Simvastatin combined with Valproate Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Skin Ulcer Hospitalization 2/13/2002 Female 1/4/2006 France
Primary
Concomitant
Convulsion Life Threatening 12/17/2005 53 Male 1/13/2006 United Kingdom
Primary
Concomitant
Bradycardia Other Serious 1/4/2006 52 Male 3/1/2006 Other Health Professional United Kingdom
Primary
Concomitant
Parkinsonism Disability 1/1/2004 65 Female 4/10/2006 Pharmacist Ireland
Primary
Concomitant
Tremor Disability 1/1/2004 65 Female 5/3/2006 Other Health Professional Denmark
Primary
Concomitant
Hypertension Death 4/1/2006 46 Female 5/19/2006 United States
Primary
Concomitant
Convulsion Life Threatening 12/17/2005 53 Male 5/22/2006 United Kingdom
Primary
Concomitant
Disorientation Other Serious 7/10/2005 77 Male 5/25/2006 Other Health Professional United Kingdom
Primary
Concomitant
Granulocytopenia Required Intervention 1/17/2006 45 Male 5/17/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/13/2005 33 Male 5/15/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/3/2005 42 Male 1/25/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/12/2005 51 Female 2/27/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/18/2005 56 Female 5/16/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/11/2005 46 Female 2/7/2006 United States
Primary
Concomitant
Subdural Haematoma Hospitalization 12/27/2005 44 Female 8/9/2006 Other Health Professional Sweden
Primary
Secondary
Concomitant
International Normalised Ratio Increased Hospitalization 4/22/2005 Male 8/17/2006 Consumer France
Primary
Concomitant
Interacting
Granulocytopenia Required Intervention 2/6/2006 47 Male 4/18/2006 Consumer United States
Primary
Concomitant
Culture Urine Positive Hospitalization 9/16/2006 71 Female 10/18/2006 Other Health Professional United Kingdom
Primary
Concomitant
Overdose Death 9/26/2006 52 Male 190 lb 10/23/2006 United States
Primary
Concomitant
Psychotic Disorder Required Intervention 35 Male 11/7/2006 United States
Primary
Concomitant
Convulsion Other Serious 7/9/2006 72 Female 11/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9/26/2006 72 Male 11/28/2006 Pharmacist United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 54 Female 12/1/2006 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Vitamin B12 Deficiency Hospitalization 2/12/2006 Female 12/1/2006 Physician Australia
Primary
Concomitant
Speech Disorder Hospitalization 11/1/2006 43 Female 179 lb 4/9/2007 Physician United Kingdom
Primary
Concomitant
Epilepsy Other Serious 6/6/2007 56 Female 190 lb 6/27/2007 Consumer United Kingdom
Primary
Concomitant
Otorhinolaryngological Surgery Hospitalization 5/24/2007 48 Male 7/6/2007 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Epilepsy Other Serious 6/6/2007 56 Female 190 lb 7/31/2007 Physician United Kingdom
Primary
Concomitant
Drug Toxicity Other Serious 76 Female 10/19/2007 United Kingdom
Primary
Concomitant
Syncope Other Serious 2/1/2007 Male 141 lb 11/15/2007 Other Health Professional United Kingdom
Primary
Concomitant
Somnolence Other Serious 52 Female 1/23/2008
Primary
Secondary
Concomitant
Drug Interaction Other Serious 1/1/2007 1/1/2008 Other Health Professional United Kingdom
Primary
Secondary
Drug Interaction Other Serious 1/1/2007 54 Female 1/31/2008 Other Health Professional United Kingdom
Primary
Secondary
Drug Interaction Other Serious 1/1/2007 54 Female 2/5/2008 Other Health Professional France
Primary
Interacting
Convulsion Hospitalization 8/1/2007 64 Female 1/17/2008 United States
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious 45 Male 2/29/2008 United States
Primary
Concomitant
Duodenal Ulcer Perforation Hospitalization 8/2/2005 69 Female 2/28/2008 Denmark
Primary
Secondary
Concomitant
Duodenal Ulcer Perforation Hospitalization 8/2/2005 69 Female 3/31/2008 Denmark
Primary
Secondary
Concomitant
Duodenal Ulcer Perforation Hospitalization 8/2/2005 69 Female 4/9/2008 Physician Denmark
Primary
Secondary
Concomitant
Drug Interaction Other Serious 1/1/2007 54 Female 6/16/2008 Other Health Professional France
Primary
Concomitant
Interacting
Urinary Incontinence Other Serious 6/2/2000 51 Female 6/18/2008 United Kingdom
Primary
Concomitant
Melaena Hospitalization 8/2/2005 69 Female 6/17/2008 Denmark
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious 45 Male 6/27/2008 United States
Primary
Concomitant
Vomiting Hospitalization 7/20/2008 Male 8/27/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Skin Burning Sensation 6/25/2008 Male 8/29/2008 United States
Primary
Concomitant
Thrombocytopenia Hospitalization 6/23/2008 Male 9/16/2008 Physician France
Primary
Concomitant
Urinary Incontinence Hospitalization 6/8/2007 Female 9/17/2008 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 7/20/2008 Male 9/17/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Drug Toxicity Hospitalization 66 Male 9/24/2008 Australia
Primary
Concomitant
Scleritis Disability 89 Female 10/28/2008 Other Health Professional United Kingdom
