Sunitinib Malate combined with Zoledronic Acid

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
No Therapeutic Response Hospitalization 4/26/2006 65 Male 176 lb 3/20/2007 Physician United States
Primary
Secondary
Concomitant
Gingival Pain Hospitalization 4/26/2006 65 Male 176 lb 4/16/2007 Physician United States
Primary
Secondary
Concomitant
Osteonecrosis Hospitalization 5/12/2006 Male 7/3/2008 Physician United States
Primary
Concomitant
Renal Cell Carcinoma Other Serious 4/26/2006 Male 170 lb 8/12/2008 Physician United States
Primary
Secondary
Concomitant
Renal Cell Carcinoma Other Serious 4/26/2006 Male 170 lb 8/12/2008 Physician United States
Primary
Secondary
Concomitant
Renal Cell Carcinoma Other Serious 4/26/2006 Male 170 lb 9/19/2008 Physician United States
Primary
Secondary
Concomitant
Sequestrectomy Other Serious 4/26/2006 Male 170 lb 9/23/2008 Physician United States
Primary
Secondary
Concomitant
Colitis Ulcerative Hospitalization 8/18/2008 56 Female 110 lb 9/24/2008 Consumer United States
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 11/1/2006 59 Male 12/31/2008 Physician Italy
Primary
Secondary
Pulmonary Embolism Life Threatening 12/29/2008 3/11/2009 Physician France
Primary
Concomitant
Vomiting Hospitalization 2/6/2009 Female 128 lb 3/19/2009 Physician United States
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 3/1/2008 3/25/2009 Physician Greece
Primary
Secondary
Cholecystitis Other Serious 4/10/2008 Female 172 lb 4/1/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pain In Jaw Other Serious 3/1/2008 48 Male 4/1/2009 Other Health Professional Greece
Primary
Concomitant
Tooth Extraction Other Serious Male 4/2/2009 Other Health Professional France
Primary
Concomitant
Osteonecrosis Other Serious 4/7/2009 Other Health Professional France
Primary
Secondary
Neutropenia Hospitalization 11/25/2008 4/9/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/6/2009 Female 128 lb 4/16/2009 Physician United States
Primary
Secondary
Concomitant
Encephalopathy Hospitalization 2/20/2008 4/22/2009 Physician Belgium
Primary
Concomitant
Neutropenia Hospitalization 11/25/2008 5/7/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 3/24/2009 79 6/1/2009 Physician Czech Republic
Primary
Concomitant
Paraesthesia Hospitalization 5/19/2009 50 6/9/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 6/10/2009 Other Health Professional France
Primary
Secondary
Thrombocytopenia Hospitalization 3/24/2009 79 6/15/2009 Physician Czech Republic
Primary
Concomitant
Neutropenia Hospitalization 11/25/2008 64 6/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Convulsion Hospitalization 5/19/2009 50 6/26/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Convulsion Hospitalization 5/19/2009 50 6/26/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Convulsion Hospitalization 5/19/2009 50 7/13/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Osteonecrosis Hospitalization 1/10/2007 Male 7/23/2009 Physician United States
Primary
Concomitant
Convulsion Hospitalization 5/19/2009 50 7/31/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 2/25/2009 79 7/31/2009 Physician Czech Republic
Primary
Concomitant
Colitis Ulcerative Hospitalization 8/18/2008 Female 110 lb 8/28/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Convulsion Hospitalization 5/19/2009 50 9/4/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/19/2007 40 9/28/2009 Other Health Professional United Kingdom
Primary
Concomitant
Skin Lesion Hospitalization 5/9/2006 69 10/13/2009 Physician France
Primary
Concomitant
Death Death 10/1/2007 45 10/30/2009 Physician Turkey
Primary
Concomitant
Vomiting Hospitalization 7/19/2007 40 Male 11/27/2009 Other Health Professional United Kingdom
Primary
Concomitant
Death Death 11/13/2009 51 Female 12/2/2009 Physician Japan
Primary
Concomitant
Metastatic Renal Cell Carcinoma Other Serious 8/29/2006 Male 212 lb 12/14/2009 Physician Argentina
