Simvastatin combined with Valproic Acid

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Neutropenia Other Serious 2/22/2005 38 Male 245 lb 4/1/2005 Pharmacist United States
Primary
Concomitant
Renal Failure Hospitalization 3/1/1998 62 Female 4/20/2006 France
Primary
Concomitant
Granulocytopenia Required Intervention 9/26/2005 53 Female 132 lb 2/8/2006 United States
Primary
Concomitant
Staphylococcal Infection Hospitalization 1/8/2001 63 Male 7/24/2006 France
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 6/19/2006 60 Female 8/10/2006 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Other Serious 6/19/2006 60 Female 10/4/2006 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Life Threatening 6/18/2006 60 Female 10/5/2006 Other Health Professional United States
Primary
Concomitant
Thrombocytopenia Other Serious 7/11/2006 68 Male 154 lb 12/19/2006 Germany
Primary
Concomitant
Postictal State Other Serious 7/13/2006 42 Female 1/3/2007 United Kingdom
Primary
Concomitant
Mental Status Changes Required Intervention 1/8/2007 57 Male 153 lb 1/8/2007 Pharmacist United States
Primary
Concomitant
Faecaloma Hospitalization 10/2/2006 Male 115 lb 3/11/2007 Pharmacist United States
Primary
Secondary
Concomitant
Staring 4/6/2007 44 Male 255 lb 4/30/2007 Pharmacist United States
Primary
Secondary
Concomitant
Tracheostomy Other Serious 43 Male 5/7/2007 Physician Brazil
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 191 lb Physician United States
Primary
Secondary
Concomitant
Drug Interaction Other Serious 1/1/2007 54 Female 1/24/2008 Other Health Professional United Kingdom
Primary
Interacting
Drug Interaction Other Serious 1/1/2007 54 Female 1/25/2008 United Kingdom
Primary
Secondary
Glossodynia Other Serious 3/3/2008 56 Female 4/4/2008 France
Primary
Concomitant
Glossodynia Other Serious 3/3/2008 Female 4/17/2008 France
Primary
Concomitant
Thrombocytopenia Hospitalization 3/3/2008 46 Male 154 lb 4/17/2008 Physician Australia
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 3/19/2008 46 Male 154 lb 5/8/2008 Other Health Professional Australia
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 3/19/2008 46 Male 154 lb 5/5/2008 Physician Australia
Primary
Secondary
Concomitant
Glossodynia Other Serious 3/2/2008 Female 5/19/2008 France
Primary
Concomitant
Urinary Incontinence Other Serious 6/2/2000 51 Female 5/29/2008 Physician United Kingdom
Primary
Concomitant
Tremor Hospitalization 76 Female 6/27/2008 Other Health Professional France
Primary
Concomitant
Intraocular Pressure Increased Hospitalization 10/10/2008 Male 10/27/2008 Other Health Professional United Kingdom
Primary
Concomitant
Scleritis Disability 89 Female 10/30/2008 United Kingdom
Primary
Concomitant
Neutropenia Other Serious 9/4/2008 Female 11/12/2008 Physician Germany
Primary
Secondary
Concomitant
Unresponsive To Stimuli Death 10/4/2008 44 Female 225 lb 2/9/2009 Pharmacist United States
Primary
Concomitant
Liver Injury Hospitalization 9/12/2008 63 Female 3/18/2009 Other Health Professional France
Primary
Secondary
Concomitant
Suicidal Ideation Hospitalization 1/23/2009 Female 216 lb 4/8/2009 Physician Austria
Primary
Concomitant
Lung Infection Hospitalization 3/31/2009 Female 90 lb 4/20/2009 Physician France
Primary
Concomitant
Pancytopenia Hospitalization 5/14/2009 54 Female 264 lb 5/26/2009 Pharmacist United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/1998 41 Male 303 lb 7/30/2009 United States
Primary
Concomitant
Wound Other Serious 1/1/2009 60 Male 8/13/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pancreatitis Other Serious 3/30/2001 48 Male 265 lb 9/23/2009 United States
Primary
Concomitant
Vision Blurred Other Serious 3/15/2006 38 Female 230 lb 9/23/2009 United States
Primary
Concomitant
Vision Blurred Other Serious 10/1/2005 51 Female 194 lb 9/23/2009 United States
