Spiriva combined with Warfarin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Chronic Obstructive Pulmonary Disease Death Male 2/14/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pneumonia Primary Atypical Life Threatening 2/17/2006 79 Male 3/17/2006 Physician Japan
Primary
Concomitant
Aortic Dissection Death Male 3/29/2006
Primary
Secondary
Dyspnoea Other Serious 11/1/2006 84 Male 3/19/2007 Physician United States
Primary
Concomitant
Visual Disturbance Hospitalization Male 4/26/2007 Consumer United States
Primary
Concomitant
Thrombosis Hospitalization 1/1/2007 Male 5/18/2007 Consumer United States
Primary
Concomitant
Dyspnoea Other Serious 11/1/2006 84 Male 123 lb 5/29/2007 Consumer United States
Primary
Concomitant
Fall Other Serious 11/1/2006 84 Male 123 lb 6/11/2007 Consumer United States
Primary
Concomitant
Dyspnoea Other Serious 11/1/2006 84 Male 123 lb 6/22/2007 Consumer United States
Primary
Concomitant
Dry Mouth 88 Female 125 lb 6/22/2007 United States
Primary
Concomitant
Thrombosis Hospitalization 1/1/2007 Male 6/22/2007 Consumer United States
Primary
Concomitant
Gastrointestinal Haemorrhage Other Serious 2/17/2006 Male 86 lb 8/28/2007 Japan
Primary
Concomitant
Gastrointestinal Haemorrhage Other Serious 2/17/2006 Male 86 lb 8/28/2007 Japan
Primary
Concomitant
Dyspnoea Other Serious 11/1/2006 84 Male 123 lb 9/24/2007 Physician United States
Primary
Concomitant
Gastrointestinal Haemorrhage Other Serious 2/17/2006 Male 86 lb 9/27/2007 Japan
Primary
Concomitant
Wheezing 8/12/2007 79 Male 9/28/2007 Consumer United States
Primary
Concomitant
Increased Bronchial Secretion 5/1/2007 57 Female 10/26/2007 Consumer United States
Primary
Concomitant
Malaise 5/29/2007 54 Female 10/26/2007 Consumer United States
Primary
Concomitant
Wheezing 12/2/2008 Female 12/30/2008 Consumer
Primary
Concomitant
Oropharyngeal Pain 10/24/2008 Female 1/9/2009 Consumer
Primary
Concomitant
Parosmia Hospitalization 12/1/2008 74 Female 1/9/2009 Consumer
Primary
Concomitant
Emphysema 11/1/2008 Male 1/12/2009 Consumer
Primary
Concomitant
Drug Effect Decreased 11/1/2008 Male 1/23/2009 Consumer
Primary
Concomitant
Therapeutic Response Decreased 1/31/2009 Male 2/6/2009 Consumer
Primary
Concomitant
Therapeutic Response Decreased 2/1/2009 Male 2/20/2009 Consumer
Primary
Concomitant
Pneumonia Hospitalization 1/1/2008 Male 4/8/2009 Consumer
Primary
Concomitant
Orthostatic Hypotension Hospitalization 11/20/2007 68 Male 4/28/2009 Physician United States
Primary
Secondary
Concomitant
Heart Rate Irregular Hospitalization 1/1/2009 66 Female 4/24/2009 Consumer United States
Primary
Secondary
Concomitant
Tonic Convulsion Death 3/8/2009 82 Male 97 lb 4/29/2009 Pharmacist Japan
Primary
Secondary
Concomitant
Sputum Culture Positive Disability 7/1/2008 Female 178 lb 4/29/2009 Physician United States
Primary
Concomitant
Sepsis Hospitalization 12/29/2008 Female 5/1/2009 Physician Canada
Primary
Concomitant
Therapeutic Reaction Time Decreased 12/1/2008 Male 5/1/2009 Physician
Primary
Concomitant
Withdrawal Syndrome Other Serious Male 230 lb 5/1/2009 Consumer United States
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 4/22/2009 Female 182 lb 5/11/2009 Consumer United States
Primary
Concomitant
Withdrawal Syndrome Other Serious Male 230 lb 6/5/2009 Consumer United States
Primary
Secondary
Concomitant
Pulmonary Fibrosis Hospitalization 11/27/2008 77 Female 183 lb 6/16/2009 Pharmacist United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 12/1/2008 81 Female 7/6/2009 Consumer
Primary
Concomitant