Primary
Concomitant
Osteonecrosis Hospitalization 1/29/2010 76 Male 3/4/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Osteonecrosis Hospitalization 1/1/2010 76 Male 3/15/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Neoplasm Malignant Other Serious 5/6/2006 74 Female 126 lb 3/26/2010 Physician France
Primary
Concomitant
Vomiting Hospitalization 7/19/2007 40 Male 4/13/2010 Other Health Professional United Kingdom
Primary
Concomitant
Osteonecrosis Of Jaw Hospitalization 1/29/2010 76 Male 5/7/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Hypoacusis Hospitalization 2/7/2006 66 Male 5/21/2010 Other Health Professional Belgium
Primary
Concomitant
Cholecystitis Other Serious 4/10/2008 43 Female 172 lb 6/11/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pleural Effusion 2/16/2009 60 Female 181 lb 6/11/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 3/10/2010 65 Male 187 lb 6/18/2010 Physician Germany
Primary
Secondary
Concomitant
Gastroenteritis Hospitalization 5/20/2010 79 Male 172 lb 6/24/2010 Other Health Professional Brazil
Primary
Secondary
Concomitant
Necrosis Other Serious 6/14/2010 71 Male 163 lb 6/24/2010 Physician Germany
Primary
Secondary
Concomitant
Cellulitis Hospitalization 6/8/2010 59 Male 128 lb 6/29/2010 Physician Taiwan, Province Of China
Primary
Secondary
Concomitant
Osteonecrosis Of Jaw Other Serious 10/18/2006 57 Male 220 lb 7/8/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 3/10/2010 65 Male 187 lb 7/9/2010 Physician Germany
Primary
Secondary
Concomitant
Osteonecrosis Of Jaw Other Serious 10/18/2006 Male 220 lb 7/22/2010 Physician United States
Primary
Concomitant
Sensory Disturbance Other Serious 51 Male 7/28/2010 Other Health Professional United Kingdom
Primary
Concomitant
Cellulitis Hospitalization 7/23/2010 59 Male 128 lb 8/5/2010 Physician Taiwan, Province Of China
Primary
Secondary
Concomitant
Muscular Weakness Hospitalization 6/8/2010 61 Female 8/10/2010 Physician Spain
Primary
Concomitant
Osteonecrosis Of Jaw Hospitalization 1/1/2010 76 Male 197 lb 8/10/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 7/23/2010 59 Male 128 lb 8/17/2010 Physician Taiwan, Province Of China
Primary
Secondary
Concomitant
Osteonecrosis Of Jaw Hospitalization 1/1/2010 76 Male 197 lb 8/27/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Osteonecrosis Of Jaw Other Serious 1/1/2010 76 Male 153 lb 8/30/2010 Physician United States
Primary
Secondary
Concomitant
Necrosis Other Serious 6/14/2010 71 Male 163 lb 8/31/2010 Physician Germany
Primary
Secondary
Concomitant
Pneumonia Bacterial Other Serious 4/14/2010 48 Male 9/7/2010 Physician Japan
Primary
Concomitant
Respiratory Disorder Other Serious 4/14/2010 48 Male 9/13/2010 Physician Japan
Primary
Concomitant
Renal Impairment Hospitalization 1/1/2010 76 Male 196 lb 9/20/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hepatic Failure Hospitalization 10/5/2010 78 Male 167 lb 10/19/2010 Other Health Professional Canada
Primary
Secondary
Concomitant
Neoplasm Malignant Other Serious 3/6/2006 74 Female 126 lb 10/25/2010 Physician France
Primary
Concomitant
Hepatic Failure Hospitalization 10/5/2010 78 Male 167 lb 10/27/2010 Other Health Professional Canada
Primary
Secondary
Concomitant
Dizziness Hospitalization 6/8/2010 59 Male 128 lb 11/2/2010 Physician Taiwan, Province Of China
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 7/23/2010 59 Male 128 lb 11/3/2010 Physician Taiwan, Province Of China
Primary
Secondary
Concomitant
Necrosis Other Serious 6/14/2010 71 Male 163 lb 11/5/2010 Physician Germany
Primary
Secondary
Concomitant
Somnolence Other Serious 3/3/2006 67 Female 121 lb 11/5/2010 Physician Germany
Primary
Concomitant
Interacting
Gastroenteritis Hospitalization 5/20/2010 79 Male 172 lb 11/9/2010 Other Health Professional Brazil
Primary
Secondary
Concomitant
Tooth Loss Other Serious 11/1/2006 59 Male 11/10/2010 Physician Italy
