Simvastatin combined with Toprol-XL

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Hypersensitivity 9/1/2005 50 Female 1/5/2006 Physician United States
Primary
Concomitant
Chest Pain 4/16/2005 52 Female 179 lb 1/5/2006 Physician United States
Primary
Concomitant
Spleen Disorder Hospitalization 12/21/2005 77 Male 2/3/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Insomnia 1/1/2005 51 Female 135 lb 1/5/2006 Consumer United States
Primary
Concomitant
Pruritus Generalised 9/13/2005 66 Female 222 lb 1/5/2006 Consumer United States
Primary
Concomitant
Haemorrhage Hospitalization 9/5/2005 85 Female 100 lb 11/21/2005 Pharmacist United States
Primary
Concomitant
Headache 10/22/2005 73 Female 154 lb 4/3/2006 Consumer United States
Primary
Concomitant
Dysgeusia 2/1/2006 84 Male 185 lb 4/3/2006 Consumer United States
Primary
Concomitant
Blood Creatine Phosphokinase Increased 5/22/2006 65 Female 301 lb 7/6/2006 Pharmacist United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 3/26/2006 79 Female 8/18/2006 Pharmacist United States
Primary
Secondary
Concomitant
Thrombosis In Device Hospitalization 6/2/2006 36 Female 334 lb 8/18/2006 Other Health Professional United States
Primary
Concomitant
White Blood Cells Urine Positive Other Serious 5/4/2006 65 Male 239 lb 8/25/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Insulin-like Growth Factor Decreased Other Serious 8/4/2006 57 Male 211 lb 9/20/2006 Other Health Professional United States
Primary
Concomitant
Impaired Work Ability Other Serious 8/4/2006 57 Male 211 lb 10/9/2006 Physician United States
Primary
Concomitant
Intestinal Resection Hospitalization 11/2/2006 62 Male 216 lb 12/2/2006 Other Health Professional United States
Primary
Concomitant
Swelling 12/1/2005 77 Male 12/28/2006 Consumer United States
Primary
Concomitant
Initial Insomnia 7/6/2006 45 Male 148 lb 10/11/2006 Consumer United States
Primary
Concomitant
Sick Sinus Syndrome Other Serious 8/14/2006 Female 199 lb 1/10/2007 Physician United States
Primary
Concomitant
Overdose Other Serious 10/16/2006 Female 125 lb 1/18/2007 Consumer United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization 1/1/2007 76 Female 2/21/2007 Physician United States
Primary
Secondary
Concomitant
Somnolence 70 Male 3/7/2007 Consumer United States
Primary
Concomitant
Therapeutic Response Delayed 1/1/2006 70 Male 3/7/2007 Consumer United States
Primary
Concomitant
Somnolence 70 Male 3/7/2007 Consumer United States
Primary
Concomitant
Systemic Lupus Erythematosus Rash Disability 2/9/2007 73 Female 3/13/2007 Physician United States
Primary
Concomitant
Tremor Hospitalization 8/1/2004 81 Male 3/30/2006 Other Health Professional United States
Primary
Concomitant
Overdose Other Serious 2/21/2007 51 Female 3/20/2007 Consumer United States
Primary
Concomitant
Pulmonary Hypertension Death 11/15/2005 73 Male 230 lb 1/23/2007 Consumer United States
Primary
Concomitant
Middle Insomnia 9/18/2006 81 Male 205 lb 1/12/2007 Consumer United States
Primary
Concomitant
Insomnia 9/19/2006 55 Female 208 lb 1/12/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Hallucination 9/30/2006 71 Male 194 lb 1/12/2007 Consumer United States
Primary
Concomitant
Pyrexia Hospitalization 1/28/2007 79 Male 3/29/2007 Physician United States
Primary
Secondary
Concomitant
Wheezing Life Threatening Male 172 lb 4/3/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/1/2006 74 Male 217 lb 4/11/2007 Consumer United States
Primary
Concomitant
Throat Tightness 10/1/2006 67 Female 1/12/2007 Consumer United States
Primary
Secondary
Concomitant
Systemic Lupus Erythematosus Rash Disability 2/9/2007 73 Female 4/16/2007 Physician United States
Primary
Secondary
Concomitant
Blood Glucose Increased Other Serious 4/1/2007 Male 170 lb 4/27/2007 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2006 74 Male 216 lb 4/30/2007 Consumer United States
Primary
Concomitant
Angioedema 12/4/2006 65 Female 2/16/2007 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 1/28/2007 79 Male 5/17/2007 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/28/2007 79 Male 5/17/2007 Physician United States
Primary
Secondary
Concomitant
Electrocardiogram Qt Corrected Interval Prolonged Other Serious 10/21/2006 88 Male 162 lb 2/28/2007 Physician United States
Primary
Concomitant
Angioedema 12/4/2006 65 Female 5/17/2007 Physician United States
Primary
Concomitant
Hepatic Enzyme Increased 12/12/2006 70 Female 5/17/2007 United States
Primary
Concomitant
Nausea 3/1/2007 55 Male 4/10/2007 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2006 74 Male 216 lb 6/12/2007 Consumer United States
Primary
Concomitant
Hypersensitivity 10/1/2006 67 Female 4/10/2007 Physician United States
Primary
Concomitant
Yawning Life Threatening 3/28/2007 Female 162 lb 6/30/2007 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 3/1/2007 63 Female 193 lb 7/10/2007 Consumer United States
