Simvastatin combined with Warfarin Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Syncope Hospitalization 2/7/2005 68 Male 170 lb 10/31/2005 Other Health Professional United States
Primary
Secondary
Concomitant
Ventricular Fibrillation Life Threatening 12/13/2005 56 Male 176 lb 1/4/2006 United States
Primary
Secondary
Concomitant
Ventricular Fibrillation Life Threatening 12/13/2005 56 Male 176 lb 1/12/2006 Netherlands
Primary
Secondary
Concomitant
Skin Oedema Other Serious 1/1/2005 79 Male 1/13/2006 United Kingdom
Primary
Secondary
Concomitant
Gynaecomastia Hospitalization 8/15/2004 70 Male 1/19/2006 Physician Sweden
Primary
Concomitant
Peripheral Embolism Other Serious 12/15/2004 Female 1/27/2006 Other Health Professional United Kingdom
Primary
Concomitant
Tetany Other Serious 12/5/2005 66 Female 141 lb 1/25/2006 Other Health Professional United Kingdom
Primary
Concomitant
Retroperitoneal Haematoma Required Intervention 12/1/2005 81 Male 190 lb 1/18/2006 Physician United States
Primary
Secondary
Concomitant
Aortic Dissection Death 4/5/2005 Male 2/1/2006 Consumer United Kingdom
Primary
Secondary
Aortic Dissection Death 4/5/2005 Male 2/1/2006 Consumer United Kingdom
Primary
Secondary
Pneumonitis Death 6/1/2005 69 Male 1/30/2006 United Kingdom
Primary
Concomitant
Pneumonitis Death 6/1/2005 69 Male 2/6/2006 United Kingdom
Primary
Concomitant
Skin Oedema Other Serious 1/1/2005 79 Male 2/7/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Spleen Disorder Hospitalization 12/21/2005 77 Male 2/3/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Somnolence 5/23/2005 79 Female 166 lb 1/5/2006 Consumer United States
Primary
Concomitant
Palpable Purpura Hospitalization 1/25/2006 66 Male 161 lb 2/14/2006 Pharmacist United States
Primary
Concomitant
Dry Mouth 9/1/2005 79 Female 166 lb 1/5/2006 Consumer United States
Primary
Concomitant
Procedural Site Reaction Hospitalization 11/21/2005 Male 2/15/2006 Pharmacist United States
Primary
Concomitant
Vomiting Other Serious 8/1/2001 76 Female 99 lb 2/24/2006 Physician United Kingdom
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 12/1/2005 Male 2/22/2006 Pharmacist United States
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 12/6/2005 Male 2/22/2006 Pharmacist United States
Primary
Secondary
Concomitant
Ventricular Fibrillation Life Threatening 12/13/2005 56 Male 181 lb 2/24/2006 Netherlands
Primary
Secondary
Concomitant
Vomiting Other Serious 8/1/2001 76 Female 99 lb 3/2/2006 Physician United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 64 Male 2/28/2006 Israel
Primary
Concomitant
Reflux Oesophagitis Hospitalization 1/31/2006 81 Male 3/8/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Venous Pressure Jugular Increased Hospitalization 79 Female 3/8/2006 United Kingdom
Primary
Concomitant
Ventricular Fibrillation Life Threatening 12/13/2005 56 Male 181 lb 3/8/2006 Netherlands
Primary
Secondary
Concomitant
Pain In Extremity Hospitalization 1/1/2002 74 Male 145 lb 12/29/2005 United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 79 Female 3/27/2006 United States
Primary
Secondary
Concomitant
Subdural Haematoma Life Threatening 12/3/2004 69 Male 231 lb 3/30/2006 Pharmacist United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2003 73 Male 139 lb 4/13/2006 United States
Primary
Concomitant
Parkinsonism Disability 1/1/2004 65 Female 4/10/2006 Pharmacist Ireland
Primary
Concomitant
Neck Pain Death 2/16/2006 82 Male 205 lb 4/4/2006 Consumer United States
Primary
Concomitant
Respiratory Rate Increased Hospitalization 4/14/2006 84 Male 165 lb 4/19/2006 Pharmacist United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2003 73 Male 139 lb 4/26/2006 Other Health Professional United States
Primary
Concomitant
Subdural Haematoma Death 1/28/2006 63 Male 1/31/2006 Pharmacist United States
Primary
Concomitant
Tachycardia Hospitalization 12/1/2001 63 Male 4/28/2006 Norway
