Simvastatin combined with Topiramate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Convulsion Life Threatening 12/17/2005 53 Male 1/13/2006 United Kingdom
Primary
Concomitant
Dysphagia Disability 11/1/2005 86 Male 174 lb 1/23/2006 Pharmacist United Kingdom
Primary
Concomitant
Tremor Hospitalization 3/6/2006 49 Female 214 lb 3/20/2006 Pharmacist United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 9/1/2001 70 Female 126 lb 4/14/2006 Physician Canada
Primary
Concomitant
Post Procedural Complication Death 2/1/2006 53 Male 5/1/2006 United States
Primary
Concomitant
Convulsion Life Threatening 12/17/2005 53 Male 5/22/2006 United Kingdom
Primary
Concomitant
Weight Increased Hospitalization 8/24/2006 69 Male 241 lb 8/30/2006 Pharmacist United States
Primary
Concomitant
Pneumonia Aspiration Death 52 Female 9/13/2006 Physician United States
Primary
Secondary
Renal Failure Acute Hospitalization 9/26/2006 69 Male 221 lb 10/5/2006 Pharmacist United States
Primary
Concomitant
Neutropenia Hospitalization 1/11/2007 47 Female 1/16/2007 Pharmacist United States
Primary
Concomitant
Sluggishness 9/7/2006 Male 289 lb 1/12/2007 Consumer United States
Primary
Concomitant
Paraesthesia Disability 67 Female 9/5/2007 Physician
Primary
Concomitant
Visual Disturbance Disability 2/19/2007 67 Female 181 lb 9/12/2007 Physician
Primary
Concomitant
Rhabdomyolysis Life Threatening 8/29/2007 52 Female 321 lb 9/26/2007 Pharmacist United States
Primary
Secondary
Concomitant
Feeling Cold 12/1/2007 Female 130 lb 3/15/2008 United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 6/1/2008 Male 230 lb 6/30/2008 Physician United States
Primary
Concomitant
Interacting
Vision Blurred Other Serious 6/1/2008 Male 230 lb 7/2/2008 Physician United States
Primary
Concomitant
Interacting
Rash Generalised Life Threatening 4/1/2008 8/8/2008 Other Health Professional United Kingdom
Primary
Concomitant
Rash Generalised Life Threatening 4/1/2008 8/25/2008 Other Health Professional United Kingdom
Primary
Concomitant
Muscle Disorder 7/16/2008 Female 120 lb 9/12/2008 Physician United States
Primary
Concomitant
Rash Generalised Other Serious 4/1/2008 9/16/2008 Other Health Professional United Kingdom
Primary
Concomitant
Rash Generalised Other Serious 4/1/2008 66 Female 10/1/2008 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 4/1/2008 66 Female 9/30/2008
Primary
Concomitant
Nasal Congestion 8/27/2008 61 Male 10/14/2008 Consumer United States
Primary
Concomitant
Rash Generalised Other Serious 5/1/2008 66 Female 11/26/2008 Other Health Professional United Kingdom
Primary
Concomitant
Headache 3/1/2008 200 lb 12/4/2008 Consumer United States
Primary
Concomitant
Vaginal Haemorrhage 6/23/1999 28 Female 194 lb 4/15/2009 Other Health Professional United States
Primary
Concomitant
Wound Infection Other Serious 1/1/2001 42 Male 240 lb 5/20/2009 United States
Primary
Secondary
Concomitant
Rash Generalised Other Serious 5/1/2008 66 Female 8/19/2009 Other Health Professional United Kingdom
Primary
Concomitant
Rash Generalised Other Serious 4/1/2008 66 Female 8/27/2009 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Embolism Life Threatening 1/1/2009 60 Female 9/15/2009 United Kingdom
Primary
Concomitant
Pancreatitis Other Serious 3/30/2001 48 Male 265 lb 9/23/2009 United States
Primary
Concomitant
Simple Partial Seizures Other Serious 7/23/2009 Male 174 lb 9/30/2009 Consumer Portugal
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/20/2004 46 Male 234 lb 10/5/2009 United States
Primary
Concomitant
Weight Decreased Other Serious 2/1/2008 45 Female 256 lb 10/14/2009 United States
Primary
Concomitant
Systemic Lupus Erythematosus Other Serious 4/1/2008 66 Female 10/23/2009 United Kingdom
Primary
Concomitant
Alopecia Other Serious 7/20/2009 44 Female 200 lb 10/5/2009 United States