Primary
Concomitant
Platelet Function Test Abnormal Hospitalization 1/1/2003 Male 177 lb 8/6/2007 Consumer United States
Primary
Concomitant
Visual Acuity Reduced Other Serious 7/1/2007 Male 158 lb 8/17/2007 Consumer United States
Primary
Secondary
Concomitant
Suicidal Ideation Other Serious Male 236 lb 8/28/2007
Primary
Concomitant
Therapeutic Response Delayed 1/1/2006 70 Male 9/6/2007 Consumer United States
Primary
Concomitant
Diarrhoea 3/13/2007 81 Male 9/6/2007 Consumer United States
Primary
Concomitant
Platelet Function Test Abnormal Hospitalization 1/1/2003 Male 177 lb 9/6/2007 Consumer United States
Primary
Concomitant
Application Site Erythema 6/27/2007 Male 9/6/2007 Pharmacist United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2004 Female 181 lb 9/10/2007 Consumer United States
Primary
Secondary
Concomitant
Skin Ulcer 6/3/2007 70 Male 8/1/2007 United States
Primary
Concomitant
Subdural Haematoma Life Threatening 8/15/2007 65 Female 9/7/2007 Pharmacist United States
Primary
Concomitant
Myocardial Infarction Other Serious 8/1/2007 Male 9/18/2007 Pharmacist United States
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 7/23/2007 81 Male 8/9/2007 Pharmacist United States
Primary
Concomitant
Hepatic Steatosis 12/1/2006 70 Female 8/16/2007 Other Health Professional United States
Primary
Concomitant
Hypoglycaemic Unconsciousness Life Threatening 3/2/2007 80 Female 8/22/2007 Consumer United States
Primary
Concomitant
Hypoglycaemic Unconsciousness Life Threatening 3/29/2007 80 Female 8/22/2007 Consumer United States
Primary
Concomitant
Rash 6/27/2007 Male 243 lb 10/2/2007 Pharmacist United States
Primary
Concomitant
Platelet Function Test Abnormal Hospitalization 1/1/2003 Male 177 lb 10/24/2007 Consumer United States
Primary
Concomitant
Respiratory Disorder 66 Male 10/25/2007 Consumer United States
Primary
Concomitant
Cough 2/1/2007 76 Female 10/26/2007 Consumer United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 1/1/2004 Female 8/29/2007 Physician United States
Primary
Concomitant
Pollakiuria Other Serious 1/1/2004 Female 130 lb 11/5/2007 Consumer United States
Primary
Concomitant
Pollakiuria Other Serious 1/1/2004 Female 130 lb 11/21/2007 Consumer United States
Primary
Concomitant
Blindness Unilateral Hospitalization 9/7/2007 59 Female 149 lb 11/23/2007 Consumer United States
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 1/1/2007 78 Female 163 lb 11/26/2007 Physician United States
Primary
Concomitant
Palpitations Other Serious 11/5/2007 54 Female 286 lb 12/12/2007 Physician United States
Primary
Secondary
Concomitant
Myalgia Hospitalization 7/23/2006 71 Female 125 lb 12/19/2007 Consumer United States
Primary
Concomitant
Blood Glucose Increased 6/1/2007 59 Female 10/8/2007 Consumer United States
Primary
Concomitant
Blindness Unilateral Hospitalization 9/7/2007 59 Female 149 lb 1/3/2008 Consumer United States
Primary
Secondary
Concomitant
Drug Ineffective 8/1/2007 69 Male 1/9/2008 Consumer United States
Primary
Concomitant
Weight Decreased Other Serious 9/11/2003 47 Female 261 lb 1/18/2008 Physician United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 10/15/2007 81 Female 134 lb 2/7/2008 Consumer United States
Primary
Concomitant
Angina Pectoris Hospitalization 3/21/2007 72 Male 2/8/2008 Physician United States
Primary
Concomitant
Pancreatitis Hospitalization 1/24/2008 78 Female 108 lb 3/3/2008 Consumer United States
Primary
Concomitant
Muscle Spasms 1/1/2008 74 Female 117 lb 3/6/2008 Consumer United States
Primary
Concomitant
Skin Odour Abnormal 3/13/2008 Consumer United States
Primary
Secondary
Concomitant
Visual Disturbance 11/8/2007 45 Female 2/4/2008 Physician United States
Primary
Concomitant
Thinking Abnormal Disability 2/4/2008 Female 126 lb 4/7/2008 Consumer United States
Primary
Concomitant
Wheelchair User Other Serious 1/28/1992 4/9/2008 United States
Primary
Secondary
Concomitant
Presyncope Other Serious 1/1/2006 Female 118 lb 4/10/2008 Consumer United States
Primary
Secondary
Concomitant
Self-injurious Ideation Other Serious Male 193 lb 4/10/2008 United States
Primary
Concomitant
Haemoglobin Decreased Hospitalization 3/22/2008 61 Female 59 lb 4/11/2008 Pharmacist United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 7/1/2005 66 Male 230 lb 4/18/2008 Physician United States
Primary
Concomitant
Oral Discomfort 78 Male 180 lb 4/18/2008 United States
Primary
Concomitant
Dysphonia 78 Female 109 lb 4/29/2008 United States
Primary
Concomitant
Chromaturia Other Serious 1/7/2008 58 Female 205 lb 5/5/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2008 Female 194 lb 5/7/2008 Consumer United States
Primary
Concomitant
Myocardial Infarction Other Serious 4/28/2008 65 Male 282 lb 5/8/2008 Consumer United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2008 Female 194 lb 5/9/2008 Consumer United States
Primary
Concomitant