Primary
Concomitant
Hypophosphataemia Life Threatening 8/31/2005 61 Female 5/1/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Tricuspid Valve Sclerosis Other Serious 1/1/2004 58 Male 4/25/2006 Denmark
Primary
Concomitant
Renal Impairment Hospitalization 3/13/2006 57 Male 4/24/2006 Brazil
Primary
Concomitant
Treatment Noncompliance Hospitalization 2/26/2006 Male 258 lb 5/2/2006 Pharmacist United States
Primary
Secondary
Concomitant
Tremor Disability 1/1/2004 65 Female 5/3/2006 Other Health Professional Denmark
Primary
Concomitant
Oedema Peripheral Other Serious 73 Male 5/5/2006 Physician United Kingdom
Primary
Secondary
International Normalised Ratio Increased Hospitalization 2/20/2006 65 Male 5/8/2006 Other Health Professional United States
Primary
Concomitant
Musculoskeletal Chest Pain Hospitalization 9/3/2005 46 Male 5/8/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
International Normalised Ratio Increased Disability 3/28/2006 61 Female 5/10/2006 United States
Primary
Secondary
Concomitant
Oedema Other Serious 3/13/2006 80 Male 162 lb 5/17/2006 Physician Canada
Primary
Concomitant
Prothrombin Time Prolonged Hospitalization 1/16/2006 Male 5/16/2006 Pharmacist United States
Primary
Concomitant
Rectal Haemorrhage Hospitalization 1/20/2006 Male 5/16/2006 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 12/6/2005 Male 5/16/2006 Pharmacist United States
Primary
Concomitant
Renal Disorder Hospitalization 76 Male 5/19/2006 Other Health Professional Japan
Primary
Concomitant
Interacting
Dysarthria Other Serious 4/1/2005 70 Male 245 lb 5/18/2006 Physician United States
Primary
Concomitant
Staphylococcal Infection Other Serious 1/1/2006 63 Male 121 lb 5/18/2006 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 5/21/2006 77 Male 211 lb 5/25/2006 Pharmacist United States
Primary
Concomitant
Cardiac Failure Other Serious 73 Male 5/31/2006 Other Health Professional United Kingdom
Primary
Secondary
Initial Insomnia 2/17/2006 81 Male 215 lb 4/3/2006 Consumer United States
Primary
Concomitant
Blood Parathyroid Hormone Increased 8/22/2005 Male 3/13/2006 United States
Primary
Secondary
Concomitant
Blood Parathyroid Hormone Increased 8/22/2005 Male 3/13/2006 United States
Primary
Secondary
Concomitant
Urinary Tract Obstruction Hospitalization 3/21/2006 81 Male 203 lb 4/28/2006 Pharmacist United States
Primary
Concomitant
Wound Infection Hospitalization 62 Male 223 lb 4/19/2006 Pharmacist United States
Primary
Secondary
Concomitant
Middle Insomnia 3/2/2006 86 Female 161 lb 4/3/2006 Consumer United States
Primary
Concomitant
Dysgeusia 11/20/2005 66 Male 270 lb 4/3/2006 Consumer United States
Primary
Concomitant
Carotid Artery Occlusion Other Serious 5/14/2006 Male 156 lb 6/5/2006 Consumer United States
Primary
Concomitant
Supraventricular Tachycardia Required Intervention 8/26/2005 77 Male 5/30/2006 Physician Ireland
Primary
Concomitant
Sinus Bradycardia Disability 3/24/2006 67 Male 187 lb 6/6/2006 Pharmacist United States
Primary
Secondary
Concomitant
Drug Ineffective 1/1/2006 77 Male 5/5/2006 Consumer United States
Primary
Concomitant
Nausea 6/7/2006 58 Male 160 lb 6/15/2006 Pharmacist United States
Primary
Concomitant
Drug Effect Decreased 63 Male 4/25/2006 United States
Primary
Concomitant
Ventricular Tachycardia Life Threatening 7/5/2005 58 Male 201 lb 6/19/2006 Pharmacist United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 73 Male 6/29/2006 Other Health Professional Australia
Primary
Concomitant
Rhabdomyolysis Hospitalization 79 Female 6/29/2006 Physician United States
Primary
Secondary
Concomitant
International Normalised Ratio Fluctuation Other Serious 54 Male 143 lb 7/6/2006 Other Health Professional United States
Primary
Concomitant
Interacting
International Normalised Ratio Increased Hospitalization 4/24/2006 67 Male 7/5/2006 Pharmacist United States
Primary
