Simvastatin combined with Warfarin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Fatigue Other Serious 11/1/2005 75 Female 1/4/2006 Consumer United Kingdom
Primary
Concomitant
Breast Cancer Stage Iii Hospitalization 9/19/2005 Female 1/5/2006 Other Health Professional United Kingdom
Primary
Concomitant
Rectal Haemorrhage Required Intervention 9/6/2005 50 Male 194 lb 1/3/2006 United States
Primary
Concomitant
Tetany Other Serious 12/5/2005 66 Female 141 lb 1/25/2006 Other Health Professional United Kingdom
Primary
Concomitant
Sepsis Death 12/1/2005 60 Male 187 lb 1/26/2006 United Kingdom
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 12/2/2005 71 Male 2/6/2006 Pharmacist United States
Primary
Concomitant
Haemorrhagic Stroke Hospitalization 11/23/2005 81 Male 172 lb 11/23/2005 Pharmacist United States
Primary
Concomitant
Haematocrit Decreased Hospitalization 12/28/2005 62 Male 2/6/2006 Pharmacist United States
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Hospitalization 60 2/13/2006 Consumer Australia
Primary
Secondary
Concomitant
Orthostatic Hypotension Hospitalization 11/13/2005 Male 171 lb 11/18/2005 Pharmacist United States
Primary
Secondary
Concomitant
Syncope Hospitalization 10/14/2005 63 Male 359 lb 12/2/2005 Pharmacist United States
Primary
Secondary
Concomitant
Nausea Hospitalization 1/1/2005 70 Female 2/16/2006 Consumer New Zealand
Primary
Concomitant
Post Procedural Complication Hospitalization 5/28/2005 68 Female 2/16/2006 Other Health Professional Australia
Primary
Secondary
Concomitant
Venous Pressure Jugular Increased Hospitalization 3/1/2000 78 Female 3/3/2006 Physician United Kingdom
Primary
Concomitant
Syncope Hospitalization 5/1/2004 40 Female 12/27/2005 Physician United States
Primary
Secondary
Concomitant
Aortic Dissection Death Male 3/29/2006
Primary
Secondary
Liver Function Test Abnormal Other Serious 1/1/2006 Male 4/10/2006 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Weight Decreased Hospitalization 2/9/2006 70 Male 170 lb 4/10/2006 Physician Canada
Primary
Concomitant
Pulse Absent Hospitalization 62 Male 4/10/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Parkinsonism Disability 1/1/2004 Female 4/14/2006 Pharmacist France
Primary
Concomitant
Interacting
Hypophosphataemia Life Threatening 8/31/2005 61 Female 4/20/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Vascular Pseudoaneurysm Hospitalization 3/27/2006 Male 5/17/2006 Pharmacist United States
Primary
Concomitant
Rales Other Serious 73 Male 6/1/2006 Consumer United Kingdom
Primary
Secondary
Telangiectasia Hospitalization 9/19/2005 73 Female 111 lb 6/13/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Muscular Weakness Other Serious 10/28/2005 75 Male 268 lb 6/26/2006 Pharmacist United States
Primary
Concomitant
Alveolitis Hospitalization 4/1/2005 Female 231 lb 8/8/2006 Other Health Professional United Kingdom
Primary
Concomitant
Rhabdomyolysis Other Serious 7/16/2006 70 Male 8/11/2006 Physician Singapore
Primary
Concomitant
Bone Marrow Disorder Hospitalization 7/5/2006 79 Male 8/11/2006 Other Health Professional France
Primary
Concomitant
Retching Hospitalization 5/14/2006 74 Male 243 lb 6/19/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Purpura Hospitalization 6/25/2006 80 Male 8/11/2006 Consumer United States
Primary
Secondary
Concomitant
Thrombosis In Device Hospitalization 6/2/2006 36 Female 334 lb 8/18/2006 Other Health Professional United States
Primary
Concomitant
Acute Leukaemia Hospitalization 7/5/2006 79 Male 9/15/2006 Other Health Professional France
Primary
Concomitant
Asthma 1/1/2005 53 Female 249 lb 1/23/2007 Other Health Professional United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 3/20/2007 52 Male 4/9/2007 Denmark
Primary