Primary
Concomitant
Confusional State Other Serious 10/24/2008 75 Female 11/17/2008 Other Health Professional United Kingdom
Primary
Concomitant
Scleritis Disability 89 Female 11/11/2008 United Kingdom
Primary
Concomitant
Hypersensitivity Male 11/20/2008 United States
Primary
Concomitant
Dysphagia Other Serious Male 11/20/2008 Pharmacist United Kingdom
Primary
Concomitant
Dysphagia Other Serious Male 11/24/2008 Pharmacist United Kingdom
Primary
Concomitant
Paraesthesia Male 11/26/2008 United States
Primary
Concomitant
Pulmonary Haematoma Other Serious 9/1/2008 Male 183 lb 12/1/2008 Other Health Professional New Zealand
Primary
Concomitant
Injection Site Pain 10/1/2008 Male 321 lb 12/12/2008 Physician United States
Primary
Concomitant
Hemiparesis Other Serious 5/1/2004 Male 12/15/2008 Other Health Professional United Kingdom
Primary
Concomitant
Accidental Exposure Other Serious 51 Male 12/29/2008 Other Health Professional Germany
Primary
Secondary
Accidental Exposure Other Serious 51 Male 12/29/2008 Other Health Professional Germany
Primary
Secondary
Tremor Hospitalization 11/3/2005 Female 1/12/2009 Other Health Professional Australia
Primary
Secondary
Concomitant
Meningioma Other Serious 5/1/2008 49 Female 1/15/2009 Other Health Professional Netherlands
Primary
Concomitant
Myocardial Infarction Life Threatening 1/18/2009 65 Male 223 lb 2/9/2009 Physician United Kingdom
Primary
Concomitant
Increased Tendency To Bruise Other Serious 10/7/2008 79 Female 2/13/2009 United Kingdom
Primary
Concomitant
Liver Injury Hospitalization 63 Female 3/11/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Vomiting Other Serious Male 256 lb 3/20/2009 Other Health Professional United Kingdom
Primary
Concomitant
Speech Disorder Other Serious 8/26/2008 Male 4/6/2009 Other Health Professional
Primary
Concomitant
Urinary Incontinence Life Threatening 12/1/2008 90 Female 4/22/2009 Other Health Professional France
Primary
Concomitant
Nerve Compression Hospitalization 3/1/2009 71 Male 5/1/2009 Pharmacist France
Primary
Concomitant
Nerve Compression Hospitalization 3/1/2009 71 Male 5/11/2009 Pharmacist France
Primary
Concomitant
Overdose Hospitalization 1/15/2009 Male 7/1/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Nerve Compression Hospitalization 3/1/2009 71 Male 7/14/2009 Pharmacist France
Primary
Concomitant
Traumatic Lung Injury Life Threatening 7/6/2009 Male 7/23/2009 Pharmacist United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 12/1/2008 Male 8/6/2009 Physician United Kingdom
Primary
Concomitant
Treatment Noncompliance Other Serious 6/6/2009 Male 9/4/2009 Pharmacist United Kingdom
Primary
Concomitant
Wrong Technique In Drug Usage Process 10/1/2008 Male 321 lb 9/12/2009 Physician United States
Primary
Concomitant
Postictal State Other Serious 7/13/2006 42 Female 9/16/2009 Other Health Professional United Kingdom
Primary
Concomitant
Syncope Hospitalization 7/31/2009 52 Male 10/13/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Syncope Hospitalization 7/31/2009 52 Male 10/14/2009 Other Health Professional France
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious 9/11/2008 62 Male 174 lb 10/6/2009 Consumer United Kingdom
Primary
Concomitant
Serum Ferritin Increased Other Serious 4/15/2009 54 Male 134 lb 10/14/2009 Physician Switzerland
Primary
Concomitant
Weight Increased Other Serious 6/1/2008 20 Female 10/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 6/1/2008 20 10/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cerebral Infarction Other Serious 8/5/2009 Male 320 lb 10/26/2009 Physician Germany
Primary
Concomitant
Vomiting Hospitalization 7/20/2008 35 Male 10/26/2009 Physician United Kingdom
Primary
Concomitant
Overdose Hospitalization 1/15/2009 61 Male 10/21/2009 Other Health Professional United Kingdom
Primary
Concomitant
Overdose Hospitalization 1/15/2009 61 Male 10/27/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Treatment Noncompliance Other Serious 6/1/2008 20 Female 10/27/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 6/1/2008 20 Female 10/22/2009 United States
Primary
Concomitant
Drug Interaction Other Serious 1/1/2007 54 Female 10/23/2009 Other Health Professional United Kingdom
Primary
Concomitant
Mental Disorder Other Serious 10/24/2008 75 Female 10/23/2009 United Kingdom
Primary
Concomitant
Multiple Drug Overdose Hospitalization 1/13/2009 61 Male 10/29/2009 Physician France
Primary
Secondary
Concomitant
Self Injurious Behaviour Other Serious 6/1/2008 20 Female 10/27/2009
Primary
Secondary
Concomitant
Syncope Other Serious 7/31/2009 52 Male 11/10/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Salivary Hypersecretion Hospitalization 7/31/2009 52 Male 11/10/2009 Other Health Professional United Kingdom
Primary
Concomitant