Renal Failure Other Serious 1/1/2005 31 Male 4/30/2008 Consumer United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2008 Female 194 lb 5/15/2008 Consumer United States
Primary
Secondary
Concomitant
Nausea Hospitalization Female 170 lb 4/27/2008 Physician United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2008 Female 194 lb 5/21/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2008 Female 194 lb 5/23/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2008 Female 194 lb 5/30/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2008 Female 194 lb 6/6/2008 Consumer United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 1/1/2005 31 Male 6/3/2008 Consumer United States
Primary
Concomitant
Headache 3/11/2008 79 Female 190 lb 6/16/2008 Consumer United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2008 Female 194 lb 6/17/2008 Consumer United States
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 6/19/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Chromaturia Other Serious 1/7/2008 58 Female 205 lb 6/23/2008 Physician United States
Primary
Secondary
Concomitant
Chromaturia Other Serious 1/7/2008 58 Female 205 lb 6/24/2008 Physician United States
Primary
Secondary
Concomitant
Rhinorrhoea 1/1/2006 Male 6/24/2008 Consumer United States
Primary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2005 Female 218 lb 6/26/2008 Consumer United States
Primary
Concomitant
Syncope Hospitalization 4/12/2008 71 Female 6/11/2008 Pharmacist United States
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 6/26/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Hypoglycaemia Other Serious 5/2/2007 62 Female 218 lb 4/30/2008 United States
Primary
Secondary
Concomitant
Self-injurious Ideation Other Serious 12/1/2007 Male 193 lb 7/1/2008 United States
Primary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 7/2/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 10/15/2007 81 Female 134 lb 7/3/2008 Consumer United States
Primary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2005 Female 218 lb 7/7/2008 Consumer United States
Primary
Concomitant
Myocardial Infarction Other Serious 6/14/2008 34 Female 150 lb 7/8/2008 Consumer United States
Primary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 7/9/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Rhinorrhoea 1/1/2006 Male 7/9/2008 Consumer United States
Primary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 7/11/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 7/22/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Chest Pain 76 Male 7/24/2008 Consumer United States
Primary
Concomitant
Fatigue 61 Female 7/24/2008 Consumer United States
Primary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 7/25/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Cholecystitis Infective Other Serious 46 Male 260 lb 7/18/2008 United States
Primary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 7/30/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Scleroderma Other Serious 3/29/2006 8/1/2008 Physician United States
Primary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 8/1/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 8/4/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Self-injurious Ideation Other Serious 12/1/2007 Male 193 lb 8/6/2008 United States
Primary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 8/8/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 8/15/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Suicidal Ideation Other Serious 8/6/2008 90 Female 102 lb 8/15/2008 United States
Primary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 8/18/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 8/21/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Thrombosis Other Serious 1/1/2008 Female 160 lb 8/22/2008 United States
Primary
Concomitant
Weight Decreased Death 5/21/2008 79 Female 243 lb 8/20/2008 Consumer United States
Primary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 8/25/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Tachycardia 8/3/2008 84 Female 8/25/2008 Consumer United States
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 8/27/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 9/3/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Hypotension Hospitalization 1/9/2008 67 Male 187 lb 9/4/2008 Consumer United States
Primary
Concomitant
Suicidal Ideation Other Serious 8/6/2008 90 Female 102 lb 9/5/2008 Physician United States
Primary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 9/5/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 9/9/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 9/11/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 2/6/2008 51 Male 9/17/2008 Lawyer United States
Primary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 194 lb 9/17/2008 Other Health Professional United States
Primary
Secondary
Concomitant

Drug Data