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2007 Female 137 lb 11/25/2009 Physician United States
Primary
Concomitant
Drug Administered At Inappropriate Site 1/7/2010 Female 1/18/2010 Consumer United States
Primary
Concomitant
Pain Disability 3/7/2010 69 Female 3/23/2010 Consumer Canada
Primary
Concomitant
Suicide Attempt Life Threatening 3/1/2010 48 Male 179 lb 4/19/2010 Other Health Professional United Kingdom
Primary
Concomitant
Suicide Attempt Life Threatening 3/1/2010 48 Male 179 lb 4/29/2010 Other Health Professional United Kingdom
Primary
Concomitant
Suicide Attempt Life Threatening 48 Male 5/3/2010 United Kingdom
Primary
Concomitant
Urticaria Other Serious 11/1/2009 50 Female 160 lb 6/4/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Swelling Other Serious 6/28/2010 78 Female 134 lb 7/7/2010 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 6/1/2010 46 Female 160 lb 8/13/2010 United States
Primary
Concomitant
Skin Burning Sensation 10/15/2009 51 Female 203 lb 8/28/2010 Consumer United States
Primary
Secondary
Concomitant
Paraesthesia Other Serious 6/29/2010 66 Female 189 lb 9/14/2010 Consumer United States
Primary
Concomitant
Weight Increased Hospitalization 10/1/2002 41 Female 225 lb 9/20/2010 United States
Primary
Concomitant
Diabetes Mellitus Hospitalization 1/1/2008 36 Female 230 lb 9/14/2010 Consumer United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 8/19/2009 45 Female 218 lb 10/1/2010 Physician Spain
Primary
Concomitant
Weight Decreased Hospitalization 6/1/2010 46 Female 160 lb 10/13/2010 United States
Primary
Concomitant
Ventricular Tachycardia Required Intervention 7/1/2010 56 Female 197 lb 10/18/2010 Pharmacist United States
Primary
Secondary
Concomitant
Vision Blurred 63 Female 10/13/2010 Consumer United States
Primary
Concomitant
Torsade De Pointes Life Threatening 6/13/2010 78 Female 11/10/2010 Physician Spain
Primary
Concomitant
Anosmia Disability 1/1/2002 77 Female 11/17/2010 Consumer United States
Primary
Secondary
Concomitant
Cerebrovascular Accident Other Serious 43 Male 172 lb 12/17/2010 Other Health Professional United States
Primary
Concomitant
Anosmia Disability 1/1/2002 77 Female 12/17/2010 Consumer United States
Primary
Secondary
Concomitant
Thrombotic Stroke Other Serious 1/1/2008 36 Female 230 lb 12/13/2010 Consumer United States
Primary
Concomitant
Completed Suicide Death 41 Male 1/4/2011 Other Health Professional United States
Primary
Secondary
Cardio-respiratory Arrest Death 37 Female 1/7/2011 Physician United States
Primary
Secondary
Tooth Decalcification Other Serious 7/1/2010 53 Female 146 lb 1/7/2011 Consumer Brazil
Primary
Secondary
Concomitant
Completed Suicide Death 1/1/2009 37 Female 1/10/2011 Physician United States
Primary
Secondary
Cardiac Arrest Death 37 Female 1/12/2011 Physician United States
Primary
Secondary
Toxicity To Various Agents Death 41 Male 1/12/2011 Physician United States
Primary
Secondary
Respiratory Arrest Death 37 Female 1/12/2011
Primary
Secondary
Completed Suicide Death 37 Female 1/19/2011 Physician United States
Primary
Secondary
Constipation Other Serious 1/1/2010 54 Female 175 lb 1/21/2011 Physician United States
Primary
Concomitant
Completed Suicide Death 37 Female 1/21/2011 Physician United States
Primary
Secondary
Tachycardia Other Serious 12/12/2006 28 Female 240 lb 1/27/2011 Lawyer United States
Primary
Secondary
Concomitant
Influenza Like Illness 1/1/2010 52 Female 262 lb 1/29/2011 Consumer United States
Primary
Secondary
Concomitant
Cardiac Arrest Death 1/1/2009 41 Male 1/19/2011 Other Health Professional United States
Primary
Concomitant
Multiple Drug Overdose Intentional Death 37 Female 1/27/2011 Physician United States
Primary
Secondary
Poisoning Death 1/1/2009 37 Female 1/27/2011 Physician United States
Primary
Secondary
