Tocilizumab combined with Voltaren

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Palpitations Hospitalization 6/1/2006 56 Female 115 lb 6/16/2006 Physician Japan
Primary
Concomitant
Cardiac Failure Life Threatening 1/20/2009 Female 77 lb 2/11/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Cardiac Failure Life Threatening 1/20/2009 Female 77 lb 3/6/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Cardiac Failure Life Threatening 1/20/2009 Female 77 lb 4/3/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 12/11/2008 Female 77 lb 4/9/2009 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Life Threatening 1/20/2009 Female 77 lb 4/16/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Gamma-glutamyltransferase Increased Hospitalization 7/4/2008 Female 77 lb 1/18/2010 Physician Japan
Primary
Secondary
Concomitant
Rash Generalised Life Threatening 7/30/2008 Male 108 lb 1/20/2010 Physician Japan
Primary
Secondary
Concomitant
Varicose Vein Ruptured Hospitalization 3/7/2009 Male 209 lb 1/21/2010 Physician Japan
Primary
Concomitant
Renal Impairment Other Serious 8/7/2008 Male 117 lb 1/22/2010 Physician Japan
Primary
Secondary
Concomitant
Septic Shock Life Threatening 12/25/2008 Female 1/27/2010 Physician Japan
Primary
Concomitant
Subcutaneous Abscess Hospitalization 4/22/2009 Female 139 lb 2/2/2010 Physician Japan
Primary
Concomitant
Renal Impairment Other Serious 8/7/2008 Male 117 lb 2/2/2010 Physician Japan
Primary
Secondary
Concomitant
Subdural Haematoma Hospitalization 9/17/2008 Female 93 lb 2/4/2010 Physician Japan
Primary
Concomitant
Thrombocytopenia Other Serious 1/1/2008 Female 130 lb 2/9/2010 Physician Japan
Primary
Secondary
Concomitant
Lymphoma Hospitalization 9/22/2009 Female 99 lb 2/9/2010 Physician Japan
Primary
Secondary
Concomitant
Shock Haemorrhagic Hospitalization 3/7/2009 Male 112 lb 2/9/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious 8/7/2008 Male 117 lb 2/11/2010 Physician Japan
Primary
Secondary
Concomitant
Skin Maceration Hospitalization 10/1/2009 Male 416 lb 2/11/2010 Physician United States
Primary
Concomitant
Dermatitis Bullous Hospitalization 4/26/2009 Female 126 lb 2/12/2010 Physician Japan
Primary
Secondary
Concomitant
Anaphylactic Shock Other Serious 5/28/2009 Female 2/12/2010 Physician Japan
Primary
Concomitant
Altered State Of Consciousness Hospitalization 1/23/2010 Female 112 lb 2/12/2010 Physician Japan
Primary
Concomitant
Rash Generalised Life Threatening 7/30/2008 Male 108 lb 2/16/2010 Physician Japan
Primary
Secondary
Concomitant
Syncope Hospitalization 10/15/2009 Female 111 lb 2/16/2010 Physician United States
Primary
Concomitant
Septic Shock Hospitalization 1/5/2010 Female 2/16/2010 Physician Japan
Primary
Secondary
Concomitant
Septic Shock Life Threatening 12/25/2008 Female 2/23/2010 Physician Japan
Primary
Secondary
Concomitant
Subdural Haematoma Hospitalization 9/17/2008 Female 93 lb 2/26/2010 Physician Japan
Primary
Secondary
Concomitant
Skin Ulcer Hospitalization 10/20/2008 Female 2/26/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 8/14/2009 Female 2/26/2010 Physician Japan
Primary
Secondary
Concomitant
Gallbladder Perforation Hospitalization 9/21/2009 Female 172 lb 3/4/2010 Physician United States