Primary
Secondary
Hepatic Failure Hospitalization 10/5/2010 78 Male 167 lb 11/10/2010 Other Health Professional Canada
Primary
Secondary
Concomitant
Somnolence Other Serious 3/3/2006 67 Female 121 lb 11/18/2010 Physician Germany
Primary
Concomitant
Interacting
Osteonecrosis Of Jaw Other Serious 11/26/2010 Physician Denmark
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 11/26/2010 Physician Denmark
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 11/26/2010 Physician Denmark
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 11/26/2010 Physician Denmark
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 11/26/2010 Physician Denmark
Primary
Secondary
Thrombocytopenia Life Threatening 7/24/2006 72 Male 170 lb 12/10/2010 Other Health Professional Belgium
Primary
Concomitant
Decreased Appetite Hospitalization 3/25/2010 59 Male 130 lb 12/10/2010 Physician Taiwan, Province Of China
Primary
Secondary
Concomitant
Cholecystitis Other Serious 4/10/2008 43 Female 172 lb 12/15/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Urosepsis Hospitalization 11/18/2009 61 Male 153 lb 12/29/2009 Other Health Professional Sweden
Primary
Secondary
Concomitant
Osteonecrosis Of Jaw Other Serious 12/22/2010 Physician Denmark
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 12/22/2010 Physician Denmark
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 12/22/2010 Physician Denmark
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 12/22/2010 Physician Denmark
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 12/22/2010 Physician Denmark
Primary
Secondary
Hepatic Failure Hospitalization 10/5/2010 78 Male 167 lb 12/22/2010 Other Health Professional Canada
Primary
Secondary
Concomitant
Cholecystitis Other Serious 4/10/2008 43 Female 172 lb 12/28/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Right Ventricle Outflow Tract Obstruction Other Serious 4/14/2010 48 Male 12/30/2010 Physician Japan
Primary
Concomitant
Cancer Pain Death 4/14/2010 48 Male 1/6/2011 Physician Japan
Primary
Concomitant
Osteonecrosis Of Jaw Other Serious 6/22/2010 70 Male 1/17/2011 Physician Denmark
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 11/22/2006 58 Male 1/20/2011 Physician Italy
Primary
Secondary
Cancer Pain Hospitalization 4/14/2010 48 Male 1/24/2011 Physician Japan
Primary
Concomitant
Osteonecrosis Of Jaw Other Serious Male 2/3/2011 Physician United Kingdom
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 2/3/2011 Physician United Kingdom
Primary
Secondary
Pain In Jaw Other Serious 9/25/2009 65 Female 2/4/2011 Physician Denmark
Primary
Secondary
Osteonecrosis Of Jaw Other Serious Male 2/4/2011 Physician United Kingdom
Primary
Secondary
Osteonecrosis Of Jaw Other Serious Male 2/10/2011 Physician United Kingdom
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 2/10/2011 Physician United Kingdom
Primary
Secondary
Osteonecrosis Of Jaw Other Serious Male 2/17/2011 Other Health Professional United Kingdom
Primary
Secondary
Thrombocytopenia Hospitalization 2/25/2009 79 Female 126 lb 2/18/2011 Physician Czech Republic
Primary
Concomitant
Osteonecrosis Of Jaw Other Serious Male 2/22/2011 Other Health Professional United Kingdom
Primary
Secondary
Osteonecrosis Of Jaw Other Serious Male 2/22/2011 Physician United Kingdom
Primary
Secondary
Osteonecrosis Of Jaw Other Serious Male 2/22/2011 Other Health Professional United Kingdom
Primary
Secondary
Haemorrhage Hospitalization 3/3/2006 67 Female 121 lb 2/23/2011 Physician Germany
Primary
Concomitant
Interacting
Bone Pain Other Serious Male 2/24/2011 Physician United Kingdom
Primary
Secondary
Dental Caries Hospitalization Male 3/3/2011 Germany
Primary
Concomitant
Osteonecrosis Of Jaw Other Serious Male 3/8/2011 Physician United Kingdom
Primary
Secondary
Oral Disorder Other Serious 11/1/2010 Male 3/24/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Proteinuria Life Threatening 61 Male 192 lb 5/4/2011 Physician Slovakia (Slovak Republic)