Respiratory Arrest Death 1/1/2009 37 Female 1/25/2011 Physician United States
Primary
Secondary
Respiratory Arrest Death 1/1/2009 41 Male 1/26/2011 Physician United States
Primary
Secondary
Completed Suicide Death 41 Male 1/28/2011 Other Health Professional Denmark
Primary
Secondary
Cardiac Arrest Death 1/1/2009 37 Female 1/25/2011 Physician United States
Primary
Secondary
Cardio-respiratory Arrest Death 37 Female 2/2/2011 United States
Primary
Secondary
Cardio-respiratory Arrest Death 41 Male 2/2/2011 United States
Primary
Secondary
Arrhythmia Hospitalization 7/1/2010 53 Female 146 lb 2/18/2011 Consumer Brazil
Primary
Secondary
Concomitant
Gallbladder Disorder Other Serious 7/1/2010 53 Female 146 lb 2/22/2011 Consumer Brazil
Primary
Secondary
Concomitant
Cardio-respiratory Arrest Death 41 Male 3/6/2011 Physician United States
Primary
Secondary
Respiratory Arrest Death 1/1/2009 37 Female 2/23/2011 Physician United States
Primary
Secondary
Concomitant
Cardio-respiratory Arrest Death 37 Female 3/9/2011 Other Health Professional United States
Primary
Secondary
Cardiac Arrest Death 37 Female 3/24/2011 Physician United States
Primary
Secondary
Hypocalcaemia Other Serious 2/5/2011 71 Female 177 lb 4/4/2011 Other Health Professional United States
Primary
Concomitant
Hypercalcaemia Other Serious 2/15/2011 48 Male 4/6/2011 Consumer Germany
Primary
Concomitant
Cardiac Arrest Death 41 Male 3/30/2011 Physician United States
Primary
Secondary
Diabetes Mellitus Other Serious Female 5/20/2011 Consumer United States
Primary
Concomitant
Pulmonary Embolism Other Serious 11/1/2007 37 Female 181 lb 5/24/2011 Lawyer United States
Primary
Secondary
Concomitant
Polyp Other Serious 10/4/2010 69 Female 5/27/2011 Consumer United States
Primary
Concomitant
Depression Hospitalization 4/1/2010 53 Female 6/17/2011 Consumer United States
Primary
Concomitant
Polycystic Ovaries Other Serious 1/1/2008 36 Female 240 lb 6/8/2011 Consumer United States
Primary
Concomitant
Cerebrovascular Accident Other Serious 1/1/2008 36 Female 240 lb 7/6/2011 Pharmacist United States
Primary
Concomitant
Pain Female 156 lb 8/6/2011 Consumer United States
Primary
Concomitant
Insomnia Hospitalization 46 Male 8/12/2011 United States
Primary
Concomitant
Headache Other Serious 6/10/2011 65 Male 185 lb 8/15/2011 Other Health Professional United Kingdom
Primary
Concomitant
Constipation Other Serious 1/1/2008 36 Female 235 lb 8/18/2011 Pharmacist United States
Primary
Secondary
Concomitant
Impaired Fasting Glucose Other Serious 6/23/2006 50 Female 9/22/2011 Other Health Professional United States
Primary
Concomitant
Diabetes Mellitus Inadequate Control Hospitalization 10/1/2002 41 Female 225 lb 9/22/2011 Other Health Professional United States
Primary
Concomitant
Infusion Related Reaction Other Serious 9/14/2011 72 Male 215 lb 9/28/2011 Other Health Professional United States
Primary
Concomitant
Oedema Peripheral Other Serious Female 223 lb 10/19/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Constipation 10/1/2010 46 Female 10/22/2011 Consumer United States
Primary
Concomitant
Sepsis Hospitalization 9/22/2011 68 Male 150 lb 10/27/2011 Physician United States
Primary
Concomitant
Glossodynia 9/27/2010 65 Female 10/24/2011 Consumer United States
Primary
Concomitant
Oropharyngeal Candidiasis 4/1/2011 68 Female 10/24/2011 Consumer United States
Primary
Concomitant
Speech Disorder 10/19/2011 45 Female 125 lb 11/1/2011 Consumer United States
Primary
Concomitant
Condition Aggravated Other Serious 1/1/2008 36 Female 218 lb 10/20/2011 Pharmacist United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 9/22/2011 68 Male 150 lb 11/4/2011 Physician United States
Primary
Concomitant
Somnambulism 1/1/2011 50 Female 130 lb 11/23/2011 Consumer United States
Primary
Secondary
Concomitant