Concomitant
Vomiting Required Intervention 3/6/2007 62 4/17/2007 Pharmacist United States
Primary
Secondary
Concomitant
International Normalised Ratio Increased Other Serious 2/15/2006 69 Male 4/30/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Septic Shock Hospitalization 73 Female 5/3/2007
Primary
Secondary
Concomitant
Death Death 1/1/2007 Male 192 lb 5/4/2007 Australia
Primary
Concomitant
Breast Cancer Stage Iii Hospitalization 9/19/2005 Female 212 lb 6/22/2007 Physician United Kingdom
Primary
Concomitant
Panic Attack Hospitalization 2/10/2007 74 Male 216 lb 8/17/2007 United States
Primary
Concomitant
Death Death 1/1/2007 Male 192 lb 8/22/2007 Australia
Primary
Concomitant
Guillain-barre Syndrome Other Serious 58 Male 8/30/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Intra-abdominal Haematoma Other Serious 8/14/2007 58 Male 280 lb 9/28/2007 Other Health Professional United Kingdom
Primary
Concomitant
Back Pain 3/1/2007 Male 291 lb 9/20/2007 Consumer United States
Primary
Concomitant
Rash 81 Male 249 lb 9/20/2007 Consumer United States
Primary
Concomitant
Sudden Death Death 9/14/2007 Male 172 lb 9/28/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Head Injury Hospitalization 6/17/2007 Female 120 lb 10/22/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Palpitations Other Serious 3/1/2007 83 Female 139 lb 1/8/2008 Consumer Germany
Primary
Concomitant
Blood Pressure Inadequately Controlled 12/1/2007 Male 1/23/2008 Consumer United States
Primary
Concomitant
Pain In Extremity Hospitalization 1/1/1983 Female 2/7/2008 Consumer United States
Primary
Concomitant
Posturing Life Threatening 6/21/2007 68 Male 4/8/2008 Pharmacist United States
Primary
Secondary
Concomitant
Rash Generalised Disability 3/4/2008 72 Male 214 lb 5/9/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rash Generalised Disability 3/4/2008 72 Male 214 lb 5/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vision Blurred Death 4/10/2008 67 Male 158 lb 5/28/2008 Consumer United States
Primary
Concomitant
Sudden Death Death 12/7/2008 72 Male 1/6/2009 Physician United Kingdom
Primary
Concomitant
Parosmia Hospitalization 12/1/2008 74 Female 1/9/2009 Consumer
Primary
Concomitant
Ubiquinone Decreased Other Serious 2/1/2006 78 Male 1/12/2009 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Constipation 80 Female 194 lb 1/12/2009 Consumer United States
Primary
Secondary
Concomitant
Emphysema 11/1/2008 Male 1/12/2009 Consumer
Primary
Concomitant
Pancreatitis Chronic Other Serious 11/15/2006 1/21/2009 Consumer United States
Primary
Concomitant
Blindness Other Serious Male 170 lb 1/23/2009 Consumer United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 1/1/2002 1/28/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Interacting
Pancreatitis Chronic Life Threatening 12/4/2008 1/28/2009 Physician Czech Republic
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/30/2008 Female 108 lb 1/29/2009 Physician United States
Primary
Secondary
Concomitant
Pruritus Hospitalization 7/28/2008 75 Female 144 lb 1/29/2009 Physician United Kingdom
Primary
Concomitant
Cardiac Failure Hospitalization 3/3/2008 72 Female 93 lb 1/29/2009 Physician Japan
Primary
Concomitant
Balance Disorder Hospitalization 1/16/2009 2/2/2009 Physician Sweden
Primary
Secondary
Concomitant
Pruritus Hospitalization 7/28/2008 75 Female 144 lb 2/5/2009 Physician United Kingdom
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 2/5/2009 United Kingdom
Primary
Secondary
Ubiquinone Decreased Other Serious 12/1/2005 78 Male 2/25/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Blood Glucose Increased Female 2/24/2009 United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 2/25/2009 Other Health Professional United Kingdom
Primary