Primary
Secondary
Concomitant
Rib Fracture Hospitalization 5/7/2009 Male 3/15/2010 Physician Japan
Primary
Concomitant
Rectal Ulcer Hospitalization 10/1/2009 Male 416 lb 3/22/2010 Physician United States
Primary
Concomitant
Altered State Of Consciousness Hospitalization 1/23/2010 Female 112 lb 3/24/2010 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 8/14/2009 Female 3/24/2010 Physician Japan
Primary
Secondary
Concomitant
Shock Haemorrhagic Hospitalization 3/7/2009 Male 112 lb 3/29/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Deep Vein Thrombosis Life Threatening 9/21/2009 Female 172 lb 3/29/2010 Physician United States
Primary
Secondary
Concomitant
Non-hodgkin's Lymphoma Hospitalization 9/22/2009 Female 99 lb 3/29/2010 Physician Japan
Primary
Secondary
Concomitant
Skin Ulcer Hospitalization 10/20/2008 Female 3/30/2010 Physician Japan
Primary
Secondary
Concomitant
Glomerulonephritis Acute Other Serious 3/16/2010 61 Female 126 lb 4/6/2010 Physician Japan
Primary
Concomitant
Lower Gastrointestinal Haemorrhage Hospitalization Female 143 lb 4/21/2010 Physician Japan
Primary
Concomitant
Oral Herpes Other Serious 8/13/2008 66 Female 143 lb 4/22/2010 Physician Japan
Primary
Concomitant
Varicose Vein Other Serious 9/26/2008 61 Female 150 lb 4/23/2010 Physician Japan
Primary
Concomitant
Lower Gastrointestinal Haemorrhage Hospitalization Female 143 lb 4/27/2010 Physician Japan
Primary
Concomitant
Small Intestinal Perforation Life Threatening 6/22/2009 74 Male 4/30/2010 Physician Japan
Primary
Secondary
Concomitant
Altered State Of Consciousness Hospitalization 1/23/2010 76 Female 112 lb 5/3/2010 Physician Japan
Primary
Concomitant
Death Death 3/1/2010 70 Female 5/12/2010 Physician Japan
Primary
Concomitant
Subcutaneous Abscess Hospitalization 4/22/2009 53 Female 139 lb 5/12/2010 Physician Japan
Primary
Concomitant
Thrombocytopenia Other Serious 1/1/2008 51 Female 130 lb 5/20/2010 Physician Japan
Primary
Secondary
Concomitant
Oral Herpes Other Serious 8/13/2008 66 Female 143 lb 5/20/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 8/14/2009 52 Female 5/27/2010 Physician Japan
Primary
Secondary
Concomitant
C-reactive Protein Increased Hospitalization 1/24/2010 76 Female 112 lb 5/27/2010 Physician Japan
Primary
Concomitant
Skin Ulcer Hospitalization 2/3/2010 58 Female 170 lb 5/27/2010 Physician Japan
Primary
Concomitant
Hypertriglyceridaemia 9/26/2008 61 Female 150 lb 5/27/2010 Physician Japan
Primary
Concomitant
Vision Blurred Hospitalization 8/11/2009 62 Female 110 lb 6/8/2010 Physician Japan
Primary
Concomitant
Oral Herpes Other Serious 8/13/2008 66 Female 143 lb 6/9/2010 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Death 2/17/2009 69 Female 144 lb 6/16/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Life Threatening 3/1/2010 70 Female 6/16/2010 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Death 5/27/2010 62 Male 6/17/2010 Physician Japan
Primary
Concomitant
Renal Impairment Hospitalization 8/7/2008 70 Male 117 lb 6/18/2010 Physician Japan
Primary
Secondary
Concomitant
Hypertriglyceridaemia Hospitalization 1/12/2010 60 Female 115 lb 6/22/2010 Physician Japan
Primary
Concomitant
Palpitations Other Serious 10/17/2008 37 Female 7/2/2010 Physician Japan