Adverse Event Other Serious 1/1/2010 44 Male 167 lb 12/7/2011 Consumer United States
Primary
Secondary
Concomitant
Oedema Peripheral 5/1/2011 69 108 lb 12/13/2011 Consumer United States
Primary
Concomitant
Completed Suicide Death 37 Female 12/19/2011 Other Health Professional United States
Primary
Secondary
Completed Suicide Death 37 Female 12/19/2011 Other Health Professional United States
Primary
Secondary
Prostatic Specific Antigen Increased Life Threatening 9/30/2011 61 Male 124 lb 12/29/2011 Physician United States
Primary
Secondary
Concomitant
Self-medication Death 37 Female 1/18/2012 Physician United States
Primary
Secondary
Device Malfunction 4/1/2010 67 Male 1/27/2012 Consumer United States
Primary
Concomitant
Back Pain 8/13/2011 53 Female 1/28/2012 Consumer United States
Primary
Concomitant
Mobility Decreased 11/13/2011 69 Female 1/29/2012 Consumer United States
Primary
Concomitant
Oropharyngeal Pain 11/14/2011 69 Female 1/29/2012 Consumer United States
Primary
Concomitant
Dysarthria Hospitalization 10/1/2003 55 Male 185 lb 1/30/2012 Lawyer United States
Primary
Concomitant
Metastases To Lung Other Serious Female 2/7/2012 United States
Primary
Secondary
Concomitant
Hypocalcaemia Other Serious 2/5/2011 71 Female 177 lb 2/13/2012 Other Health Professional United States
Primary
Concomitant
Therapeutic Product Ineffective Required Intervention 8/30/2010 80 Male 260 lb 2/9/2012 Other Health Professional United States
Primary
Concomitant
Hypocalcaemia Other Serious 2/5/2011 71 Female 177 lb 2/27/2012 Other Health Professional United States
Primary
Concomitant
Aphasia Other Serious 2/20/2012 74 Female 165 lb 3/15/2012 Physician Germany
Primary
Concomitant
Medication Error Other Serious 4/2/2012 Consumer United States
Primary
Concomitant
Dyspnoea Hospitalization 10/25/2011 54 Male 5/21/2012 Physician United States
Primary
Secondary
Concomitant
Migraine Female 201 lb 5/22/2012 Consumer United States
Primary
Concomitant
Feeling Abnormal Female 201 lb 5/24/2012 Consumer United States
Primary
Concomitant
Interstitial Lung Disease Hospitalization 10/25/2011 54 Male 5/25/2012 Physician United States
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 10/25/2011 54 Male 179 lb 5/29/2012 Physician United States
Primary
Secondary
Concomitant
Pain Female 200 lb 5/29/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Tooth Loss 11/1/2011 56 Female 201 lb 5/29/2012 Other Health Professional United States
Primary
Concomitant
Amnesia 1/1/2011 74 Male 210 lb 6/4/2012 Consumer United States
Primary
Concomitant
Cardiac Arrest Death 1/1/2009 37 Female 6/3/2012 Physician United States
Primary
Secondary
Completed Suicide Death 37 Female 6/3/2012 Physician United States
Primary
Secondary
Cardio-respiratory Arrest Death 37 Female 6/5/2012 Physician United States
Primary
Secondary
Rash Macular Other Serious 6/2/2012 66 Female 163 lb 6/19/2012 Consumer Brazil
Primary
Concomitant
Dry Mouth Other Serious Female 6/19/2012 Consumer Brazil
Primary
Secondary
Somnolence 1/1/2011 74 Male 210 lb 6/24/2012 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis Other Serious 8/1/2011 54 Female 6/25/2012 Consumer United States
Primary
Concomitant
Initial Insomnia 3/12/2012 55 Female 225 lb 7/3/2012 Consumer United States
Primary
Concomitant
Interstitial Lung Disease Hospitalization 10/25/2011 54 Male 179 lb 7/6/2012 Physician United States
Primary
Secondary
Concomitant
Anxiety Other Serious 59 Male 196 lb 7/20/2012 Consumer United States
Primary
Concomitant
Memory Impairment 42 Female 140 lb 7/26/2012 Consumer United States
Primary
Concomitant
Flushing 4/1/2011 67 Female 8/3/2012 Consumer United States
Primary
Concomitant
Pruritus Generalised 2/24/2012 68 Male 195 lb 8/3/2012 Consumer United States
Primary
Concomitant
Diabetes Insipidus Other Serious Female 8/8/2012 Consumer Brazil
Primary
Concomitant

Drug Data