 8/19/2011 Physician Japan
Primary
Concomitant
Convulsion Other Serious 67 Male 8/24/2011 Other Health Professional Japan
Primary
Concomitant
Status Epilepticus Hospitalization Female 8/26/2011 Physician Japan
Primary
Concomitant
Cervical Vertebral Fracture Other Serious 2/9/2011 27 Female 134 lb 8/19/2011 Physician United States
Primary
Concomitant
Hypotension Hospitalization 8/19/2011 45 Male 8/26/2011 United States
Primary
Concomitant
Malaise Other Serious 1/1/2008 67 Male 9/2/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Feeling Abnormal Other Serious 1/1/2008 67 Male 9/2/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Band Neutrophil Percentage Increased Hospitalization 8/4/2011 51 Female 9/2/2011 Physician Japan
Primary
Concomitant
Feeling Abnormal Other Serious 1/1/2008 67 Male 9/6/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 7/27/2011 19 Female 9/14/2011 Physician Japan
Primary
Concomitant
Vomiting Other Serious 7/1/2011 Male 9/19/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Haematocrit Increased Hospitalization 8/4/2011 51 Female 9/19/2011 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 7/14/2011 36 Female 229 lb 9/23/2011 Consumer United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 8/4/2011 51 Female 9/23/2011 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 7/14/2011 36 Female 229 lb 10/3/2011 Consumer United States
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 7/14/2011 Male 10/3/2011 Physician Japan
Primary
Secondary
Concomitant
Mucosal Erosion Hospitalization 8/4/2011 51 Female 10/5/2011 Physician Japan
Primary
Concomitant
Hallucination, Auditory Other Serious 4/13/2011 21 Female 10/12/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Drug Prescribing Error Other Serious 7/1/2011 Male 10/14/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Epilepsy Death 10/1/2009 23 Female 10/17/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Liver Disorder Hospitalization 10/1/2009 23 Female 10/19/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Liver Disorder Death 10/1/2009 23 Female 10/20/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Dyshidrosis Other Serious 7/1/2011 Male 10/24/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Psychomotor Retardation Other Serious Male 10/24/2011 Other Health Professional India
Primary
Secondary
Concomitant
Cellulitis Hospitalization 1/9/2010 35 Male 11/4/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 7/1/2011 Male 11/4/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Drug Prescribing Error Other Serious 6/27/2011 Male 11/11/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Hyperammonaemia Death 10/1/2009 23 Female 11/14/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Suicidal Ideation Hospitalization 1/14/2003 34 Male 11/21/2011 Consumer United States
Primary
Concomitant
Somnolence Other Serious 2/14/2009 42 Female 11/23/2011 Consumer United States
Primary
Concomitant
Fatigue 6/7/2011 55 Female 9/8/2011 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 7/19/2011 3 Male 12/19/2011 Physician Japan
Primary
Secondary
Concomitant
Near Drowning Hospitalization 10/1/2009 23 Female 1/13/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Dehydration Hospitalization 7/1/2011 Male 1/17/2012 Physician Japan
Primary
Secondary
Concomitant
Poisoning Death 6/9/2009 59 Female 157 lb 1/20/2012 Physician United States
Primary
Secondary
Concomitant
Convulsion Other Serious 21 Female 2/7/2012 Other Health Professional United States
Primary
Secondary
Rash 11/6/2011 56 Female 135 lb 12/10/2011 United States
Primary
Concomitant
Memory Impairment Hospitalization 1/10/2000 15 Female 12/13/2011 Consumer United States
Primary
Concomitant
Malaise Other Serious 29 Female 220 lb 12/13/2011 Consumer United States
Primary
Concomitant
Adverse Drug Reaction Hospitalization 1/1/2009 39 Female 12/13/2011 United States
Primary
Concomitant
Myoclonic Epilepsy Hospitalization 4/23/2011 6 Male 12/13/2011 United States
Primary
Concomitant
Cyanosis Other Serious 2/4/2011 43 Female 3/9/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 9/6/2001 4 Female 40 lb 3/9/2012 Japan
Primary
Secondary
Cyanosis Other Serious 2/4/2011 43 Female 3/16/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Injection Site Rash Other Serious 1/1/2010 53 Female 8/18/2011 Physician United States
Primary
Concomitant
Ecchymosis Other Serious 1/1/2010 53 Female 8/18/2011 Physician United States
Primary
Concomitant
Death Other Serious 3/5/2012 90 Female 3/22/2012 Pharmacist United States
Primary
Concomitant
Hypoaesthesia Other Serious 53 Female 5/18/2011 Physician United States
Primary
Concomitant
Injection Site Erythema Other Serious 53 Female 5/18/2011 Physician United States
Primary
Concomitant
Cyanosis Other Serious 2/4/2011 43 Female 5/22/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Abscess Hospitalization 7/27/2009 9 Male 35 lb 5/30/2012 Physician Japan
Primary
Concomitant
Partial Seizures Other Serious 31 Female 6/20/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Protrusion Tongue Other Serious 31 Female 7/9/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Gait Disturbance Other Serious 31 Female 7/13/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Partial Seizures Other Serious 31 Female 7/10/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Movement Disorder Other Serious 31 Female 7/10/2012 Consumer United Kingdom
Primary
Secondary
Concomitant
Mobility Decreased Other Serious 31 Female 7/10/2012 Consumer United Kingdom
Primary
Secondary
Concomitant
General Physical Health Deterioration Other Serious 31 Female 7/10/2012 Other Health Professional
Primary
Secondary
Concomitant

Drug Data