Primary
Concomitant
Platelet Count Decreased Hospitalization 7/31/2009 52 Male 10/6/2009 Other Health Professional United Kingdom
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2004 51 Male 286 lb 10/15/2009 United States
Primary
Concomitant
Restlessness Hospitalization 66 Female 99 lb 10/12/2009 United States
Primary
Concomitant
Overdose Hospitalization 1/15/2009 61 Male 10/22/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Application Site Rash 4/1/2009 67 Male 10/29/2009 Consumer
Primary
Concomitant
Overdose Hospitalization 61 Male 11/5/2009 United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 20 Female 11/5/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Rash Pruritic 4/1/2009 66 Male 11/13/2009 Physician
Primary
Concomitant
Weight Increased 7/16/2009 51 Male 209 lb 12/9/2009 Consumer United States
Primary
Concomitant
Urinary Incontinence Other Serious 59 Female 157 lb 12/23/2009 Pharmacist United States
Primary
Secondary
Concomitant
Drug Toxicity Death 60 Female 1/8/2010 Other Health Professional United States
Primary
Secondary
Death Death 10/23/2009 47 Male 12/30/2009 Pharmacist United States
Primary
Concomitant
Myoclonus Other Serious 66 Female 99 lb 1/14/2010 United States
Primary
Concomitant
Drug Toxicity Other Serious 60 Female 1/20/2010 Physician United States
Primary
Secondary
Poisoning Death 60 Female 1/20/2010 Physician United States
Primary
Secondary
Poisoning Death 1/1/2008 60 Female 2/1/2010 Physician United States
Primary
Secondary
Liver Injury Hospitalization 9/5/2008 63 Female 190 lb 2/15/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Liver Injury Hospitalization 9/12/2008 63 Female 2/15/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Liver Injury Hospitalization 9/12/2008 63 Female 2/15/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Liver Injury Hospitalization 9/12/2008 63 Female 2/15/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Completed Suicide Death 60 Female 2/22/2010 United States
Primary
Secondary
Completed Suicide Death 60 Female 3/5/2010 Other Health Professional United States
Primary
Secondary
Pain Hospitalization 9/5/2008 63 Female 190 lb 3/1/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Death Death 1/1/2008 60 Female 3/25/2010 Other Health Professional United States
Primary
Secondary
Weight Decreased Other Serious 4/1/2006 54 Male 4/14/2010 United States
Primary
Secondary
Concomitant
Vomiting Other Serious 8/1/2009 72 Female 4/15/2010 Netherlands
Primary
Secondary
Concomitant
Vomiting Other Serious 8/1/2009 72 Female 4/27/2010 Netherlands
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 4/13/2010 69 Female 6/3/2010 Physician Denmark
Primary
Concomitant
Vitamin B12 Deficiency Other Serious 1/16/2004 59 Male 6/11/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 4/1/2006 54 Male 6/21/2010 United States
Primary
Secondary
Concomitant
Rash 6/24/2008 43 Male 266 lb 6/29/2010 Consumer United States
Primary
Concomitant
Vitamin B12 Deficiency Other Serious 1/16/2004 59 Male 7/14/2010 United States
Primary
Concomitant
Somnolence Other Serious 1/1/2009 49 Male 235 lb 5/18/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 4/1/2006 54 Male 7/29/2010 United States
Primary
Secondary
Concomitant
Sedation Other Serious 6/14/2010 45 Female 7/27/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Other Serious 4/1/2006 54 Male 8/23/2010 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 4/1/2006 54 Male 8/26/2010 United States
Primary
Secondary
Concomitant
Pruritus Male 200 lb 8/29/2010 Consumer United States
Primary
Concomitant
Vision Blurred Other Serious 3/15/2006 38 Female 230 lb 9/20/2010 United States
Primary
Concomitant
Paranoia Disability 38 Male 192 lb 10/29/2010 United Kingdom
Primary
Concomitant
Respiratory Arrest Life Threatening 10/23/2010 69 Female 11/12/2010 Physician United States