Haemoptysis Other Serious 5/13/2009 60 7/6/2009 Pharmacist Japan
Primary
Concomitant
Pulmonary Hypertension Life Threatening 7/22/2008 72 7/7/2009 Physician Japan
Primary
Concomitant
Haemoglobin Decreased Hospitalization 6/6/2009 Male 164 lb 7/14/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Haemoptysis Other Serious 5/13/2009 60 8/6/2009 Pharmacist Japan
Primary
Concomitant
Dyspnoea 6/1/2009 70 Female 8/11/2009 Consumer
Primary
Concomitant
Haemoptysis Other Serious 5/13/2009 60 8/14/2009 Pharmacist Japan
Primary
Concomitant
Lung Disorder Other Serious 7/1/2009 Male 168 lb 8/4/2009 United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 10/13/2006 65 Female 167 lb 8/13/2009 Lawyer United States
Primary
Concomitant
Drug Ineffective Female 8/21/2009 Consumer
Primary
Concomitant
Haemoptysis Other Serious 5/13/2009 60 9/1/2009 Pharmacist Japan
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 76 Male 9/15/2009 United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 65 Female 9/24/2009 Consumer United States
Primary
Concomitant
Drug Ineffective Other Serious 8/1/2009 Male 245 lb 9/30/2009 Physician United States
Primary
Concomitant
Stomatitis Hospitalization 11/1/2008 82 Male 10/1/2009 Physician
Primary
Concomitant
Sepsis Other Serious 7/1/2009 Male 157 lb 10/2/2009 Other Health Professional United States
Primary
Concomitant
Right Atrial Dilatation Other Serious 12/3/2008 Female 10/5/2009 Physician Australia
Primary
Concomitant
Pulmonary Congestion 1/1/2008 Female 10/6/2009 Consumer
Primary
Concomitant
Renal Failure Acute Other Serious 8/22/2009 70 Female 187 lb 10/6/2009 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Embolism Hospitalization 65 Female 11/23/2009 Consumer United States
Primary
Secondary
Concomitant
Vomiting Other Serious 2/26/2009 Female 174 lb 11/25/2009 United States
Primary
Secondary
Concomitant
Serotonin Syndrome Other Serious 10/2/2009 Female 123 lb 12/16/2009 Pharmacist United States
Primary
Concomitant
Interacting
Urinary Retention Hospitalization 61 Male 12/10/2009 United States
Primary
Concomitant
Urinary Tract Disorder Hospitalization 10/1/2009 59 Female 198 lb 1/1/2010 Other Health Professional United States
Primary
Concomitant
Increased Upper Airway Secretion 8/1/2009 Male 1/4/2010 Consumer
Primary
Concomitant
Atrial Fibrillation Hospitalization 9/1/2009 Male 1/14/2010 Consumer
Primary
Concomitant
Aphthous Stomatitis 1/1/2007 Male 1/26/2010 Consumer
Primary
Secondary
Concomitant
Tachycardia Hospitalization 3/10/2009 82 Male 97 lb 2/16/2010 Physician Japan
Primary
Secondary
Concomitant
Somnolence Other Serious 12/1/2009 60 Female 2/25/2010 Consumer United States
Primary
Concomitant
Ventricular Hypokinesia Hospitalization 64 Male 201 lb 3/25/2010 United States
Primary
Concomitant
Infection Hospitalization 5/14/2001 64 Male 91 lb 5/31/2010 Physician Japan
Primary
Concomitant
Pharyngeal Oedema Other Serious 5/21/2010 78 Female 205 lb 6/2/2010 Consumer United States
Primary
Concomitant
Urinary Tract Infection Hospitalization Female 5/28/2010 Consumer United States
Primary
Concomitant
Oxygen Saturation Decreased Female 6/3/2010 Consumer
Primary
Concomitant
Nephrolithiasis Hospitalization 6/1/2010 66 Male 6/9/2010 Physician United States
Primary
Concomitant
Stress Hospitalization 5/14/2001 64 Male 91 lb 6/17/2010 Physician Japan
Primary
Concomitant
Death Death 6/16/2010 59 Male 6/21/2010 Consumer United States
Primary
Concomitant
Drug Ineffective 7/1/2008 75 Female 6/22/2010 Consumer
Primary
Concomitant
Urinary Incontinence 4/1/2010 83 Female 6/25/2010 Consumer
Primary
Concomitant