Secondary
Concomitant
International Normalised Ratio Increased Hospitalization 4/26/2006 61 Male 7/6/2006 Pharmacist United States
Primary
Concomitant
Gastritis Hospitalization 2/25/2006 79 Female 7/5/2006 Denmark
Primary
Secondary
Concomitant
International Normalised Ratio Fluctuation Other Serious 54 Male 143 lb 6/30/2006 Pharmacist United States
Primary
Secondary
Concomitant
Ischaemic Stroke Hospitalization 5/10/2006 Male 150 lb 7/13/2006 Physician United Kingdom
Primary
Concomitant
Angioneurotic Oedema Other Serious 74 Male 7/13/2006 United Kingdom
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Life Threatening 5/19/2006 81 Male 110 lb 7/14/2006 Pharmacist United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 7/20/2006 Other Health Professional Sweden
Primary
Concomitant
Ventricular Extrasystoles Hospitalization 2/25/2006 79 Female 7/18/2006 Other Health Professional Denmark
Primary
Secondary
Concomitant
Renal Failure Hospitalization 7/15/2006 57 Female 212 lb 7/19/2006 Pharmacist United States
Primary
Concomitant
Platelet Count Decreased Life Threatening 4/1/2006 Male 7/18/2006 Pharmacist United States
Primary
Concomitant
Syncope Other Serious 6/8/2006 63 Male 189 lb 6/26/2006 Pharmacist United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 5/5/2001 77 Male 7/21/2006 United States
Primary
Concomitant
Treatment Noncompliance Death 3/28/2005 68 Male 163 lb 7/25/2006 Pharmacist United States
Primary
Concomitant
Ventricular Extrasystoles Hospitalization 2/25/2006 79 Female 7/27/2006 Denmark
Primary
Secondary
Concomitant
Middle Insomnia 3/1/2006 78 Female 200 lb 7/12/2006 Consumer United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 2/12/2006 60 Male 8/1/2006 Pharmacist United States
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 8/4/2006 Other Health Professional Sweden
Primary
Concomitant
Vomiting Hospitalization 7/25/2006 67 Male 8/7/2006 Physician United Kingdom
Primary
Concomitant
Ventricular Hypokinesia Other Serious 66 Male 8/2/2006 Other Health Professional United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 4/22/2005 Male 8/17/2006 Consumer France
Primary
Concomitant
Interacting
Vomiting Hospitalization 7/25/2006 67 Male 8/18/2006 Physician United Kingdom
Primary
Concomitant
Lung Infiltration Hospitalization 5/14/2006 78 Male 7/31/2006 Physician United States
Primary
Secondary
Concomitant
Hypoaesthesia Hospitalization 8/9/2006 69 Male 155 lb 8/18/2006 Pharmacist United States
Primary
Secondary
Concomitant
Refusal Of Treatment By Patient Hospitalization 4/11/2006 78 Male 186 lb 6/23/2006 Pharmacist United States
Primary
Concomitant
Vomiting Hospitalization Male 159 lb 6/20/2006 Pharmacist United States
Primary
Secondary
Concomitant
Haemorrhoids Hospitalization 6/26/2006 51 Male 220 lb 7/18/2006 Pharmacist United States
Primary
Secondary
Concomitant
Vasculitis Disability 10/21/2005 72 165 lb 8/25/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 8/25/2006 Other Health Professional Sweden
Primary
Concomitant
Vasculitis Disability 10/21/2005 72 Unknown 165 lb 8/28/2006 United Kingdom
Primary
Secondary
Concomitant
Tachycardia Life Threatening 5/21/2006 73 Female 207 lb 6/15/2006 Pharmacist United States
Primary
Concomitant
Pneumonia Hospitalization 2/25/2006 79 Female 8/29/2006 Denmark
Primary
Secondary
Concomitant
Vasculitis Other Serious 10/21/2005 72 8/30/2006 United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 8/24/2006 69 Male 241 lb 8/30/2006 Pharmacist United States
Primary
Concomitant
Respiratory Failure Death 6/27/2005 Male 176 lb 9/1/2006 United Kingdom
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 9/8/2006 Other Health Professional Sweden
Primary
Concomitant
Transient Ischaemic Attack Other Serious 7/30/2004 Female 9/8/2006 Other Health Professional Sweden
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 6/20/2006 Male 9/11/2006 Pharmacist United States