Primary
Concomitant
Palpitations Other Serious 10/17/2008 37 Female 7/6/2010 Physician Japan
Primary
Concomitant
Lymphopenia Other Serious 6/1/2009 71 Male 139 lb 7/9/2010 Physician Japan
Primary
Concomitant
Septic Shock Hospitalization 1/5/2010 68 Female 7/10/2010 Physician Japan
Primary
Secondary
Concomitant
Breast Cancer Hospitalization 3/4/2010 63 Female 7/16/2010 Physician Japan
Primary
Concomitant
Lung Neoplasm Malignant Hospitalization Female 7/19/2010 Physician Japan
Primary
Concomitant
Vasculitis Hospitalization 12/13/2009 52 Female 88 lb 7/20/2010 Physician Japan
Primary
Concomitant
Spinal Compression Fracture Hospitalization 8/13/2009 61 Female 7/22/2010 Physician Japan
Primary
Secondary
Concomitant
Retinal Detachment Hospitalization 12/28/2009 55 Male 118 lb 7/23/2010 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 1/24/2010 76 Female 112 lb 7/30/2010 Physician Japan
Primary
Concomitant
Benign Intracranial Hypertension Hospitalization 5/25/2010 14 Female 188 lb 8/6/2010 Physician Canada
Primary
Concomitant
Sciatica Life Threatening 1/1/2008 68 Female 8/6/2010 Physician Japan
Primary
Concomitant
Upper Respiratory Tract Inflammation Hospitalization 9/2/2008 47 Male 8/17/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Spinal Compression Fracture Hospitalization 8/13/2009 61 Female 8/23/2010 Physician Japan
Primary
Secondary
Concomitant
Hypertriglyceridaemia Hospitalization 11/17/2009 60 Female 115 lb 8/23/2010 Physician Japan
Primary
Concomitant
Sciatica Life Threatening 3/19/2010 70 Female 86 lb 8/23/2010 Physician Japan
Primary
Concomitant
Upper Respiratory Tract Inflammation Hospitalization 9/2/2008 47 Male 8/27/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Pneumoperitoneum Other Serious 6/17/2009 78 Female 9/7/2010 Physician Japan
Primary
Concomitant
Hepatitis Cholestatic Hospitalization 8/30/2010 69 Female 121 lb 9/13/2010 Physician Germany
Primary
Secondary
Concomitant
Breast Cancer Hospitalization 3/4/2010 63 Female 9/15/2010 Physician Japan
Primary
Concomitant
Thrombosis Death 6/30/2010 58 Male 152 lb 9/15/2010 Physician Japan
Primary
Concomitant
Skin Ulcer Hospitalization 2/3/2010 58 Female 170 lb 9/16/2010 Physician Japan
Primary
Concomitant
Vasculitis Hospitalization 12/13/2009 52 Female 88 lb 9/20/2010 Physician Japan
Primary
Concomitant
Hepatitis Cholestatic Hospitalization 8/30/2010 69 Female 121 lb 9/22/2010 Physician Germany
Primary
Secondary
Concomitant
Glomerulonephritis Acute Other Serious 3/16/2010 61 Female 126 lb 9/23/2010 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Hospitalization 11/6/2009 55 Male 9/24/2010 Physician Japan
Primary
Concomitant
Pneumoperitoneum Other Serious 6/17/2009 78 Female 126 lb 9/27/2010 Physician Japan
Primary
Concomitant
Palpitations Hospitalization 10/17/2008 37 Female 9/29/2010 Physician Japan
Primary
Concomitant
Thrombosis Death 6/30/2010 58 Male 152 lb 9/29/2010 Physician Japan
Primary
Concomitant
Hepatitis Cholestatic Hospitalization 8/30/2010 69 Female 121 lb 9/30/2010 Physician Germany
Primary
Secondary
Concomitant
Vision Blurred Hospitalization 8/11/2009 62 Female 110 lb 10/4/2010 Physician Japan
Primary
Secondary
Concomitant