Rhinitis Other Serious 4/1/2010 72 Female 165 lb 6/29/2010 Physician United States
Primary
Concomitant
Atrial Fibrillation 1/1/2007 66 Female 230 lb 6/29/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Gastric Ulcer Haemorrhage Hospitalization 5/14/2001 64 Male 91 lb 6/27/2010 Physician Japan
Primary
Concomitant
Monoplegia Other Serious 1/1/2007 78 Female 100 lb 6/28/2010 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis 8/11/2009 71 Female 184 lb 6/29/2010 Consumer United States
Primary
Concomitant
Oxygen Saturation Decreased Female 6/30/2010 Physician
Primary
Concomitant
Vision Blurred 5/1/2010 79 Male 7/6/2010 Consumer
Primary
Concomitant
Monoplegia Other Serious 1/1/2007 78 Female 100 lb 7/7/2010 Consumer United States
Primary
Concomitant
Urinary Tract Infection Hospitalization Female 7/1/2010 Physician United States
Primary
Concomitant
Alopecia Other Serious 11/21/2009 69 Male 108 lb 7/9/2010 Physician
Primary
Concomitant
No Adverse Event 1/21/2007 54 Female 137 lb 7/9/2010 Consumer United States
Primary
Concomitant
Overdose Male 7/14/2010 Consumer United States
Primary
Concomitant
Haemothorax Death 6/13/2007 80 Male 7/14/2010 Lawyer United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 1/1/2007 41 Female 280 lb 7/14/2010 Lawyer United States
Primary
Concomitant
Weight Decreased Other Serious 55 Male 254 lb 7/8/2010 United States
Primary
Concomitant
Dyspnoea Hospitalization Female 165 lb 7/28/2010 Consumer United States
Primary
Concomitant
Heart Rate Abnormal Hospitalization 5/28/2010 74 Female 122 lb 8/5/2010 United States
Primary
Concomitant
Vision Blurred Hospitalization 1/1/2008 76 Male 8/5/2010 Consumer
Primary
Concomitant
Hernia Other Serious 1/1/2010 79 Male 8/12/2010 Physician
Primary
Concomitant
Hypoxia Hospitalization Male 240 lb 8/13/2010 Physician United States
Primary
Concomitant
Death Death Female 8/13/2010 Physician United States
Primary
Concomitant
Renal Impairment Other Serious 6/14/2010 78 Male 101 lb 8/16/2010 Japan
Primary
Concomitant
Cardiac Arrest Death 7/27/2010 71 Male 178 lb 8/17/2010 Other Health Professional United States
Primary
Concomitant
Pneumonia Hospitalization 7/26/2010 80 Male 199 lb 8/18/2010 United States
Primary
Concomitant
Pyrexia Hospitalization 8/1/2010 55 Female 8/23/2010 Consumer United States
Primary
Concomitant
Feeling Abnormal 6/1/2010 67 Female 8/24/2010 Consumer
Primary
Concomitant
Hypoxia Hospitalization 8/14/2010 79 Male 240 lb 8/25/2010 Physician United States
Primary
Concomitant
Oropharyngeal Spasm Other Serious 1/1/2009 45 Male 280 lb 9/3/2010 Consumer United States
Primary
Concomitant
Interstitial Lung Disease Death 8/2/2010 62 Male 130 lb 9/7/2010 Physician Japan
Primary
Concomitant
Oesophageal Cancer Metastatic Other Serious Male 9/8/2010 Consumer United States
Primary
Secondary
Concomitant
Ventricular Fibrillation Life Threatening 6/13/2007 80 Male 236 lb 9/8/2010 Lawyer United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization Female 9/8/2010 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 10/13/2006 65 Female 167 lb 9/3/2010 United States
Primary
Concomitant
Deep Vein Thrombosis Death 9/5/2010 49 Female 9/17/2010 Pharmacist United States
Primary
Concomitant
Incision Site Pain Hospitalization 9/1/2010 73 Female 9/22/2010 Consumer
Primary
Concomitant
Drug Ineffective 8/1/2010 48 Female 136 lb 9/22/2010 Other Health Professional United States
Primary
Concomitant
Deep Vein Thrombosis Hospitalization Female 9/23/2010 Physician United States
Primary
Concomitant
Renal Impairment Other Serious 6/14/2010 78 Male 101 lb 9/23/2010 Pharmacist Japan