Primary
Concomitant
Nephrotic Syndrome Life Threatening 8/25/2010 61 Male 192 lb 5/9/2011 Physician Slovakia (Slovak Republic)
Primary
Concomitant
Osteonecrosis Of Jaw Death 1/1/2006 62 Male 5/30/2011 Other Health Professional Italy
Primary
Secondary
Concomitant
Osteonecrosis Of Jaw Other Serious 1/1/2006 5/30/2011 Physician United Kingdom
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 9/1/2009 Male 5/30/2011 Physician United Kingdom
Primary
Secondary
Drug Tolerance Decreased Disability 1/1/2006 Male 5/31/2011 Physician United Kingdom
Primary
Secondary
Osteonecrosis Of Jaw Disability 9/1/2009 48 Male 5/31/2011 Physician United Kingdom
Primary
Secondary
Gingival Recession Disability 12/1/2009 54 Male 6/1/2011 Physician United Kingdom
Primary
Interacting
Osteonecrosis Of Jaw Other Serious 11/15/2010 61 Female 6/1/2011 Physician United Kingdom
Primary
Secondary
Osteonecrosis Of Jaw Disability 10/1/2006 29 Male 6/1/2011 Physician United Kingdom
Primary
Concomitant
Interacting
Oral Discomfort Other Serious 51 Male 6/2/2011 Other Health Professional United Kingdom
Primary
Concomitant
Osteonecrosis Of Jaw Other Serious 9/1/2009 Male 6/8/2011 Physician United Kingdom
Primary
Secondary
Death Disability 9/1/2009 48 Male 6/8/2011 Physician United Kingdom
Primary
Secondary
Drug Intolerance Other Serious Male 6/13/2011 Physician United Kingdom
Primary
Secondary
Osteonecrosis Of Jaw Disability 12/1/2009 54 Male 6/20/2011 Physician United Kingdom
Primary
Concomitant
Interacting
Renal Failure Other Serious 11/15/2010 61 Female 6/20/2011 Other Health Professional United Kingdom
Primary
Concomitant
Osteonecrosis Of Jaw Hospitalization 8/5/2010 68 Male 168 lb 6/20/2011 United States
Primary
Concomitant
Gingival Infection Other Serious 9/1/2009 Male 6/23/2011 Physician United Kingdom
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 1/1/2006 6/23/2011 Physician United Kingdom
Primary
Secondary
Mucosal Inflammation Other Serious 57 Female 6/24/2011 Other Health Professional Germany
Primary
Concomitant
Osteonecrosis Of Jaw Other Serious 72 Male 6/23/2011 Other Health Professional Germany
Primary
Concomitant
Exposed Bone In Jaw Other Serious 9/1/2009 Male 7/1/2011 Physician United Kingdom
Primary
Secondary
Glomerulonephritis Hospitalization 5/6/2011 84 Female 181 lb 7/27/2011 United States
Primary
Secondary
Tooth Loss Other Serious 11/1/2009 48 Male 8/5/2011 Physician United Kingdom
Primary
Secondary
Fistula Other Serious 9/1/2009 Male 8/9/2011 Physician United Kingdom
Primary
Secondary
Neoplasm Malignant Hospitalization 7/11/2006 68 Male 121 lb 8/18/2011 United States
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 1/1/2006 8/19/2011 Physician United Kingdom
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 1/1/2006 8/29/2011 Physician United Kingdom
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 1/1/2006 9/9/2011 Physician United Kingdom
Primary
Secondary
Bone Fistula Death 11/1/2009 48 Male 9/19/2011 Physician United Kingdom
Primary
Secondary
Mouth Haemorrhage Other Serious 7/1/2009 42 Male 10/24/2011 Other Health Professional Japan
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 7/1/2009 42 Male 11/7/2011 Other Health Professional Japan
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 6/22/2010 70 Male 11/16/2011 Physician Denmark
Primary
Secondary
Concomitant
Cardiopulmonary Failure Death 6/15/2011 68 Male 205 lb 11/16/2011 Physician Slovakia (Slovak Republic)
Primary
Concomitant
Osteonecrosis Of Jaw Other Serious 9/25/2009 65 Female 11/23/2011 Physician Denmark
Primary
Secondary
Concomitant
Pain In Jaw Other Serious 6/22/2010 70 Male 11/27/2011 Physician Denmark
Primary
Secondary
Concomitant
Osteonecrosis Of Jaw Hospitalization 10/21/2009 73 Male 194 lb 12/2/2011 Physician United States
Primary
Concomitant

Drug Data