Retinal Detachment Hospitalization 10/13/2009 55 Male 118 lb 10/5/2010 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 4/26/2009 76 Female 104 lb 10/6/2010 Physician Japan
Primary
Secondary
Concomitant
Enterocolitis Haemorrhagic Hospitalization 5/3/2010 63 Female 162 lb 10/13/2010 Other Health Professional Germany
Primary
Concomitant
Tinea Pedis Hospitalization 4/2/2009 69 Female 105 lb 10/15/2010 Physician Japan
Primary
Concomitant
Rash Generalised Life Threatening 7/30/2008 56 Male 108 lb 10/18/2010 Physician Japan
Primary
Secondary
Concomitant
Pericarditis Rheumatic Other Serious 4/20/2009 59 Female 10/19/2010 Physician Japan
Primary
Concomitant
Neoplasm Malignant Life Threatening 9/22/2008 53 Female 153 lb 10/19/2010 Physician Japan
Primary
Concomitant
Peripheral Vascular Disorder Life Threatening 3/19/2010 70 Female 86 lb 10/19/2010 Physician Japan
Primary
Concomitant
Breast Cancer Hospitalization 11/8/2009 53 Female 10/21/2010 Physician Japan
Primary
Concomitant
Hepatitis Cholestatic Hospitalization 8/30/2010 69 Female 121 lb 10/22/2010 Physician Germany
Primary
Secondary
Concomitant
Spinal Cord Neoplasm Hospitalization 8/7/2010 55 Male 130 lb 10/26/2010 Physician Japan
Primary
Concomitant
Psoriasis Other Serious 3/1/2010 67 Male 176 lb 10/26/2010 Physician Germany
Primary
Concomitant
Tinea Manuum Hospitalization 2/17/2010 76 Female 10/28/2010 Physician Japan
Primary
Concomitant
Tachycardia Other Serious 3/1/2010 70 Female 86 lb 11/1/2010 Physician Japan
Primary
Secondary
Concomitant
Thrombosis Other Serious 10/9/2008 57 Male 152 lb 11/4/2010 Physician Japan
Primary
Concomitant
Renal Disorder Hospitalization 3/1/2010 61 Female 134 lb 11/15/2010 Physician Japan
Primary
Concomitant
Spinal Cord Neoplasm Hospitalization 8/7/2010 55 Male 130 lb 11/15/2010 Physician Japan
Primary
Concomitant
Tachycardia Other Serious 3/1/2010 70 Female 86 lb 11/17/2010 Physician Japan
Primary
Secondary
Concomitant
Tachycardia Other Serious 3/1/2010 70 Female 86 lb 11/18/2010 Physician Japan
Primary
Secondary
Concomitant
Tinea Manuum 2/17/2010 76 Female 11/22/2010 Physician Japan
Primary
Concomitant
Hepatitis Cholestatic Hospitalization 8/22/2010 69 Female 121 lb 11/23/2010 Physician Germany
Primary
Secondary
Concomitant
Spinal Cord Neoplasm Hospitalization 8/7/2010 55 Male 130 lb 12/1/2010 Physician Japan
Primary
Concomitant
Renal Cell Carcinoma Life Threatening 9/22/2008 53 Female 153 lb 12/1/2010 Physician Japan
Primary
Secondary
Concomitant
Subdural Haematoma Hospitalization 9/17/2008 70 Female 93 lb 12/3/2010 Physician Japan
Primary
Secondary
Concomitant
Tachycardia Other Serious 3/1/2010 70 Female 86 lb 12/6/2010 Physician Japan
Primary
Secondary
Concomitant
Soft Tissue Infection Other Serious 1/1/2010 71 Female 88 lb 12/9/2010 Physician Japan
Primary
Concomitant
Lumbar Vertebral Fracture Hospitalization 10/25/2010 74 Female 120 lb 12/22/2010 Physician Japan
Primary
Secondary
Concomitant
Benign Intracranial Hypertension Hospitalization 5/25/2010 14 Female 188 lb 12/23/2010 Physician Canada
Primary
Concomitant
Breast Cancer Female Hospitalization 10/8/2009 53 Female 12/28/2010 Physician Japan
Primary
Concomitant
Lymphopenia Hospitalization 2/4/2009 71 Male 137 lb 12/28/2010 Physician Japan
Primary
Concomitant