Hyponatraemia Hospitalization 7/31/2009 52 Male 11/17/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Convulsion Hospitalization 2/14/2009 49 Female 194 lb 11/19/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Syncope Life Threatening 7/31/2009 52 Male 11/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Syncope Life Threatening 7/31/2009 52 Male 11/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Syncope Hospitalization 7/31/2009 52 Male 11/13/2009 United Kingdom
Primary
Concomitant
Hyponatraemia Hospitalization 7/31/2009 52 Male 11/19/2009
Primary
Secondary
Concomitant
Syncope Hospitalization 7/31/2009 52 Male 12/8/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Convulsion Hospitalization 2/14/2009 49 Female 194 lb 12/11/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Partial Seizures Other Serious Male 12/14/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Vomiting Other Serious 9/7/2009 Male 12/31/2009 Other Health Professional United Kingdom
Primary
Concomitant
Convulsion Hospitalization 2/14/2009 49 Female 194 lb 1/4/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Syncope Hospitalization 7/31/2009 52 Male 1/8/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Convulsion Hospitalization 2/14/2009 49 Female 1/13/2010 Physician France
Primary
Secondary
Concomitant
Convulsion Hospitalization 2/14/2009 49 Female 1/20/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Convulsion Hospitalization 2/14/2009 49 Female 1/21/2010 Physician France
Primary
Secondary
Concomitant
Post Procedural Infection Hospitalization Male 1/22/2010 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/2001 Male 2/3/2010 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 9/5/2008 63 Female 2/18/2010 Other Health Professional France
Primary
Secondary
Concomitant
Partial Seizures Male 2/11/2010 Physician Germany
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/2001 Male 2/23/2010 Other Health Professional United Kingdom
Primary
Concomitant
Restlessness Other Serious 1/1/2010 41 Male 2/26/2010 Physician United Kingdom
Primary
Concomitant
Restlessness Other Serious Male 3/3/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Restlessness Other Serious 41 Male 3/5/2010 Other Health Professional France
Primary
Secondary
Concomitant
Restlessness Other Serious 41 Male 3/9/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 9/5/2008 63 Female 3/23/2010 Other Health Professional France
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/2001 Male 3/30/2010 Other Health Professional United Kingdom
Primary
Concomitant
Cerebrovascular Accident Hospitalization 3/25/2010 61 Male 198 lb 4/5/2010
Primary
Secondary
Concomitant
Weight Increased Hospitalization Male 4/12/2010 Pharmacist United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/2001 45 Male 4/13/2010 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased Hospitalization Male 4/14/2010 Pharmacist United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/2001 45 Male 4/15/2010 Other Health Professional United Kingdom
Primary
Concomitant
International Normalised Ratio Other Serious 75 Male 4/9/2010
Primary
Secondary
Concomitant
Vomiting Other Serious 6/25/2009 32 Male 4/28/2010 Other Health Professional United Kingdom
Primary
Concomitant
Post Procedural Infection Hospitalization Male 4/28/2010 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased Hospitalization Male 4/29/2010 Pharmacist United Kingdom
Primary
Concomitant
Sinus Tachycardia Other Serious 19 Male 4/30/2010 Other Health Professional France
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 3/23/2010 61 Male 198 lb 5/3/2010
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/2001 45 Male 5/4/2010 Other Health Professional United Kingdom
Primary
Concomitant
Post Procedural Infection Hospitalization Male 5/7/2010 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Other Serious 6/25/2009 32 Male 5/19/2010 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/2010 85 Female 5/26/2010 Consumer Switzerland
Primary
Concomitant
Vomiting Hospitalization 44 Male 95 lb 5/27/2010 Consumer United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/26/2010 49 Female 5/27/2010 Other Health Professional France
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/2/2010 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 2/23/2010 85 Female 6/2/2010 Consumer Switzerland
Primary
Concomitant
Cerebrovascular Accident Hospitalization 3/25/2010 61 Male 198 lb 6/3/2010
Primary
Concomitant
Vomiting Hospitalization 44 Male 95 lb 6/3/2010 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 44 Male 95 lb 6/3/2010 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 44 Male 95 lb 6/7/2010 Consumer United Kingdom
Primary
Concomitant
Vomiting Hospitalization 5/11/2010 6/9/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 44 Male 6/10/2010 United Kingdom
Primary
Concomitant
Pulmonary Eosinophilia Other Serious 52 Male 6/21/2010 Physician France
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/26/2010 49 Female 6/23/2010 Other Health Professional France
Primary
Secondary
Concomitant
Vomiting Hospitalization 44 Male 95 lb 6/28/2010 Consumer United Kingdom
Primary
Concomitant

Drug Data