Primary
Concomitant
Syncope Hospitalization 6/1/2010 39 Female 150 lb 12/30/2010 Physician Germany
Primary
Secondary
Concomitant
Heart Rate Decreased Other Serious 6/1/2010 39 Female 150 lb 1/7/2011 Other Health Professional Germany
Primary
Concomitant
Dry Skin Hospitalization 10/1/2009 72 Female 143 lb 1/25/2011 Physician Germany
Primary
Concomitant
Back Pain 1/2/2010 51 Male 1/28/2011 United States
Primary
Concomitant
Mania Hospitalization 1/31/2011 72 Female 4/6/2011 Physician Austria
Primary
Concomitant
Mania Hospitalization 1/31/2011 72 Female 4/27/2011 Consumer Austria
Primary
Concomitant
Deep Vein Thrombosis Hospitalization 3/1/2011 70 Male 5/17/2011 Consumer Norway
Primary
Concomitant
Renal Mass Hospitalization 2/22/2011 72 Male 5/25/2011 Physician United Kingdom
Primary
Concomitant
Constipation Hospitalization 2/22/2011 72 Male 6/8/2011 Other Health Professional United Kingdom
Primary
Concomitant
Dyspnoea Hospitalization 6/9/2004 71 Male 6/8/2011 Other Health Professional Canada
Primary
Concomitant
Liver Injury Hospitalization 9/5/2008 63 Female 190 lb 6/16/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 8/7/2004 60 Male 7/5/2011 Consumer United States
Primary
Concomitant
Completed Suicide Death 1/1/2008 60 Female 7/22/2011 Physician United States
Primary
Secondary
Completed Suicide Death 1/1/2008 60 Female 7/22/2011 Physician United States
Primary
Secondary
Palpitations 1/1/2000 44 Male 257 lb 8/5/2011 Consumer United States
Primary
Concomitant
Toxicity To Various Agents Death 71 Male 119 lb 8/16/2011 Other Health Professional United Kingdom
Primary
Concomitant
Toxicity To Various Agents Death 71 Male 8/24/2011 Other Health Professional Denmark
Primary
Concomitant
Diabetic Complication Other Serious 10/11/2005 51 Female 215 lb 9/22/2011 Consumer United States
Primary
Concomitant
Cough Hospitalization 8/25/2011 59 Female 227 lb 9/23/2011 Other Health Professional United Kingdom
Primary
Concomitant
Influenza Like Illness Other Serious 7/6/2011 44 132 lb 9/20/2011 Other Health Professional United Kingdom
Primary
Concomitant
Tremor Disability 8/1/2010 87 Male 135 lb 9/26/2011 Other Health Professional United Kingdom
Primary
Concomitant
Tremor Other Serious 8/1/2010 87 Male 135 lb 9/26/2011 Other Health Professional United Kingdom
Primary
Concomitant
Haemorrhage Hospitalization 7/27/2011 84 Male 9/26/2011 Physician Sweden
Primary
Secondary
Concomitant
Hyperhidrosis Other Serious 44 Female 9/23/2011 Other Health Professional Denmark
Primary
Concomitant
Hyperhidrosis Other Serious 7/6/2011 44 Female 132 lb 9/29/2011 Other Health Professional United Kingdom
Primary
Concomitant
Hyperhidrosis Other Serious 7/7/2011 44 Female 132 lb 10/5/2011 Other Health Professional United Kingdom
Primary
Concomitant
Hyperhidrosis Other Serious 7/7/2011 44 Female 10/7/2011 Other Health Professional Denmark
Primary
Concomitant
Hyperhidrosis Other Serious 7/7/2011 44 Female 132 lb 10/13/2011 Other Health Professional United Kingdom
Primary
Concomitant
Completed Suicide Death 70 10/17/2011 Other Health Professional United States
Primary
Secondary
Pruritus Other Serious 9/1/2011 64 Female 11/25/2011 Consumer Finland
Primary
Concomitant
Hypersensitivity Hospitalization 52 Female 149 lb 1/11/2012 Other Health Professional France
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 30 Male 1/26/2012 Physician Israel
Primary
Concomitant
Mobility Decreased Other Serious 8/1/2010 87 Male 135 lb 2/1/2012 Other Health Professional United Kingdom
Primary
Concomitant
Oxygen Saturation Decreased Hospitalization 10/25/2011 50 Female 2/9/2012 Physician United Kingdom
Primary
Concomitant
Dry Skin Hospitalization 10/1/2009 72 Female 143 lb 2/21/2012 Physician Germany
Primary
Concomitant