Primary
Concomitant
Weight Decreased Other Serious 1/1/2010 74 Female 9/23/2010 Consumer
Primary
Concomitant
Weight Decreased Hospitalization Female 290 lb 9/24/2010 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 8/1/2010 48 Female 136 lb 9/28/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Septic Shock Hospitalization Male 240 lb 10/5/2010 Physician United States
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 9/22/2010 80 Male 157 lb 9/30/2010 Pharmacist United States
Primary
Concomitant
Oropharyngeal Pain 1/1/2009 81 Male 10/21/2010 Consumer
Primary
Concomitant
Erythema 72 Male 11/2/2010 Consumer United States
Primary
Concomitant
Ventricular Hypokinesia Other Serious 4/21/2010 67 Male 11/5/2010 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 10/1/2010 62 Male 260 lb 11/9/2010 Other Health Professional United States
Primary
Concomitant
Vision Blurred 5/12/2010 79 Male 11/11/2010 Physician
Primary
Concomitant
Dyspnoea Male 11/12/2010 Consumer
Primary
Concomitant
Dyspnoea Male 11/16/2010 Consumer
Primary
Concomitant
Dyspnoea Male 11/23/2010 Consumer
Primary
Concomitant
Rib Fracture Other Serious Male 11/24/2010 Consumer United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 1/1/2010 67 Male 11/30/2010 Consumer United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 9/10/2010 70 Female 12/2/2010 Physician United States
Primary
Secondary
Concomitant
Traumatic Lung Injury Hospitalization 71 Male 12/6/2010 Consumer United States
Primary
Concomitant
Traumatic Lung Injury Hospitalization 71 Male 12/7/2010 Consumer United States
Primary
Concomitant
Oropharyngeal Spasm Other Serious 1/1/2009 45 Male 280 lb 12/10/2010 Physician United States
Primary
Concomitant
Weight Increased Required Intervention 12/9/2010 72 Male 12/9/2010 Pharmacist United States
Primary
Concomitant
Oedema Peripheral Other Serious 1/1/2010 62 Male 278 lb 12/28/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Contusion Other Serious Male 1/10/2011 Consumer United States
Primary
Concomitant
Cerebrovascular Disorder Hospitalization 12/27/2010 77 Male 112 lb 1/13/2011 Physician Japan
Primary
Concomitant
Loss Of Consciousness Death 12/27/2010 77 Male 1/23/2011 Physician Japan
Primary
Concomitant
Non-cardiac Chest Pain Hospitalization 71 Male 1/24/2011 Consumer United States
Primary
Concomitant
Cerebral Infarction Hospitalization 12/27/2010 77 Male 112 lb 1/24/2011 Physician Japan
Primary
Concomitant
Cerebral Infarction Hospitalization 12/27/2010 77 Male 112 lb 1/24/2011 Physician Japan
Primary
Concomitant
Pneumonia Bacterial Hospitalization 3/24/2010 68 Male 157 lb 1/26/2011 Physician Japan
Primary
Concomitant
Pneumonia Hospitalization 41 Female 201 lb 1/28/2011 Consumer United States
Primary
Concomitant
Cellulitis Death 1/1/2010 82 Male 1/28/2011 Physician United States
Primary
Concomitant
Cellulitis Hospitalization 4/15/2007 76 Female 143 lb 2/2/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Rib Fracture Hospitalization 71 Male 2/2/2011 Consumer United States
Primary
Concomitant
Drug Dose Omission Hospitalization 1/1/2010 67 Male 2/4/2011 Consumer United States
Primary
Concomitant
Sinus Disorder 11/1/2010 75 Male 2/8/2011 Consumer United States
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Death 12/27/2010 77 Male 2/9/2011 Physician Japan
Primary
Concomitant
Dyspnoea Death 3/1/2010 2/8/2011 Physician United States
Primary
Concomitant
Oedema Peripheral Other Serious 1/1/2010 62 Male 278 lb 2/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant

Drug Data