Secondary
International Normalised Ratio Increased Other Serious 1/1/2006 2/27/2009 United Kingdom
Primary
Secondary
Ventricular Fibrillation Other Serious 2/4/2009 Male 110 lb 3/3/2009 Physician Japan
Primary
Secondary
Concomitant
Pancreatitis Chronic Other Serious 11/15/2006 269 lb 3/2/2009 Consumer United States
Primary
Concomitant
Haemorrhage Urinary Tract Other Serious 2/1/2009 Male 179 lb 3/10/2009 Consumer United States
Primary
Secondary
Concomitant
Sensory Loss Other Serious 2/3/2009 Female 131 lb 3/24/2009 Physician United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 3/31/2009 Other Health Professional United Kingdom
Primary
Secondary
Pancreatitis Chronic Other Serious 11/1/2006 269 lb 3/31/2009 Consumer United States
Primary
Concomitant
Pulmonary Oedema Other Serious 1/1/2009 4/2/2009 Other Health Professional Canada
Primary
Secondary
Concomitant
Pancreatitis Chronic Life Threatening 12/4/2008 4/2/2009 Physician Czech Republic
Primary
Secondary
Concomitant
Speech Disorder Other Serious 8/26/2008 Male 4/6/2009 Other Health Professional
Primary
Concomitant
Stent Placement Hospitalization 9/1/2008 Male 4/8/2009 Other Health Professional United States
Primary
Concomitant
Stent Placement Other Serious Male 170 lb 4/22/2009 Physician United States
Primary
Secondary
Concomitant
Polyneuropathy Other Serious 12/1/2005 78 Male 4/17/2009
Primary
Secondary
Concomitant
Ventricular Fibrillation Life Threatening 12/27/2008 4/24/2009 Other Health Professional Sweden
Primary
Secondary
Concomitant
Sepsis Death 75 Male 4/21/2009 United States
Primary
Concomitant
Blood Pressure Increased Other Serious 3/20/2009 Male 4/22/2009 Other Health Professional United Kingdom
Primary
Concomitant
Pain In Extremity Hospitalization 3/24/2009 77 Female 4/22/2009 Consumer United States
Primary
Concomitant
Transfusion Reaction Hospitalization 11/1/2007 5/1/2009 Consumer United States
Primary
Secondary
Concomitant
Sepsis Other Serious Male 4/30/2009 Consumer United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 1/29/2009 77 Male 5/4/2009 Other Health Professional United Kingdom
Primary
Concomitant
Sepsis Death Male 304 lb 5/5/2009 Consumer
Primary
Secondary
Concomitant
Syncope Other Serious 1/6/2009 79 Female 5/6/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Haemorrhage Urinary Tract Other Serious 2/1/2009 Male 179 lb 5/7/2009 Consumer United States
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 5/14/2009 54 Female 264 lb 5/26/2009 Pharmacist United States
Primary
Concomitant
Movement Disorder Hospitalization 5/14/2009 83 6/3/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 12/12/2008 78 6/5/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Drug Resistance Hospitalization 71 Female 6/8/2009 United States
Primary
Concomitant
Weight Decreased Other Serious 5/1/2008 Male 176 lb 6/9/2009 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis Death 89 Female 6/21/2009 United States
Primary
Concomitant
Gout Other Serious 3/12/2009 72 Female 6/25/2009 Physician United Kingdom
Primary
Concomitant
Gout Other Serious 3/12/2009 72 Female 7/2/2009 Other Health Professional United Kingdom
Primary
Concomitant
Stent Placement Other Serious Male 170 lb 7/2/2009 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/30/2008 Female 108 lb 7/2/2009 Physician United States
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 6/21/2009 74 7/10/2009 Other Health Professional Sweden
Primary
Secondary
Concomitant
Movement Disorder Hospitalization 5/13/2009 83 7/10/2009 Other Health Professional Japan
Primary
Concomitant
Rash Morbilliform Other Serious 7/27/2009 Female 170 lb 7/30/2009 Other Health Professional United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 7/25/2009 82 Female 126 lb 8/9/2009 Pharmacist United States