Thrombocytopenia Other Serious 6/16/2010 48 Male 2/22/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Oxygen Saturation Decreased Other Serious 10/25/2011 50 Female 2/22/2012 Other Health Professional United Kingdom
Primary
Concomitant
Psychotic Disorder Hospitalization 6/16/2010 48 Male 2/22/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Oxygen Saturation Decreased Other Serious 10/25/2011 50 Female 2/22/2012 Physician United Kingdom
Primary
Concomitant
Gait Disturbance Disability 8/1/2010 87 Male 135 lb 2/23/2012 Other Health Professional United Kingdom
Primary
Concomitant
Alanine Aminotransferase Increased Death 1/9/2012 36 Male 2/17/2012 Consumer United Kingdom
Primary
Secondary
Concomitant
Dyspnoea Other Serious 10/25/2011 50 Female 2/29/2012 Physician United Kingdom
Primary
Concomitant
Pain Hospitalization 10/1/2009 72 Female 146 lb 3/1/2012 Other Health Professional Germany
Primary
Concomitant
Salivary Hypersecretion Hospitalization 6/16/2010 48 Male 3/2/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Hepatitis C Virus Test Positive Hospitalization 6/16/2010 48 Male 3/2/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Neutrophil Count Decreased Other Serious 10/25/2011 50 Female 3/5/2012 Physician United Kingdom
Primary
Concomitant
Neutropenia Other Serious 6/16/2010 48 Male 3/5/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Salivary Hypersecretion Hospitalization 6/16/2010 48 Male 3/1/2012 United Kingdom
Primary
Secondary
Concomitant
Skeletal Injury Other Serious 30 Male 3/2/2012 Physician Israel
Primary
Concomitant
Neutropenia Hospitalization 6/16/2010 48 Male 3/7/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Salivary Hypersecretion Hospitalization 6/16/2010 48 Male 3/9/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Lower Respiratory Tract Infection Hospitalization 10/25/2011 50 Female 3/9/2012 Pharmacist United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 6/16/2010 48 Male 3/9/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Wrong Drug Administered 2/1/2012 60 Female 3/9/2012 Physician United States
Primary
Concomitant
Neutropenia Hospitalization 6/16/2010 48 Male 3/5/2012 Physician
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 6/16/2010 48 Male 3/12/2012 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Salivary Hypersecretion Hospitalization 6/16/2010 48 Male 3/12/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 6/16/2010 48 Male 3/8/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 6/16/2010 48 Male 3/13/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 6/16/2010 48 Male 3/15/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 6/16/2010 48 Male 3/15/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Salivary Hypersecretion Hospitalization 6/16/2010 48 Male 3/16/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Eosinophil Count Decreased Other Serious 6/16/2010 48 Male 3/16/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Psychotic Disorder Hospitalization 6/16/2010 48 Male 3/14/2012 Pharmacist
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 30 Male 3/20/2012 Physician Israel
Primary
Concomitant
Somnolence Other Serious 10/25/2011 50 Female 3/20/2012 Pharmacist United Kingdom
Primary
Concomitant
Neutropenia Other Serious 6/16/2010 48 Male 3/15/2012 Pharmacist
Primary
Secondary
Concomitant
Mood Swings Other Serious 58 Female 3/21/2012 Other Health Professional Sweden
Primary
Secondary
Concomitant
Decreased Activity Other Serious 58 Female 3/21/2012 Other Health Professional Sweden
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 6/16/2010 48 Male 3/28/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Eosinophil Count Decreased Hospitalization 10/25/2011 50 Female 3/30/2012 Physician United Kingdom
Primary
Concomitant
Hepatitis C Virus Test Positive Hospitalization 6/16/2010 48 Male 3/26/2012 Pharmacist
Primary
Secondary
Concomitant

Drug Data