Spinal Column Stenosis Hospitalization 10/25/2010 74 Female 120 lb 1/4/2011 Physician Japan
Primary
Secondary
Concomitant
Joint Arthroplasty Hospitalization 9/22/2008 30 Female 88 lb 1/31/2011 Physician Japan
Primary
Concomitant
Cytomegalovirus Infection Hospitalization 3/3/2010 61 Female 134 lb 1/31/2011 Other Health Professional Japan
Primary
Concomitant
C-reactive Protein Increased Life Threatening 9/3/2010 63 Male 115 lb 1/31/2011 Physician Japan
Primary
Concomitant
Neoplasm Hospitalization 8/7/2010 55 Male 130 lb 2/1/2011 Other Health Professional Japan
Primary
Concomitant
Blood Cholesterol Increased Hospitalization 2/1/2009 72 Male 2/2/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Life Threatening 5/27/2010 62 Male 137 lb 2/16/2011 Other Health Professional Japan
Primary
Concomitant
Hepatitis Toxic Hospitalization 8/22/2010 69 Female 121 lb 2/16/2011 Physician Germany
Primary
Secondary
Concomitant
Non-hodgkin's Lymphoma Hospitalization 9/22/2009 62 Female 99 lb 2/23/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumococcal Bacteraemia Hospitalization 1/1/2010 71 Female 88 lb 3/3/2011 Physician Japan
Primary
Concomitant
Anaemia Life Threatening 9/3/2010 63 Male 115 lb 3/3/2011 Physician Japan
Primary
Concomitant
Abortion Spontaneous Other Serious 1/28/2008 41 Female 3/15/2011 Physician United States
Primary
Secondary
Cellulitis Hospitalization 3/7/2009 71 Male 112 lb 3/15/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Blood Creatinine Decreased Life Threatening 4/26/2009 76 Female 104 lb 3/16/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Pancreatitis Acute Life Threatening 12/27/2009 52 Female 3/16/2011 Other Health Professional Japan
Primary
Concomitant
C-reactive Protein Increased Hospitalization 1/25/2010 62 Female 108 lb 3/22/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Rheumatoid Vasculitis Hospitalization 3/5/2011 68 Male 3/24/2011 Consumer Canada
Primary
Concomitant
Oxygen Saturation Decreased Hospitalization 7/23/2008 67 Female 3/25/2011 Other Health Professional Japan
Primary
Concomitant
Muscle Haemorrhage Hospitalization 7/14/2008 81 Male 126 lb 3/28/2011 Physician Japan
Primary
Concomitant
Joint Destruction Hospitalization 9/17/2008 70 Female 93 lb 3/29/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 3/1/2011 56 Female 118 lb 4/7/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Bronchitis Hospitalization 5/12/2009 59 Female 4/7/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 3/20/2011 56 Female 118 lb 4/12/2011 Physician Japan
Primary
Secondary
Concomitant
Rheumatoid Vasculitis Hospitalization 3/7/2011 68 Male 143 lb 4/12/2011 Physician Canada
Primary
Concomitant
Colitis Ischaemic Hospitalization 6/2/2010 38 Female 4/13/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Hypertriglyceridaemia Hospitalization 9/17/2008 70 Female 93 lb 4/15/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Arthritis Hospitalization 2/1/2009 72 Male 4/18/2011 Physician Japan
Primary
Secondary
Concomitant
C-reactive Protein Increased Hospitalization 12/1/2009 62 Female 108 lb 4/20/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Gait Disturbance Hospitalization 7/14/2008 81 Male 126 lb 4/26/2011 Physician Japan
Primary
Secondary
Concomitant

Drug Data