Primary
Secondary
Concomitant
Death Death Male 8/11/2009 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 8/7/2009 Female 8/11/2009 Pharmacist United States
Primary
Concomitant
Tachycardia Hospitalization 63 Male 178 lb 8/11/2009 United States
Primary
Concomitant
Varices Oesophageal Hospitalization 11/23/2007 67 Male 8/12/2009 Consumer United States
Primary
Concomitant
Pruritus 8/1/2008 Male 8/22/2009 Other Health Professional United States
Primary
Concomitant
Skin Burning Sensation 10/30/2008 Female 8/22/2009 United States
Primary
Concomitant
Skin Warm 12/21/2008 Male 8/22/2009 United States
Primary
Concomitant
Paraesthesia Male 8/22/2009 United States
Primary
Concomitant
Paraesthesia Male 8/22/2009 United States
Primary
Concomitant
Paraesthesia Female 8/22/2009 United States
Primary
Concomitant
Pruritus Male 8/22/2009 United States
Primary
Concomitant
Syncope Male 8/22/2009 United States
Primary
Concomitant
Urticaria 4/1/2009 Female 132 lb 8/22/2009 United States
Primary
Concomitant
Paraesthesia 1/1/2009 Male 8/22/2009 United States
Primary
Concomitant
Feeling Hot Male 197 lb 8/23/2009 United States
Primary
Concomitant
Flushing 5/5/2009 Male 175 lb 8/23/2009 Consumer United States
Primary
Concomitant
Rash 7/6/2009 Male 275 lb 8/23/2009 United States
Primary
Concomitant
Nervousness 4/1/2009 Male 145 lb 8/25/2009 Physician United States
Primary
Concomitant
Ventricular Fibrillation Death 8/25/2009 82 9/4/2009 Other Health Professional Sweden
Primary
Secondary
Concomitant
Urinary Tract Infection Death 89 Female 9/3/2009 United States
Primary
Concomitant
Weight Decreased Hospitalization 72 Male 9/4/2009 United States
Primary
Concomitant
Weight Decreased Hospitalization 61 Female 9/2/2009 Lawyer United States
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 11/23/2007 66 Male 802 lb 9/3/2009 Lawyer United States
Primary
Concomitant
Ventricular Fibrillation Death 8/25/2009 82 9/15/2009 Other Health Professional Sweden
Primary
Secondary
Concomitant
Injury Death 64 Female 9/10/2009 Lawyer United States
Primary
Concomitant
Sinus Bradycardia Hospitalization 69 Female 9/14/2009 United States
Primary
Concomitant
No Therapeutic Response Other Serious 1/3/2007 68 Female 9/16/2009 United Kingdom
Primary
Concomitant
Visual Acuity Reduced Other Serious 6/23/2006 78 Male 9/17/2009
Primary
Concomitant
Weight Increased Other Serious 12/1/2008 Male 9/28/2009 Consumer United States
Primary
Concomitant
Visual Impairment Other Serious 60 Male 215 lb 9/16/2009 United States
Primary
Concomitant
Leukocytoclastic Vasculitis Other Serious 5/12/2008 66 Male 208 lb 7/30/2009 United States
Primary
Concomitant
Varices Oesophageal Hospitalization 11/23/2007 64 Male 364 lb 9/18/2009 United States
Primary
Concomitant
White Clot Syndrome Other Serious 11/11/2007 67 Male 179 lb 9/29/2009 Lawyer United States
Primary
Concomitant
Pulmonary Oedema Hospitalization 8/1/2009 51 Male 9/30/2009 Consumer United States
Primary
Concomitant
Stomatitis Hospitalization 11/1/2008 82 Male 10/1/2009 Physician
Primary
Concomitant
Ventricular Fibrillation Hospitalization 8/25/2009 82 10/2/2009 Other Health Professional Sweden
Primary
Secondary
Concomitant
Flushing Hospitalization 7/14/2009 Male 184 lb 10/6/2009 Pharmacist United States
Primary
Concomitant
Pneumonia Other Serious 1/1/2009 Male 200 lb 10/23/2009 Consumer United States
Primary
Concomitant
Pneumonia Other Serious 1/1/2009 Male 200 lb 11/13/2009 Consumer United States
Primary
Concomitant
Prostate Cancer Other Serious 1/1/2009 65 Male 190 lb 11/20/2009 Consumer United States
Primary
Secondary
Concomitant
Peritonitis Bacterial Other Serious 1/1/2009 62 Male 11/3/2009 Other Health Professional United States
Primary
Concomitant

Drug Data