Primary
Secondary
Concomitant
Subdural Haematoma Hospitalization 6/19/2006 Male 9/11/2006 Pharmacist United States
Primary
Concomitant
Skin Inflammation Other Serious 72 Male 9/12/2006 United Kingdom
Primary
Secondary
Concomitant
Haemoglobin Decreased Hospitalization 1/13/2006 Male 9/12/2006 Pharmacist United States
Primary
Concomitant
Hyperkalaemia Hospitalization 6/20/2006 70 Male 9/13/2006 Pharmacist United States
Primary
Secondary
Concomitant
International Normalised Ratio Increased Hospitalization 4/25/2006 Male 203 lb 4/26/2006 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased Other Serious 8/2/2006 82 Male 9/14/2006 Physician United Kingdom
Primary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Rash Other Serious 7/18/2006 74 Male 341 lb 7/18/2006 Pharmacist United States
Primary
Concomitant
Platelet Count Decreased Life Threatening 6/28/2006 80 Male 108 lb 9/22/2006 Other Health Professional United Kingdom
Primary
Concomitant
Nausea Hospitalization 9/25/2006 44 Male 283 lb 9/26/2006 Pharmacist United States
Primary
Concomitant
Procedural Hypotension Life Threatening 1/13/2006 33 Male 361 lb 9/26/2006 Pharmacist United States
Primary
Concomitant
Serotonin Syndrome Other Serious 9/23/2006 38 Female 225 lb 9/28/2006 Pharmacist United States
Primary
Concomitant
Sudden Death Death 4/5/2005 Male 9/28/2006 Physician United Kingdom
Primary
Secondary
Hyperkalaemia Hospitalization 78 Male 10/5/2006
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 78 Male 10/9/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 6/18/2006 87 Male 179 lb 10/4/2006 Pharmacist United States
Primary
Concomitant
Hypotension Hospitalization 7/6/2006 85 Male 172 lb 10/4/2006 Pharmacist United States
Primary
Concomitant
Ill-defined Disorder Hospitalization 7/7/2006 82 Male 192 lb 10/4/2006 Pharmacist United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 6/13/2006 77 Male 311 lb 10/4/2006 Pharmacist United States
Primary
Concomitant
Hyperkalaemia Hospitalization 78 Male 10/10/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 74 Female 175 lb 10/10/2006 Physician
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 9/26/2006 69 Male 221 lb 10/5/2006 Pharmacist United States
Primary
Concomitant
Liver Function Test Abnormal Hospitalization 78 Male 8/9/2006 Other Health Professional United States
Primary
Concomitant
Hyperkalaemia Hospitalization 78 Male 10/10/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 78 Male 10/9/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 74 Female 10/16/2006 Physician
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 78 Male 10/6/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hyperkalaemia Required Intervention 78 Male 10/10/2006 Other Health Professional Denmark
Primary
Concomitant
Blindness Unilateral Other Serious 1/1/2005 76 Male 10/11/2006 Sweden
Primary
Concomitant
Haemorrhagic Stroke Hospitalization 7/4/2006 80 Female 10/11/2006 United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/18/2006 75 Female 10/11/2006 United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Other Serious 68 Male 10/11/2006 Other Health Professional United States
Primary
Concomitant
Neutropenic Sepsis Life Threatening 9/1/2006 78 Female 10/13/2006 United Kingdom
Primary
Concomitant
International Normalised Ratio Increased Other Serious 2/15/2006 69 Male 130 lb 10/16/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vaginal Haemorrhage Hospitalization 8/14/2006 77 Female 207 lb 10/16/2006 Other Health Professional United Kingdom
Primary
Concomitant
Neutropenia Other Serious 74 Female 10/23/2006 Physician
Primary
Secondary
Concomitant
Neutropenia Other Serious 74 Female 175 lb 10/18/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tremor Hospitalization 8/28/2006 Male 10/23/2006 Pharmacist United States
Primary
Concomitant

Drug Data